JOHN C contact LONGHURST

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Acupuncture regulation of blood pressure: two decades of research
    John C Longhurst
    Department of Medicine, Physiology and Biophysics, and Pharmacology, School of Medicine, University of California, Medical Sciences, Irvine, California, USA Electronic address
    Int Rev Neurobiol 111:257-71. 2013
  2. pmc Point specificity in acupuncture
    Emma M Choi
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine CA 92697 4075, USA
    Chin Med 7:4. 2012
  3. doi request reprint Defining meridians: a modern basis of understanding
    John C Longhurst
    Samueli Center for Integrative Medicine, Departments of Medicine, Physiology and Biophysics, Pharmacology and Biomedical Engineering, Schools of Medicine and Engineering, University of California, Irvine, USA
    J Acupunct Meridian Stud 3:67-74. 2010
  4. pmc Exercise in hypoxic environments: the mechanism remains elusive
    John Longhurst
    College of Medicine, Med Sci I, Room C240, Irvine, CA 92697 4075, USA
    J Physiol 550:335. 2003
  5. ncbi request reprint Cardiac sympathetic afferent activation provoked by myocardial ischemia and reperfusion. Mechanisms and reflexes
    J C Longhurst
    Department of Medicine, Medical Sciences 1, C240, University of California at Irvine, Irvine, CA 92697, USA
    Ann N Y Acad Sci 940:74-95. 2001
  6. pmc Serotonergic projection from nucleus raphe pallidus to rostral ventrolateral medulla modulates cardiovascular reflex responses during acupuncture
    Ali Moazzami
    Susan Samueli Center for Integrative Medicine, Department of Medicine, Medical Science 1 C240, School of Medicine, University of California, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 108:1336-46. 2010
  7. pmc Spinal nociceptin mediates electroacupuncture-related modulation of visceral sympathoexcitatory reflex responses in rats
    Wei Zhou
    Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Am J Physiol Heart Circ Physiol 297:H859-65. 2009
  8. ncbi request reprint Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats
    Melissa M Crisostomo
    Medical Science 1, C240, College of Medicine, University of California Irvine, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 98:2056-63. 2005
  9. ncbi request reprint Role of activated platelets in excitation of cardiac afferents during myocardial ischemia in cats
    Liang Wu Fu
    Department of Medicine, College of Medicine, C240 Medical Sciences I, University of California, Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 282:H100-9. 2002
  10. pmc Nitric oxide in rostral ventrolateral medulla regulates cardiac-sympathetic reflexes: role of synthase isoforms
    Zhi Ling Guo
    Department of Medicine, School of Medicine, University of California, Susan Samueli Center for Integrative Medicine, Irvine, Irvine, California 92697 4075, USA
    Am J Physiol Heart Circ Physiol 297:H1478-86. 2009

Research Grants

  1. Mechanisms of Cardiac Afferents and CNS Reflex Processing
    JOHN C contact LONGHURST; Fiscal Year: 2010
  2. Mechanisms of CNS Autonomic Regulation by EA
    John Longhurst; Fiscal Year: 2007
  3. Neural Substrates of EA in Cardiovascular Control
    John Longhurst; Fiscal Year: 2007
  4. Mechanisms of Cardiac Afferents and their Reflexes
    John Longhurst; Fiscal Year: 2007
  5. Mechanims of CNS Autonomic Regulation by EA
    John Longhurst; Fiscal Year: 2009
  6. Mechanisms of Cardiac Afferents and their Reflexes
    John Longhurst; Fiscal Year: 2009
  7. Neural Substrates of EA in Cardiovascular Control
    John Longhurst; Fiscal Year: 2009
  8. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2010
  9. Neural Substrates of EA in Cardiovascular Control
    John C Longhurst; Fiscal Year: 2010
  10. Mechanisms of Cardiac Afferents and their Reflexes
    John Longhurst; Fiscal Year: 2006

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Acupuncture regulation of blood pressure: two decades of research
    John C Longhurst
    Department of Medicine, Physiology and Biophysics, and Pharmacology, School of Medicine, University of California, Medical Sciences, Irvine, California, USA Electronic address
    Int Rev Neurobiol 111:257-71. 2013
    ..Thus, acupuncture has the capability of profoundly regulating cardiovascular function in patients with disease, for example, hypertension, and the experimental laboratory is directing best approaches to study its actions in humans. ..
