Xiaochun Long

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi Mitogen-activated protein kinase 14 is a novel negative regulatory switch for the vascular smooth muscle cell contractile gene program
    Xiaochun Long
    Department of Medicine, Aab Cardiovascular Research Institute, Box CVRI, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 33:378-86. 2013
  2. pmc Transforming growth factor-beta1 (TGF-beta1) utilizes distinct pathways for the transcriptional activation of microRNA 143/145 in human coronary artery smooth muscle cells
    Xiaochun Long
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 286:30119-29. 2011
  3. pmc Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein
    Qiang Sun
    Aab Cardiovascular Research Institute of the University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:32582-90. 2009
  4. pmc Smooth muscle calponin: an unconventional CArG-dependent gene that antagonizes neointimal formation
    Xiaochun Long
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Arterioscler Thromb Vasc Biol 31:2172-80. 2011
  5. pmc The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin
    Xiaochun Long
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:33671-82. 2009
  6. doi Expression and functional activity of four myocardin isoforms
    Masaaki Imamura
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Gene 464:1-10. 2010
  7. pmc Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle
    Chad M Kitchen
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Gene 513:82-9. 2013
  8. doi Myocardin and microRNA-1 modulate bladder activity through connexin 43 expression during post-natal development
    Masaaki Imamura
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Cell Physiol 228:1819-26. 2013
  9. pmc SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells
    Robert D Bell
    Center for Neurodegenerative and Vascular Brain Disorders, Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Cell Biol 11:143-53. 2009
  10. pmc Retinoid-induced expression and activity of an immediate early tumor suppressor gene in vascular smooth muscle cells
    Jeffrey W Streb
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 6:e18538. 2011

Collaborators

Detail Information

Publications19

  1. doi Mitogen-activated protein kinase 14 is a novel negative regulatory switch for the vascular smooth muscle cell contractile gene program
    Xiaochun Long
    Department of Medicine, Aab Cardiovascular Research Institute, Box CVRI, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 33:378-86. 2013
    ..Here, we evaluate the effects of knocking down a dominant p38MAPK isoform on VSMC differentiation...
  2. pmc Transforming growth factor-beta1 (TGF-beta1) utilizes distinct pathways for the transcriptional activation of microRNA 143/145 in human coronary artery smooth muscle cells
    Xiaochun Long
    Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 286:30119-29. 2011
    ..These results demonstrate a dual pathway for TGF-β1-induced transcription of miR143/145, thus revealing a novel mechanism underlying TGF-β1-induced human vascular SMC differentiation...
  3. pmc Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein
    Qiang Sun
    Aab Cardiovascular Research Institute of the University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:32582-90. 2009
    ..These results demonstrate the ability of MYOCD to discriminate among several juxtaposed CArG elements, presumably through its novel partnership with NKX3.1, to optimally transactivate the human ACTG2 promoter...
  4. pmc Smooth muscle calponin: an unconventional CArG-dependent gene that antagonizes neointimal formation
    Xiaochun Long
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    Arterioscler Thromb Vasc Biol 31:2172-80. 2011
    ..The objectives here were to evaluate these CArG elements for activity in transgenic mice and determine the effect of human CNN1 on injury-induced vascular remodeling...
  5. pmc The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin
    Xiaochun Long
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 284:33671-82. 2009
    ..These results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC contractile phenotype...
  6. doi Expression and functional activity of four myocardin isoforms
    Masaaki Imamura
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Gene 464:1-10. 2010
    ..We propose a new myocardin nomenclature reflecting the dominant splice variants expressed in cardiac muscle (Myocd_v1 and v2) versus SMC-rich tissues (Myocd_v3 and v4)...
  7. pmc Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle
    Chad M Kitchen
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Gene 513:82-9. 2013
    ..Collectively, these data demonstrate that Itga8 expression is CArG-SRF independent, but MYOCD dependent through an as yet unknown sequence module that is distal from the promoter region...
  8. doi Myocardin and microRNA-1 modulate bladder activity through connexin 43 expression during post-natal development
    Masaaki Imamura
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Cell Physiol 228:1819-26. 2013
    ..These results suggest that MYOCD down-regulates GJA1 expression via miR-1 up-regulation, thereby contributing to maintenance of normal sensitivity and development of bladder capacity...
  9. pmc SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells
    Robert D Bell
    Center for Neurodegenerative and Vascular Brain Disorders, Arthur Kornberg Medical Research Building, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Nat Cell Biol 11:143-53. 2009
    ..Hypoxia stimulated SRF/MYOCD expression in human cerebral VSMCs and in animal models of AD. We suggest that SRF and MYOCD function as a transcriptional switch, controlling Abeta cerebrovascular clearance and progression of AD...
  10. pmc Retinoid-induced expression and activity of an immediate early tumor suppressor gene in vascular smooth muscle cells
    Jeffrey W Streb
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 6:e18538. 2011
    ....
  11. pmc Myocardin is sufficient for a smooth muscle-like contractile phenotype
    Xiaochun Long
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 211 Bailey Road, Rochester, New York 14586, USA
    Arterioscler Thromb Vasc Biol 28:1505-10. 2008
    ..Here, we sought to ascertain whether Myocd-mediated gene expression confers a structural and physiological cardiac or SMC phenotype...
  12. pmc Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA
    Robert D Bell
    From the Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY R D B, X L, V N, S L C, Q Z, Y H, J M M Department of Genetics M L, D Z and Departments of Neurology and Neuroscience D Z, Albert Einstein College of Medicine, Bronx, NY and Cold Spring Harbor Laboratory, Cold Spring Harbor, NY J H B, D L S
    Arterioscler Thromb Vasc Biol 34:1249-59. 2014
    ..Thus, we set out to identify novel lncRNA genes in human vascular smooth muscle cells and to gain insight into their role in the control of smooth muscle cell phenotypes...
  13. ncbi Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus
    Joseph M Miano
    Cardiovascular Research Institute, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Physiol Cell Physiol 292:C70-81. 2007
    ..This review summarizes the recent genomic and genetic analyses of CArG-SRF that support its role as an ancient, master regulator of the actin cytoskeleton and contractile machinery...
  14. pmc Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation
    Xiaochun Long
    The Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 104:16570-5. 2007
    ....
  15. ncbi Remote control of gene expression
    Xiaochun Long
    Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 282:15941-5. 2007
    ..This review summarizes current approaches to characterize remote control of gene expression in transgenic mice and inherent limitations for accurately interpreting the essential nature of CRM activity...
  16. pmc Platelet factor 4 mediates vascular smooth muscle cell injury responses
    Guanfang Shi
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Blood 121:4417-27. 2013
    ..Our data indicate an important mechanistic role for platelets and PF4 in VSMC injury responses both in vitro and in vivo...
  17. pmc Identifying functional single nucleotide polymorphisms in the human CArGome
    Craig C Benson
    University of Rochester Medical Center, Rochester, NY, USA
    Physiol Genomics 43:1038-48. 2011
    ..Such information may find utility in genetic association studies of human disease where little insight is known regarding the functionality of rSNPs...
  18. pmc Defining the mammalian CArGome
    Qiang Sun
    Cardiovascular Research Institute, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Genome Res 16:197-207. 2006
    ..We suggest one function of SRF is that of an ancient master regulator of the actin cytoskeleton...
  19. pmc Fibronectin matrix polymerization regulates smooth muscle cell phenotype through a Rac1 dependent mechanism
    Feng Shi
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 9:e94988. 2014
    ..These data define a Rac1-dependent pathway wherein fibronectin polymerization promotes the SMC synthetic phenotype by modulating the expression of smooth muscle cell differentiation proteins. ..