Edythe London

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry
    D E Payer
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Transl Psychiatry 2:e80. 2012
  2. pmc Character pathology and neuropsychological test performance in remitted opiate dependence
    James M Prosser
    Department of Psychiatry and Behavioral Sciences, Beth Israel Medical Center, First Avenue at 16th St, New York, NY 10003, USA
    Subst Abuse Treat Prev Policy 3:23. 2008
  3. pmc Is all risk bad? Young adult cigarette smokers fail to take adaptive risk in a laboratory decision-making test
    Andy C Dean
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Psychopharmacology (Berl) 215:801-11. 2011
  4. ncbi request reprint Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024 1759, USA
    Biol Psychiatry 58:770-8. 2005
  5. pmc Short-term plasticity of gray matter associated with leptin deficiency and replacement
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
    J Clin Endocrinol Metab 96:E1212-20. 2011
  6. ncbi request reprint Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, University of California Los Angeles, 760 Westwood Plaza, PO Box 175919, Los Angeles, CA 90024 1759, USA
    Arch Gen Psychiatry 61:73-84. 2004
  7. pmc Effect of the TaqIA polymorphism on ethanol response in the brain
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
    Psychiatry Res 174:163-70. 2009
  8. pmc Neural correlates of affect processing and aggression in methamphetamine dependence
    Doris E Payer
    Department of Psychiatry, University of California, Los Angeles, USA
    Arch Gen Psychiatry 68:271-82. 2011
  9. pmc Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
    Buyean Lee
    Department of Psychiatry, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90024, USA
    J Neurosci 29:14734-40. 2009
  10. pmc Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary study
    Jiansong Xu
    Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90024, USA
    Psychiatry Res 148:103-9. 2006

Detail Information

Publications75

  1. pmc Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry
    D E Payer
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Transl Psychiatry 2:e80. 2012
    ....
  2. pmc Character pathology and neuropsychological test performance in remitted opiate dependence
    James M Prosser
    Department of Psychiatry and Behavioral Sciences, Beth Israel Medical Center, First Avenue at 16th St, New York, NY 10003, USA
    Subst Abuse Treat Prev Policy 3:23. 2008
    ..Understanding the relationship between the two in vulnerable, opiate-addicted patients may contribute to the design of better treatment and relapse prevention strategies...
  3. pmc Is all risk bad? Young adult cigarette smokers fail to take adaptive risk in a laboratory decision-making test
    Andy C Dean
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Psychopharmacology (Berl) 215:801-11. 2011
    ..Initial studies have suggested that smokers display greater risk-taking on this task than nonsmokers, but these studies did not account for drug abuse and psychiatric comorbidities, which are commonplace among smokers...
  4. ncbi request reprint Cerebral metabolic dysfunction and impaired vigilance in recently abstinent methamphetamine abusers
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024 1759, USA
    Biol Psychiatry 58:770-8. 2005
    ..The links between cognitive impairment and these cerebral abnormalities are not established...
  5. pmc Short-term plasticity of gray matter associated with leptin deficiency and replacement
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
    J Clin Endocrinol Metab 96:E1212-20. 2011
    ..We previously reported that leptin supplementation increased gray matter (GM) concentration in the anterior cingulate gyrus (ACG), cerebellum, and inferior parietal lobule, areas that are also involved in food intake...
  6. ncbi request reprint Mood disturbances and regional cerebral metabolic abnormalities in recently abstinent methamphetamine abusers
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, University of California Los Angeles, 760 Westwood Plaza, PO Box 175919, Los Angeles, CA 90024 1759, USA
    Arch Gen Psychiatry 61:73-84. 2004
    ..Mood disturbances in methamphetamine (MA) abusers likely influence drug use, but the neurobiological bases for these problems are poorly understood...
  7. pmc Effect of the TaqIA polymorphism on ethanol response in the brain
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
    Psychiatry Res 174:163-70. 2009
    ..Although these results require replication in a larger sample, alcohol-induced negative reinforcement may explain the greater risk for alcoholism associated with the A1 allele...
  8. pmc Neural correlates of affect processing and aggression in methamphetamine dependence
    Doris E Payer
    Department of Psychiatry, University of California, Los Angeles, USA
    Arch Gen Psychiatry 68:271-82. 2011
    ..Methamphetamine abuse is associated with high rates of aggression but few studies have addressed the contributing neurobiological factors...
