Coeli M B Lopes

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies
    Coeli M B Lopes
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Neuron 34:933-44. 2002
  2. ncbi request reprint Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels
    Coeli M B Lopes
    Department of Medicine, Cardiovascular Research Institute, University of Rochester, Rochester, New York 14642, USA
    Channels (Austin) 1:124-34. 2007
  3. doi request reprint Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients
    Christian Jons
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Sci Transl Med 3:76ra28. 2011
  4. ncbi request reprint PKA and PKC partially rescue long QT type 1 phenotype by restoring channel-PIP2 interactions
    Alessandra Matavel
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY, USA
    Channels (Austin) 4:3-11. 2010
  5. pmc Ion channel mechanisms related to sudden cardiac death in phenotype-negative long-QT syndrome genotype-phenotype correlations of the KCNQ1(S349W) mutation
    Samuel Horr
    Cardiology Division, Department of Medicine, Cardiovascular Research Institute Department of Nephrology, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 22:193-200. 2011
  6. pmc Molecular basis of decreased Kir4.1 function in SeSAME/EAST syndrome
    David M Williams
    Department of Medicine, Nephrology Division, University of Rochester, Rochester, New York 14642, USA
    J Am Soc Nephrol 21:2117-29. 2010
  7. pmc PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors
    Alessandra Matavel
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    J Mol Cell Cardiol 46:704-12. 2009
  8. doi request reprint Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1
    Bong Sook Jhun
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester, Rochester, NY, USA
    Circ Res 110:59-70. 2012
  9. pmc A novel mitochondrial K(ATP) channel assay
    Andrew P Wojtovich
    Department of Pharmacology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Circ Res 106:1190-6. 2010
  10. ncbi request reprint PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents
    Hailin Zhang
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Neuron 37:963-75. 2003

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies
    Coeli M B Lopes
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Neuron 34:933-44. 2002
    ..We find basic residues that interact with PIP(2), two of which have been associated with Andersen's and Bartter's syndromes. We show that several naturally occurring mutants decrease channel-PIP(2) interactions, leading to disease...
  2. ncbi request reprint Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels
    Coeli M B Lopes
    Department of Medicine, Cardiovascular Research Institute, University of Rochester, Rochester, New York 14642, USA
    Channels (Austin) 1:124-34. 2007
    ..Our results suggest that PKA phosphorylation of these channels affects Gq-coupled receptor inhibition through modulation of the channel sensitivity to PIP2...
  3. doi request reprint Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients
    Christian Jons
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Sci Transl Med 3:76ra28. 2011
    ..Our results indicate that genotype and biophysical phenotype analysis may be useful for risk stratification of LQT1 patients and suggest that slow channel activation is associated with an increased risk of cardiac events...
  4. ncbi request reprint PKA and PKC partially rescue long QT type 1 phenotype by restoring channel-PIP2 interactions
    Alessandra Matavel
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, Rochester, NY, USA
    Channels (Austin) 4:3-11. 2010
    ..Our data indicates that stimulation by PKA and PKC can partially rescue LQT1 mutant channels with weakened response to PIP(2) by strengthening channel interactions with PIP(2)...
  5. pmc Ion channel mechanisms related to sudden cardiac death in phenotype-negative long-QT syndrome genotype-phenotype correlations of the KCNQ1(S349W) mutation
    Samuel Horr
    Cardiology Division, Department of Medicine, Cardiovascular Research Institute Department of Nephrology, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 22:193-200. 2011
    ....
  6. pmc Molecular basis of decreased Kir4.1 function in SeSAME/EAST syndrome
    David M Williams
    Department of Medicine, Nephrology Division, University of Rochester, Rochester, New York 14642, USA
    J Am Soc Nephrol 21:2117-29. 2010
    ..In conclusion, perturbed pH gating may underlie the loss of channel function for the disease-associated mutant Kir4.1 channels and may have important physiologic consequences...
  7. pmc PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors
    Alessandra Matavel
    Cardiovascular Research Institute, Department of Medicine, University of Rochester, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    J Mol Cell Cardiol 46:704-12. 2009
    ..Our results indicate that the depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC of the KCNE1 subunit underlies the GqPCR-mediated channel activation...
  8. doi request reprint Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1
    Bong Sook Jhun
    Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester, Rochester, NY, USA
    Circ Res 110:59-70. 2012
    ..ObjecTIVE: To determine if Rem1 function is physiologically regulated by adrenergic signaling and thus impacts voltage-gated L-type calcium channel (VLCC) activity in the heart...
  9. pmc A novel mitochondrial K(ATP) channel assay
    Andrew P Wojtovich
    Department of Pharmacology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Circ Res 106:1190-6. 2010
    ..The validity of current methods to assay mK(ATP) activity is disputed...
  10. ncbi request reprint PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents
    Hailin Zhang
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Neuron 37:963-75. 2003
    ..Finally, native or recombinant channels inhibited by muscarinic agonists can be activated by PIP(2). Our data strongly suggest that PIP(2) acts as a membrane-diffusible second messenger to regulate directly the activity of KCNQ currents...
  11. ncbi request reprint PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain
    Tibor Rohacs
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1218, New York, New York 10029, USA
    Nat Neurosci 8:626-34. 2005
    ..These data suggest that the TRP domain of these channels may serve as a PI(4,5)P(2)-interacting site and that regulation by PI(4,5)P(2) is a common feature of members of the TRP channel family...
  12. pmc PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels
    Coeli M B Lopes
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Physiol 564:117-29. 2005
    ..Our results suggest that PIP2 is a common gating molecule for K+ channel families despite their distinct structures and physiological properties...
  13. ncbi request reprint Sorcin regulates excitation-contraction coupling in the heart
    Marian B Meyers
    Department of Medicine and Pediatrics, New York University School of Medicine, New York, New York, 10016, USA
    J Biol Chem 278:28865-71. 2003
    ..Together, these data indicate that sorcin modulates intracellular Ca2+ cycling and Ca2+ influx pathways in the heart...
  14. pmc Specificity of activation by phosphoinositides determines lipid regulation of Kir channels
    Tibor Rohacs
    Department of Physiology and Biophysics, Mount Sinai School of Medicine of New York University, New York, NY 10029, USA
    Proc Natl Acad Sci U S A 100:745-50. 2003
    ..1 channel decreasing phosphoinositide specificity allow activation by LC acyl-CoA. Our data demonstrate that differences in phosphoinositide specificity determine the modulation of Kir channel activity by distinct regulatory lipids...