B Lonnerdal

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Calcium and iron absorption--mechanisms and public health relevance
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Int J Vitam Nutr Res 80:293-9. 2010
  2. ncbi Bioactive proteins in breast milk
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, California 95616, USA
    J Paediatr Child Health 49:1-7. 2013
  3. ncbi Preclinical assessment of infant formula
    Bo Lonnerdal
    Department of Nutrition, University of California Davis, CA 95616, USA
    Ann Nutr Metab 60:196-9. 2012
  4. ncbi Bovine lactoferrin can be taken up by the human intestinal lactoferrin receptor and exert bioactivities
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Pediatr Gastroenterol Nutr 53:606-14. 2011
  5. ncbi Human milk proteins: key components for the biological activity of human milk
    Bo Lonnerdal
    Department of Nutrition and Program of International Nutrition, University of California, Davis, CA 95616, USA
    Adv Exp Med Biol 554:11-25. 2004
  6. ncbi Iron metabolism in infants and children
    Bo Lonnerdal
    Department of Nutrition, Program in International Nutrition, University of California, 1 Shields Ave, Davis, CA 95616, USA
    Food Nutr Bull 28:S491-9. 2007
  7. ncbi Zinc absorption from low phytic acid genotypes of maize (Zea mays L.), Barley (Hordeum vulgare L.), and Rice (Oryza sativa L.) assessed in a suckling rat pup model
    Bo Lonnerdal
    Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, California 95616, United States
    J Agric Food Chem 59:4755-62. 2011
  8. ncbi Intestinal regulation of copper homeostasis: a developmental perspective
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 88:846S-50S. 2008
  9. ncbi Genetically modified plants for improved trace element nutrition
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 133:1490S-3S. 2003
  10. ncbi Nutritional and physiologic significance of human milk proteins
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, 95616, USA
    Am J Clin Nutr 77:1537S-1543S. 2003

Research Grants

  1. Mammalian Lactoferrin Receptors: Structure and Function
    Bo Lonnerdal; Fiscal Year: 2007

Collaborators

Detail Information

Publications89

  1. ncbi Calcium and iron absorption--mechanisms and public health relevance
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Int J Vitam Nutr Res 80:293-9. 2010
    ..Thus, the effect of Ca on Fe absorption may be of short duration and adaptation may occur with time. This may explain why studies on long-term Ca supplementation of different groups fail to show any adverse effects on Fe status...
  2. ncbi Bioactive proteins in breast milk
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, California 95616, USA
    J Paediatr Child Health 49:1-7. 2013
    ..Some bovine milk proteins, for example, lactoferrin and tumour growth factor β, may also resist proteolysis and be capable of exerting bioactivities similar to those of human milk proteins...
  3. ncbi Preclinical assessment of infant formula
    Bo Lonnerdal
    Department of Nutrition, University of California Davis, CA 95616, USA
    Ann Nutr Metab 60:196-9. 2012
    ..The use of modern methods in genomics and proteomics should be considered in these evaluation processes as well as novel methods to evaluate outcomes, including metabolomics and molecular techniques to assess the microbiome...
  4. ncbi Bovine lactoferrin can be taken up by the human intestinal lactoferrin receptor and exert bioactivities
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Pediatr Gastroenterol Nutr 53:606-14. 2011
    ..To achieve some of the benefits of breast-fed infants, we investigated the feasibility of adding commercially available bovine LF (CbLF) to infant formula...
  5. ncbi Human milk proteins: key components for the biological activity of human milk
    Bo Lonnerdal
    Department of Nutrition and Program of International Nutrition, University of California, Davis, CA 95616, USA
    Adv Exp Med Biol 554:11-25. 2004
    ..Thus, some qualities provided by human milk may be included into other diets, although it is highly unlikely that all unique components of human milk can be copied this way...
  6. ncbi Iron metabolism in infants and children
    Bo Lonnerdal
    Department of Nutrition, Program in International Nutrition, University of California, 1 Shields Ave, Davis, CA 95616, USA
    Food Nutr Bull 28:S491-9. 2007
    ..Interactions among iron, vitamin A, zinc, and copper need to be considered when evaluating the effects of iron supplementation on infants and children...