  9. pmc Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
    Buyean Lee
    Department of Psychiatry, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90024, USA
    J Neurosci 29:14734-40. 2009
    ..12 corrected). The findings suggest that low striatal D(2)/D(3) receptor availability may mediate impulsive temperament and thereby influence addiction...
  10. pmc Effects of acute smoking on brain activity vary with abstinence in smokers performing the N-Back task: a preliminary study
    Jiansong Xu
    Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90024, USA
    Psychiatry Res 148:103-9. 2006
    ..This interaction merits further examination in larger studies specifically designed to consider this issue...
  11. pmc Working memory in cigarette smokers: comparison to non-smokers and effects of abstinence
    Adrianna Mendrek
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA
    Addict Behav 31:833-44. 2006
    ..These findings provide further evidence for a deficit in working memory associated with acute abstinence from smoking, which may contribute to the difficulty of smoking cessation...
  12. pmc Brain activity in cigarette smokers performing a working memory task: effect of smoking abstinence
    Jiansong Xu
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 58:143-50. 2005
    ..Our aim, therefore, was to identify abnormalities in the circuitry that mediates working memory in nicotine-dependent subjects after they initiate abstinence from smoking...
  13. pmc Effect of cigarette smoking on prefrontal cortical function in nondeprived smokers performing the Stroop Task
    Jiansong Xu
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Neuropsychopharmacology 32:1421-8. 2007
    ..Even after brief abstinence from smoking, therefore, smokers exhibit compromised functional efficiency in the right FEF and adjacent precentral sulcus in a test of selective attention; and smoking ameliorates this condition...
  14. pmc Differences in cortical activity between methamphetamine-dependent and healthy individuals performing a facial affect matching task
    Doris E Payer
    Neuroscience Interdepartmental Program, University of California, Los Angeles, CA 90024 1759, USA
    Drug Alcohol Depend 93:93-102. 2008
    ..Together, the results point to cortical abnormalities that could underlie the socially inappropriate behaviors often shown by individuals who abuse MA...
  15. pmc Severity of nicotine dependence moderates performance on perceptual-motor tests of attention
    Allen Azizian
    Department of Psychiatry and Biobehavioral Sciences, Laboratory of Molecular Neuroimaging, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Nicotine Tob Res 10:599-606. 2008
    ..The findings suggest that severity of nicotine dependence and slowness in perceptual-motor tasks of attention share an underlying basis...
  16. ncbi request reprint Differences in regional brain metabolism associated with marijuana abuse in methamphetamine abusers
    Bradley Voytek
    Department of Psychiatry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
    Synapse 57:113-5. 2005
  17. pmc Predicting adherence to treatment for methamphetamine dependence from neuropsychological and drug use variables
    Andy C Dean
    Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute, 760 Westwood Plaza, Box 951759, Los Angeles, CA 90095, USA
    Drug Alcohol Depend 105:48-55. 2009
    ..On the basis of these findings, we recommend that research groups seeking to identify new predictors of treatment outcome compare the predictors to methamphetamine usage variables to assure that unique predictive power is attained...
  18. ncbi request reprint Deficits in response inhibition associated with chronic methamphetamine abuse
    John R Monterosso
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
    Drug Alcohol Depend 79:273-7. 2005
    ..If such differences are established then response inhibition may serve as a marker for investigating MA abuse in basic science and clinical trials...
  19. pmc Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 63:808-16. 2006
    ..Preclinical studies demonstrate that nicotine administration leads to dopamine release in the ventral striatum. However, human studies reveal considerable interindividual variability in the extent of smoking-induced dopamine release...
  20. pmc Gender effects on mood and cigarette craving during early abstinence and resumption of smoking
    Jiansong Xu
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angles, Los Angeles, CA, USA
    Nicotine Tob Res 10:1653-61. 2008
    ..These differences may contribute to the greater likelihood of relapse when women try to quit smoking...