  2. pmc Point specificity in acupuncture
    Emma M Choi
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine CA 92697 4075, USA
    Chin Med 7:4. 2012
    ..Further research is needed to elucidate the point-specific actions of acupuncture...
  3. doi request reprint Defining meridians: a modern basis of understanding
    John C Longhurst
    Samueli Center for Integrative Medicine, Departments of Medicine, Physiology and Biophysics, Pharmacology and Biomedical Engineering, Schools of Medicine and Engineering, University of California, Irvine, USA
    J Acupunct Meridian Stud 3:67-74. 2010
    ..The meridian maps and associated acupoints located along them are best viewed as road maps that can guide practitioners towards applying acupuncture to achieve optimal clinical results...
  4. pmc Exercise in hypoxic environments: the mechanism remains elusive
    John Longhurst
    College of Medicine, Med Sci I, Room C240, Irvine, CA 92697 4075, USA
    J Physiol 550:335. 2003
  5. ncbi request reprint Cardiac sympathetic afferent activation provoked by myocardial ischemia and reperfusion. Mechanisms and reflexes
    J C Longhurst
    Department of Medicine, Medical Sciences 1, C240, University of California at Irvine, Irvine, CA 92697, USA
    Ann N Y Acad Sci 940:74-95. 2001
    ..Thus, stimulation of cardiac sympathetic afferents during ischemia and reperfusion and the resulting reflex events form a multifactorial process resulting from activation of a number of chemical pathways in the myocardium...
  6. pmc Serotonergic projection from nucleus raphe pallidus to rostral ventrolateral medulla modulates cardiovascular reflex responses during acupuncture
    Ali Moazzami
    Susan Samueli Center for Integrative Medicine, Department of Medicine, Medical Science 1 C240, School of Medicine, University of California, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 108:1336-46. 2010
    ..Thus activation of the NRP, through a mechanism involving serotonergic neurons and 5-HT1A receptors in the rVLM during somatic stimulation with EA, attenuates sympathoexcitatory cardiovascular reflexes...
  7. pmc Spinal nociceptin mediates electroacupuncture-related modulation of visceral sympathoexcitatory reflex responses in rats
    Wei Zhou
    Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Am J Physiol Heart Circ Physiol 297:H859-65. 2009
    ..These results suggest that nociceptin in the spinal cord mediates part of the EA-related modulation of visceral reflex responses...
  8. ncbi request reprint Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats
    Melissa M Crisostomo
    Medical Science 1, C240, College of Medicine, University of California Irvine, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 98:2056-63. 2005
    ..Thus, in addition to the classical opioid system, nociceptin, through opioid receptor-like-1 receptor stimulation in the rVLM, participates in the modulatory influence of EA on reflex-induced increases in blood pressure...
  9. ncbi request reprint Role of activated platelets in excitation of cardiac afferents during myocardial ischemia in cats
    Liang Wu Fu
    Department of Medicine, College of Medicine, C240 Medical Sciences I, University of California, Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 282:H100-9. 2002
    ..These data indicate activated platelets stimulate ischemia-sensitive cardiac spinal afferents and contribute to activation of these afferents during ischemia...
  10. pmc Nitric oxide in rostral ventrolateral medulla regulates cardiac-sympathetic reflexes: role of synthase isoforms
    Zhi Ling Guo
    Department of Medicine, School of Medicine, University of California, Susan Samueli Center for Integrative Medicine, Irvine, Irvine, California 92697 4075, USA
    Am J Physiol Heart Circ Physiol 297:H1478-86. 2009
    ..These data suggest that NO, specifically nNOS, mediates sympathetic cardiac-cardiovascular responses through its action in the rVLM...
