Barry London

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias
    Barry London
    Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
    Circulation 116:2260-8. 2007
  2. ncbi request reprint Fatty acid metabolism and arrhythmias
    Barry London
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    J Cardiovasc Electrophysiol 15:1317-8. 2004
  3. ncbi request reprint Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesi
    Barry London
    Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
    Circulation 116:e320-35. 2007
  4. ncbi request reprint Electrical remodeling of cardiac myocytes from mice with heart failure due to the overexpression of tumor necrosis factor-alpha
    Polina S Petkova-Kirova
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Physiol Heart Circ Physiol 290:H2098-107. 2006
  5. ncbi request reprint Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    Dennis M McNamara
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Am Coll Cardiol 44:2019-26. 2004
  6. ncbi request reprint Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of tumor necrosis factor-{alpha}
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop St, Scaife S572, Pittsburgh, PA 15213, USA
    Am J Physiol Heart Circ Physiol 289:H1456-67. 2005
  7. pmc Prevention of adverse electrical and mechanical remodeling with biventricular pacing in a rabbit model of myocardial infarction
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Heart Rhythm 5:124-30. 2008
  8. pmc Adrenergic stimulation promotes T-wave alternans and arrhythmia inducibility in a TNF-alpha genetic mouse model of congestive heart failure
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Physiol Heart Circ Physiol 298:H440-50. 2010
  9. pmc Effect of right ventricular versus biventricular pacing on electrical remodeling in the normal heart
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Circ Arrhythm Electrophysiol 3:79-87. 2010
  10. ncbi request reprint Genetic susceptibility to atrial fibrillation in patients with congestive heart failure
    Maninder Bedi
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania, USA
    Heart Rhythm 3:808-12. 2006