  7. ncbi Zinc absorption from low phytic acid genotypes of maize (Zea mays L.), Barley (Hordeum vulgare L.), and Rice (Oryza sativa L.) assessed in a suckling rat pup model
    Bo Lonnerdal
    Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, California 95616, United States
    J Agric Food Chem 59:4755-62. 2011
    ..Therefore, reducing the phytic acid content of staple cereal grains may contribute to enhancing Zn nutrition of populations consuming these staple foods...
  8. ncbi Intestinal regulation of copper homeostasis: a developmental perspective
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 88:846S-50S. 2008
    ..The mechanisms behind this maturation, including both transcriptional and posttranscriptional regulation, require further studies...
  9. ncbi Genetically modified plants for improved trace element nutrition
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 133:1490S-3S. 2003
    ..Finally, a combination of all of these approaches perhaps complemented with conventional breeding techniques may prove successful...
  10. ncbi Nutritional and physiologic significance of human milk proteins
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, 95616, USA
    Am J Clin Nutr 77:1537S-1543S. 2003
    ....
  11. ncbi Bioactive proteins in human milk: mechanisms of action
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA, USA
    J Pediatr 156:S26-30. 2010
    ..In vitro digestibility assays can be helpful to assess which human milk proteins can resist proteolysis and to what extent...
  12. ncbi Nutritional roles of lactoferrin
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, California 95616, USA
    Curr Opin Clin Nutr Metab Care 12:293-7. 2009
    ..In this review, the potential biological functions of dietary lactoferrin are described and critically examined...
  13. ncbi Trace element transport in the mammary gland
    Bo Lonnerdal
    Department of Nutrition, University of California at Davis, CA, USA
    Annu Rev Nutr 27:165-77. 2007
    ..The control of mammary gland uptake and milk secretion of iron, copper, and zinc protects both the mammary gland and the breast-fed infant against deficiency and excess of these nutrients...
  14. ncbi The importance and bioavailability of phytoferritin-bound iron in cereals and legume foods
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Int J Vitam Nutr Res 77:152-7. 2007
    ..In conclusion, iron is well absorbed from phytoferritin and may represent a means of biofortification of staple foods...
  15. ncbi Copper nutrition during infancy and childhood
    B Lonnerdal
    Department of Nutrition, University of California, Davis 95616, USA
    Am J Clin Nutr 67:1046S-1053S. 1998
    ..The possibility of copper excess also needs to be considered because there are limited opportunities to diagnose copper toxicity. Finally, the role of homeostatic regulation of copper metabolism in infants needs to be evaluated...
  16. ncbi Absorption of iron from recombinant human lactoferrin in young US women
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 83:305-9. 2006
    ..Lactoferrin is a major protein component of human milk, and it binds iron with high affinity. Because the human small intestine has receptors for lactoferrin, a role for it in iron absorption has been suggested...
  17. ncbi Identification of an alpha2-macroglobulin receptor in human mammary epithelial cells
    D Beshgetoor
    Department of Nutrition, University of California, Davis, CA 95616, U S Fax 530 752 8966 Tel 530 752 8347 E mail
    J Nutr 129:152-7. 1999
    ..Results from this study present evidence for receptor-mediated uptake of alpha2-M in human mammary epithelial cells, which in turn, provides a potential mechanism for Zn acquisition by the cell...
  18. ncbi Effect of reducing the phytate content and of partially hydrolyzing the protein in soy formula on zinc and copper absorption and status in infant rhesus monkeys and rat pups
    B Lonnerdal
    Department of Nutrition and the California Regional Primate Research Center, University of California, Davis 95616, USA
    Am J Clin Nutr 69:490-6. 1999
    ..Although soy formulas have been designed to meet the nutrient requirements of human infants, they also contain phytate, which may negatively affect trace element absorption...
  19. ncbi Iron absorption from soybean ferritin in nonanemic women
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, Davis, CA 95616, USA
    Am J Clin Nutr 83:103-7. 2006
    ..Plant ferritin, the most common dietary ferritin, has not been studied. Iron from animal ferritin is absorbed as well as is iron from FeSO4 in women...
  20. ncbi Trace element nutrition of infants--molecular approaches
    Bo Lonnerdal
    Department of Nutrition, University of California, One Shields Avenue, Davis, CA 95616, USA
    J Trace Elem Med Biol 19:3-6. 2005
    ..The consequences of trace element interactions during infancy also need to be investigated in more detail...
