Ivan Lopez

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Histopathological and ultrastructural analysis of vestibular endorgans in Meniere's disease reveals basement membrane pathology
    Andrew A McCall
    Surgery Department, Division of Head and Neck David Geffen School of Medicine, at UCLA, Los Angeles, California, USA
    BMC Ear Nose Throat Disord 9:4. 2009
  2. ncbi request reprint Mild carbon monoxide exposure diminishes selectively the integrity of the cochlea of the developing rat
    Ivan Lopez
    Surgery Department, Division of Head and Neck, David Geffen School of Medicine, Los Angeles, California 90095, USA
    J Neurosci Res 74:666-75. 2003
  3. ncbi request reprint Immunolocalization of voltage-gated calcium channel alpha1 subunits in the chinchilla cochlea
    Ivan Lopez
    Department of Surgery, Division of Head and Neck, 31 25 Rehabilitation Center, UCLA School of Medicine, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Cell Tissue Res 313:177-86. 2003
  4. ncbi request reprint Time course of auditory impairment in mice lacking the electroneutral sodium bicarbonate cotransporter NBC3 (slc4a7)
    Ivan A Lopez
    Department of Surgery, Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Brain Res Dev Brain Res 160:63-77. 2005
  5. ncbi request reprint Stem/progenitor cells in the postnatal inner ear of the GFP-nestin transgenic mouse
    Ivan A Lopez
    Department of Surgery, Division of Head and Neck, 31 25 Rehabilitation Center, 1000 Veteran Avenue, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Int J Dev Neurosci 22:205-13. 2004
  6. ncbi request reprint Oxidative stress and the deleterious consequences to the rat cochlea after prenatal chronic mild exposure to carbon monoxide in air
    I A Lopez
    Surgery Department Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuroscience 151:854-67. 2008
  7. pmc Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air)
    Ivan A Lopez
    Mental Retardation Research Center, Neuroscience Research Building, Room 260C, 635 Charles E Young Drive South, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7332, USA
    BMC Neurosci 10:53. 2009
  8. doi request reprint Neuroglobin expression in the cochlea of rat pups exposed to chronic very mild carbon monoxide (25ppm) in air during and after the prenatal period
    Ivan A Lopez
    Dept of Surgery, Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Brain Res 1327:56-68. 2010
  9. ncbi request reprint Histopathology of the vestibular end organs after intratympanic gentamicin failure for Meniere's disease
    Gail Ishiyama
    Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Acta Otolaryngol 127:34-40. 2007
  10. ncbi request reprint Regional estimates of hair cells and supporting cells in the human crista ampullaris
    Ivan Lopez
    Surgery Department, Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurosci Res 82:421-31. 2005

Detail Information

Publications28

  1. pmc Histopathological and ultrastructural analysis of vestibular endorgans in Meniere's disease reveals basement membrane pathology
    Andrew A McCall
    Surgery Department, Division of Head and Neck David Geffen School of Medicine, at UCLA, Los Angeles, California, USA
    BMC Ear Nose Throat Disord 9:4. 2009
    ..Other findings included hair cell and supporting cell microvessicles, increased intercellular clear spaces in the stroma, and endothelial cell vacuolization and stromal perivascular BM thickening...
  2. ncbi request reprint Mild carbon monoxide exposure diminishes selectively the integrity of the cochlea of the developing rat
    Ivan Lopez
    Surgery Department, Division of Head and Neck, David Geffen School of Medicine, Los Angeles, California 90095, USA
    J Neurosci Res 74:666-75. 2003
    ..We conclude that components of the cochlea are selectively affected by mild chronic CO exposure during development...
  3. ncbi request reprint Immunolocalization of voltage-gated calcium channel alpha1 subunits in the chinchilla cochlea
    Ivan Lopez
    Department of Surgery, Division of Head and Neck, 31 25 Rehabilitation Center, UCLA School of Medicine, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Cell Tissue Res 313:177-86. 2003
    ..The presence of alpha1A, the pore-forming subunit of the P/Q type channels, has not previously been demonstrated in inner and outer hair cells, and its function in the cochlear hair cell is unknown...
  4. ncbi request reprint Time course of auditory impairment in mice lacking the electroneutral sodium bicarbonate cotransporter NBC3 (slc4a7)
    Ivan A Lopez
    Department of Surgery, Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Brain Res Dev Brain Res 160:63-77. 2005
    ..The vestibular sensory epithelia from slc4a7-/- mice were normal from P2 to P90. Damage of the sensory epithelia at the high frequency zone of the cochlea suggests that NBC3 may play an important physiological role in this region...
