Research Topics
Genomes and Genes | Wt LongstrethSummaryAffiliation: University of Washington Country: USA Publications
| Collaborators
|
Detail Information
Publications
Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control studyBrian Custer
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
BMC Cancer 6:152. 2006..The role of exogenous hormone exposures in the development of meningioma is unclear, but these exposures have been proposed as one hypothesis to explain the over-abundance of such tumors in women...
Incidence, manifestations, and predictors of worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health StudyW T Longstreth
Department of Neurology, University of Washington, Seattle, Wash, USA
Stroke 36:56-61. 2005..Magnetic resonance imaging (MRI) scans in the elderly commonly show white matter findings that may raise concerns. We sought to document incidence, manifestations, and predictors of worsening white matter grade on serial imaging...- Prevalence of narcolepsy in King County, Washington, USAW T Longstreth
University of Washington, Seattle, WA, USA
Sleep Med 10:422-6. 2009..Relatively few epidemiologic studies have focused on narcolepsy, a disabling sleep disorder with a strong association with HLA-DQB1 *0602... - The epidemiology of narcolepsyW T Longstreth
Neuroepidemiology Research Group, University of Washington, Seattle, WA, USA
Sleep 30:13-26. 2007..Identification of modifiable risk factors will help to prevent this disease... - Randomized clinical trial of magnesium, diazepam, or both after out-of-hospital cardiac arrestW T Longstreth
Department of Neurology, University of Washington, Seattle, USA
Neurology 59:506-14. 2002..To evaluate the feasibility, safety, and efficacy of interventions aimed at improving neurologic outcome after cardiac arrest... - Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health StudyW T Longstreth
Department of Neurology, University of Washington, Seattle, USA
Stroke 33:2376-82. 2002..MRI-defined infarcts are common in the elderly. We sought to explore incidence, manifestations, and predictors of such infarcts... - Associations between findings on cranial magnetic resonance imaging and retinal photography in the elderly: the Cardiovascular Health StudyWt Longstreth
Department of Neurology, University of Washington, Seattle, WA 98104 2420, USA
Am J Epidemiol 165:78-84. 2007..Evidence of small vessel disease in the retina increases the likelihood of finding it in the brain. Associations were less prominent in this elderly population than have been described in middle-aged people... - Scanning speech and word historyW T Longstreth
Department of Neurology, University of Washington, Seattle, USA
Neurology 65:1328. 2005 - Hypothesis: a motor neuron toxin produced by a clostridial species residing in gut causes ALSW T Longstreth
Department of Neurology, School of Medicine, University of Washington, Seattle, Washington, USA
Med Hypotheses 64:1153-6. 2005..If this hypothesis were correct, treatment with appropriate antibiotics or antitoxins might slow or halt progression of disease, and immunization might prevent disease... - Apolipoprotein E genotypes and outcome from out of hospital cardiac arrestW T Longstreth
Department of Neurology, University of Washington, USA
J Neurol Neurosurg Psychiatry 74:1441-3. 2003..We failed to confirm previous studies and found no significant associations between APOE genotype and outcome from out of hospital cardiac arrest... - Dental X-rays and the risk of intracranial meningioma: a population-based case-control studyW T Longstreth
Department of Neurology, School of Medicine, University of Washington, Seattle, Washington, USA
Cancer 100:1026-34. 2004..The authors determined whether the risk of intracranial meningioma was associated with past dental X-rays-specifically, posterior bitewings, full-mouth series, and lateral cephalometric and panoramic radiographs... - Associations between microinfarcts and other macroscopic vascular findings on neuropathologic examination in 2 databasesW T Longstreth
Department of Neurology, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104 2420, USA
Alzheimer Dis Assoc Disord 23:291-4. 2009..9, 95% CI: 1.4, 6.3). These neuropathologic associations suggest that people whose cranial MRI shows macroinfarcts, hemorrhages, or leukoencephalopathy are more likely also to have microinfarcts... - Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health StudyW T Longstreth
Department of Neurology, University of Washington, Seattle, USA
Arch Neurol 55:1217-25. 1998..To identify risk factors for and functional consequences of lacunar infarct in elderly people... - Clinical correlates of ventricular and sulcal size on cranial magnetic resonance imaging of 3,301 elderly people. The Cardiovascular Health Study. Collaborative Research GroupW T Longstreth
Department of Neurology, University of Washington, Seattle, USA
