Adriana Lopes

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc PKC phosphorylates HEXIM1 and regulates P-TEFb activity
    Koh Fujinaga
    Departments of Medicine, Microbiology and Immunology, Rosalind Russell Research Center, University of California, San Francisco, San Francisco, CA 94143 0703, USA
    Nucleic Acids Res 40:9160-70. 2012
  2. pmc Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription
    Kristina Zumer
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Nucleic Acids Res 39:7908-19. 2011
  3. pmc Lost in transcription: molecular mechanisms that control HIV latency
    Ran Taube
    The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva 84105, Israel
    Viruses 5:902-27. 2013
  4. pmc Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages
    Xavier Contreras
    Universite Paul Sabatier, EA 3038, 118 route de Narbonne, Toulouse 31062, France
    Retrovirology 9:37. 2012
  5. pmc Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes
    Kristina Zumer
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Mol Cell Biol 32:1354-62. 2012
  6. pmc Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1
    Luciana J Costa
    Molecular Virology Laboratory, Dep of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Retrovirology 3:33. 2006
  7. pmc 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription
    B Matija Peterlin
    Department of Medicine, Rosalind Russel Medical Research Center, University of California, San Francisco, CA, USA
    Wiley Interdiscip Rev RNA 3:92-103. 2012
  8. ncbi request reprint Controlling the elongation phase of transcription with P-TEFb
    B Matija Peterlin
    Department of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, San Francisco, California 94143, USA
    Mol Cell 23:297-305. 2006
  9. pmc Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element
    Koh Fujinaga
    Department of Medicine, Rosalind Russell Medical Research Center, University of California at San Francisco, 3rd and Parnassus Avenue, San Francisco, CA 94143 0703, USA
    Mol Cell Biol 24:787-95. 2004
  10. pmc Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression
    Koh Fujinaga
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0703, USA
    J Virol 76:10873-81. 2002

Research Grants

  1. Tat Transactivation
    BORIS PETERLIN; Fiscal Year: 2001
  2. CIITA and MHC II Transcription
    BORIS PETERLIN; Fiscal Year: 2006
  3. Tat Transactivation
    BORIS PETERLIN; Fiscal Year: 2006
  4. Tat Transactivation
    B Matija Peterlin; Fiscal Year: 2007
  5. CIITA and MHC II Transcription
    BORIS PETERLIN; Fiscal Year: 2007
  6. Tat Transactivation
    BORIS PETERLIN; Fiscal Year: 2009
  7. Tat Transactivation
    BORIS MATIJA PETERLIN; Fiscal Year: 2010
  8. Tat Transactivation
    BORIS MATIJA PETERLIN; Fiscal Year: 2011
  9. Mechanism of HIV 1 Nef Action
    BORIS PETERLIN; Fiscal Year: 2006
  10. Mechanism of HIV 1 Nef Action
    BORIS PETERLIN; Fiscal Year: 2005

Collaborators

Detail Information

Publications52

  1. pmc PKC phosphorylates HEXIM1 and regulates P-TEFb activity
    Koh Fujinaga
    Departments of Medicine, Microbiology and Immunology, Rosalind Russell Research Center, University of California, San Francisco, San Francisco, CA 94143 0703, USA
    Nucleic Acids Res 40:9160-70. 2012
    ..These results indicate that the phosphorylation of HEXIM1 by PKC represents a major regulatory step of P-TEFb activity in cells...
  2. pmc Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription
    Kristina Zumer
    Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia
    Nucleic Acids Res 39:7908-19. 2011
    ..Indeed, the inhibition of CDK9, the kinase subunit of P-TEFb, inhibited AIRE-induced pre-mRNA splicing of these genes. Thus, AIRE requires P-TEFb to activate transcription elongation and co-transcriptional processing of target genes...
  3. pmc Lost in transcription: molecular mechanisms that control HIV latency
    Ran Taube
    The Shraga Segal Department of Microbiology Immunology and Genetics, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 653, Beer Sheva 84105, Israel
    Viruses 5:902-27. 2013
    ....
  4. pmc Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages
    Xavier Contreras
    Universite Paul Sabatier, EA 3038, 118 route de Narbonne, Toulouse 31062, France
    Retrovirology 9:37. 2012
    ..Of note, current antiviral therapies do not target macrophages efficiently. Previously, it was demonstrated that interactions between CCR5 and gp120 stimulate PKC. However, the PKC isozymes involved were not identified...
