Valter Longo

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Calorie restriction and cancer prevention: metabolic and molecular mechanisms
    Valter D Longo
    The Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA
    Trends Pharmacol Sci 31:89-98. 2010
  2. doi request reprint Fasting: molecular mechanisms and clinical applications
    Valter D Longo
    Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 2520, USA Electronic address
    Cell Metab 19:181-92. 2014
  3. pmc Replicative and chronological aging in Saccharomyces cerevisiae
    Valter D Longo
    Longevity Institute, School of Gerontology, Department of Biological Sciences, and Norris Cancer Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Cell Metab 16:18-31. 2012
  4. pmc Growth factors, nutrient signaling, and cardiovascular aging
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Circ Res 110:1139-50. 2012
  5. pmc Inference of transcription modification in long-live yeast strains from their expression profiles
    Chao Cheng
    Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 2910, USA
    BMC Genomics 8:219. 2007
  6. ncbi request reprint Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells
    V D Longo
    Department of Biological Sciences, University of Southern Californiia, Los Angeles 90089 0191, USA
    Neurobiol Aging 20:479-86. 1999
  7. ncbi request reprint Ras: the other pro-aging pathway
    Valter D Longo
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Sci Aging Knowledge Environ 2004:pe36. 2004
  8. ncbi request reprint Programmed and altruistic ageing
    Valter D Longo
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089, USA
    Nat Rev Genet 6:866-72. 2005
  9. ncbi request reprint Sirtuins in aging and age-related disease
    Valter D Longo
    Department of Molecular and Computational Biology, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089, USA
    Cell 126:257-68. 2006
  10. doi request reprint Turning anti-ageing genes against cancer
    Valter D Longo
    Andrus Gerontology Center, Molecular and Computational Biology Department, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191, USA
    Nat Rev Mol Cell Biol 9:903-10. 2008