  21. ncbi Extent of thermal processing of infant formula affects copper status in infant rhesus monkeys
    B Lonnerdal
    Department of Nutrition, University of California at Davis, 95616 8669, USA
    Am J Clin Nutr 73:914-9. 2001
    ..Infants fed powdered formula from birth exhibit normal growth and have blood variables similar to those of breast-fed infants...
  22. ncbi Expression of human milk proteins in plants
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis 95616, USA
    J Am Coll Nutr 21:218S-221S. 2002
    ..These recombinant proteins showed a stability and activities similar to those of the native milk proteins, suggesting that they may be able to exert biological activities in infants when added to formula or baby foods...
  23. ncbi Soybean ferritin: implications for iron status of vegetarians
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA, USA
    Am J Clin Nutr 89:1680S-1685S. 2009
    ..In conclusion, iron is well absorbed from ferritin and may represent a means of biofortification of staple foods such as soybeans...
  24. ncbi Glycomacropeptide and alpha-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys
    Shannon L Kelleher
    Department of Nutrition and California National Primate Research Center, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 77:1261-8. 2003
    ....
  25. ncbi Iron in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic women
    Penni Davila-Hicks
    Department of Nutrition, University of California, Davis, CA, USA
    Am J Clin Nutr 80:936-40. 2004
    ..CONCLUSIONS: Iron is equally well absorbed from ferritin and ferrous sulfate independent of the phosphate content of the ferritin iron mineral. Thus, dietary ferritin iron is likely to be a good source of iron...
  26. ncbi Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation
    Shannon L Kelleher
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 132:3280-5. 2002
    ..These results indicate that milk Zn level is maintained through coordinated regulation of mammary gland zinc transporters and documents an effect of vitamin A on zinc homeostasis at the molecular level during lactation...
  27. ncbi Iron supplementation during infancy--effects on expression of iron transporters, iron absorption, and iron utilization in rat pups
    Weng-In Leong
    Department of Nutrition, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA
    Am J Clin Nutr 78:1203-11. 2003
    ..The current findings provide evidence of the developmental regulation of iron absorption, which emphasizes the need for caution when giving iron supplements to infants at an early age...
  28. ncbi Iron transporters in rat mammary gland: effects of different stages of lactation and maternal iron status
    Weng-In Leong
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 81:445-53. 2005
    ..Mammary gland regulation of DMT and FPN1 during low iron status appears to be different from that in the intestine...
  29. ncbi Expression, characterization, and biologic activity of recombinant human lactoferrin in rice
    Yasushi A Suzuki
    Department of Nutrition, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    J Pediatr Gastroenterol Nutr 36:190-9. 2003
    ....
  30. ncbi miR-584 mediates post-transcriptional expression of lactoferrin receptor in Caco-2 cells and in mouse small intestine during the perinatal period
    Y Liao
    Department of Nutrition, University of California, One Shields Ave, Davis, CA 95616, USA
    Int J Biochem Cell Biol 42:1363-9. 2010
    ..These findings demonstrate a novel example of how microRNAs may be involved in regulation of nutrient metabolism in the newborn...
  31. ncbi Tissue-specific alterations in zinc transporter expression in intestine and liver reflect a threshold for homeostatic compensation during dietary zinc deficiency in weanling rats
    Ming Yu Jou
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 139:835-41. 2009
    ..These results assist in our understanding of how mammals regulate Zn homeostasis...
  32. ncbi Mammalian lactoferrin receptors: structure and function
    Y A Suzuki
    Department of Nutrition, University of California, Davis, 95616, USA
    Cell Mol Life Sci 62:2560-75. 2005
    ..The detailed mechanisms behind the receptor-Lf interactions still need to be elucidated...
  33. ncbi Effects of dietary factors on iron uptake from ferritin by Caco-2 cells
    Swati Kalgaonkar
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr Biochem 19:33-9. 2008
    ..These results suggest that Fe uptake occurs from both undigested as well as digested Ft but, possibly, via different mechanisms. The Fe-Ft stability shown here could minimize Fe-induced oxidation of Fe-supplemented food products...