  5. pmc Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes
    Kristina Zumer
    Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Mol Cell Biol 32:1354-62. 2012
    ..Importantly, mutations in the putative DNA-binding residues in its SAND domain had no effect on the transcriptional effects of AIRE. Thus, AIRE is recruited to TRA genes in chromatin via cooperative interactions with H3K4me0 and DNA-PK...
  6. pmc Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1
    Luciana J Costa
    Molecular Virology Laboratory, Dep of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Retrovirology 3:33. 2006
    ..In this report, we investigated further the ability of Nef to facilitate the replication of HIV-1...
  7. pmc 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription
    B Matija Peterlin
    Department of Medicine, Rosalind Russel Medical Research Center, University of California, San Francisco, CA, USA
    Wiley Interdiscip Rev RNA 3:92-103. 2012
    ..Regulated release of P-TEFb determines the expression pattern of many of the genes that respond to environmental stimuli and regulate growth, proliferation, and differentiation of cells...
  8. ncbi request reprint Controlling the elongation phase of transcription with P-TEFb
    B Matija Peterlin
    Department of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, San Francisco, California 94143, USA
    Mol Cell 23:297-305. 2006
    ..Phylogenetic analyses of the components of the human elongation control machinery indicate that the number of mechanisms utilized to regulate P-TEFb function increased as organisms developed more complex developmental patterns...
  9. pmc Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element
    Koh Fujinaga
    Department of Medicine, Rosalind Russell Medical Research Center, University of California at San Francisco, 3rd and Parnassus Avenue, San Francisco, CA 94143 0703, USA
    Mol Cell Biol 24:787-95. 2004
    ..These results better define the transition from abortive to productive transcription and thus replication of HIV...
  10. pmc Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression
    Koh Fujinaga
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0703, USA
    J Virol 76:10873-81. 2002
    ..This chimera inhibited Tat transactivation and HIV gene expression in human cells. Therefore, this dominant-negative kinase-inactive mutant Cdk9.hCycT1 chimera could be used for antiviral gene therapy...
  11. pmc Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes
    Ran Taube
    Howard Hughes Medical Institute, Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0703, USA
    Mol Cell Biol 22:321-31. 2002
    ..This binding was required for the subsequent expression of full-length transcripts from target genes. Thus, P-TEFb could mediate effects of enhancers on the elongation of transcription...
  12. pmc Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells
    Xavier Contreras
    Department of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:6782-9. 2009
    ..Thus SAHA, which is a Food and Drug Administration-approved drug, might be considered to accelerate the decay of the latent reservoir in HAART-treated infected humans...
  13. ncbi request reprint Transcriptional interference antagonizes proviral gene expression to promote HIV latency
    Tina Lenasi
    Department of Medicine, Rosalind Russell Medical Research Center, University of California San Francisco, San Francisco, CA 94143, USA
    Cell Host Microbe 4:123-33. 2008
    ..Collectively, our findings suggest that TI contributes significantly to HIV latency and should be considered when attempting to purge the latent reservoir...
  14. pmc Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir
    Xin Lin
    Department of Medicine, San Francisco General Hospital, Center For AIDS Research and Department of Pathology, University of California, San Francisco, USA
    J Virol 77:8227-36. 2003
    ..In their cells, T-cell activation or exogenous Tat could induce viral replication equivalently. Thus, P-TEFb could activate the majority of the latent HIV, in this case by Tat...
  15. pmc AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells
    Irena Oven
    Department of Medicine, Rosalind Russell Medical Research Center, University of California San Francisco, San Francisco, California 94143 0703, USA
    Mol Cell Biol 27:8815-23. 2007
    ..Our findings reveal critical steps by which AIRE regulates the transcription of genes that control central tolerance in the thymus...
  16. ncbi request reprint Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
    Warner C Greene
    Gladstone Institute of Virology and Immunology, Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    Nat Med 8:673-80. 2002
    ..Understanding the dynamic interplay of host cell and virus is essential to the effort to eradicate HIV...
  17. ncbi request reprint Hide, shield and strike back: how HIV-infected cells avoid immune eradication
    B Matija Peterlin
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, California 94143 0703, USA
    Nat Rev Immunol 3:97-107. 2003
    ..A better understanding of these strategies might lead to new approaches in the fight against AIDS...