  11. pmc Electroacupuncture modulates vlPAG release of GABA through presynaptic cannabinoid CB1 receptors
    Liang Wu Fu
    Department of Medicine, University of California, Irvine, CA 92697, USA
    J Appl Physiol (1985) 106:1800-9. 2009
    ..33.8 +/- 8.7 nM, Glu vs. GABA). These results suggest that EA modulates the sympathoexcitatory reflex responses by decreasing the release of GABA, but not Glu, in the vlPAG, most likely through a presynaptic CB(1) receptor mechanism...
  12. pmc Processing cardiovascular information in the vlPAG during electroacupuncture in rats: roles of endocannabinoids and GABA
    Stephanie C Tjen-A-Looi
    School of Medicine, University of California, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 106:1793-9. 2009
    ..Reduction of GABA release disinhibits vlPAG cells, which, in turn, modulate the activity of rVLM neurons to attenuate the sympathoexcitatory reflex responses...
  13. pmc Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2?
    Liang Wu Fu
    Department of Medicine, Susan Samueli Center for Integrative Medicine, School of Mediicne, University of California, Irvine, Irvine, CA 92697, USA
    Am J Physiol Heart Circ Physiol 295:H2530-40. 2008
    ..These data indicate that endogenous TxA2 participates in myocardial ischemia-mediated sympathoexcitatory reflex responses through a TP receptor mechanism...
  14. pmc Responses of opioid and serotonin containing medullary raphe neurons to electroacupuncture
    Zhi Ling Guo
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, CA 92697, USA
    Brain Res 1229:125-36. 2008
    ..These results suggest that the medullary raphe nuclei, particularly the NRP, process somatic signals during EA and participate in EA-related modulation of cardiovascular function through an opioid or serotonergic mechanism...
  15. pmc Undiscovered role of endogenous thromboxane A2 in activation of cardiac sympathetic afferents during ischaemia
    Liang Wu Fu
    Department of Medicine, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    J Physiol 586:3287-300. 2008
    ....
  16. pmc Bradykinin and thromboxane A2 reciprocally interact to synergistically stimulate cardiac spinal afferents during myocardial ischemia
    Liang Wu Fu
    Department of Medicine, School of Medicine, University of California, Irvine, CA 92697, USA
    Am J Physiol Heart Circ Physiol 298:H235-44. 2010
    ....
  17. pmc Electroacupuncture enhances preproenkephalin mRNA expression in rostral ventrolateral medulla of rats
    Min Li
    Department of Medicine and Susan Samueli Center of Integrative Medicine, College of Medicine, University of California, Irvine, CA 92697 4075, United States
    Neurosci Lett 477:61-5. 2010
    ....
  18. pmc Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats
    Stephanie C Tjen-A-Looi
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, California 92697 4075, USA
    Am J Physiol Heart Circ Physiol 300:H1003-12. 2011
    ..Efferent chronotropic responses involve both increased parasympathetic and reduced sympathetic activity, whereas the decrease in BP is mediated by reduced α-adrenergic tone...
  19. pmc A new function for ATP: activating cardiac sympathetic afferents during myocardial ischemia
    Liang Wu Fu
    Department of Medicine, School of Medicine, University of California, Irvine, Irvine, California, USA
    Am J Physiol Heart Circ Physiol 299:H1762-71. 2010
    ....
  20. pmc Activation of reciprocal pathways between arcuate nucleus and ventrolateral periaqueductal gray during electroacupuncture: involvement of VGLUT3
    Zhi Ling Guo
    Department of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Brain Res 1360:77-88. 2010
    ....
  21. pmc Nucleus raphe pallidus participates in midbrain-medullary cardiovascular sympathoinhibition during electroacupuncture
    Peng Li
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1369-76. 2010
    ..These results indicate that EA activates the vlPAG, which excites the NRP to, in turn, inhibit rVLM presympathetic neurons and reflex cardiovascular sympathoexcitatory responses...
  22. pmc Long-loop pathways in cardiovascular electroacupuncture responses
    Peng Li
    Department of Medicine, University of California, Irvine, CA, USA
    J Appl Physiol (1985) 106:620-30. 2009
    ..Direct projections from the ARC to the rVLM, which serve as an important source of beta-endorphin, appear also to exist...
