Research Topics
Genomes and Genes
Species | Sandra LooSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Executive functioning among Finnish adolescents with attention-deficit/hyperactivity disorderSandra K Loo
University of California, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 46:1594-604. 2007..The present study examined cognitive functioning in a population sample of adolescents with and without attention-deficit/hyperactivity disorder (ADHD) from the Northern Finland Birth Cohort 1986...
Clinical utility of EEG in attention-deficit/hyperactivity disorder: a research updateSandra K Loo
Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
Neurotherapeutics 9:569-87. 2012....
Genome-wide association study of intelligence: additive effects of novel brain expressed genesSandra K Loo
University of California Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90024, USA
J Am Acad Child Adolesc Psychiatry 51:432-440.e2. 2012..The purpose of the present study was to identify common genetic variants that are associated with human intelligence or general cognitive ability...- Familial clustering and DRD4 effects on electroencephalogram measures in multiplex families with attention deficit/hyperactivity disorderSandra K Loo
Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 49:368-77. 2010.... - Cortical activity patterns in ADHD during arousal, activation and sustained attentionSandra K Loo
Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, United States
Neuropsychologia 47:2114-9. 2009..The goal of the present study is to test whether there are Attention-Deficit Hyperactivity Disorder (ADHD)-related differences in brain electrical activity patterns across arousal, activation and vigilance states... - Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genesSandra K Loo
UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA, USA
J Child Psychol Psychiatry 49:950-7. 2008..This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD)... - Functional effects of the DAT1 polymorphism on EEG measures in ADHDSandra K Loo
Department of Psychiatry and Biobehavioral Sciences, UCLA NPI, Los Angeles, USA
J Am Acad Child Adolesc Psychiatry 42:986-93. 2003..This paper examines whether dopamine transporter gene (DAT1) allele status mediates medication-related change in cognitive and neurophysiological measures among children with attention-deficiency/hyperactivity disorder (ADHD)... - Preliminary report of familial clustering of EEG measures in ADHDSandra K Loo
Department of Psychiatry and Biobehavioral Sciences, Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, California, USA
Am J Med Genet B Neuropsychiatr Genet 147:107-9. 2008..Cognitive task performance did not exhibit familial clustering in our sample. EEG measures (i.e., alpha power) recorded during cognitive activation is a strongly familial trait in ADHD and may be a putative endophenotype for ADHD... - Genome-wide scan of reading ability in affected sibling pairs with attention-deficit/hyperactivity disorder: unique and shared genetic effectsS K Loo
Center for Neurobehavioral Genetics, University of California, Los Angeles, USA
Mol Psychiatry 9:485-93. 2004..The eventual identification of genes underlying these unique and shared linkages may increase our understanding of ADHD, RD and the relationship between the two... - Clinical utility of EEG in attention deficit hyperactivity disorderSandra K Loo
UCLA Neuropsychiatric Institute, Los Angeles, California 90024, USA
Appl Neuropsychol 12:64-76. 2005.... - EEG correlates of methylphenidate response in ADHD: association with cognitive and behavioral measuresSandra K Loo
Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024, USA
J Clin Neurophysiol 21:457-64. 2004..Increased cortical arousal and activation in the frontal cortex is strongly associated with sustained attention and response inhibition and with parent-rated attention and hyperactivity/impulsivity... - Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorderAke T Lu
Department of Human Genetics, University of California, Los Angeles, California, USA
Am J Med Genet B Neuropsychiatr Genet 147:1488-94. 2008..01 for C-G). These observations require replication, however, they suggest that the CNR1 gene may be a risk factor for ADHD and possibly PTSD, and that this gene warrants further investigation for a role in neuropsychiatric disorders... - Psychiatric comorbidity in adult attention deficit hyperactivity disorder: findings from multiplex familiesJames J McGough
Center for Neurobehavioral Genetics, David Geffen School of Medicine, Suite 1414, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
Am J Psychiatry 162:1621-7. 2005..Patterns of psychiatric comorbidity were assessed in adults with and without attention deficit hyperactivity disorder (ADHD) identified through a genetic study of families containing multiple children with ADHD... - Atypical alpha asymmetry in adults with ADHDT Sigi Hale
Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, United States
Neuropsychologia 47:2082-8. 2009..The current study explores whether increased rightward alpha asymmetry is also evident in adults with ADHD... - Mindfulness and attention deficit hyperactivity disorderSusan L Smalley
Mindful Awareness Research Center, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
J Clin Psychol 65:1087-98. 2009..It further suggests that interventions that increase mindfulness might improve symptoms of ADHD and increase self-directedness and/or self-transcendence... - A candidate gene analysis of methylphenidate response in attention-deficit/hyperactivity disorderJames J McGough
Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine, University of California, Los Angeles, USA
J Am Acad Child Adolesc Psychiatry 48:1155-64. 2009..This study examines the potential role of candidate genes in moderating treatment effects of methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD)... - ADHD familial loading and abnormal EEG alpha asymmetry in children with ADHDT Sigi Hale
Division of Child and Adolescent Psychiatry and Center for Neurobehavioral Genetics at the UCLA Semel Institute, 760 Westwood Plaza, Room 47 448, Los Angeles, CA 90095, United States