  18. pmc A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb
    Fan Zhang
    Departments of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California at San Francisco, San Francisco, CA 94143, USA
    Genes Dev 17:748-58. 2003
    ..It binds CycT1 via an alanine-containing heptapeptide repeat and inhibits transcriptional elongation. Thus, our findings reveal a new mechanism by which repressors inhibit eukaryotic transcription...
  19. pmc Distal regulation of alternative splicing by splicing enhancer in equine beta-casein intron 1
    Tina Lenasi
    University of Ljubljana, Biotechnical Faculty, Department of Animal Science, Groblje, Slovenia
    RNA 12:498-507. 2006
    ..Thus, the ISE1 remains in close proximity to the mRNA exit groove throughout transcription and influences all weak exons as soon as they are copied...
  20. ncbi request reprint P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA
    Xin Lin
    Department of Medicine, University of California at San Francisco, California 94143 0703, USA
    J Biol Chem 277:16873-8. 2002
    ..Moreover, these transcriptional effects required the CTD of RNAPII in cells. Thus, CycK functions as P-TEFb only via RNA, which suggests the presence of cellular RNA-bound activators that require CycK for their transcriptional activity...
  21. pmc Runx1 binds positive transcription elongation factor b and represses transcriptional elongation by RNA polymerase II: possible mechanism of CD4 silencing
    Huimin Jiang
    Department of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California at San Francisco, 94143 0703, USA
    Mol Cell Biol 25:10675-83. 2005
    ..These results suggest that active repression by Runx1 occurs by blocking the elongation by RNAPII, which may contribute to CD4 silencing during T-cell development...
  22. pmc Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cells
    Yong Hui Zheng
    Department of Medicine, Rosalind Russell Arthritis Research Center, University of California, San Francisco, CA 94143 0703, USA
    Retrovirology 2:25. 2005
    ..These processes also offer a tantalizing glimpse at basic cellular mechanisms that might restrict the movement of mobile genetic elements and protect the genome...
  23. ncbi request reprint Newly identified host factors modulate HIV replication
    Yong Hui Zheng
    Department of Medicine, Rosalind Russell Arthritis Research Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Immunol Lett 97:225-34. 2005
  24. pmc A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation
    Matjaz Barboric
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, USA
    PLoS Biol 3:e76. 2005
  25. ncbi request reprint Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb
    Takeshi Kurosu
    Department of Medicine, Rosalind Russell Medical Research Center, University of California at San Francisco, San Francisco, CA 94143 0703, USA
    Gene 343:173-9. 2004
    ..Moreover, this domain bound RNAPII via its CTD and PIE-1 blocked its effects. Thus, CycT2 not only contains two domains that target RNAPII but this substrate recognition is necessary for its transcriptional activity via DNA...
  26. doi request reprint Tat-SIRT1 tango
    Dalibor Blazek
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, San Francisco, CA 94143 0703, USA
    Mol Cell 29:539-40. 2008
    ..2008) report that the human immunodeficiency virus (HIV) transactivator Tat inhibits the SIRT1 deacetylase, resulting in increased acetylation of the NF-kappaB p65 subunit and subsequently in T cell hyperactivation...
  27. ncbi request reprint APOBEC3 proteins and reverse transcription
    Renato S Aguiar
    Department of Medicine, Microbiology and Immunology, University of California, San Francisco UCSF, 533 Parnassus Avenue U422, San Francisco, CA 94143 0703, USA
    Virus Res 134:74-85. 2008
    ..Together, these proteins provide strong and immediate intracellular immunity against incoming pathogens and restrict the movement of mobile genetic elements protecting the genome...
  28. pmc 7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development
    Matjaz Barboric
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143 0703, USA
    Proc Natl Acad Sci U S A 106:7798-803. 2009
    ..These findings reveal a key role for P-TEFb in coupling transcription elongation with alternative splicing, and suggest that maintaining core 7SK snRNP is essential for vertebrate development...
  29. ncbi request reprint c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis
    Satoshi Kanazawa
    Departments of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143 0703, USA
    Oncogene 22:5707-11. 2003
    ..Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc...
  30. pmc Major histocompatibility complex class II transcriptional platform: assembly of nuclear factor Y and regulatory factor X (RFX) on DNA requires RFX5 dimers
    Nabila Jabrane-Ferrat
    Department of Surgery, University of California San Francisco, San Francisco, CA 94115 0703, USA
    Mol Cell Biol 22:5616-25. 2002
    ..These findings offer one explanation of why in the Bare Lymphocyte Syndrome, which is a congenital severe combined immunodeficiency, MHC-II promoters are bare when any subunit of RFX is mutated or missing...