  21. ncbi request reprint Frontoparietal cortical activity of methamphetamine-dependent and comparison subjects performing a delay discounting task
    John R Monterosso
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90024, USA
    Hum Brain Mapp 28:383-93. 2007
    ..Therefore, while apparent inefficiency of cortical processing related to decision-making in MA abusers may contribute to the neural basis of enhanced delay discounting by this population, other factors remain to be identified...
  22. pmc Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette
    Arthur L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Int J Neuropsychopharmacol 12:305-16. 2009
    ..Furthermore, smoking a denicotinized cigarette resulted in substantial nAChR occupancy...
  23. ncbi request reprint Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys
    Buyean Lee
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuropsychopharmacology 32:2125-34. 2007
    ..These data support the hypothesis that phasic DA release, acting through D(2)-like receptors, mediates behavioral flexibility...
  24. pmc Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette
    Arthur L Brody
    UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 34:282-9. 2009
    ..Thus, nicotine delivered through cigarette smoking appears to be important for ventral striatal DA release. Study findings also suggest that mood improvement from smoking is specifically related to ventral striatal DA release...
  25. pmc Effects of cigarette smoking and abstinence on Stroop task performance
    Catherine P Domier
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, Los Angeles, CA, USA
    Psychopharmacology (Berl) 195:1-9. 2007
    ..Selective attention may be important in this regard, but earlier literature presents inconsistent findings on how smoking abstinence and resumption of smoking influence this cognitive function...
  26. pmc Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 63:907-15. 2006
    ....
  27. pmc Effects of treatment for tobacco dependence on resting cerebral glucose metabolism
    Matthew R Costello
    Greater Los Angeles Veterans Administration Healthcare System, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 35:605-12. 2010
    ..Thus, this study supports the theory that active treatments for tobacco dependence move the brain into a more goal-oriented state...
  28. pmc Methamphetamine craving induced in an online virtual reality environment
    Christopher Culbertson
    Department of Psychiatry, UCLA, Los Angeles, CA, USA
    Pharmacol Biochem Behav 96:454-60. 2010
    ....
  29. ncbi request reprint Brain metabolic changes during cigarette craving
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:1162-72. 2002
    ..The objective of this study was to determine changes in regional cerebral glucose metabolism and correlations between craving and regional metabolism in heavy cigarette smokers exposed to cigarette-related cues...
  30. pmc Neural substrates of resisting craving during cigarette cue exposure
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
    Biol Psychiatry 62:642-51. 2007
    ..We sought to determine changes in brain activity in response to cigarette cues when smokers actively resist craving...
  31. pmc Effect of bupropion treatment on brain activation induced by cigarette-related cues in smokers
    Christopher S Culbertson
    Department of Psychiatry, University of California, Los Angeles, CA, USA
    Arch Gen Psychiatry 68:505-15. 2011
    ..Bupropion hydrochloride treatment reduces cue-induced craving in cigarette smokers; however, the mechanism by which bupropion exerts this effect has not yet been described...
  32. pmc Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence
    Arthur L Brody
    Department of Psychiatry, UCLA, Los Angeles, CA 90095, USA
    Psychiatry Res 183:218-24. 2010
    ..These data indicate that smoking-induced DA release is dose-dependent, and is not significantly affected by reductions in daily smoking levels or treatment type...
  33. pmc Attenuation of cue-induced cigarette craving and anterior cingulate cortex activation in bupropion-treated smokers: a preliminary study
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, David Geffen Schol of Medicine, University of Californai at Los Angeles, and Positron Emission Tomography Center, Greater Los Angeles Veterans Affairs Healthcare System, USA
    Psychiatry Res 130:269-81. 2004
    ..These results are consistent with the known effects of bupropion HCl, including its enhancement of catecholaminergic neurotransmission...
  34. ncbi request reprint Differences between smokers and nonsmokers in regional gray matter volumes and densities
    Arthur L Brody
    Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90095, USA
    Biol Psychiatry 55:77-84. 2004
    ..Using MRI, we examined these regions for differences in gray matter between smokers and nonsmokers...
  35. ncbi request reprint Structural abnormalities in the brains of human subjects who use methamphetamine
    Paul M Thompson
    Laboratory of Neuroimaging, Brain Mapping Division, Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurosci 24:6028-36. 2004
    ..These brain substrates may help account for the symptoms of MA abuse, providing therapeutic targets for drug-induced brain injury...