Research Grants

Collaborators

Detail Information

Publications44

  1. pmc Calorie restriction and cancer prevention: metabolic and molecular mechanisms
    Valter D Longo
    The Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA
    Trends Pharmacol Sci 31:89-98. 2010
    ..Here, we discuss the link between nutritional interventions and cancer prevention with focus on the mechanisms that might be responsible for these effects in simple systems and mammals with a view to developing chemoprevention agents...
  2. doi request reprint Fasting: molecular mechanisms and clinical applications
    Valter D Longo
    Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 2520, USA Electronic address
    Cell Metab 19:181-92. 2014
    ..Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic dietary interventions. ..
  3. pmc Replicative and chronological aging in Saccharomyces cerevisiae
    Valter D Longo
    Longevity Institute, School of Gerontology, Department of Biological Sciences, and Norris Cancer Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Cell Metab 16:18-31. 2012
    ..cerevisiae will continue to serve as a leading model organism for studying pathways relevant to human aging and disease...
  4. pmc Growth factors, nutrient signaling, and cardiovascular aging
    Luigi Fontana
    Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Circ Res 110:1139-50. 2012
    ..Here, we review the link between growth factors, cardiac function, and heart disease with focus on the cardioprotective and sensitizing effect of growth factors in both model organisms and humans...
  5. pmc Inference of transcription modification in long-live yeast strains from their expression profiles
    Chao Cheng
    Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 2910, USA
    BMC Genomics 8:219. 2007
    ..However, the mechanisms of longevity, especially the underlying transcription program have not been fully understood...
  6. ncbi request reprint Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells
    V D Longo
    Department of Biological Sciences, University of Southern Californiia, Los Angeles 90089 0191, USA
    Neurobiol Aging 20:479-86. 1999
    ..Taken together, the published studies suggest that survival may be regulated by similar fundamental mechanisms in many eukaryotes and that simple model systems will contribute to our understanding of the aging process in mammals...
  7. ncbi request reprint Ras: the other pro-aging pathway
    Valter D Longo
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Sci Aging Knowledge Environ 2004:pe36. 2004
    ..Here I review the data from experiments at both the organismal and cellular levels that support a role for Ras in the regulation of stress resistance and life span in eukaryotes...
  8. ncbi request reprint Programmed and altruistic ageing
    Valter D Longo
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089, USA
    Nat Rev Genet 6:866-72. 2005
    ....
  9. ncbi request reprint Sirtuins in aging and age-related disease
    Valter D Longo
    Department of Molecular and Computational Biology, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089, USA
    Cell 126:257-68. 2006
    ..Here we examine the roles of Sirtuins in diverse eukaryotic species, with special emphasis on their links to aging and age-related diseases including cancer, diabetes, and neurodegenerative disorders...
  10. doi request reprint Turning anti-ageing genes against cancer
    Valter D Longo
    Andrus Gerontology Center, Molecular and Computational Biology Department, University of Southern California, 3715 McClintock Avenue, Los Angeles, California 90089 0191, USA
    Nat Rev Mol Cell Biol 9:903-10. 2008
    ..This raises the possibility that cancer can be reduced by chronic downregulation of pro-ageing pathways...
  11. doi request reprint Linking sirtuins, IGF-I signaling, and starvation
    Valter D Longo
    Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA
    Exp Gerontol 44:70-4. 2009
    ..Here, I review the studies linking SirT1, IGF-I signaling and starvation in various model organisms with a focus on the post-mitotic cells, which indicate that sirtuins can play both protective and pro-aging roles...
  12. ncbi request reprint Search for methuselah genes heats up
    Valter D Longo
    Leonard Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 0191, USA
    Sci Aging Knowledge Environ 2004:pe6. 2004
    ..The role of multiple transcription factors in extending life span in yeast and worms raises the possibility that many transcriptional regulators can contribute to longevity extension...
  13. ncbi request reprint Evolutionary medicine: from dwarf model systems to healthy centenarians?
    Valter D Longo
    Andrus Gerontology Center, Division of Biogerontology, and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Science 299:1342-6. 2003
    ..This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects...
  14. doi request reprint Chronological Aging in Saccharomyces cerevisiae
    Valter D Longo
    Department of Biological Sciences, Andrus Gerontology Center, University of Southern California, Los Angeles, CA, 90089 0191, USA
    Subcell Biochem 57:101-21. 2012
    ....
  15. ncbi request reprint Oxygen? No thanks, I'm on a diet
    Valter D Longo
    Andrus Gerontology Center, Division of Biogerontology, and Department of Biological Sciences at the University of Southern California, Los Angeles, CA 90089 0191, USA
    Sci Aging Knowledge Environ 2002:pe10. 2002
    ..The implications of these results are discussed in this Perspective...
  16. ncbi request reprint Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans?
    V D Longo
    Division of Biogerontology, Andrus Gerontology Center, University of Southern California, Los Angeles 90089 0191, USA
    Cell Mol Life Sci 59:903-8. 2002
    ....