  31. ncbi request reprint Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells
    Yong Hui Zheng
    Department of Medicine, Rosalind Russell Medical Research Center, Mt Zion Research Building Room N231, 2340 Sutter Street, University of California, San Francisco, CA 94115, USA
    Nat Cell Biol 5:611-8. 2003
    ..A single substitution in hp32 of Gly 35 to Asp 35, which is found in mp32, abrogates this activity. Thus, hp32 overcomes an important post-transcriptional block to HIV replication in murine cells...
  32. pmc Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb
    Matjaz Barboric
    Department of Medicine, Rosalind Russell Medical Research Center, University of California at San Francisco, San Francisco, CA 94143 0703, USA
    EMBO J 24:4291-303. 2005
    ..We propose a model where the interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct its binding to P-TEFb and subcellular localization that culminates in the inhibition of transcription...
  33. pmc Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication
    Yong Hui Zheng
    Departments of Medicine, Microbiology, and Immunology, University of California, San Francisco, 3rd and Parnassus Ave, San Francisco, CA 94143 0703, USA
    J Virol 78:6073-6. 2004
    ..Thus, APOBEC family members might have evolved as a general defense mechanism of the body against retroviruses, retrotransposons, and other mobile genetic elements...
  34. pmc Ubiquitylation of Cdk9 by Skp2 facilitates optimal Tat transactivation
    Matjaz Barboric
    Rosalind Russell Medical Research Center, Department of Medicine, University of California, San Francisco, 94143, USA
    J Virol 79:11135-41. 2005
    ..Thus, our findings underscore the requirement of ubiquitylation for the coactivator function in regulating HIV-1 transcriptional elongation...
  35. pmc A minimal chimera of human cyclin T1 and tat binds TAR and activates human immunodeficiency virus transcription in murine cells
    Koh Fujinaga
    Departments of Medicine, Microbiology and Immunology, UCSF Mt Zion Cancer Center, University of California at San Francisco, 2340 Sutter Street, San Francisco, CA 94143 0703, USA
    J Virol 76:12934-9. 2002
    ..We conclude that this minimal chimera not only reproduces the high-affinity binding among P-TEFb, Tat, and TAR but also will be invaluable for determining the three-dimensional structure of this RNA-protein complex...
  36. ncbi request reprint Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA
    Kenneth E Lind
    Department of Pharmaceutical Chemistry, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Chem Biol 9:185-93. 2002
    ..Eleven compounds (between 0.1 and 1 microM) inhibited the Tat-TAR interaction, and some inhibited Tat transactivation in cells. NMR spectra verified specific binding to the 5' bulge and no interaction with other regions of TAR...
  37. ncbi request reprint Vpr.A3A chimera inhibits HIV replication
    Renato S Aguiar
    Department of Medicine, Microbiology, and Immunology, University of California at San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143 0703, USA
    J Biol Chem 283:2518-25. 2008
    ..Thus, by targeting appropriately a potent single domain cytidine deaminase, we rendered HIV and simian immunodeficiency virus restriction resistant to Vif...
  38. ncbi request reprint VP16 and ubiquitin; binding of P-TEFb via its activation domain and ubiquitin facilitates elongation of transcription of target genes
    Takeshi Kurosu
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, San Francisco, CA 94115, USA
    Curr Biol 14:1112-6. 2004
    ..Thus, the ubiquitylation of AADs increases their interaction with P-TEFb and augments rates of elongation of transcription...
  39. pmc Genetic analysis of P-TEFb function via heterologous nucleic acid tethering systems
    Qintong Li
    Departments of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California San Francisco, San Francisco, CA 94143, USA
    Methods 48:375-80. 2009
    ..In this paper, we describe various heterologous nucleic acid tethering systems that can be used to examine transcription factors that function via P-TEFb...
  40. pmc Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb
    Dalibor Blazek
    Department of Medicine, Rosalind Russell Medical Research Center, University of California at San Francisco, San Francisco, CA 94143 0703, USA
    Nucleic Acids Res 33:7000-10. 2005
    ..Our results suggest that two independent regions in HEXIM1 form oligomers to incorporate P-TEFb into the large complex and determine the inhibition of transcriptional elongation...