  36. pmc Methamphetamine dependence and neuropsychological functioning: evaluating change during early abstinence
    Sara L Simon
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095 1759, USA
    J Stud Alcohol Drugs 71:335-44. 2010
    ..The purpose of this work was to assess neuropsychological functioning of individuals in early abstinence from methamphetamine dependence and to test for cognitive change over the first month of abstinence...
  37. ncbi request reprint Smoking-induced ventral striatum dopamine release
    Arthur L Brody
    Veterans Affairs Greater Los Angeles Healthcare, 300 UCLA Medical Plaza, Suite 2200, Los Angeles, CA 90095, USA
    Am J Psychiatry 161:1211-8. 2004
    ..The authors used [(11)C]raclopride bolus-plus-continuous-infusion positron emission tomography (PET) to determine smoking-induced ventral striatum dopamine release in humans...
  38. pmc Effect of a history of major depressive disorder on smoking-induced dopamine release
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA
    Biol Psychiatry 66:898-901. 2009
    ..We sought to determine if cigarette smokers with a history of MDD and current mild depressive symptoms have abnormal smoking-induced DA release (measured indirectly as change in (11)C-raclopride binding potential [BP(ND)])...
  39. pmc Neuroimaging evidence of cerebellar involvement in premenstrual dysphoric disorder
    Andrea J Rapkin
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095 1740, USA
    Biol Psychiatry 69:374-80. 2011
    ..Despite a prevalence of up to 8% in women of reproductive age, few studies have investigated the brain mechanisms that underlie this disorder...
  40. pmc Effect of modafinil on learning and task-related brain activity in methamphetamine-dependent and healthy individuals
    Dara G Ghahremani
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Neuropsychopharmacology 36:950-9. 2011
    ..These results suggest that modafinil may be a suitable pharmacological adjunct for enhancing the efficiency of cognitive-based therapies for MA dependence...
  41. pmc White-matter abnormalities in brain during early abstinence from methamphetamine abuse
    Marc C Tobias
    Semel Institute for Neuroscience and Biobehavioral Studies, University of California Los Angeles, Los Angeles, CA, USA
    Psychopharmacology (Berl) 209:13-24. 2010
    ..As certain metabolic changes in the brain first manifest after early abstinence from methamphetamine, it is also possible that microstructural white-matter abnormalities are not yet present during early abstinence...
  42. ncbi request reprint Impaired performance in a test of decision-making by opiate-dependent tobacco smokers
    Erin Rotheram-Fuller
    Friends Research Institute Inc, Los Angeles, CA 90025, USA
    Drug Alcohol Depend 73:79-86. 2004
    ..The findings suggest that among opiate-dependent individuals, tobacco smoking may be a marker for a more severe form of substance abuse disorder, reflecting impaired decision-making, as modeled by GT...
  43. pmc Acute cigarette smoking reduces latencies on a Smoking Stroop test
    Catherine P Canamar
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, CA 90024, USA
    Addict Behav 37:627-31. 2012
    ..Assessments of attentional bias in research participants who smoke cigarettes have used Smoking Stroop tasks, which are variations of emotional Stroop tasks in which the stimuli are smoking-related and neutral words...
  44. ncbi request reprint Corticolimbic dysregulation and chronic methamphetamine abuse
    Kate Baicy
    Department of Psychiatry and Biobehavioral Science, University of California Los Angeles, Los Angeles, CA, USA
    Addiction 102:5-15. 2007
    ..This review aims to present and interpret evidence that methamphetamine dependence is associated with disorder of brain function that is required for top-down control of behavior...
  45. pmc Smoking reduces conflict-related anterior cingulate activity in abstinent cigarette smokers performing a Stroop task
    Allen Azizian
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Neuropsychopharmacology 35:775-82. 2010
    ..Resumption of smoking may enhance cognitive control in smokers, involving a reduction in ACC response conflict activity together with improvement in conflict resolution involving the dorsolateral prefrontal cortex...
  46. pmc Abuse of amphetamines and structural abnormalities in the brain
    Steven Berman
    Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
    Ann N Y Acad Sci 1141:195-220. 2008
    ..Longitudinal designs in which multimodal datasets are acquired and are subjected to multivariate analyses would enhance our ability to provide general conclusions regarding the associations between amphetamine abuse and brain structure...