Research Grants

Detail Information

Publications53

  1. pmc Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias
    Barry London
    Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
    Circulation 116:2260-8. 2007
    ..We previously used positional cloning to identify a new locus on chromosome 3p24 in a large family with Brugada syndrome and excluded SCN5A as a candidate gene...
  2. ncbi request reprint Fatty acid metabolism and arrhythmias
    Barry London
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    J Cardiovasc Electrophysiol 15:1317-8. 2004
  3. ncbi request reprint Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesi
    Barry London
    Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
    Circulation 116:e320-35. 2007
  4. ncbi request reprint Electrical remodeling of cardiac myocytes from mice with heart failure due to the overexpression of tumor necrosis factor-alpha
    Polina S Petkova-Kirova
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Physiol Heart Circ Physiol 290:H2098-107. 2006
    ..2, Kv4.3, and Kv1.5. Thus decreased K+ channel expression is largely responsible for the prolonged APD in the TNF mice and may, along with abnormalities in Ca2+ handling, contribute to arrhythmias...
  5. ncbi request reprint Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    Dennis M McNamara
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Am Coll Cardiol 44:2019-26. 2004
    ..We evaluated the interaction of angiotensin-converting enzyme (ACE) inhibitor therapy with the effect of the ACE D/I polymorphism on heart failure survival...
  6. ncbi request reprint Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of tumor necrosis factor-{alpha}
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop St, Scaife S572, Pittsburgh, PA 15213, USA
    Am J Physiol Heart Circ Physiol 289:H1456-67. 2005
    ..Thus abnormalities in action potential propagation and Ca(2+) handling contribute to the initiation of atrial arrhythmias in this mouse model of heart failure...
  7. pmc Prevention of adverse electrical and mechanical remodeling with biventricular pacing in a rabbit model of myocardial infarction
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Heart Rhythm 5:124-30. 2008
    ..Biventricular (BIV) pacing can improve cardiac function in heart failure (HF)...
  8. pmc Adrenergic stimulation promotes T-wave alternans and arrhythmia inducibility in a TNF-alpha genetic mouse model of congestive heart failure
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Physiol Heart Circ Physiol 298:H440-50. 2010
    ..006 and 0.009) but not in TNF-alpha mice. In conclusion, TWA is present in a TNF-alpha model of CHF and can be further promoted by adrenergic stimulation, along with the enhanced susceptibility for ventricular arrhythmias...
  9. pmc Effect of right ventricular versus biventricular pacing on electrical remodeling in the normal heart
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Circ Arrhythm Electrophysiol 3:79-87. 2010
    ..Biventricular (BIV) pacing can improve cardiac function in heart failure by altering the mechanical and electric substrates. We investigated the effect of BIV versus right ventricular (RV) pacing on the normal heart...
  10. ncbi request reprint Genetic susceptibility to atrial fibrillation in patients with congestive heart failure
    Maninder Bedi
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania, USA
    Heart Rhythm 3:808-12. 2006
    ..Previous reports demonstrate an association between atrial fibrillation (AF) and certain polymorphisms in genes controlling the production of angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS)...
  11. ncbi request reprint Epidemiology and determinants of outcome of admissions for atrial fibrillation in the United States from 1996 to 2001
    Farhat Khairallah
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Cardiol 94:500-4. 2004
    ....
  12. ncbi request reprint Renal insufficiency predicts the time to first appropriate defibrillator shock
    Haitham Hreybe
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am Heart J 151:852-6. 2006
    ..We investigated the effect of renal function on the incidence and time to first appropriate ICD shock...
  13. ncbi request reprint Interaction of implantable defibrillator therapy with angiotensin-converting enzyme deletion/insertion polymorphism
    Maninder S Bedi
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    J Cardiovasc Electrophysiol 15:1162-6. 2004
    ..If the ACE D genotype increases the risk of sudden death, implantable cardioverter defibrillator (ICD) therapy should diminish its negative impact. We sought to evaluate the effect of ICD therapy on ACE D genetic risk...
  14. ncbi request reprint Dual-dye optical mapping after myocardial infarction: does the site of ventricular stimulation alter the properties of electrical propagation?
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Cardiovasc Electrophysiol 19:197-202. 2008
    ..We investigated the effect of MI on the regional voltage and calcium (Ca) signals and their propagation properties, with special attention to the effect of the site of ventricular pacing on these properties...
  15. pmc Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT
    Barry London
    University of Pittsburgh, Cardiovascular Institute, Pittsburgh, PA 15213, USA
    J Physiol 578:115-29. 2007
    ..2DN mice. Thus, dispersion of repolarization (DR) appears to be an important determinant of arrhythmia vulnerability...
  16. doi request reprint Cardiac levels of NOS1AP RNA from right ventricular tissue recovered during lead extraction
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Heart Rhythm 9:399-404. 2012
    ..There is a scarcity of cardiac tissue available for research...
  17. ncbi request reprint Effect of the TNF-alpha-promoter polymorphism on cardiac allograft rejection
    Maninder Bedi
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Heart Lung Transplant 23:696-700. 2004
    ..We examined the effect of the TNFA2 allele on the risk of allograft rejection in adult cardiac transplant recipients...
  18. ncbi request reprint Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation
    Hsiao Huei Chen
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Circulation 110:2980-7. 2004
    ..In animal models of heart failure, cardiac alpha1-adrenergic signaling is constitutively activated. Here, we report the effects of constitutive activation of alpha1-adrenergic signaling on connexin phosphorylation and cardiac conduction...
  19. pmc Mathematical modeling mechanisms of arrhythmias in transgenic mouse heart overexpressing TNF-α
    Polina S Petkova-Kirova
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Physiol Heart Circ Physiol 302:H934-52. 2012
    ....
  20. ncbi request reprint Cardiac autonomic modulation by estrogen in female mice undergoing ambulatory monitoring and in vivo electrophysiologic testing
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213
    Ann Noninvasive Electrocardiol 9:142-8. 2004
    ..Estrogen is an important modulator of cardiovascular risk, but its mechanism of action is not fully understood. We investigated the effect of ovariectomy and its timing on the cardiac electrophysiology in mice...
  21. doi request reprint Arrhythmia phenotype in mouse models of human long QT
    Guy Salama
    Department of Cell Biology and Physiology, School of Medicine, University of Pittsburgh, S312 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
    J Interv Card Electrophysiol 24:77-87. 2009
    ..10%). A comparison of mouse models of LQT based on K(+) channel mutations important to human and mouse repolarization emphasizes DR as a major determinant of arrhythmia vulnerability...