  41. pmc Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene
    Audrey Low
    Department of Molecular Biology and Biochemistry, and Cancer Research Institute, University of California, Irvine, California 92697 3905, USA
    Virology 385:455-63. 2009
    ..These studies indicate that mA3 restricts replication and pathogenesis of M-MuLV in vivo...
  42. ncbi request reprint Mutation in a winged-helix DNA-binding motif causes atypical bare lymphocyte syndrome
    Nada Nekrep
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143 0703, USA
    Nat Immunol 3:1075-81. 2002
    ..Its wild-type counterpart restored binding of the RFX complex to DNA, transcription of all MHC class II genes and the appearance of these determinants on the surface of BLS cells...
  43. pmc Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
    Maureen A Su
    Diabetes Center, Department of Pediatric, UCSF, San Francisco, California 94143, USA
    J Clin Invest 118:1712-26. 2008
    ..Together, these results may demonstrate a mechanism by which autoimmune predisposition to phenotypes distinct from APS 1 can be mediated in a dominant-negative fashion by Aire...
  44. pmc Differential chromatin looping regulates CD4 expression in immature thymocytes
    Huimin Jiang
    Departments of Medicine, Microbiology, and Immunology, Rosalind Russell Medical Research Center, University of California at San Francisco, San Francisco, California 94143, USA
    Mol Cell Biol 28:907-12. 2008
    ..Thus, differential looping and decoying of P-TEFb away from the promoter mediate active repression of the CD4 gene during thymocyte development...
  45. pmc Nef binds p6* in GagPol during replication of human immunodeficiency virus type 1
    Luciana J Costa
    Department of Medicine, University of California San Francisco, UCSF Mt Zion Cancer Center, 2340 Sutter Street, San Francisco, CA 94115, USA
    J Virol 78:5311-23. 2004
    ..Our data demonstrate that the retention of Nef in the intermediate compartment interferes with viral replication and suggest a new role for Nef in the production of HIV-1...
  46. pmc HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription
    Xavier Contreras
    Department of Medicine, Rosalind Russell Medical Research Center, University of California San Francisco, San Francisco, California, USA
    PLoS Pathog 3:1459-69. 2007
    ..Thus, our studies reveal how HIV transcription is induced by HMBA and suggest how modifications in the equilibrium between active and inactive P-TEFb could contribute to cell differentiation...
  47. pmc Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions
    Yong Hui Zheng
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143 0703, USA
    Proc Natl Acad Sci U S A 100:8460-5. 2003
    ..Thus, Nef also transports newly synthesized cholesterol to the site of viral budding. As such, it provides essential building blocks for the formation of viruses that replicate optimally in the host...
  48. pmc P bodies inhibit retrotransposition of endogenous intracisternal a particles
    Chunye Lu
    Department of Medicine, Microbiology, University of California at San Francisco, San Francisco, California 94143 0703, USA
    J Virol 85:6244-51. 2011
    ..Although IAP mRNA localized to P bodies, Gag was targeted to the endoplasmic reticulum (ER), from which IAP buds. Thus, by sequestering IAP mRNA away from Gag, P bodies inhibit rather than promote IAP retrotransposition...
  49. pmc Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters
    Jiri Kohoutek
    Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143 0703, USA
    Proc Natl Acad Sci U S A 103:17349-54. 2006
    ..Thus, modulating ratios between active and inactive P-TEFb complexes is an additional mechanism of regulating transcriptional activators such as CIITA...
  50. ncbi request reprint Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery
    Matthias Geyer
    Department of Medicine, University of California, San Francisco, California 94143 0703, USA
    J Biol Chem 277:28521-9. 2002
    ..Finally, blocking the expression of V1H decreased the enhancement of virion infectivity by Nef. Thus, V1H can function as an adaptor for interactions between Nef and AP-2...
  51. pmc HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4+ T cells
    Metka Lenassi
    Departments of Medicine, Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    Traffic 11:110-22. 2010
    ..Thus, HIV-infected cells export Nef in bioactive vesicles, which facilitate the depletion of CD4(+) T cells that is a hallmark of acquired immunodeficiency syndrome (AIDS)...
  52. ncbi request reprint Sequential modifications in class II transactivator isoform 1 induced by lipopolysaccharide stimulate major histocompatibility complex class II transcription in macrophages
    Gorazd Drozina
    Department of Medicine, Rosalind Russell Medical Research Center, University of California San Francisco, San Francisco, California 94143, USA
    J Biol Chem 281:39963-70. 2006
    ..Subsequent polyubiquitylation results in the degradation of CIITA isoform 1. Thus, the signaling cascade from Toll-like receptor 4 to CIITA isoform 1 represents one connection between innate and adaptive immunity in macrophages...