  34. ncbi The prevalence of low serum zinc and copper levels and dietary habits associated with serum zinc and copper in 12- to 36-month-old children from low-income families at risk for iron deficiency
    Julie M Schneider
    Department of Nutrition, University of California, Davis, California, USA
    J Am Diet Assoc 107:1924-9. 2007
    ..We determined the prevalence of zinc and copper deficiency and examined factors associated with serum zinc and copper in young children from low-income families at risk of iron deficiency...
  35. ncbi Recombinant human milk proteins
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA, USA
    Nestle Nutr Workshop Ser Pediatr Program 58:207-15; discussion 215-7. 2006
    ..These recombinant human milk proteins may be incorporated into infant formulas, baby foods and complementary foods, and used with the goal to reduce infectious diseases...
  36. ncbi Effects of copper supplementation on copper absorption, tissue distribution, and copper transporter expression in an infant rat model
    Kathryn A Bauerly
    Department of Nutrition, University of California Davis, One Shields Ave, Davis, California 95616, USA
    Am J Physiol Gastrointest Liver Physiol 288:G1007-14. 2005
    ..Despite these adaptive changes, Cu supplementation resulted in elevated alanine aminotransferase levels, suggesting a risk of Cu toxicity with supplementation during infancy...
  37. ncbi Functional and molecular responses of suckling rat pups and human intestinal Caco-2 cells to copper treatment
    Kathryn A Bauerly
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr Biochem 15:155-62. 2004
    ..This study demonstrates the functional response of intestinal cells to Cu treatment and suggests that both Ctr1 and Atp7A may regulate Cu absorption...
  38. ncbi Effects of zinc exposure on zinc transporter expression in human intestinal cells of varying maturity
    Ming Yu Jou
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Pediatr Gastroenterol Nutr 50:587-95. 2010
    ..We hypothesized that intestinal Zn homeostasis is developmentally regulated and depends on intestinal maturation, which in turn affects Zn transporter regulation...
  39. ncbi The use of multiple logistic regression to identify risk factors associated with anemia and iron deficiency in a convenience sample of 12-36-mo-old children from low-income families
    Julie M Schneider
    Nutrition and Food Sciences Department, California State University, Chico, CA, USA
    Am J Clin Nutr 87:614-20. 2008
    ..Determination of risk factors associated with ID is needed to allow children with identifiable risk factors to receive appropriate education, testing, and follow-up...
  40. ncbi Mechanisms of vitamin B(12) absorption in breast-fed infants
    Yuriko Adkins
    Department of Nutrition university of California, Davis, California 95616, USA
    J Pediatr Gastroenterol Nutr 35:192-8. 2002
    ..However, IF levels may be too low in early life to participate in vitamin B(12) absorption; therefore, haptocorrin may mediate vitamin B(12) absorption until the absorption function can be taken over by a more mature IF system...
  41. ncbi Stability of recombinant human alpha-1-antitrypsin produced in rice in infant formula
    Winyoo Chowanadisai
    Department of Nutrition, University of California, Davis 95616, USA
    J Nutr Biochem 14:386-93. 2003
    ..This study shows that recombinant AAT may survive the conditions of the infant stomach and duodenum and affect protein digestion in the infant small intestine...
  42. ncbi Supplementation of infant formula with the probiotic lactobacillus reuteri and zinc: impact on enteric infection and nutrition in infant rhesus monkeys
    Shannon L Kelleher
    Department of Nutrition, University of California, Davis California 95616, USA
    J Pediatr Gastroenterol Nutr 35:162-8. 2002
    ..CONCLUSION: -supplementation of infant formula is safe, improves iron status and decreases diarrhea severity in infant rhesus monkeys and thus may help protect formula-fed human infants from infection and nutritional deficiencies...
  43. ncbi DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption
    Weng In Leong
    Department of Nutrition, University of California, Davis, California 95616, USA
    Am J Physiol Gastrointest Liver Physiol 285:G1153-61. 2003
    ..In summary, the molecular mechanisms regulating iron absorption during early infancy differ from late infancy when they are similar to adult animals, indicating developmental regulation of iron absorption...