  17. ncbi request reprint The Ras and Sch9 pathways regulate stress resistance and longevity
    Valter D Longo
    Division of Biogerontology and Department of Biological Sciences, Andrus Gerontology Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Exp Gerontol 38:807-11. 2003
    ..Although only one intracellular pathway that includes genes homologous to SCH9 and SOD2 has been identified in worms, our studies in yeast suggest that longevity in higher eukaryotes may also be negatively regulated by the Ras pathway...
  18. ncbi request reprint Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines
    V D Longo
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 0191, USA
    J Neurochem 75:1977-85. 2000
    ..Abeta neurotoxicity was partially blocked by the iron chelator deferoxamine. These data suggest that increased superoxide generation and the release of iron from 4Fe-4S clusters are early events in Abeta1-42 neurotoxicity...
  19. ncbi request reprint Sir2 blocks extreme life-span extension
    Paola Fabrizio
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
    Cell 123:655-67. 2005
    ..Our results demonstrate that effects of SIR2 on chronological life span are opposite to replicatve life span and suggest that the relevant activities of Sir2-like deacetylases may also be complex in higher eukaryotes...
  20. pmc Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9
    Min Wei
    Andrus Gerontology Center, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 4:e13. 2008
    ..Notably, the anti-aging effect caused by the inactivation of both pathways is much more potent than that caused by CR...
  21. pmc Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polzeta-dependent mechanism
    Federica Madia
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    J Cell Biol 186:509-23. 2009
    ....
  22. pmc Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system
    Federica Madia
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    J Cell Biol 180:67-81. 2008
    ..The conserved function of Akt/S6k homologues in lifespan regulation raises the possibility that modulation of the IGF-I-Akt-56K pathway can protect against premature aging syndromes in mammals...
  23. ncbi request reprint The chronological life span of Saccharomyces cerevisiae
    Paola Fabrizio
    Andrus Gerontology Center, Division of Biogerontology and Department of Biological Sciences, University of Southern California, Los Angeles 90089 0191, USA
    Aging Cell 2:73-81. 2003
    ..We will review the yeast S. cerevisiae model system with emphasis on the chronological life span as a model system to study aging and the regulation of stress resistance in eukaryotes...
  24. pmc Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension
    Min Wei
    Andrus Gerontology Center, University of Southern California, Los Angeles, CA, USA
    PLoS Genet 5:e1000467. 2009
    ....
  25. pmc Significant and systematic expression differentiation in long-lived yeast strains
    Chao Cheng
    Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America
    PLoS ONE 2:e1095. 2007
    ..The three yeast mutants sch9Delta, ras2Delta, tor1Delta show extended chronological life span up to three folds. Our aim is to dissect the mechanisms that lead to the yeast life span extension...
  26. pmc Comparative analyses of time-course gene expression profiles of the long-lived sch9Delta mutant
    Huanying Ge
    Andrus Gerontology Center, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Nucleic Acids Res 38:143-58. 2010
    ....
  27. pmc Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index
    Changhan Lee
    Andrus Gerontology Center, Department of Biological Sciences and Norris Cancer Center, University of Southern California, Los Angeles, California 90089 0191, USA
    Cancer Res 70:1564-72. 2010
    ..We conclude that normal cells and mice can be protected against chemotherapy-dependent damage by reducing circulating IGF-I levels and by a mechanism that involves downregulation of proto-oncogene signals...
  28. pmc Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae
    Paola Fabrizio
    Andrus Gerontology Center and Dept of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    J Cell Biol 166:1055-67. 2004
    ..The role of similar pathways in the regulation of longevity in organisms ranging from yeast to mice raises the possibility that mammals may also undergo programmed aging...
  29. pmc SOD2 functions downstream of Sch9 to extend longevity in yeast
    Paola Fabrizio
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 0191, USA
    Genetics 163:35-46. 2003
    ..cerevisiae to superoxide dismutases and suggest that the induction of other stress-resistance genes regulated by Msn2/4 and Rim15 is required for maximum longevity extension...
  30. pmc Cell resilience in species life spans: a link to inflammation?
    Caleb E Finch
    University of Southern California, Los Angeles, CA 90089 0191, USA
    Aging Cell 9:519-26. 2010
    ..We suggest expanding the battery of stressors and markers used for comparative studies to additional cell types and additional parameters relevant to host defense and to their ecological specificities...
  31. doi request reprint Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain
    Edoardo Parrella
    Division of Neurogerontology Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA
    ScientificWorldJournal 10:161-77. 2010
    ..Taken together, these studies indicate that simple model systems will contribute to our comprehension of aging of the mammalian nervous system and will stimulate novel neurotherapeutic strategies in humans...
  32. pmc Chronological aging-induced apoptosis in yeast
    Paola Fabrizio
    Andrus Gerontology Center, Division of Biogerontology, University of Southern California, Los Angeles, CA 90089 0191, USA
    Biochim Biophys Acta 1783:1280-5. 2008