Research Grants21

  1. Tat Transactivation
    BORIS PETERLIN; Fiscal Year: 2001
    ..Findings in vitro will be correlated with chromatin immunoprecipitations in cells. ..
  2. CIITA and MHC II Transcription
    BORIS PETERLIN; Fiscal Year: 2006
    ..Collectively, these studies will reveal the normal physiology of CIITA, why it oligomerizes and shuttles, and create new tools to manipulate the immune response in health and disease. ..
  3. Tat Transactivation
    BORIS PETERLIN; Fiscal Year: 2006
    ..These studies will reveal the complex RNA-protein world of P-TEFb and how HIV subverts these cellular complexes for its replication in cells. ..
  4. Tat Transactivation
    B Matija Peterlin; Fiscal Year: 2007
    ..These studies will reveal the complex RNA-protein world of P-TEFb and how HIV subverts these cellular complexes for its replication in cells. ..
  5. CIITA and MHC II Transcription
    BORIS PETERLIN; Fiscal Year: 2007
    ..Collectively, these studies will reveal the normal physiology of CIITA, why it oligomerizes and shuttles, and create new tools to manipulate the immune response in health and disease. ..
  6. Tat Transactivation
    BORIS PETERLIN; Fiscal Year: 2009
    ..These studies will reveal the complex RNA-protein world of P-TEFb and how HIV subverts these cellular complexes for its replication in cells. ..
  7. Tat Transactivation
    BORIS MATIJA PETERLIN; Fiscal Year: 2010
    ..These studies will reveal the complex RNA-protein world of P-TEFb and how HIV subverts these cellular complexes for its replication in cells. ..
  8. Tat Transactivation
    BORIS MATIJA PETERLIN; Fiscal Year: 2011
    ..This proposal will investigate how Tat uses these complexes for optimal HIV replication and how these Cdks could be manipulated pharmacologically in the future. ..
  9. Mechanism of HIV 1 Nef Action
    BORIS PETERLIN; Fiscal Year: 2006
    ..Moreover, properties of an unusual allele of Nef, from HIV-1/F12 will be investigated for its dominant negative properties in viral replication. ..
  10. Mechanism of HIV 1 Nef Action
    BORIS PETERLIN; Fiscal Year: 2005
    ..Moreover, properties of an unusual allele of Nef, from HIV-1/F12 will be investigated for its dominant negative properties in viral replication. ..
  11. Mechanism of HIV 1 Nef Action
    BORIS PETERLIN; Fiscal Year: 2002
    ..Moreover, properties of an unusual allele of Nef, from HIV-1/F12 will be investigated for its dominant negative properties in viral replication. ..
  12. Tat Transactivation
    BORIS PETERLIN; Fiscal Year: 2002
    ..Findings in vitro will be correlated with chromatin immunoprecipitations in cells. ..
  13. Tat Transactivation
    BORIS PETERLIN; Fiscal Year: 2003
    ..Findings in vitro will be correlated with chromatin immunoprecipitations in cells. ..
  14. Mechanism of HIV 1 Nef Action
    BORIS PETERLIN; Fiscal Year: 2003
    ..Moreover, properties of an unusual allele of Nef, from HIV-1/F12 will be investigated for its dominant negative properties in viral replication. ..
  15. CIITA and MHC II Transcription
    BORIS PETERLIN; Fiscal Year: 2003
    ..Collectively, these studies will reveal the normal physiology of CIITA, why it oligomerizes and shuttles, and create new tools to manipulate the immune response in health and disease. ..
  16. Mechanism of HIV 1 Nef Action
    BORIS PETERLIN; Fiscal Year: 2004
    ..Moreover, properties of an unusual allele of Nef, from HIV-1/F12 will be investigated for its dominant negative properties in viral replication. ..
  17. Tat Transactivation
    BORIS PETERLIN; Fiscal Year: 2004
    ..Findings in vitro will be correlated with chromatin immunoprecipitations in cells. ..
  18. Tat Transactivation
    BORIS MATIJA PETERLIN; Fiscal Year: 2010
    ..These studies will reveal the complex RNA-protein world of P-TEFb and how HIV subverts these cellular complexes for its replication in cells. ..