  44. ncbi Absorption of iron from unmodified maize and genetically altered, low-phytate maize fortified with ferrous sulfate or sodium iron EDTA
    C Mendoza
    Institute of Nutrition of Central America and Panama, Guatemala City, Guatemala
    Am J Clin Nutr 73:80-5. 2001
    ..Fractional iron absorption from a genetically modified strain of low-phytate maize (LPM) increased significantly, by 50%...
  45. ncbi Effect of genetically modified, low-phytic acid maize on absorption of iron from tortillas
    C Mendoza
    Institute of Nutrition of Central America and Panama, Guatemala City, Guatemala
    Am J Clin Nutr 68:1123-7. 1998
    ..Genetically modified, low-phytic acid strains of maize were developed to enhance mineral absorption, but have not been tested previously in humans...
  46. ncbi Zinc supplementation reduces iron absorption through age-dependent changes in small intestine iron transporter expression in suckling rat pups
    Shannon L Kelleher
    Department of Nutritional Biology, University of California, Davis, CA 95616, USA
    J Nutr 136:1185-91. 2006
    ....
  47. ncbi Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency
    Winyoo Chowanadisai
    Department of Nutrition, University of California, Davis, California 95616, USA
    J Biol Chem 281:39699-707. 2006
    ..Further studies are needed to evaluate the incidence and penetrance of this mutation in the human population...
  48. ncbi Mammary gland copper transport is stimulated by prolactin through alterations in Ctr1 and Atp7A localization
    Shannon L Kelleher
    Department of Nutrition, University of California Davis, Davis, CA 95616, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1181-91. 2006
    ..Although the molecular mechanisms responsible for these posttranslational changes are not understood, transient changes in prolactin signaling play a role in the regulation of mammary gland Cu secretion during lactation...
  49. ncbi Galvanizing action: conclusions and next steps for mainstreaming zinc interventions in public health programs
    Kenneth H Brown
    Department of Nutrition, University of California, Davis, California 95616, USA
    Food Nutr Bull 30:S179-84. 2009
    ....
  50. ncbi Neurobehavioral evaluation of rhesus monkey infants fed cow's milk formula, soy formula, or soy formula with added manganese
    Mari S Golub
    Department of Internal Medicine, CNPRC, Rm 1925, University of California, One Shields Ave, Davis, CA 95616, USA
    Neurotoxicol Teratol 27:615-27. 2005
    ..This experiment suggests that components of soy formula, including Mn, may influence brain development as reflected in behavioral measures...
  51. ncbi Molecular regulation of milk trace mineral homeostasis
    Shannon L Kelleher
    Department of Nutrition, University of California Davis, Davis, CA 95616, USA
    Mol Aspects Med 26:328-39. 2005
    ....
  52. ncbi Zip6 (LIV-1) regulates zinc uptake in neuroblastoma cells under resting but not depolarizing conditions
    Winyoo Chowanadisai
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Brain Res 1199:10-9. 2008
    ....
  53. ncbi Zip3 plays a major role in zinc uptake into mammary epithelial cells and is regulated by prolactin
    Shannon L Kelleher
    Dept of Nutrition, Univ of California, Davis, One Shields Ave, Davis, CA 95616, USA
    Am J Physiol Cell Physiol 288:C1042-7. 2005
    ....
  54. ncbi Low vitamin a intake affects milk iron level and iron transporters in rat mammary gland and liver
    Shannon L Kelleher
    Department of Nutrition, University of California Davis, Davis, CA 95616, USA
    J Nutr 135:27-32. 2005
    ....
  55. ncbi Effect of a micronutrient fortificant mixture and 2 amounts of calcium on iron and zinc absorption from a processed food supplement
    Concepcion Mendoza
    Program in International Nutrition, Department of Nutrition, University of California, Davis, CA 95616, USA
    Am J Clin Nutr 79:244-50. 2004
    ..Iron, zinc, and calcium can interact with each other in a way that inhibits their respective absorption. On the other hand, mineral fortification has been used to improve simultaneous iron and zinc absorption from food supplements...
  56. ncbi Zinc supplementation does not affect growth, morbidity, or motor development of US term breastfed infants at 4-10 mo of age
    M Jane Heinig
    Department of Nutrition, University of California, Davis, Davis, CA 95616 8669, USA
    Am J Clin Nutr 84:594-601. 2006
    ..It has been documented that growth patterns differ between breastfed and formula-fed infants. Some investigators have suggested that these differences may be related to differences in zinc nutriture...