  23. pmc An arcuate-ventrolateral periaqueductal gray reciprocal circuit participates in electroacupuncture cardiovascular inhibition
    Peng Li
    Department of Medicine, Susan Samueli Center for Integrative Medicine, School of Medicine, University of California, Irvine, CA 92697 4075, United States
    Auton Neurosci 158:13-23. 2010
    ..Thus, a reciprocal excitatory glutamatergic neural circuit between the arcuate and vlPAG contributes to long-lasting EA cardiovascular inhibition. ACh in the arcuate but not in the vlPAG participates in the reciprocal excitation...
  24. pmc Neural mechanism of electroacupuncture's hypotensive effects
    Peng Li
    Department of Medicine, Susan Samueli Center for Integrative Medicine, University of California, Irvine, California 92697, USA
    Auton Neurosci 157:24-30. 2010
    ..Thus, a number of mechanisms underlying the long-lasting effect of EA on cardiovascular function have been identified but clearly further investigation is warranted...
  25. pmc Endogenous endothelin stimulates cardiac sympathetic afferents during ischaemia
    Liang Wu Fu
    Department of Medicine, School of Medicine, University of California, Irvine, CA 92697, USA
    J Physiol 588:2473-86. 2010
    ....
  26. ncbi request reprint Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats
    Stephanie C Tjen-A-Looi
    Department of Medicine, Susan Samueli Center for Integrative Medicine, School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 293:H3627-35. 2007
    ..Furthermore, in the rVLM, opioids and GABA, but not nociceptin, participate in the long-term EA-related inhibition of sympathoexcitatory cardiovascular responses...
  27. pmc Expression of c-Fos in arcuate nucleus induced by electroacupuncture: relations to neurons containing opioids and glutamate
    Zhi Ling Guo
    Susan Samueli Center for Integrative Medicine and Department of Medicine, School of Medicine, University of California, Irvine, CA 92697, USA
    Brain Res 1166:65-76. 2007
    ..The results imply that EA at P5-P6 has the potential to influence ARC neurons containing multiple neuronal substances that subsequently modulate cardiovascular function...
  28. pmc Interactions between histamine and bradykinin in stimulation of ischaemically sensitive cardiac afferents in felines
    Liang Wu Fu
    Department of Medicine, College of Medicine, University of California at Irvine, Irvine, CA 92697, USA
    J Physiol 565:1007-17. 2005
    ..BK sensitizes cardiac afferents responding to histamine in a time-dependent fashion, and the BK sensitization effect is dependent on an intact cyclooxygenase pathway. Conversely, histamine reduces the response of most afferents to BK...
  29. ncbi request reprint Histamine contributes to ischemia-related activation of cardiac spinal afferents: role of H1 receptors and PKC
    Liang Wu Fu
    Department of Medicine, C240 Medical Sciences I, University of California, Irvine, Irvine, CA 92697, USA
    J Neurophysiol 93:713-22. 2005
    ....
  30. ncbi request reprint Electroacupuncture induces c-Fos expression in the rostral ventrolateral medulla and periaqueductal gray in cats: relation to opioid containing neurons
    Zhi Ling Guo
    Department of Medicine, C240 Medical Science 1, University of California, Irvine, CA 92697 4075, USA
    Brain Res 1030:103-15. 2004
    ..These neurons likely form the substrate for EA's influence on sympathoexcitatory cardiovascular reflexes...
  31. ncbi request reprint Afferent mechanisms underlying stimulation modality-related modulation of acupuncture-related cardiovascular responses
    Wei Zhou
    Department of Medicine, College of Medicine, University of California, Irvine, CA 92697, USA
    J Appl Physiol (1985) 98:872-80. 2005
    ..The similarity of the responses to EA and MA and the lack of cardiovascular response to high-frequency EA appear to be largely a function of somatic afferent responses...
