Research Topics
Genomes and GenesSpecies | M R LooneySummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Transfusion-related acute lung injury: a reviewMark R Looney
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143 0130, USA
Chest 126:249-58. 2004..Treatment is supportive, with a prognosis substantially better than most causes of clinical acute lung injury...- Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injuryAxelle Caudrillier
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0130, USA
Curr Pharm Des 18:3260-6. 2012..In conclusion, experimental studies are elucidating the role of platelets in acute lung injury and with this new understanding, clinical trials of anti-platelet agents should be considered... 
Inhaled activated protein C: a novel therapy for acute lung injury?Kathleen D Liu
Division of Nephrology and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0624, USA
Crit Care 13:150. 2009..Future studies are needed to determine plasma and airspace APC levels when administered by the inhaled route, and to determine if inhaled APC has a similar effect in other models of ALI...- Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injuryMark R Looney
Department of Medicine, UCSF, San Francisco, California 94143 0130, USA
J Clin Invest 119:3450-61. 2009..Furthermore, our data offer an explanation for the increased incidence of TRALI in patients with immune priming conditions, and we suggest what we believe to be a novel therapeutic approach... - Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injuryMark R Looney
Cardiovascular Research Institute, Department of Medicine, UCSF, San Francisco, California, USA
J Clin Invest 116:1615-23. 2006..In conclusion, in a clinically relevant in vivo mouse model of TRALI using an MHC I mAb, the mechanism of lung injury was dependent on neutrophils and their Fc gamma receptors... 
Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injuryM R Looney
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0130, USA
Thorax 64:114-20. 2009..The role of APC in hyperoxic acute lung injury was tested by studying the physiology of lung injury development, measurement of key coagulation proteins and treatment with murine APC (mAPC)...- Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenzaMark R Looney
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Clin Chest Med 27:591-600; abstract viii. 2006..This article discusses the clinical importance, pathogenesis, diagnosis, management, and prevention of these newly recognized causes of respiratory failure... - Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injuryMark R Looney
Department of Medicine, Cardiovascular Research Institute, University of California, 505 Parnassus Avenue, San Francisco, California 94143 0130, USA
Crit Care 10:239. 2006..This article critically reviews these studies, with a focus on potential mechanisms of action... - Animal models of transfusion-related acute lung injuryMark R Looney
Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California-San Francisco, CA, USA
Crit Care Med 34:S132-6. 2006..There is a lack of clinically relevant animal models that explain why transfusion of donor antibodies to cognate antigens in the recipient does not always lead to TRALI... - Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearanceMark R Looney
Cardiovascular Research Institute and the Department of Medicine and Anesthesia, University of California, San Francisco, 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 289:L104-10. 2005.... - Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injuryXiao Su
Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 297:L1-5. 2009..In summary, BAL RAGE is an indicator of ALI, and it may be useful in distinguishing direct from indirect models of ALI as well as assessing the response to specific therapies... - Pathophysiology of transfusion-related acute lung injuryMark R Looney
Cardiovascular Research Institute, San Francisco, CA 94143 0624, USA
Curr Opin Hematol 17:418-23. 2010..The purpose of this review is to summarize the recent experimental and clinical literature on the pathogenesis of transfusion-related acute lung injury (TRALI)... - CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumoniaXiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 180:6947-53. 2008..coli pneumonia had an improved survival rate. Taken together, deficiency of CD47 protects mice from LPS-induced acute lung injury and E. coli pneumonia. Targeting CD47 may be a novel pathway for treatment of acute lung injury... - Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literatureG D Church
Cardiovascular Research Institute, Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143 0130, USA
Transfus Med 16:343-8. 2006..Finally, our first case also highlights the potential danger of directed maternal blood donations, which may increase the risk of paediatric TRALI... - Constitutively active endothelial Notch4 causes lung arteriovenous shunts in miceDoug Miniati
Laboratory for Accelerated Vascular Research, Division of Vascular Surgery, San Francisco, CA 94143 0507, USA
Am J Physiol Lung Cell Mol Physiol 298:L169-77. 2010..Together, our results indicate the importance of Notch signaling in maintaining the lung vasculature and offer a new, reliable model with which to study the pathobiology of lung arteriovenous shunts and malformations... - Acute lung injury after blood product transfusion: are the times changing?Mark R Looney
Crit Care Med 36:1968-70. 2008
Research Grants
- Experimental transfusion-related acute lung injuryMark Looney; Fiscal Year: 2007..Looney, and at the end of the grant period, Dr. Looney will be well equipped to embark on a successful career as an independent investigator in the field of acute lung injury. (End of Abstract) ..