  57. ncbi Iron supplementation affects growth and morbidity of breast-fed infants: results of a randomized trial in Sweden and Honduras
    Kathryn G Dewey
    Department of Nutrition and Program in International Nutrition, University of California, Davis, USA
    J Nutr 132:3249-55. 2002
    ..05). We conclude that routine iron supplementation of breast-fed infants may benefit those with low Hb but may present risks for those with normal Hb...
  58. ncbi Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells
    Shannon L Kelleher
    Department of Nutrition, University of California Davis, Davis, CA 95616, USA
    J Nutr 133:3378-85. 2003
    ....
  59. ncbi Marginal maternal Zn intake in rats alters mammary gland Cu transporter levels and milk Cu concentration and affects neonatal Cu metabolism
    Shannon L Kelleher
    Department of Nutrition, University of California Davis, 95616, USA
    J Nutr 133:2141-8. 2003
    ..The combination of high milk Cu concentration and immature neonatal Cu transport exposes the suckling neonate to excess Cu; however, whether this occurs in humans is not yet known...
  60. ncbi Alpha(1)-antitrypsin and antichymotrypsin in human milk: origin, concentrations, and stability
    Winyoo Chowanadisai
    Department of Nutrition, The University of California, Davis 95616, USA
    Am J Clin Nutr 76:828-33. 2002
    ..It has been hypothesized that alpha(1)-antitrypsin and antichymotrypsin may modulate digestion in the infant gut...
  61. ncbi Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide
    Daniel Lopez de Romaña
    Program in International Nutrition, Department of Nutrition, University of California, Davis, USA
    Am J Clin Nutr 78:279-83. 2003
    ..Several chemical forms of zinc have been proposed for food fortification, but information is needed on their absorption from common cereals having varied phytate content...
  62. ncbi miR-214 regulates lactoferrin expression and pro-apoptotic function in mammary epithelial cells
    Yalin Liao
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 140:1552-6. 2010
    ..05). In summary, our data showed that miR-214 is directly involved in lactoferrin expression and lactoferrin mediated cancer susceptibility (proapoptotic activities) in mammary epithelial cells...
  63. ncbi Zinc deficiency is associated with increased brain zinc import and LIV-1 expression and decreased ZnT-1 expression in neonatal rats
    Winyoo Chowanadisai
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 135:1002-7. 2005
    ..Our results indicate that Zn deficiency results in alterations in Zn transporter expression, which facilitates increased brain Zn uptake and results in the conservation of brain Zn during Zn deficiency...
  64. ncbi A graded model of dietary zinc deficiency: effects on growth, insulin-like growth factor-I, and the glucose/insulin axis in weanling rats
    Andrew G Hall
    Department of Nutrition, University of California Davis, Sacramento 95817, USA
    J Pediatr Gastroenterol Nutr 41:72-80. 2005
    ..We examined the effects of graded levels of low Zn intake on growth, insulin-like growth factor-I (IGF-I) and glucose homeostasis in weanling rats...
  65. ncbi Receptor-mediated uptake of ferritin-bound iron by human intestinal Caco-2 cells
    Swati Kalgaonkar
    Department of Nutrition, University of California Davis, Davis, CA 95616, USA
    J Nutr Biochem 20:304-11. 2009
    ..These results suggest that Ft uptake by enterocytes is carried out via endocytosis when Ft levels are within a physiological range, whereas Ft at higher concentrations may be absorbed using the additional mechanism of macropinocytosis...
  66. ncbi Maternal zinc deficiency raises plasma prolactin levels in lactating rats
    Winyoo Chowanadisai
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 134:1314-9. 2004
    ..In addition, increased circulating prolactin concentration is not due to altered nursing behavior, but may be due to alterations in the prolactin regulatory pathway in the pituitary gland...
  67. ncbi Nutritional and physiologic significance of alpha-lactalbumin in infants
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Nutr Rev 61:295-305. 2003
    ....
  68. ncbi Potential host-defense role of a human milk vitamin B-12-binding protein, haptocorrin, in the gastrointestinal tract of breastfed infants, as assessed with porcine haptocorrin in vitro
    Yuriko Adkins
    Department of Nutrition, The University of California, Davis, CA 95616, USA
    Am J Clin Nutr 77:1234-40. 2003
    ..CONCLUSION: These results suggest that haptocorrin may exert a host-defense function against pathogens in the gastrointestinal tracts of breastfed infants...