J Psychiatr Res 44:605-15. 2010..Previous studies have shown increased rightward alpha asymmetry in ADHD. We tested whether this was more pronounced in ADHD children with increased ADHD family loading... - Atypical EEG beta asymmetry in adults with ADHDT Sigi Hale
Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
Neuropsychologia 48:3532-9. 2010..The current study investigates whether this ABL characteristic occurs in adults with ADHD absent comorbid language impairment... - Rethinking a right hemisphere deficit in ADHDT Sigi Hale
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
J Atten Disord 13:3-17. 2009..If true, RH pathology in ADHD should reflect interhemispherically networked and overactivated functioning. The authors evaluated these assertions... - CBCL pediatric bipolar disorder profile and ADHD: comorbidity and quantitative trait loci analysisJames J McGough
Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine
J Am Acad Child Adolesc Psychiatry 47:1151-7. 2008..We used CBCL-PBD profiles to distinguish patterns of comorbidity and to search for quantitative trait loci in a genomewide scan in a sample of multiple affected ADHD sibling pairs... - Toward localizing genes underlying cerebral asymmetry and mental healthSusan L Smalley
Center for Neurobehavioral Genetics, UCLA Neuropsychiatric Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90024, USA
Am J Med Genet B Neuropsychiatr Genet 135:79-84. 2005..Because ACA is associated with certain aspects of creativity, such risk genes may also be enhancer genes for creativity... - Familial association and frequency of learning disabilities in ADHD sibling pair familiesMelissa Del'Homme
Department of Psychiatry and Biobehavioral Sciences, Semel Institute of Neuroscience and Human Behavior, University of California, 300 UCLA Medical Plaza, Suite 1416, Los Angeles, CA 90095 6967, USA
J Abnorm Child Psychol 35:55-62. 2007..Despite the high comorbidity of ADHD and LD among parents, the presence of ADHD in the parents did not predict child LD supporting independent familial factors underlying ADHD and LD... - Prevalence and psychiatric comorbidity of attention-deficit/hyperactivity disorder in an adolescent Finnish populationSusan L Smalley
Semel Institute, University of California, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 46:1575-83. 2007..The purpose of the study was to estimate the prevalence of attention-deficit/hyperactivity disorder (ADHD) and its clinical characteristics in the Northern Finland Birth Cohort 1986... - Temperament and character profiles and the dopamine D4 receptor gene in ADHDDeborah E Lynn
UCLA Department of Child and Adolescent Psychiatry, 10850 Wilshire Blvd, Suite 200, Los Angeles, CA 90024, USA
Am J Psychiatry 162:906-13. 2005..This study was designed to investigate the link among attention deficit hyperactivity disorder (ADHD) in adults, novelty-seeking temperament, and the 48-base pair (bp) dopamine D4 receptor (DRD4) gene variant... - Relationship of family environment and parental psychiatric diagnosis to impairment in ADHDLeah J Pressman
Department of Psychiatry, UCLA Semel Institute, Los Angeles, CA 90095-1759, USA
J Am Acad Child Adolesc Psychiatry 45:346-54. 2006..CONCLUSIONS: There are strong links between impairment in children with ADHD and family environment. Different processes and mechanisms may contribute to impairment in different children in the same family... - Social functioning difficulties in ADHD: association with PDD riskErika Carpenter Rich
Center for Neurobehavioral Genetics, University of California, Los Angeles, USA
Clin Child Psychol Psychiatry 14:329-44. 2009..51) than Peer Rejection (beta = .29) factors. Social Immaturity was also associated with a greater number of hyperactive symptoms while high Peer Rejection was associated with increased aggression and lower IQ in the ADHD children... - Attention deficit hyperactivity disorder: fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11Matthew N Ogdie
Human Genetics, University of California Los Angeles, Los Angeles, CA, USA
Am J Hum Genet 75:661-8. 2004..The refinement of linkage within each of these regions lays the foundation for subsequent investigations using association methods to detect risk genes of moderate effect size... - Subtypes versus severity differences in attention-deficit/hyperactivity disorder in the Northern Finnish Birth CohortGitta H Lubke
University of Notre Dame, Notre Dame, IN, USA
J Am Acad Child Adolesc Psychiatry 46:1584-93. 2007.... - ADHD symptoms and subtypes: relationship between childhood and adolescent symptomsTuula Hurtig
University of Oulu, Finland
J Am Acad Child Adolesc Psychiatry 46:1605-13. 2007..To study attention-deficit/hyperactivity disorder (ADHD) symptoms and DSM-IV subtypes in childhood and adolescence... - ADHD candidate gene study in a population-based birth cohort: association with DBH and DRD2Emma S Nyman
National Public Health Institute, Helsinki, Finland
J Am Acad Child Adolesc Psychiatry 46:1614-21. 2007..This study tests a series of allelic variants within such candidate genes to determine their potential influence on ADHD susceptibility...
Research Grants
- Genetic Underpinnings of EEG Patterns in ADHDSandra Loo; Fiscal Year: 2006..Given the applicant's prior training, proposed mentorship, and outstanding resources, a K23 Award will enable her to become an independent and productive researcher in the genetics and developmental neuropsychology of ADHD. ..
- Genetics of EEG Patterns in ADHDSandra Loo; Fiscal Year: 2007..We are thus able to collect EEG data at a very low cost in a well characterized sample of ADHD ASPs upon which linkage studies (and candidate gene association work) are readily available. ..
- Genetics of EEG Patterns in ADHDSandra Loo; Fiscal Year: 2009..We are thus able to collect EEG data at a very low cost in a well characterized sample of ADHD ASPs upon which linkage studies (and candidate gene association work) are readily available. ..
- Genetics of EEG Patterns in ADHDSandra K Loo; Fiscal Year: 2010..We are thus able to collect EEG data at a very low cost in a well characterized sample of ADHD ASPs upon which linkage studies (and candidate gene association work) are readily available. ..