Neuroepidemiology 19:30-42. 2000..Significant age-adjusted correlations between ventricular grade and the Digit-Symbol Substitution Test were found for men and women. Prospective studies will be needed to extend findings of this cross-sectional analysis... - Asymptomatic internal carotid artery stenosis defined by ultrasound and the risk of subsequent stroke in the elderly. The Cardiovascular Health StudyW T Longstreth
Department of Neurology, University of Washington, Seattle, Wash, USA
Stroke 29:2371-6. 1998..We sought in this study to relate carotid ultrasound findings in asymptomatic older adults to the 5-year risk of various cerebrovascular outcomes used in the Asymptomatic Carotid Atherosclerosis Study (ACAS)... - Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health StudyW T Longstreth
Department of Neurology, University of Washington, Seattle, USA
Stroke 27:1274-82. 1996..Our aim was to identify potential risk factors for and clinical manifestations of white matter findings on cranial MRI in elderly people... - Risk of stroke in young women and two prothrombotic mutations: factor V Leiden and prothrombin gene variant (G20210A)W T Longstreth
Department of Neurology, University of Washington, Seattle, USA
Stroke 29:577-80. 1998..Factor V Leiden and a prothrombin gene variant, G20210A, are mutations associated with a thrombotic risk. The aim of our study was to assess whether these mutations increase the risk of stroke in women under 45 years of age... - Intravenous tissue plasminogen activator and stroke in the elderlyW T Longstreth
Department of Neurology, University of Washington, Seattle, 98195, USA
Am J Emerg Med 28:359-63. 2010.... - Frequency and predictors of stroke death in 5,888 participants in the Cardiovascular Health StudyW T Longstreth
Departments of Neurology and Epidemiology, University of Washington, Seattle, USA
Neurology 56:368-75. 2001..Few population-based studies have examined in detail issues of stroke-related deaths in elderly people... - The Kozak sequence polymorphism of platelet glycoprotein Ibalpha and risk of nonfatal myocardial infarction and nonfatal stroke in young womenM B Frank
Division of Hematology, Department of Medicine, University of Washington, Seattle, WA, USA
Blood 97:875-9. 2001..Paradoxically, the C allele may even be associated with a reduced risk of MI in this population. This finding requires further study... - Intracranial meningioma and ionizing radiation in medical and occupational settingsL E Phillips
Neuroepidemiology Group, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, USA
Neurology 64:350-2. 2005..7, 95% CI 1.5 to 9.5), especially for neoplastic conditions. Only four patients (2%) had meningiomas that followed high-dose cranial radiation... - Does narcolepsy symptom severity vary according to HLA-DQB1*0602 allele status?Nathaniel F Watson
Sleep Institute, University of Washington, Seattle, WA 98104 2499, USA
Sleep 33:29-35. 2010..To investigate associations between HLA-DQB1*0602 allele status and measures of narcolepsy symptom severity... - Prognosis in amyotrophic lateral sclerosis: a population-based studyM A del Aguila
Department of Dental Public Health Sciences, University of Washington, Seattle, USA
Neurology 60:813-9. 2003..Older age, female sex, any bulbar features at onset, short time from symptom onset to diagnosis, lack of a marital partner, and disease severity are key prognostic factors. Serial measurement of severity would likely improve predictions... - 5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating studySamir N P Kelada
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
Hum Mol Genet 15:3055-62. 2006..66 (95% CI: 1.73-18.53). Thus, allelic variants in SLC6A3, which affect gene expression, are associated with PD in this population and may interact with occupational pesticide exposure to increase PD risk... - Short-term and long-term risk of incident ischemic stroke after transient ischemic attackEvan L Thacker
Department of Epidemiology, University of Washington, Seattle, Wash, USA
Stroke 41:239-43. 2010..We sought to estimate short-term and long-term relative risks of ischemic stroke associated with clinically diagnosed TIA... - Active and passive cigarette smoking and risk of intracranial meningiomaLeslie E Phillips
Department of Neurology, School of Public Health and Community Medicine, University of Washington, Seattle, Wash, USA
Neuroepidemiology 24:117-22. 2005..0; 95% CI 1.1-3.5), and risk increased with increasing duration of exposure (p for trend = 0.02). Uncertain is whether these findings reflect a true biological phenomenon or result from chance or uncontrolled confounding... - No associations between Parkinson's disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genesStarlyn Okada
Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234, Seattle, WA 98195 7234, USA
Neurosci Lett 375:178-80. 2005..No associations were detected for either gene variant or for any allele combinations... - Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE ConsortiumStephanie Debette
Department of Neurology, Boston University School of Medicine, Boston, Mass, USA