  69. ncbi Hepcidin, the recently identified peptide that appears to regulate iron absorption
    Weng-In Leong
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 134:1-4. 2004
    ..Transcription factors, such as C/EBPalpha, are also suggested to be involved in the regulation of hepcidin gene expression. However, much remains to be investigated in the regulation of hepcidin by iron, hypoxia and inflammation...
  70. ncbi Cellular internalization of lactoferrin in intestinal epithelial cells
    Kinya Ashida
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Biometals 17:311-5. 2004
    ..These findings suggest that ingested Lf might be internalized by the intestinal epithelium in a manner different from Tf and might function in the nucleus...
  71. ncbi International Zinc Nutrition Consultative Group (IZiNCG) technical document #1. Assessment of the risk of zinc deficiency in populations and options for its control
    Kenneth H Brown
    Program in International Nutrition, University of California, Davis, USA
    Food Nutr Bull 25:S99-203. 2004
  72. ncbi Anemia, iron deficiency, and iron deficiency anemia in 12-36-mo-old children from low-income families
    Julie M Schneider
    Department of Nutrition, University of California, Davis, USA
    Am J Clin Nutr 82:1269-75. 2005
    ..2% and 40.0%, respectively). CONCLUSIONS: Anemia and ID were prevalent in this WIC sample, but IDA was uncommon. Low hemoglobin is a poor predictor of ID...
  73. ncbi Beta-catenin/TCF4 transactivates miR-30e during intestinal cell differentiation
    Y Liao
    Department of Nutrition, University of California, One Shields Ave, Davis, CA, 95616, USA
    Cell Mol Life Sci 67:2969-78. 2010
    ..These results demonstrate that beta-catenin/TCF4 transactivates miR-30e during intestinal cell differentiation...
  74. ncbi Frataxin expression rescues mitochondrial dysfunctions in FRDA cells
    G Tan
    Department of Molecular Biosciences, University of California, Davis, CA 95616, USA
    Hum Mol Genet 10:2099-107. 2001
    ..The observation that frataxin deficiency (either directly or indirectly) causes an increase in filtrable mitochondrial iron provides a new hypothesis for the mechanism of cell death in this disease, and could be a target for therapy...
  75. ncbi Molecular cloning and functional expression of a human intestinal lactoferrin receptor
    Y A Suzuki
    Department of Nutrition, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Biochemistry 40:15771-9. 2001
    ..7 and 3.4 times, respectively, compared to those in mock-transfected cells. Our findings demonstrate the presence of a unique receptor-mediated mechanism for nutrient uptake by the newborn...
  76. ncbi Spot ferritin assay for serum samples dried on filter paper
    N Ahluwalia
    Department of Nutrition, Pennsylvania State University, University Park 16802, USA
    Am J Clin Nutr 67:88-92. 1998
    ..Capillary blood can be sampled to avoid the costs and concerns associated with venipuncture and spotted serum samples can be stored at room temperature for > or = 4 wk, eliminating the need for freezing during storage and transportation...
  77. ncbi Maternal zinc deficiency in rats affects growth and glucose metabolism in the offspring by inducing insulin resistance postnatally
    Ming Yu Jou
    Department of Nutrition, University of California, Davis, CA 95616, USA
    J Nutr 140:1621-7. 2010
    ..These findings suggest that suboptimal maternal Zn status induces long-term changes in the offspring related to abnormal glucose tolerance...
  78. ncbi Viral, nutritional, and bacterial safety of flash-heated and pretoria-pasteurized breast milk to prevent mother-to-child transmission of HIV in resource-poor countries: a pilot study
    Kiersten Israel-Ballard
    Division of Epidemiology, School of Public Health, University of California, Berkeley, CA, USA
    J Acquir Immune Defic Syndr 40:175-81. 2005
    ..This study compared the impact of flash-heating (FH) and Pretoria pasteurization (PP) on HIV, nutrients, and antimicrobial properties in human milk...