  5. ncbi request reprint Stem/progenitor cells in the postnatal inner ear of the GFP-nestin transgenic mouse
    Ivan A Lopez
    Department of Surgery, Division of Head and Neck, 31 25 Rehabilitation Center, 1000 Veteran Avenue, David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Int J Dev Neurosci 22:205-13. 2004
    ....
  6. ncbi request reprint Oxidative stress and the deleterious consequences to the rat cochlea after prenatal chronic mild exposure to carbon monoxide in air
    I A Lopez
    Surgery Department Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuroscience 151:854-67. 2008
    ....
  7. pmc Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air)
    Ivan A Lopez
    Mental Retardation Research Center, Neuroscience Research Building, Room 260C, 635 Charles E Young Drive South, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7332, USA
    BMC Neurosci 10:53. 2009
    ..Quantitative real time PCR assays were performed for inducible (iNOS), neuronal (nNOS), and endothelial (eNOS) nitric oxide synthases...
  8. doi request reprint Neuroglobin expression in the cochlea of rat pups exposed to chronic very mild carbon monoxide (25ppm) in air during and after the prenatal period
    Ivan A Lopez
    Dept of Surgery, Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Brain Res 1327:56-68. 2010
    ....
  9. ncbi request reprint Histopathology of the vestibular end organs after intratympanic gentamicin failure for Meniere's disease
    Gail Ishiyama
    Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Acta Otolaryngol 127:34-40. 2007
    ..Objective: To describe the histopathology and morphometry of the vestibular end organs from a 59-year-old Meniere's patient who underwent transmastoid labyrinthectomy for recurrent vertigo after failed intratympanic gentamicin...
  10. ncbi request reprint Regional estimates of hair cells and supporting cells in the human crista ampullaris
    Ivan Lopez
    Surgery Department, Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurosci Res 82:421-31. 2005
    ..34+/-0.10, and HC density was 0.63 cells/100 microm2. A significant decline in type I, type II, and total HC number and density was found in groups 2 and 3, with individuals exceeding the average human life span...
  11. ncbi request reprint Unbiased quantification of Scarpa's ganglion neurons in aminoglycoside ototoxicity
    Gail Ishiyama
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Vestib Res 15:197-202. 2005
    ..109). These findings may be consistent with either retrograde degeneration or a direct neurotoxic effect of the aminoglycosides on the vestibular ganglion neuron...
  12. ncbi request reprint Limiting iron availability confers neuroprotection from chronic mild carbon monoxide exposure in the developing auditory system of the rat
    Douglas S Webber
    Mental Retardation Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Neurosci Res 80:620-33. 2005
    ....
  13. pmc Unbiased stereological estimation of the spiral ligament and stria vascularis volumes in aging and Ménière's disease using archival human temporal bones
    Gail Ishiyama
    Neurology Department, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    J Assoc Res Otolaryngol 8:8-17. 2007
    ....
  14. ncbi request reprint Estimation of the number of nerve fibers in the human vestibular endorgans using unbiased stereology and immunohistochemistry
    Ivan Lopez
    Division of Head and Neck Surgery, CHS 62 132, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Neurosci Methods 145:37-46. 2005
    ..These methods can be applied for studies of normal aging and pathological conditions of the vestibular periphery...
  15. ncbi request reprint Canavan's leukodystrophy is associated with defects in cochlear neurodevelopment and deafness
    Gail Ishiyama
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neurology 60:1702-4. 2003
    ..The vestibular end organs and ganglia were normal. These findings implicate a role of aminoacylase II in the neurodevelopment of the organ of Corti...
  16. ncbi request reprint Murine auditory brainstem evoked response: putative two-channel differentiation of peripheral and central neural pathways
    Gary Galbraith
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles 90095 7332, USA
    J Neurosci Methods 153:214-20. 2006
    ..10 ms. Results in wild type (WT) and knockout (KO) mice, as well as rats, show significant differences in absolute latencies as well as CCT...
  17. ncbi request reprint Unbiased quantification of the microdissected human Scarpa's ganglion neurons
    Akira Ishiyama
    Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Laryngoscope 114:1496-9. 2004
    ..The objective of the present study was to obtain unbiased estimates of the total number of Scarpa's vestibular ganglion neurons in individuals with normal vestibular function...