    ..cerevisiae. We also describe the use of a genome-wide screening technique to gain further insights into the mechanisms of programmed death in populations of chronologically aging S. cerevisiae...
  33. ncbi request reprint The chronological life span of Saccharomyces cerevisiae
    Paola Fabrizio
    Adrus Gerontology Center, Division of Biogerentology and Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA
    Methods Mol Biol 371:89-95. 2007
    ..Here, we describe the standard procedures to measure the chronological life span, including both the normal and calorie restriction paradigms...
  34. pmc Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation
    Paola Fabrizio
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, California, United States of America
    PLoS Genet 6:e1001024. 2010
    ..The high degree of conservation of these novel yeast longevity determinants in other species raises the possibility that their role in senescence might be conserved...
  35. ncbi request reprint Analysis of gene expression profile in yeast aging chronologically
    Paola Fabrizio
    Andrus Gerontology Center, Division of Biogerontology, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Mech Ageing Dev 126:11-6. 2005
    ..We also discuss a novel genomics method for the identification of chronologically long-lived yeast mutants...
  36. pmc Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy
    Lizzia Raffaghello
    Andrus Gerontology Center, Department of Biological Sciences and Norris Cancer Center, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Proc Natl Acad Sci U S A 105:8215-20. 2008
    ....
  37. doi request reprint The chronological life span of Saccharomyces cerevisiae to study mitochondrial dysfunction and disease
    Edoardo Parrella
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089 0191, USA
    Methods 46:256-62. 2008
    ..Here, we describe the use of S. cerevisiae CLS in combination with three methods to quantify age-dependent mitochondrial damage and the accumulation of mitochondrial DNA mutations...
  38. ncbi request reprint Superoxide inhibits 4Fe-4S cluster enzymes involved in amino acid biosynthesis. Cross-compartment protection by CuZn-superoxide dismutase
    Matthew Alan Wallace
    Department of Chemistry and Biochemistry, UCLA, Los Angeles, California 90095 1569, USA
    J Biol Chem 279:32055-62. 2004
    ..Thus, we conclude that when Sod1p is absent a lysine auxotrophy is induced because Lys4p is inactivated in the matrix by superoxide that originates in the intermembrane space and diffuses across the inner membrane...
  39. pmc SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
    Ying Li
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    Cell Metab 8:38-48. 2008
    ..These results are consistent with findings in S. cerevisiae and other model systems, suggesting that mammalian sirtuins can play both protective and proaging roles...
  40. ncbi request reprint Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia
    Zhong Xie
    Division of Biogerontology, Andrus Gerontology Center, and Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 0191, USA
    J Neurosci 22:3484-92. 2002
    ..These results implicate peroxynitrite as a mediator of the toxicity of activated microglia, which may play a major role in Abeta1-42 neurotoxicity and Alzheimer's disease...
  41. pmc Fasting and cancer treatment in humans: A case series report
    Fernando M Safdie
    Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Aging (Albany NY) 1:988-1007. 2009
    ..Only controlled-randomized clinical trials will determine the effect of fasting on clinical outcomes including quality of life and therapeutic index...
  42. ncbi request reprint Aging as a mitochondria-mediated atavistic program: can aging be switched off?
    Vladimir P Skulachev
    Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119992, Russia
    Ann N Y Acad Sci 1057:145-64. 2005
    ..Aging of higher animals is accompanied by an increase in damage induced by mitochondrial ROS. Perhaps prevention of such damage by scavenging of mitochondrial ROS might slow down or even switch off the aging programs...
  43. ncbi request reprint Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic
    Christi M Gendron
    Max Planck Institute for Demographic Research, Konrad Zuse Strasse 1, Rostock D 18057, Germany
    Mech Ageing Dev 124:1059-63. 2003
    ..Furthermore, we observed this pattern in different experiments and in different genotypes and established that this pattern was not due to genetic heterogeneity of the populations...
  44. ncbi request reprint Genetics of aging and diseases: from rare mutations and model systems to disease prevention
    Valter D Longo
    Arch Neurol 59:1706-8. 2002

Research Grants14

  1. Chronological Age-Dependent Genomic Instability in Yeast
    Valter Longo; Fiscal Year: 2007
    ..Thus, chronologically aging S. cerevisiae can serve as a model to identify genes that regulate genomic instability and understand the mechanisms responsible for age-dependent DNA mutations and cancer in mammals. ..
  2. Mechanisms of Longevity Regulation in Yeast
    Valter D Longo; Fiscal Year: 2010
    ..For example, mutations that cause activation of Akt or Ras accelerate aging in yeast but are also found in a major portion of human cancers. ..
  3. Mechanisms of Longevity Regulation in Yeast
    Valter Longo; Fiscal Year: 2007
    ..abstract_text> ..
  4. 4 iron-4sulfur Clusters in Aging and Alzheimer's Disease
    Valter Longo; Fiscal Year: 2004
    ..abstract_text> ..
  5. Chronological Age-Dependent Genomic Instability in Yeast
    Valter D Longo; Fiscal Year: 2010
    ..Thus, chronologically aging S. cerevisiae can serve as a model to identify genes that regulate genomic instability and understand the mechanisms responsible for age-dependent DNA mutations and cancer in mammals. ..