Affiliation: University of California
Huang F, Shao W, Fujinaga K, Peterlin B. Bromodomain-containing protein 4-independent transcriptional activation by autoimmune regulator (AIRE) and NF-κB. J Biol Chem. 2018;293:4993-5004 pubmed publisher
..We conclude that direct interactions between AIRE, NF-κB, and P-TEFb result in efficient transcription of their target genes. ..
Fujinaga K, Luo Z, Schaufele F, Peterlin B. Visualization of positive transcription elongation factor b (P-TEFb) activation in living cells. J Biol Chem. 2015;290:1829-36 pubmed publisher
..Thus, our visualization of P-TEFb activation by fluorescent complementation assay could be used to find new P-TEFb-releasing agents, compare different classes of agents, and assess their efficacy singly and/or in combination. ..
Peterlin B, Brogie J, Price D. 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription. Wiley Interdiscip Rev RNA. 2012;3:92-103 pubmed publisher
..Regulated release of P-TEFb determines the expression pattern of many of the genes that respond to environmental stimuli and regulate growth, proliferation, and differentiation of cells. ..
Shao W, Zumer K, Fujinaga K, Peterlin B. FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator). J Biol Chem. 2016;291:17953-63 pubmed publisher
..Because P-TEFb is required for the transition from initiation to elongation of transcription, this interaction ensures proper expression of AIRE-responsive tissue-specific antigens in the thymus. ..
Sabino Cunha M, Lima Sampaio T, Peterlin B, Jesus da Costa L. A Truncated Nef Peptide from SIVcpz Inhibits the Production of HIV-1 Infectious Progeny. Viruses. 2016;8: pubmed publisher
..This study demonstrates for the first time that naturally-occurring Nef peptides can potently block lentiviral processing and infectivity. ..
Pak V, Eifler T, JÃ¤ger S, Krogan N, Fujinaga K, Peterlin B. CDK11 in TREX/THOC Regulates HIV mRNA 3' End Processing. Cell Host Microbe. 2015;18:560-70 pubmed publisher
..In contrast, higher levels of CDK11 increased the length of HIV poly(A) tails and the stability of mature viral transcripts. We conclude that CDK11 plays a critical role for the cotranscriptional processing of all HIV mRNA species. ..