ANTHONY DOUGLAS LONG

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Fine scale structural variants distinguish the genomes of Drosophila melanogaster and D. pseudoobscura
    Stuart J Macdonald
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    Genome Biol 7:R67. 2006
  2. pmc A low-cost open-source SNP genotyping platform for association mapping applications
    Stuart J Macdonald
    Department of Ecology and Evolutionary Biology, University of California Irvine, CA 92697 2525, USA
    Genome Biol 6:R105. 2005
  3. pmc A wing expressed sequence tag resource for Bicyclus anynana butterflies, an evo-devo model
    Patricia Beldade
    Department of Ecology and Evolutionary Biology, University of California at Irvine, Irvine, USA
    BMC Genomics 7:130. 2006
  4. pmc Estimation of population heterozygosity and library construction-induced mutation rate from expressed sequence tag collections
    A D Long
    Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA
    Genetics 176:711-4. 2007
  5. pmc The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits
    A D Long
    Department of Ecology and Evolutionary Biology, University of California at Irvine, Irvine, California 92697 2525, USA
    Genome Res 9:720-31. 1999
  6. pmc Genetic architecture of thermal adaptation in Escherichia coli
    M M Riehle
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    Proc Natl Acad Sci U S A 98:525-30. 2001
  7. ncbi request reprint A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes
    P Baldi
    Department of Information and Computer Science, University of California at Irvine, Irvine, CA 92697 3425, USA
    Bioinformatics 17:509-19. 2001
  8. ncbi request reprint Improved statistical inference from DNA microarray data using analysis of variance and a Bayesian statistical framework. Analysis of global gene expression in Escherichia coli K12
    A D Long
    Department of Ecology, School of Biological Sciences, University of California, Irvine, California 92697, USA
    J Biol Chem 276:19937-44. 2001
  9. pmc Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in Drosophila melanogaster
    A D Long
    Center for Population Biology, University of California, Davis, California 95616, USA
    Genetics 149:999-1017. 1998
  10. pmc Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea mays ssp. mays L.)
    M I Tenaillon
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 98:9161-6. 2001

Research Grants

Collaborators

Detail Information

Publications13

  1. pmc Fine scale structural variants distinguish the genomes of Drosophila melanogaster and D. pseudoobscura
    Stuart J Macdonald
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    Genome Biol 7:R67. 2006
    ..Any survey of genomic variation is incomplete without an assessment of structural changes...
  2. pmc A low-cost open-source SNP genotyping platform for association mapping applications
    Stuart J Macdonald
    Department of Ecology and Evolutionary Biology, University of California Irvine, CA 92697 2525, USA
    Genome Biol 6:R105. 2005
    ..The cost-effective, open-source nature of our methodology may make it particularly attractive to those working in nonmodel systems...
  3. pmc A wing expressed sequence tag resource for Bicyclus anynana butterflies, an evo-devo model
    Patricia Beldade
    Department of Ecology and Evolutionary Biology, University of California at Irvine, Irvine, USA
    BMC Genomics 7:130. 2006
    ..Here, we describe an Expression Sequence Tag (EST) project for Bicyclus anynana that has identified the largest available collection to date of expressed genes for any butterfly...
  4. pmc Estimation of population heterozygosity and library construction-induced mutation rate from expressed sequence tag collections
    A D Long
    Ecology and Evolutionary Biology, University of California, Irvine, California 92697, USA
    Genetics 176:711-4. 2007
    ..We describe an estimator of population heterozygosity that utilizes only SNPs unlikely to be library construction artifacts...
  5. pmc The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits
    A D Long
    Department of Ecology and Evolutionary Biology, University of California at Irvine, Irvine, California 92697 2525, USA
    Genome Res 9:720-31. 1999
    ..Estimates of 4Nc for a number of gene regions and human populations will be of use in determining the density of SNPs that are likely to be required for successful association studies...
  6. pmc Genetic architecture of thermal adaptation in Escherichia coli
    M M Riehle
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    Proc Natl Acad Sci U S A 98:525-30. 2001
    ..These results provide additional evidence for the idea that gene duplication plays an integral role in adaptation, specifically as a means for gene amplification...
  7. ncbi request reprint A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes
    P Baldi
    Department of Information and Computer Science, University of California at Irvine, Irvine, CA 92697 3425, USA
    Bioinformatics 17:509-19. 2001
    ..Current methods are unsatisfactory due to the lack of a systematic framework that can accommodate noise, variability, and low replication often typical of microarray data...
  8. ncbi request reprint Improved statistical inference from DNA microarray data using analysis of variance and a Bayesian statistical framework. Analysis of global gene expression in Escherichia coli K12
    A D Long
    Department of Ecology, School of Biological Sciences, University of California, Irvine, California 92697, USA
    J Biol Chem 276:19937-44. 2001
    ..All the described tests are implemented in a simple-to-use web interface called Cyber-T that is located on the University of California at Irvine genomics web site...
  9. pmc Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in Drosophila melanogaster
    A D Long
    Center for Population Biology, University of California, Davis, California 95616, USA
    Genetics 149:999-1017. 1998
    ....
  10. pmc Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea mays ssp. mays L.)
    M I Tenaillon
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 98:9161-6. 2001
    ..Intragenic linkage disequilibrium declines within 100-200 bp on average, suggesting that genome-wide surveys for association analyses require SNPs every 100-200 bp...
  11. pmc High resolution mapping of genetic factors affecting abdominal bristle number in Drosophila melanogaster
    A D Long
    Center for Population Biology, University of California, Davis 95616, USA
    Genetics 139:1273-91. 1995
    ..All factors mapped to the approximate positions of likely candidate loci (ASC, bb, emc, h, mab, Dl and E(spl), previously characterized by mutations with large effects on bristle number...
  12. pmc Both naturally occurring insertions of transposable elements and intermediate frequency polymorphisms at the achaete-scute complex are associated with variation in bristle number in Drosophila melanogaster
    A D Long
    Center for Population Biology, University of California, Davis, California 95616, USA
    Genetics 154:1255-69. 2000
    ....
  13. pmc Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster
    A D Long
    Center for Population Biology, University of California, Davis 95616, USA
    Genetics 144:1497-510. 1996
    ....

Research Grants7

  1. USING DISEQUILIBRIUM MAPPING TO DISSECT COMPLEX TRAITS
    Anthony Long; Fiscal Year: 2003
    ..The set of candidate causative polymorphism will allow the above hypotheses to be directly addressed. ..
  2. Drosophila as a model for chemotherapy pharmacogenomics
    ANTHONY DOUGLAS LONG; Fiscal Year: 2010
    ..Similar outcomes are expected for additional chemotherapy agents. ..