M R Looney

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Transfusion-related acute lung injury: a review
    Mark R Looney
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143 0130, USA
    Chest 126:249-58. 2004
  2. doi request reprint Live imaging of the lung
    Mark R Looney
    Departments of Medicine and Laboratory Medicine, University of California, San Francisco, California 94143 email
    Annu Rev Physiol 76:431-45. 2014
  3. ncbi request reprint Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury
    Axelle Caudrillier
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0130, USA
    Curr Pharm Des 18:3260-6. 2012
  4. pmc Inhaled activated protein C: a novel therapy for acute lung injury?
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0624, USA
    Crit Care 13:150. 2009
  5. pmc Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury
    Mark R Looney
    Department of Medicine, UCSF, San Francisco, California 94143 0130, USA
    J Clin Invest 119:3450-61. 2009
  6. pmc Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury
    Mark R Looney
    Cardiovascular Research Institute, Department of Medicine, UCSF, San Francisco, California, USA
    J Clin Invest 116:1615-23. 2006
  7. ncbi request reprint Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza
    Mark R Looney
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Clin Chest Med 27:591-600; abstract viii. 2006
  8. pmc Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury
    Mark R Looney
    Department of Medicine, Cardiovascular Research Institute, University of California, 505 Parnassus Avenue, San Francisco, California 94143 0130, USA
    Crit Care 10:239. 2006
  9. doi request reprint Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury
    M R Looney
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0130, USA
    Thorax 64:114-20. 2009
  10. ncbi request reprint Animal models of transfusion-related acute lung injury
    Mark R Looney
    Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California San Francisco, CA, USA
    Crit Care Med 34:S132-6. 2006

Research Grants

Detail Information

Publications17

  1. ncbi request reprint Transfusion-related acute lung injury: a review
    Mark R Looney
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143 0130, USA
    Chest 126:249-58. 2004
    ..Treatment is supportive, with a prognosis substantially better than most causes of clinical acute lung injury...
  2. doi request reprint Live imaging of the lung
    Mark R Looney
    Departments of Medicine and Laboratory Medicine, University of California, San Francisco, California 94143 email
    Annu Rev Physiol 76:431-45. 2014
    ..New applications of live lung imaging and the limitations of current techniques are discussed. ..
  3. ncbi request reprint Platelet-neutrophil interactions as a target for prevention and treatment of transfusion-related acute lung injury
    Axelle Caudrillier
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143 0130, USA
    Curr Pharm Des 18:3260-6. 2012
    ..In conclusion, experimental studies are elucidating the role of platelets in acute lung injury and with this new understanding, clinical trials of anti-platelet agents should be considered...
  4. pmc Inhaled activated protein C: a novel therapy for acute lung injury?
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0624, USA
    Crit Care 13:150. 2009
    ..Future studies are needed to determine plasma and airspace APC levels when administered by the inhaled route, and to determine if inhaled APC has a similar effect in other models of ALI...
  5. pmc Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury
    Mark R Looney
    Department of Medicine, UCSF, San Francisco, California 94143 0130, USA
    J Clin Invest 119:3450-61. 2009
    ..Furthermore, our data offer an explanation for the increased incidence of TRALI in patients with immune priming conditions, and we suggest what we believe to be a novel therapeutic approach...
  6. pmc Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury
    Mark R Looney
    Cardiovascular Research Institute, Department of Medicine, UCSF, San Francisco, California, USA
    J Clin Invest 116:1615-23. 2006
    ..In conclusion, in a clinically relevant in vivo mouse model of TRALI using an MHC I mAb, the mechanism of lung injury was dependent on neutrophils and their Fc gamma receptors...
  7. ncbi request reprint Newly recognized causes of acute lung injury: transfusion of blood products, severe acute respiratory syndrome, and avian influenza
    Mark R Looney
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Clin Chest Med 27:591-600; abstract viii. 2006
    ..This article discusses the clinical importance, pathogenesis, diagnosis, management, and prevention of these newly recognized causes of respiratory failure...
  8. pmc Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury
    Mark R Looney
    Department of Medicine, Cardiovascular Research Institute, University of California, 505 Parnassus Avenue, San Francisco, California 94143 0130, USA
    Crit Care 10:239. 2006
    ..This article critically reviews these studies, with a focus on potential mechanisms of action...
  9. doi request reprint Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury
    M R Looney
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0130, USA
    Thorax 64:114-20. 2009
    ..The role of APC in hyperoxic acute lung injury was tested by studying the physiology of lung injury development, measurement of key coagulation proteins and treatment with murine APC (mAPC)...
  10. ncbi request reprint Animal models of transfusion-related acute lung injury
    Mark R Looney
    Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California San Francisco, CA, USA
    Crit Care Med 34:S132-6. 2006
    ..To examine the existing animal models of transfusion-related acute lung injury (TRALI) for insight into disease pathogenesis...
  11. ncbi request reprint Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance
    Mark R Looney
    Cardiovascular Research Institute and the Department of Medicine and Anesthesia, University of California, San Francisco, 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 289:L104-10. 2005
    ....
  12. pmc Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1-5. 2009
    ..In summary, BAL RAGE is an indicator of ALI, and it may be useful in distinguishing direct from indirect models of ALI as well as assessing the response to specific therapies...
  13. doi request reprint Pathophysiology of transfusion-related acute lung injury
    Mark R Looney
    Cardiovascular Research Institute, San Francisco, CA 94143 0624, USA
    Curr Opin Hematol 17:418-23. 2010
    ..The purpose of this review is to summarize the recent experimental and clinical literature on the pathogenesis of transfusion-related acute lung injury (TRALI)...
  14. pmc CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 180:6947-53. 2008
    ..coli pneumonia had an improved survival rate. Taken together, deficiency of CD47 protects mice from LPS-induced acute lung injury and E. coli pneumonia. Targeting CD47 may be a novel pathway for treatment of acute lung injury...
  15. ncbi request reprint Transfusion-related acute lung injury in the paediatric patient: Two case reports and a review of the literature
    G D Church
    Cardiovascular Research Institute, Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143 0130, USA
    Transfus Med 16:343-8. 2006
    ..Finally, our first case also highlights the potential danger of directed maternal blood donations, which may increase the risk of paediatric TRALI...
  16. pmc Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice
    Doug Miniati
    Laboratory for Accelerated Vascular Research, Division of Vascular Surgery, San Francisco, CA 94143 0507, USA
    Am J Physiol Lung Cell Mol Physiol 298:L169-77. 2010
    ..Together, our results indicate the importance of Notch signaling in maintaining the lung vasculature and offer a new, reliable model with which to study the pathobiology of lung arteriovenous shunts and malformations...
  17. ncbi request reprint Acute lung injury after blood product transfusion: are the times changing?
    Mark R Looney
    Crit Care Med 36:1968-70. 2008

Research Grants2

  1. Experimental transfusion-related acute lung injury
    Mark Looney; Fiscal Year: 2007
    ..Looney, and at the end of the grant period, Dr. Looney will be well equipped to embark on a successful career as an independent investigator in the field of acute lung injury. (End of Abstract) ..