  32. ncbi request reprint Inhibitory effect of electroacupuncture (EA) on the pressor response induced by exercise stress
    Peng Li
    Dept of Medicine, University of California, Irvine Medical Science I, C235, Irvine, CA 92697 4075, USA
    Clin Auton Res 14:182-8. 2004
    ..We conclude that EA at specific acupoints improves exercise capacity and reduces the hemodynamic responses in approximately 70% of normal subjects...
  33. ncbi request reprint Medullary substrate and differential cardiovascular responses during stimulation of specific acupoints
    Stephanie C Tjen-A-Looi
    Medical Science 1 C240, College of Medicine, Univ of California, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 287:R852-62. 2004
    ....
  34. ncbi request reprint Prolonged inhibition of rostral ventral lateral medullary premotor sympathetic neurons by electroacupuncture in cats
    Stephanie C Tjen-A-Looi
    Department of Internal Medicine, University of California at Irvine, Irvine, CA 92697 4075, USA
    Auton Neurosci 106:119-31. 2003
    ..Through an opioid mechanism, EA inhibits splanchnic nerve-induced excitatory responses of these rVLM neurons. Many of these neurons receiving convergent visceral and somatic input exhibit long-lasting inhibition by EA...
  35. pmc Xanthine oxidase, but not neutrophils, contributes to activation of cardiac sympathetic afferents during myocardial ischaemia in cats
    Stephanie C Tjen-A-Looi
    Department of Internal Medicine, College of Medicine, University of California, Irvine, CA 92697 4075, USA
    J Physiol 543:327-36. 2002
    ..This study demonstrates that ROS generated from the oxidation of purines contribute to the stimulation of ischaemically sensitive cardiac sympathetic afferents, whereas PMNs do not play a major role in this process...
  36. pmc Activated platelets contribute to stimulation of cardiac afferents during ischaemia in cats: role of 5-HT(3) receptors
    Liang Wu Fu
    Department of Medicine, University of California, Irvine 92697, USA
    J Physiol 544:897-912. 2002
    ..These data indicate that during myocardial ischaemia the activated platelets stimulate cardiac sympathetic afferents, at least in part, through a 5-HT(3) receptor mechanism...
  37. ncbi request reprint Brain stem mechanisms underlying acupuncture modality-related modulation of cardiovascular responses in rats
    Wei Yi Syuu Zhou
    Department of Medicine, College of Medicine, Univ of California, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 99:851-60. 2005
    ....
  38. ncbi request reprint Role of unmyelinated fibers in electroacupuncture cardiovascular responses
    Stephanie C Tjen-A-Looi
    Medical Science 1, Department of Medicine, College of Medicine, University of California, Irvine, CA 92697 4075, USA
    Auton Neurosci 118:43-50. 2005
    ..This study demonstrates that the inhibitory effect of EA at P5-P6 on cardiovascular autonomic excitatory reflexes involves unmyelinated group IV fibers of the median nerves...
  39. ncbi request reprint Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat
    Zhi Ling Guo
    Department of Medicine, C240D Medical Science I, University of California at Irvine, Irvine, CA 92697 4075, USA
    Brain Res 925:55-66. 2002
    ..These findings indicate that the activated neurons in the medulla, especially in the VLM, are involved in integration of cardiac-cardiovascular sympathoexcitatory reflexes...
  40. ncbi request reprint Role of glutamate in the rostral ventrolateral medulla in acupuncture-related modulation of visceral reflex sympathoexcitation
    Wei Zhou
    Department of Medicine and Susan Samueli Center for Integrative Medicine, College of Medicine, University of California, Irvine, California 92697 4075, USA
    Am J Physiol Heart Circ Physiol 292:H1868-75. 2007
    ..These data suggest that EA attenuates BK-induced visceral sympathoexcitatory reflexes through opioid-mediated inhibition of Glu's action in the rVLM...
  41. ncbi request reprint Role of glutamate in a visceral sympathoexcitatory reflex in rostral ventrolateral medulla of cats
    Wei Zhou
    Susan Samueli Center for Integrative Medicine, Department of Medicine, School of Medicine, University of California, Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 291:H1309-18. 2006
    ..These results suggest that glutamate in the rVLM serves as an excitatory neurotransmitter through a baroreflex-independent mechanism and that both NMDA and AMPA receptors mediate the visceral sympathoexcitatory reflex responses...