  47. ncbi request reprint Common substrates of dysphoria in stimulant drug abuse and primary depression: therapeutic targets
    Kate Baicy
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles California 90024, USA
    Int Rev Neurobiol 65:117-45. 2005
  48. ncbi request reprint Self-administration of 5-iodo-A-85380, a beta2-selective nicotinic receptor ligand, by operantly trained rats
    Xiu Liu
    Department of Psychiatry, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Neuroreport 14:1503-5. 2003
    ..This finding suggests that interaction with beta2-containing nAChRs, without direct involvement of alpha7 receptors, can produce reinforcement and thereby can support self-administration behavior...
  49. ncbi request reprint 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans
    Alane S Kimes
    NIDA Intramural Research Program Baltimore, Maryland 21224, USA
    FASEB J 17:1331-3. 2003
    ..180 +/- 30 mSv/MBq or 0.7 rem/mCi with a 2.4 h void interval) suggests that multiple studies could be performed in a single subject. The results predict that quantitative PET imaging of nAChRs in human brain with 2-[18F]FA is feasible...
  50. ncbi request reprint Intramuscular testosterone treatment in elderly men: evidence of memory decline and altered brain function
    Pauline M Maki
    Center for Cognitive Medicine, Neuropsychiatric Institute MC 913, University of Illinois at Chicago, 912 South Wood Street, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 92:4107-14. 2007
    ..Recent clinical trials of im testosterone in eugonadal men suggest positive effects on verbal memory, but other studies find no effect...
  51. ncbi request reprint Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography
    D Bruce Vaupel
    NIDA IRP, Neuroimaging Research Branch, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 312:355-65. 2005
    ..v.) to elevate blood pressure and heart rate by 10% in humans and should elicit no clinically significant effects and have acceptable dosimetry...
  52. ncbi request reprint Neural systems and cue-induced cocaine craving
    Katherine R Bonson
    Brain Imaging Center, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Neuropsychopharmacology 26:376-86. 2002
    ....
  53. ncbi request reprint Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 0135, USA
    Eur J Nucl Med Mol Imaging 30:1620-9. 2003
    ..These results demonstrate the feasibility of quantifying high-affinity type nAChRs using [123I]5-I-A-85380 in humans and support the use of VT' measured by bolus studies...
  54. ncbi request reprint Frontal cortical tissue composition in abstinent cocaine abusers: a magnetic resonance imaging study
    John A Matochik
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Neuroimage 19:1095-102. 2003
    ..These results extend our previous findings of defective frontal cortical activation (indexed by cerebral blood flow) in cocaine abusers to include abnormalities in gray matter tissue density in the same frontal cortical regions...
  55. ncbi request reprint Neural substrates of decision making in adults with attention deficit hyperactivity disorder
    Monique Ernst
    Intramural Research Program, NIMH, Natioanl Institute on Drug Abuse, Baltimore, MD, USA
    Am J Psychiatry 160:1061-70. 2003
    ..The study examined reward responsivity in ADHD by comparing the neural correlates of decision making in adults with childhood-onset ADHD and in healthy adults...
  56. ncbi request reprint PET studies of the influences of nicotine on neural systems in cigarette smokers
    Jed E Rose
    Veterans Affairs Medical Center, Durham, NC, USA
    Am J Psychiatry 160:323-33. 2003
    ..The effects of acute nicotine administration and smoking on brain function were investigated in two studies, with the primary goal of identifying neural systems that mediate these effects...
  57. ncbi request reprint Graphical analysis of 2-[18F]FA binding to nicotinic acetylcholine receptors in rhesus monkey brain
    Svetlana I Chefer
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    Synapse 48:25-34. 2003
    ..1 nmol/kg body weight. The findings suggest that 2-[(18)F]FA is a promising ligand for quantitation of nAChRs in human brain...
  58. ncbi request reprint Decision making in adolescents with behavior disorders and adults with substance abuse
    Monique Ernst
    NIH NIMH MAP, 15K North Dr, Room 118, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 160:33-40. 2003
    ....