  79. ncbi Recent advances in knowledge of zinc nutrition and human health
    Sonja Y Hess
    Department of Nutrition, University of California, Davis, California 95616, USA
    Food Nutr Bull 30:S5-11. 2009
    ..The following papers will then review the intervention strategies individually...
  80. ncbi Prevalence and predictors of iron deficiency in fully breastfed infants at 6 mo of age: comparison of data from 6 studies
    Zhenyu Yang
    Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, CA, USA
    Am J Clin Nutr 89:1433-40. 2009
    ..Iron deficiency (ID) can occur among exclusively breastfed infants before 6 mo of age...
  81. ncbi Ontogenic changes in lactoferrin receptor and DMT1 in mouse small intestine: implications for iron absorption during early life
    Veronica Lopez
    Department of Nutrition, University of California, 3217C Meyer Hall, One Shields Ave, Davis, CA 95616, USA
    Biochem Cell Biol 84:337-44. 2006
    ..In conclusion, our findings support the notion that until the development-dependent expression of DMT1 in the intestine is induced, mLfR may serve as an alternative iron uptake pathway...
  82. ncbi The N1 domain of human lactoferrin is required for internalization by caco-2 cells and targeting to the nucleus
    Yasushi A Suzuki
    Department of Nutrition, University of California, Davis, California 95616, USA
    Biochemistry 47:10915-20. 2008
    ..These results indicate that the N1.1 subdomain of hLf is sufficient for binding, internalization, and targeting to the nucleus of Caco-2 cells...
  83. ncbi Future challenges of nutrition in pregnancy and lactation
    Bo Lonnerdal
    Department of Nutrition and Program of International Nutrition, University of California, Davis, California, USA
    Nestle Nutr Workshop Ser Pediatr Program 55:235-44; discussion 244-8. 2005
  84. ncbi Serum leptin concentrations in infants: effects of diet, sex, and adiposity
    B Lonnerdal
    Department of Nutrition, The University of California, Davis 95616 8669, USA
    Am J Clin Nutr 72:484-9. 2000
    ..Immunoreactive leptin was detected recently in breast milk and it has been hypothesized that leptin may be absorbed and may contribute to differences in body composition between breast-fed and formula-fed infants...
  85. ncbi Baculovirus expression of mouse lactoferrin receptor and tissue distribution in the mouse
    Yasushi A Suzuki
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Biometals 17:301-9. 2004
    ..In summary, the MLfR functions as a receptor for MLf, is expressed and localized in various tissues, and may be involved in the indispensable function of MLf during early embryonic development...
  86. ncbi Personalizing nutrient intakes of formula-fed infants: breast milk as a model
    Bo Lonnerdal
    Department of Nutrition, University of California, Davis, CA, USA
    Nestle Nutr Workshop Ser Pediatr Program 62:189-98; discussion 198-203. 2008
    ..However, there has been no systematic attempt to gradually change the composition of infant formula in a manner similar to the changing pattern of breast milk. This represents a technical and nutritional challenge, but is now possible...
  87. ncbi Cloning of a pig homologue of the human lactoferrin receptor: expression and localization during intestinal maturation in piglets
    Yalin Liao
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Comp Biochem Physiol A Mol Integr Physiol 148:584-90. 2007
    ..These findings suggest a mechanism by which pig Lf can be internalized in the intestine...
  88. ncbi Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells
    Robert A Schoenfeld
    Department of Molecular Biosciences, University of California, Davis 95616, USA
    Hum Mol Genet 14:3787-99. 2005
    ..As ataxic symptoms occur in other diseases of heme deficiency, the heme defect we observe in frataxin-deficient cells could be primary to the pathophysiological process...
  89. ncbi Comparison of plasma ferritin concentration with the ratio of plasma transferrin receptor to ferritin in estimating body iron stores: results of 4 intervention trials
    Zhenyu Yang
    Program in International and Community Nutrition, Department of Nutrition, University of California, Davis, Davis, CA 95616, USA
    Am J Clin Nutr 87:1892-8. 2008
    ..Efforts to develop global programs for the control of iron deficiency require simple, low-cost, and accurate indicators of iron status...

Research Grants4

  1. Mammalian Lactoferrin Receptors: Structure and Function
    Bo Lonnerdal; Fiscal Year: 2007
    ..Overall, our understanding of the physiological significance of Lf and its receptor will be increased. ..