  42. ncbi request reprint Responses of neurons containing VGLUT3/nNOS-cGMP in the rVLM to cardiac stimulation
    Zhi Ling Guo
    Department of Medicine, University of California, Irvine, Irvine, California 92697 4075, USA
    Neuroreport 17:255-9. 2006
    ..Findings indicate activation of rostral ventrolateral medulla glutamatergic neurons by cardiac stimulation, which may be influenced by nitric oxide via cGMP...
  43. ncbi request reprint Midbrain vlPAG inhibits rVLM cardiovascular sympathoexcitatory responses during electroacupuncture
    Stephanie C Tjen-A-Looi
    Department of Medicine, Susan Samueli Center for Integrative Medicine, UCI School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 290:H2543-53. 2006
    ..We conclude that the inhibitory influence of EA involves vlPAG stimulation, which, in turn, inhibits rVLM neurons in the EA-related attenuation of the cardiovascular excitatory response during visceral afferent stimulation...
  44. ncbi request reprint Excitatory projections from arcuate nucleus to ventrolateral periaqueductal gray in electroacupuncture inhibition of cardiovascular reflexes
    Peng Li
    Department of Medicine, Susan Samueli Center for Integrative Medicine, UCI School of Medicine, University of California Irvine, CA 92697 4075, USA
    Am J Physiol Heart Circ Physiol 290:H2535-42. 2006
    ..These results suggest that excitatory projections from the ARC to the vlPAG are essential to the EA inhibition of the reflex increase in BP induced by SN or gallbladder visceral afferent stimulation...
  45. ncbi request reprint Modulation of cardiovascular excitatory responses in rats by transcutaneous magnetic stimulation: role of the spinal cord
    Wei Zhou Yi Syuu
    Department of Medicine, Medical Science 1 C240, College of Medicine, Univ of California, Irvine, CA 92697 4075, USA
    J Appl Physiol (1985) 100:926-32. 2006
    ....
  46. ncbi request reprint Stimulation of cardiac sympathetic afferents activates glutamatergic neurons in the parabrachial nucleus: relation to neurons containing nNOS
    Zhi Ling Guo
    Department of Medicine, C240 Medical Science 1, University of California, Irvine, Irvine, CA 92697 4075, USA
    Brain Res 1053:97-107. 2005
    ..Nitric oxide has the potential to influence the action of glutamatergic neurons in regulation of excitatory cardiovascular responses induced by activation of cardiac sympathetic afferents...
  47. ncbi request reprint Effect of electroacupuncture on pressor reflex during gastric distension
    Peng Li
    Department of Internal Medicine, College of Medicine, University of California, Irvine, California 92697 4075, USA
    Am J Physiol Regul Integr Comp Physiol 283:R1335-45. 2002
    ....
  48. ncbi request reprint Electroacupuncture treatment of arrhythmias in myocardial ischemia
    John C Longhurst
    Am J Physiol Heart Circ Physiol 292:H2032-4. 2007

Research Grants26

  1. Mechanisms of Cardiac Afferents and CNS Reflex Processing
    JOHN C contact LONGHURST; Fiscal Year: 2010
    ..The current application will provide important new information on both mediators and mechanism of action in the brain during myocardial ischemia and its elevated blood pressure. ..
  2. Mechanisms of CNS Autonomic Regulation by EA
    John Longhurst; Fiscal Year: 2007
    ..Improved understanding of acupuncture will assist practicing acupuncturists and will provide physicians and scientists with a stronger rationale for using and studying this alternative therapy. ..
  3. Neural Substrates of EA in Cardiovascular Control
    John Longhurst; Fiscal Year: 2007
    ..g., in patients with cardiovascular disease. Furthermore, knowledge of the mechanistic basis of acupuncture may allow practitioners to optimize the clinical cardiovascular responses to treatment. ..
  4. Mechanisms of Cardiac Afferents and their Reflexes
    John Longhurst; Fiscal Year: 2007
    ....