Stroke 41:210-7. 2010..We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium... - Dietary fats, cholesterol and iron as risk factors for Parkinson's diseaseKaren M Powers
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195 7234, USA
Parkinsonism Relat Disord 15:47-52. 2009..Epidemiologic findings suggest that dietary components may contribute to the etiology of Parkinson's disease (PD). This population-based case-control study evaluated PD risk and dietary intake of fats, cholesterol and iron... - Parkinsonism and occupational exposure to pesticidesL S Engel
Department of Epidemiology, University of Washington, Seattle, WA, USA
Occup Environ Med 58:582-9. 2001..To examine the risk of parkinsonism related to lifetime occupational exposure to pesticides among a cohort of men, mostly orchardists, in Washington State... - Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular diseaseS Claiborne Johnston
Department of Neurology, University of California, San Francisco, San Francisco, California 94143-0114, USA
Ann Intern Med 140:237-47. 2004..The persistence of the association after adjustment for right-sided stenosis indicates that the association is not due to underlying vascular risk factors or atherosclerosis in general... - Quantitative assessment of spasticity in human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesisJ R Zunt
Harborview Medical Center, Department of Neurology, University of Washington School of Medicine, Seattle, WA 98104, USA
J Neurovirol 11:70-3. 2005..Tone in the 34 patients was more than double that of women with asymptomatic HTLV-I infection. The device may help to track progression in HTLV-I infection... - Dopamine transporter (SLC6A3) 5' region haplotypes significantly affect transcriptional activity in vitro but are not associated with Parkinson's diseaseSamir N Kelada
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
Pharmacogenet Genomics 15:659-68. 2005..In addition, our findings provide further evidence supporting an association of PD with the VNTR polymorphism... - Genome-wide analysis of genetic loci associated with Alzheimer diseaseSudha Seshadri
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
JAMA 303:1832-40. 2010..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)... - Nonsteroidal anti-inflammatory drugs and risk of Parkinson's diseaseThanh G Ton
Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA
Mov Disord 21:964-9. 2006..Our results provide only limited support for the hypothesis that use of aspirin may reduce the risk of this disease, and no indication of protection from other NSAIDs... - Prior antiplatelet therapy, platelet infusion therapy, and outcome after intracerebral hemorrhageClaire J Creutzfeldt
Department of Neurology, University of Washington, Seattle, WA 98104 242, USA
J Stroke Cerebrovasc Dis 18:221-8. 2009..The effect of platelet infusion therapy (PIT) on outcome in patients with ICH taking APT is unknown... - Midlife and late-life obesity and the risk of dementia: cardiovascular health studyAnnette L Fitzpatrick
Department of Epidemiology, University of Washington, Collaborative Health Studies Coordinating Center, Seattle, 98115, USA
Arch Neurol 66:336-42. 2009..While high adiposity in middle age appears to be related to greater dementia risk, studies exploring this association in the elderly are conflicting... - The functional polymorphism of the hemoglobin-binding protein haptoglobin influences susceptibility to idiopathic Parkinson's diseasePaola Costa-Mallen
Department of Laboratory Medicine, University of Washington, Seattle, Washington 98104, USA
Am J Med Genet B Neuropsychiatr Genet 147:216-22. 2008..To our knowledge, this is the first study that investigates the association of Hp genotypes with the risk of PD... - An unsuccessful trial of immunomodulatory therapy in delayed posthypoxic demyelinationSandeep Khot
Department of Neurology, University of Washington, Seattle, WA 98104, United States
Neurocrit Care 7:253-6. 2007..Delayed posthypoxic demyelination is hypothesized to be immunemediated, with support coming from recent animal experiments... - Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal salineFrancis Kim
Department of Medicine, Box 359748, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
Circulation 115:3064-70. 2007..The aims of the present pilot study were to assess the feasibility, safety, and effectiveness of in-field cooling... - Occupational factors and risk of Parkinson's disease: A population-based case-control studyJordan A Firestone
Department of Neurology, University of Washington, Seattle, USA
Am J Ind Med 53:217-23. 2010..Parkinson's disease (PD) has been associated with various workplace factors, but the evidence is inconsistent... - Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis: viral load and muscle tone are correlatedJ R Zunt
Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA
J Neurovirol 12:466-71. 2006..48, P = .02), suggesting viral load may play a role in expression of symptomatic neurologic disease. Longitudinal studies are needed to determine if treatments that reduce viral load will reduce muscle tone... - Education and the cognitive decline associated with MRI-defined brain infarctJ S Elkins
Department of Neurology, University of California, San Francisco, CA 94143, USA
Neurology 67:435-40. 2006..To assess whether educational attainment, a correlate of cognitive reserve, predicts the amount of cognitive decline associated with a new brain infarct... - Pilot study of rapid infusion of 2 L of 4 degrees C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrestFrancis Kim
Department of Medicine, Harborview Medical Center, University of Washington, Seattle, WA, USA
Circulation 112:715-9. 2005..Infusion of cold, intravenous fluid has been proposed as a safe, effective, and inexpensive technique to induce mild hypothermia after cardiac arrest... - Environmental toxins and risk of narcolepsy among people with HLA DQB1*0602Thanh G N Ton
Neuroepidemiology Group, University of Washington, Seattle, WA, USA
Environ Res 110:565-70. 2010..03), paints (p<0.03), and bug or weed killer (p<0.02). Additional studies are needed to replicate these findings and continue the search for specific toxins that could damage hypocretin neurons in genetically susceptible people... - Pesticides and risk of Parkinson disease: a population-based case-control studyJordan A Firestone
Department of Neurology, University of Washington, PO Box 359739, Seattle, WA 98104, USA
Arch Neurol 62:91-5. 2005..Pesticide exposures are suspected risk factors for Parkinson disease (PD), but epidemiological observations have been inconsistent... - Elevated risk of stroke among patients with end-stage renal diseaseStephen L Seliger
Division of Nephrology, University of Washington, Seattle, Washington, USA
Kidney Int 64:603-9. 2003..Although prior public health initiatives have focused primarily on cardiac disease among patients treated with dialysis, our data suggest that new initiatives are needed to control the high risk of stroke in this population... - Parkinson's disease risks associated with cigarette smoking, alcohol consumption, and caffeine intakeHarvey Checkoway
University of Washington, School of Public Health and Community Medicine, Department of Environmental Health, Seattle, WA 98195, USA
Am J Epidemiol 155:732-8. 2002..4, 95% CI: 0.2, 0.9) and two or more cola drinks/day (OR = 0.6, 95% CI: 0.3, 1.4). The associations for tea and cola drinks were not confounded by smoking or coffee consumption... - Intra-arterial urokinase for acute ischemic stroke: factors associated with complicationsD L Tirschwell
Department of Neurology, University of Washington, Seattle 98104 2499, USA
Neurology 57:1100-3. 2001..Although urokinase is no longer manufactured, these findings identify patients at risk for complications from other intra-arterial thrombolytics... - Shortening the NIH Stroke scale for use in the prehospital settingDavid L Tirschwell
Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, Seattle
Stroke 33:2801-6. 2002..The goal of this study was to identify a subset of the 15 items in the National Institutes of Health Stroke Scale (NIHSS-15) that measures stroke severity and predicts outcomes... - Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's diseaseSamir N Kelada
Department of Environmental Health, University of Washington, Seattle 98195, USA
Neurotoxicology 23:515-9. 2002..These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD... - Validating administrative data in stroke researchDavid L Tirschwell
Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, Seattle 98104 2499, USA
Stroke 33:2465-70. 2002..Research based on administrative data has advantages, including large numbers, consistent data, and low cost. This study was designed to compare different methods of stroke classification using administrative data... - Polymorphisms of coagulation factor XIII subunit A and risk of nonfatal hemorrhagic stroke in young white womenA P Reiner
Department of Medicine, Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, USA
Stroke 32:2580-6. 2001.... - Hormone replacement therapy and associated risk of stroke in postmenopausal womenRozenn N Lemaitre
Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle 98101, USA
Arch Intern Med 162:1954-60. 2002..There is little information about the risk of stroke in relation to time since initiation of hormone therapy and in relation to estrogen dose... - Withdrawal of support in intracerebral hemorrhage may lead to self-fulfilling propheciesK J Becker
Department of Neurology, Harborview Medical Center, University of Washington School of Medicine, Seattle 98104 2499, USA
Neurology 56:766-72. 2001.... - Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertensionBruce M Psaty
Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
JAMA 287:1680-9. 2002..Whether this genetic variant modifies the effect of diuretic therapy on the incidence of myocardial infarction (MI) and stroke is unknown... - Family history as a risk factor for stroke in young womenHelen Kim
Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
Am J Prev Med 27:391-6. 2004..A population-based, case-control study was conducted to examine the association of FHS and risk of stroke in young women, and to determine whether the association is independent of other stroke risk factors... - Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase geneS M Schwartz
Department of Epidemiology, University of Washington, Seattle 98101, USA
Circulation 96:412-7. 1997.... - DNA sequence analysis of monoamine oxidase B gene coding and promoter regions in Parkinson's disease cases and unrelated controlsPaola Costa-Mallen
Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195 6099, USA
Mov Disord 19:76-83. 2004..5%, but it was not associated with PD risk. No commonly occurring (>10%) polymorphisms were found in the exons or the intronic sequences flanking the exons, although several rare variants were detected in the coding and promoter regions... - Physical activity and subarachnoid haemorrhage: a population based case-control studyJ R Fann
Departments of Psychiatry and Behavioral Sciences, Box 356560, University of Washington, Seattle, WA 98195, USA
J Neurol Neurosurg Psychiatry 69:768-72. 2000..To evaluate physical activity as a risk factor for subarachnoid haemorrhage... - Stroke and use of low-dose oral contraceptives in young women: a pooled analysis of two US studiesS M Schwartz
Cardiovascular Health Research Unit, Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, USA
Stroke 29:2277-84. 1998..We sought more precise estimates by conducting a pooled analysis of data from 2 US population-based case-control studies... - Control of blood pressure and risk of stroke among pharmacologically treated hypertensive patientsO H Klungel
Department of Epidemiology, Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, USA
Stroke 31:420-4. 2000..We estimated the proportion of strokes occurring among treated hypertensive patients that may be attributable to uncontrolled blood pressure... - Genetic variants of platelet glycoprotein receptors and risk of stroke in young womenA P Reiner
Departments of Medicine, University of Washington, Seattle, WA 98195 9756, USA
Stroke 31:1628-33. 2000..Data on the association of these genetic susceptibility markers with ischemic stroke are more limited, and their role in hemorrhagic stroke has not been previously examined... - Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health StudyMyriam Fornage
Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Stroke 39:1952-9. 2008.... - Coagulation factor XIII polymorphisms and the risk of myocardial infarction and ischaemic stroke in young womenAlexander P Reiner
Department of Medicine, University of Washington, Seattle, USA
Br J Haematol 116:376-82. 2002..The relationship of factor XIIIA polymorphisms to cerebrovascular disease requires further study... - Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohortJared D Sturgeon
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second St, Minneapolis, MN 55454 1015, USA
Stroke 39:2268-73. 2008..The purpose of this study was to identify novel risk factors for intracerebral hemorrhagic stroke (ICH)... - Fish consumption and stroke risk in elderly individuals: the cardiovascular health studyDariush Mozaffarian
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Harvard School of Public Health, Boston, MA, USA
Arch Intern Med 165:200-6. 2005..Additionally, such relationships have not been specifically evaluated in the elderly, in whom disease burden may be high and diet less influential... - Alcohol consumption and subclinical findings on magnetic resonance imaging of the brain in older adults: the cardiovascular health studyK J Mukamal
Division of General Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Stroke 32:1939-46. 2001..The extent to which these competing associations influence overall brain function will require further study... - Longitudinal study of blood pressure and stroke in over 37,000 People in ChinaX H Fang
Department of Neuroepidemiology, Beijing Neurosurgical Institute, Beijing, People's Republic of China
Cerebrovasc Dis 11:225-9. 2001..These results emphasize the importance of systolic blood pressure, as opposed to diastolic, as a risk factor for stroke. In this study, the risk of stroke is increased by about 25% with each 10 mm Hg increase in systolic blood pressure... - Serum potassium and stroke risk among treated hypertensive adultsNicholas L Smith
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Am J Hypertens 16:806-13. 2003..Stroke risk associated with more recent assessments of hypokalemia has not been examined... - Fish consumption and risk of subclinical brain abnormalities on MRI in older adultsJ K Virtanen
University of Kuopio, School of Public Health and Clinical Nutrition, Research Institute of Public Health, P O Box 1627, 70211 Kuopio, Finland
Neurology 71:439-46. 2008..To investigate the association between fish consumption and subclinical brain abnormalities... 