  59. ncbi request reprint Cognitive performance and autonomic reactivity in abstinent drug abusers and nonusers
    Diana Fishbein
    RTI International, Rockville, MD, USA
    Exp Clin Psychopharmacol 13:25-40. 2005
    ..In conclusion, complex tasks involving decision making, sensitivity to consequences, and emotional regulation discriminated between drug abusers and controls...
  60. ncbi request reprint Risky decision making and the anterior cingulate cortex in abstinent drug abusers and nonusers
    Diana H Fishbein
    Transdisciplinary Behavioral Science Program, RTI International, 6801 Eastern Avenue, Suite 203, Baltimore, MD 21224, USA
    Brain Res Cogn Brain Res 23:119-36. 2005
    ..Attenuated activation of the pregenual ACC in the drug abusers relative to the controls during performance on the RDMT may underlie the abusers' tendency to choose risky outcomes...
  61. pmc Education-associated cortical glucose metabolism during sustained attention
    Daniel P Eisenberg
    Department of Psychiatry and Behavioral Sciences, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY, USA
    Neuroreport 16:1473-6. 2005
    ..Previously, these structures have shown early impairment in dementia. Further investigation should explore whether metabolic changes in these regions contribute to the possible protective effect of education on cognition...
  62. pmc Cerebral metabolism and mood in remitted opiate dependence
    Igor I Galynker
    Department of Psychiatry and Behavioral Sciences, Beth Israel Medical Center, Albert Einstein College of Medicine, First Avenue at 16th Street, New York, NY 10003, USA
    Drug Alcohol Depend 90:166-74. 2007
    ..Methadone-maintenance therapy (MMT) may mitigate this vulnerability, but controversy surrounds its long-term use. Little is known about the neurobiology of mood dysregulation in individuals receiving or removed from MMT...
  63. ncbi request reprint Estimation of D2-like receptor occupancy by dopamine in the putamen of hemiparkinsonian Monkeys
    Svetlana I Chefer
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH DHHS, Baltimore, MD, USA
    Neuropsychopharmacology 33:270-8. 2008
    ....
  64. ncbi request reprint Increased occupancy of dopamine receptors in human striatum during cue-elicited cocaine craving
    Dean F Wong
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuropsychopharmacology 31:2716-27. 2006
    ..These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine...
  65. ncbi request reprint Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    J Neurosci 26:8707-14. 2006
    ..Greater beta2*-nAChR availability during early abstinence may impact the ability of smokers to maintain abstinence...
  66. ncbi request reprint Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123i]5-i-A-85380 in healthy human subjects
    Masahiro Fujita
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, VA Connecticut 116A2, West Haven 06516, USA
    Eur J Nucl Med Mol Imaging 29:183-90. 2002
    ..These results suggest that [123I]5-I-A-85380 is a promising SPET agent to image alpha4beta2 nAChRs in humans, with acceptable dosimetry and high brain uptake...
  67. ncbi request reprint Whole-body radiation dosimetry of 2-[18F]Fluoro-A-85380 in human PET imaging studies
    Sebastian L Obrzut
    Department of Radiology, Division of Nuclear Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Nucl Med Biol 32:869-74. 2005
    ..184 rad/mCi) and the kidneys (0.0470 mGy/MBq, 0.174 rad/mCi). The mean effective dose equivalent is estimated to be 0.0278 mSv/MBq (0.103 rem/mCi), indicating that radiation dosimetry associated with 2-[18F]FA is within acceptable limits...
  68. ncbi request reprint Decision-making in a risk-taking task: a PET study
    Monique Ernst
    Intramural Research Program of the National Institute on Drug Abuse, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    Neuropsychopharmacology 26:682-91. 2002
    ..The findings provide a framework for future investigations of decision-making in maladaptive behaviors...
  69. ncbi request reprint Incorporating brain research findings into standard treatment: an example using the Matrix Model
    Jeanne L Obert
    Matrix Institute on Addictions, 12304 Santa Monica Blvd, Suite 200, West Los Angeles, CA 90024, USA
    J Subst Abuse Treat 23:107-13. 2002
    ..The translation and adaptation of the Matrix manual for cocaine users in Mexico and methamphetamine users in Thailand will offer opportunities to evaluate this approach with very diverse populations of stimulant users...