  5. Mechanims of CNS Autonomic Regulation by EA
    John Longhurst; Fiscal Year: 2009
    ..The current application will provide important new information on both efficacy and mechanism of action in acupuncture treatment of either elevated or low blood pressure. ..
  6. Mechanisms of Cardiac Afferents and their Reflexes
    John Longhurst; Fiscal Year: 2009
    ....
  7. Neural Substrates of EA in Cardiovascular Control
    John Longhurst; Fiscal Year: 2009
    ..g., in patients with cardiovascular disease. Furthermore, knowledge of the mechanistic basis of acupuncture may allow practitioners to optimize the clinical cardiovascular responses to treatment. ..
  8. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2010
    ..The current application will provide important new information on both efficacy and mechanism of action in acupuncture treatment of either elevated or low blood pressure. ..
  9. Neural Substrates of EA in Cardiovascular Control
    John C Longhurst; Fiscal Year: 2010
    ..g., in patients with cardiovascular disease. Furthermore, knowledge of the mechanistic basis of acupuncture may allow practitioners to optimize the clinical cardiovascular responses to treatment. ..
  10. Mechanisms of Cardiac Afferents and their Reflexes
    John Longhurst; Fiscal Year: 2006
    ....
  11. Neural Substrates of EA in Cardiovascular Control
    John Longhurst; Fiscal Year: 2006
    ..Such knowledge, along with the current clinical trials, will encourage acceptance of this therapy by scientists and clinicians in the US and other Western countries. ..
  12. MECHANISMS OF REGULATION OF CARDIAC AFFERENTS
    John Longhurst; Fiscal Year: 2002
    ....
  13. CNS AUTONOMIC REGULATION BY ELECTROACUPUNCTURE
    John Longhurst; Fiscal Year: 2002
    ..The Pl indicates that this project has important clinical implications. ..
  14. Neural Substrates of EA in Cardiovascular Control
    John Longhurst; Fiscal Year: 2003
    ..Such knowledge, along with the current clinical trials, will encourage acceptance of this therapy by scientists and clinicians in the US and other Western countries. ..
  15. MECHANISMS OF REGULATION OF CARDIAC AFFERENTS
    John Longhurst; Fiscal Year: 2003
    ....
  16. Mechanisms of CNS Autonomic Regulation by EA
    John Longhurst; Fiscal Year: 2004
    ..Improved understanding of acupuncture will assist practicing acupuncturists and will provide physicians and scientists with a stronger rationale for using and studying this alternative therapy. ..
  17. Neural Substrates of EA in Cardiovascular Control
    John Longhurst; Fiscal Year: 2004
    ..Such knowledge, along with the current clinical trials, will encourage acceptance of this therapy by scientists and clinicians in the US and other Western countries. ..
  18. Mechanisms of CNS Autonomic Regulation by EA
    John Longhurst; Fiscal Year: 2005
    ..Improved understanding of acupuncture will assist practicing acupuncturists and will provide physicians and scientists with a stronger rationale for using and studying this alternative therapy. ..
  19. Neural Substrates of EA in Cardiovascular Control
    John Longhurst; Fiscal Year: 2005
    ..Such knowledge, along with the current clinical trials, will encourage acceptance of this therapy by scientists and clinicians in the US and other Western countries. ..
  20. MECHANISMS OF REGULATION OF CARDIAC AFFERENTS
    John Longhurst; Fiscal Year: 2005
    ....
  21. Mechanisms of CNS Autonomic Regulation by EA
    John Longhurst; Fiscal Year: 2006
    ..Improved understanding of acupuncture will assist practicing acupuncturists and will provide physicians and scientists with a stronger rationale for using and studying this alternative therapy. ..
  22. MECHANISMS OF REGULATION OF CARDIAC AFFERENTS
    John Longhurst; Fiscal Year: 2004
    ....
  23. CNS AUTONOMIC REGULATION BY ELECTROACUPUNCTURE
    John Longhurst; Fiscal Year: 2001
    ..The Pl indicates that this project has important clinical implications. ..