Home use of automated external defibrillators for sudden cardiac arrestGust H Bardy
Seattle Institute for Cardiac Research, Seattle, WA 98103 4819, USA
N Engl J Med 358:1793-804. 2008..Consequently, home use of an automated external defibrillator (AED) might offer an opportunity to improve survival for patients at risk...- Antidepressant treatment and worsening white matter on serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health StudyDavid C Steffens
Department of Psychiatry, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
Stroke 39:857-62. 2008..We hypothesized that Cardiovascular Health Study participants taking SSRIs would less often have worsening white matter on serial MRI than participants not on antidepressants... - Stroke risk factors and loss of high cognitive functionJ S Elkins
University of California, San Francisco, CA 94143-0114, USA
Neurology 63:793-9. 2004..Additional studies are needed to determine whether modification of stroke risk factors can reduce the cognitive decline that is often attributed to normal aging... - Alcohol use and risk of ischemic stroke among older adults: the cardiovascular health studyKenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Stroke 36:1830-4. 2005..The association of light to moderate alcohol consumption with risk of ischemic stroke remains uncertain, as are the roles of potentially mediating factors and modification by apolipoprotein E (apoE) genotype... - Vascular events, mortality, and preventive therapy following ischemic stroke in the elderlyR C Kaplan
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Neurology 65:835-42. 2005..The authors studied mortality, vascular events, and preventive therapies following ischemic stroke among adults aged > or =65 years... - Cystatin C and subclinical brain infarctionStephen L Seliger
Division of Nephrology, University of Maryland, Baltimore, MD 21201, USA
J Am Soc Nephrol 16:3721-7. 2005..Compared with creatinine, CysC, a novel marker of renal function, has a stronger and more direct association with SBI in the elderly... - A prospective analysis of risk factors for white matter disease in the brain stem: the Cardiovascular Health StudyJingzhong Ding
Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, 615 N Wolfe Street, Room W6009, Baltimore, MD 21205, USA
Neuroepidemiology 22:275-82. 2003..However, no epidemiologic study has examined the associations between cardiovascular risk factors and WMD in the brain stem... - Diabetes, smoking, and other medical conditions in relation to Parkinson's disease riskKaren M Powers
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, 98195-7234, USA
Parkinsonism Relat Disord 12:185-9. 2006..However, among diabetics, the PD risk was especially reduced in non-smoking men (OR = 0.09, 95% CI = 0.02, 0.44). Other medical conditions showed no strong relations with PD... - Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health StudyKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Am Geriatr Soc 54:30-7. 2006..To evaluate several aspects of the relationship between alcohol use and coronary heart disease in older adults, including beverage type, mediating factors, and type of outcome... - Prospective study of alcohol consumption and risk of dementia in older adultsKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, RO 114, Boston, Mass 02215, USA
JAMA 289:1405-13. 2003..Alcohol consumption has been associated with complex changes in cerebral vasculature and structure in older adults. How alcohol consumption affects the incidence of dementia is less clear... - White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health studyLewis H Kuller
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, 130 N Bellefield Ave, Rm 550, Pittsburgh, PA 15213, United States
Neurobiol Aging 28:1307-15. 2007..Low WMG and VG on MRI is a powerful determinant of long-term survival among older individuals... - Calcium channel blockers and beta-blockers in relation to Parkinson's diseaseThanh G N Ton
Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195 7326, USA
Parkinsonism Relat Disord 13:165-9. 2007..The weakness of these associations and the absence of additional influence of dose or duration of use argue against any causal interpretation... - Hormone replacement therapy, prothrombotic mutations, and the risk of incident nonfatal ischemic stroke in postmenopausal womenRozenn N Lemaitre
Arterioscler Thromb Vasc Biol 22:1051-2. 2002 - The association of PAI-1 promoter 4G/5G insertion/deletion polymorphism with myocardial infarction and stroke in young womenLucia A Hindorff
Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
J Cardiovasc Risk 9:131-7. 2002..Whether these results apply to young women is not known... - Risk factors for intracerebral hemorrhage in a pooled prospective studyJared D Sturgeon
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
Stroke 38:2718-25. 2007..We studied risk factors for ICH in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS)... - Gait variability is associated with subclinical brain vascular abnormalities in high-functioning older adultsCaterina Rosano
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuroepidemiology 29:193-200. 2007..The brain anatomical correlates of gait variability have not been studied in high-functioning community-dwelling older adults... - Association of cholesterol with stroke risk varies in stroke subtypes and patient subgroupsD L Tirschwell
Department of Neurology, University of Washington, Seattle, USA
Neurology 63:1868-75. 2004..To perform a health maintenance organization-based case-control study to evaluate the association of total and high density lipoprotein (HDL) cholesterol with the risk of stroke subtypes and in patient subgroups...