  18. ncbi request reprint Unbiased stereologic type I and type II hair cell counts in human utricular macula
    Quinton Gopen
    Division of Head and Neck Surgery, Medical Center, University of California Los Angeles School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Laryngoscope 113:1132-8. 2003
    ..The objective of the study was to obtain unbiased estimates of the total number of type I and type II hair cells in human utricular macula from individuals with documented normal vestibular function...
  19. ncbi request reprint Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3
    Dean Bok
    Department of Neurobiology, Jules Stein Eye Institute, Los Angeles, California, 90095, USA
    Nat Genet 34:313-9. 2003
    ..Our results indicate that in certain sensory organs, in which the requirement to transduce specific environmental signals with speed, sensitivity and reliability is paramount, the choice of the H+ disposal mechanism used is limited...
  20. ncbi request reprint Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit
    Nora Rozengurt
    Department of Pathology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Hear Res 177:71-80. 2003
    ..in stria vascularis, Kir4.1 helps to generate the cochlear endolymph; and (2). in spiral and vestibular ganglia, Kir4.1 in surrounding glial cells helps to support the spiral and vestibular ganglion neurons and their projecting axons...
  21. ncbi request reprint Subcellular immunolocalization of NMDA receptor subunit NR1, 2A, 2B in the rat vestibular periphery
    Gail Ishiyama
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Brain Res 935:16-23. 2002
    ..The receptor subtype(s) may be a combination of NR1/NR2A, NR1/NR2B, and/or NR1/NR2A/NR2B...
  22. ncbi request reprint Synaptophysin immunohistochemistry during vestibular hair cell recovery after gentamicin treatment
    Ivan Lopez
    Victor Goodhill Ear Center, Division of Head and Neck Surgery, School of Medicine, University of California, Los Angeles, Calif 90095 1624, USA
    Audiol Neurootol 8:80-90. 2003
    ..Also, these results demonstrate a significant level of reinnervation of the newly regenerated hair cells, forecasting the potential for functionality of the regenerated hair cells...
  23. ncbi request reprint In vivo and in vitro localization of brain-derived neurotrophic factor, fibroblast growth factor-2 and their receptors in the bullfrog vestibular end organs
    Ricardo Cristobal
    Victor Goodhill Ear Center, Division of Head and Neck Surgery, University of California, Los Angeles School of Medicine, CHS, Room 62 129, 10833 Le Conte Ave, Los Angeles, CA 90095 1624, USA
    Brain Res Mol Brain Res 102:83-99. 2002
    ..The findings suggest that BDNF has a role in the maintenance of the vestibular epithelia while FGF-2 may regulate the proliferation of supporting cells...
  24. doi request reprint Opsoclonus: clinical and immunological features
    Joanna C Jen
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, United States
    J Neurol Sci 320:61-5. 2012
    ..Opsoclonus is felt to be a saccadic oscillation disorder but the neuroanatomical substrate for generating the abnormal eye movements is poorly understood...
  25. ncbi request reprint Application of unbiased stereology on archival human temporal bone
    Yong Tang
    Department of Neurology, University of California Los Angeles School of Medicine, 90095, USA
    Laryngoscope 112:526-33. 2002
    ..The current report presents unbiased stereological sampling and counting strategies for estimating the total number of neurons in the spiral and vestibular ganglia of the archival human temporal bone...
  26. ncbi request reprint Gene expression analysis of distinct populations of cells isolated from mouse and human inner ear FFPE tissue using laser capture microdissection--a technical report based on preliminary findings
    Nitin A Pagedar
    Department of Otolaryngology Head and Neck Surgery, University Hospitals of Cleveland, Lakeside 4500, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Brain Res 1091:289-99. 2006
    ..Also, this method can be applied for analysis of human archival ear tissue...
  27. pmc Human temporal bone consortium for research resource enhancement
    Saumil N Merchant
    Otol Neurotol 29:271-4. 2008
  28. ncbi request reprint Calcitonin gene-related Peptide and choline acetyltransferase colocalization in the human vestibular periphery
    Paul Popper
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Audiol Neurootol 7:298-302. 2002
    ..As in the animal models, no CGRPi was found within Scarpa's ganglion. This study provides evidence for CGRPi in the human vestibular periphery and validates the biomedical relevance of the current animal models...