  70. ncbi request reprint In vitro characterization of 6-[18F]fluoro-A-85380, a high-affinity ligand for alpha4beta2* nicotinic acetylcholine receptors
    Daniela G√ľndisch
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA
    Synapse 55:89-97. 2005
    ..These results suggest that 6-[18F]fluoro-A-85380 is a promising radioligand for in vivo imaging of brain alpha4beta2* nicotinic receptors...
  71. doi request reprint Inhibitory control deficits in childhood and risk for substance use disorders: a review
    Iliyan Ivanov
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Drug Alcohol Abuse 34:239-58. 2008
    ..Hypotheses developed using this approach can be more definitively evaluated in longitudinal studies with these same populations, extending through the period of maximal risk for SUD in adolescence and early adulthood...
  72. ncbi request reprint Intravenous nicotine reduces cerebral glucose metabolism: a preliminary study
    June M Stapleton
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
    Neuropsychopharmacology 28:765-72. 2003
    ..The findings indicate that nicotine resembles other drugs of abuse in reducing brain metabolism, perhaps by a common mechanism...
  73. pmc Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment
    James Prosser
    Department of Psychiatry and Behavioral Sciences, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY 10003, USA
    Drug Alcohol Depend 84:240-7. 2006
    ..This study tests the hypothesis that former heroin users who have detoxified from methadone maintenance therapy and are drug-free have less pronounced cognitive impairment than patients continuing long-term MMT...
  74. ncbi request reprint Age-related decline in striatal volume in rhesus monkeys: assessment of long-term calorie restriction
    John A Matochik
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neurobiol Aging 25:193-200. 2004
    ..Further study, involving sequential imaging, is warranted in order to clarify the possible effects of CR on age-related changes in striatal volume...
  75. ncbi request reprint Behavioral predictors of substance-use initiation in adolescents with and without attention-deficit/hyperactivity disorder
    Monique Ernst
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Pediatrics 117:2030-9. 2006
    ..Our goal was to examine substance-use initiation in healthy adolescents and in adolescents who have been diagnosed with attention-deficit/hyperactivity disorder...

Research Grants17

  1. Methamphetamine Abuse, Inhibitory Control: Implications for Treatment
    Edythe London; Fiscal Year: 2007
    ....
  2. Nicotine Withdrawal, Smoking & Cognition: an fMRI Study
    Edythe London; Fiscal Year: 2001
    ..Nonsmokers, serving as controls, will be re-tested at corresponding times. ..
  3. Neural Systems, Inhibitory Control, and Methamphetamine Dependence
    Edythe London; Fiscal Year: 2007
    ..abstract_text> ..
  4. Neural Systems, Inhibitory Control, and Methamphetamine Dependence
    Edythe London; Fiscal Year: 2006
    ..abstract_text> ..
  5. Neural Systems, Inhibitory Control, and Methamphetamine Dependence
    Edythe London; Fiscal Year: 2005
    ..abstract_text> ..
  6. Early Methamphetamine Abstinence: fMRI and Cognition
    Edythe London; Fiscal Year: 2004
    ..We expect that changes in activation pattern with abstinence will normalize functional relationships (or strengthen new routes of activation). ..
  7. Early Methamphetamine Abstinence: fMRI and Cognition
    Edythe London; Fiscal Year: 2005
    ..We expect that changes in activation pattern with abstinence will normalize functional relationships (or strengthen new routes of activation). ..
  8. Early Methamphetamine Abstinence: fMRI and Cognition
    Edythe London; Fiscal Year: 2004
    ..We expect that changes in activation pattern with abstinence will normalize functional relationships (or strengthen new routes of activation). ..
  9. Nicotine Withdrawal, Smoking & Cognition: an fMRI Study
    Edythe London; Fiscal Year: 2003
    ..Nonsmokers, serving as controls, will be re-tested at corresponding times. ..
  10. Early Methamphetamine Abstinence: fMRI and Cognition
    Edythe London; Fiscal Year: 2003
    ..We expect that changes in activation pattern with abstinence will normalize functional relationships (or strengthen new routes of activation). ..
  11. Nicotine Withdrawal, Smoking & Cognition: an fMRI Study
    Edythe London; Fiscal Year: 2002
    ..Nonsmokers, serving as controls, will be re-tested at corresponding times. ..