  22. pmc The many faces of repolarization instability: which one is prognostic?
    Vladimir Shusterman
    University of Pittsburgh, Pittsburgh, PA, USA
    J Electrocardiol 42:511-6. 2009
    ..Therefore, the assessment of TWA needs to be dynamic and personalized to take into account the time evolution of risk and individual history...
  23. pmc Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy
    Marwan M Refaat
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Heart Rhythm 9:390-6. 2012
    ..Dilated cardiomyopathy (DCM) is a leading cause of heart failure and death. The etiology of DCM is genetically heterogeneous...
  24. doi request reprint Nocturnal peak in atrial tachyarrhythmia occurrence as a function of arrhythmia burden
    Vladimir Shusterman
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Cardiovasc Electrophysiol 23:604-11. 2012
    ..We examined circadian periodicity of atrial tachyarrhythmias (AT/AF) in a large group of patients with implantable devices, which allow continuous collection of the event data over prolonged periods of time...
  25. ncbi request reprint Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop St, Room B535, Pittsburgh, PA 15213, USA
    Circulation 113:2880-7. 2006
    ..We examined continuous dynamics of repolarization in Holter electrocardiograms with spontaneous sustained (>30 seconds) VTA...
  26. pmc Targeting device therapy: genomics of sudden death
    J Michael Frangiskakis
    Division of Cardiology, Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Heart Fail Clin 6:93-100. 2010
    ..Ultimately, we hope to identify a handful of SNPs that modulate the risk of sudden death in heart failure and to develop an algorithm to predict risk based on genotype...
  27. pmc Immunosuppression decreases inflammation and increases AAV6-hSERCA2a-mediated SERCA2a expression
    Xiaodong Zhu
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Hum Gene Ther 23:722-32. 2012
    ..However, the hSERCA2a protein level is reduced by host immune responses. Immunosuppression alleviates immune responses and sustains transgene expression, and may be an important adjuvant for clinical gene therapy trials...
  28. pmc Ventricular arrhythmia risk after subarachnoid hemorrhage
    J Michael Frangiskakis
    Cardiovascular Institute, University of Pittsburgh Medical Center, S572 Scaife Hall, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Neurocrit Care 10:287-94. 2009
    ..Our objective was to test the relationships between QTc prolongation, VA, and survival after SAH...
  29. pmc Mouse models of long QT syndrome
    Guy Salama
    Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Physiol 578:43-53. 2007
    ..Our goal is to provide the reader with a comprehensive overview of mouse models with long QT syndrome and to emphasize the advantages and limitations of these models...
  30. ncbi request reprint Calcium-dependent arrhythmias in transgenic mice with heart failure
    Barry London
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 284:H431-41. 2003
    ....
  31. ncbi request reprint Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 282:H2076-83. 2002
    ..Strain-specific differences should be considered in selecting the strains of mice used for transgenic and gene targeting experiments...
  32. ncbi request reprint Detecting instabilities of cardiac rhythm
    Vladimir Shusterman
    University of Pittsburgh, PA 15213, USA
    J Electrocardiol 36:219-26. 2003
    ....
  33. ncbi request reprint Clinical and molecular heterogeneity in the Brugada syndrome: a novel gene locus on chromosome 3
    Raul Weiss
    Cardiovascular Institute, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
    Circulation 105:707-13. 2002
    ..Mutations in other genes have not been identified, and it is not known if the efficacy of drug testing or the malignancy of arrhythmias correlates to the gene defect...
  34. doi request reprint Women and minorities are less likely to receive an implantable cardioverter defibrillator for primary prevention of sudden cardiac death
    Ure Mezu
    University of Pittsburgh Medical Center, 200 Lothrop Street, UPMC Presbyterian, Suite B 535, Pittsburgh, PA 15213 2582, USA
    Europace 14:341-4. 2012
    ..We investigated whether women and minorities are as likely as white men to receive an ICD for primary prevention of sudden cardiac death...
  35. ncbi request reprint Knockin animal models of inherited arrhythmogenic diseases: what have we learned from them?
    Kathy M Nilles
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Cardiovasc Electrophysiol 18:1117-25. 2007
    ..Our goal is to provide the reader with a general understanding of studies done on knockin mouse models of inherited arrhythmias as well as ideas for future directions...
  36. ncbi request reprint Clinical importance of beta-adrenoceptor polymorphisms in cardiovascular disease
    Dennis M McNamara
    Department of Medicine, Heart Failure Section, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Am J Pharmacogenomics 2:73-8. 2002
    ..Importantly, the pharmacogenetic impact of these variants on the effectiveness of beta-adrenergic blockade remains unknown...
  37. ncbi request reprint Utilization of implantable cardioverter-defibrillators in survivors of cardiac arrest in the United States from 1996 to 2001
    Andrew Voigt
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania, USA
    J Am Coll Cardiol 44:855-8. 2004
    ..We analyzed the incidence of implantable cardioverter-defibrillator (ICD) therapy in survivors of cardiac arrest (CA) in the U.S. from 1996 through 2001...
  38. ncbi request reprint Autonomic blockade unmasks maturational differences in rate-dependent atrioventricular nodal conduction and facilitation in the mouse
    Samir Saba
    Division of Cardiac Electrophysiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Cardiovasc Electrophysiol 14:191-5. 2003
    ..In this study, we investigated whether the properties of AVN conduction and facilitation are altered by autonomic blockade in the mouse and whether this effect is age dependent...
  39. ncbi request reprint Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure
    Dennis M McNamara
    Heart Failure Section, Cardiovascular Institute, University of Pittsburgh Medical Center, 558 Scaife Hall, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Circulation 107:1598-602. 2003
    ..Given the importance of nitric oxide in the heart failure syndrome, we evaluated the effect of this variant on event-free survival in a population with systolic dysfunction...
  40. ncbi request reprint What is the mechanism of this wide-complex tachycardia? More questions than answers
    Anca Iliescu
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Pacing Clin Electrophysiol 28:149-51. 2005
  41. ncbi request reprint Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotype
    Bharathi Aravamudan
    Department of Pharmacology, University of Pittsburgh School of Medicine, PA 15261, USA
    Hum Mol Genet 12:2777-88. 2003
    ..In addition, these findings suggest that caveolin-3 transgenic mice may represent a valid mouse model for studying the molecular mechanisms underlying cardiomyopathies associated with Duchenne muscular dystrophy...
  42. ncbi request reprint A second ACE of hearts
    Barry London
    J Mol Cell Cardiol 35:1009-10. 2003
  43. ncbi request reprint CaM kinase inhibition: apply directly to the heart?
    Barry London
    Circ Res 99:1027-8. 2006
  44. pmc A sodium channel pore mutation causing Brugada syndrome
    Arnold E Pfahnl
    Division of Cardiology, Atlanta Veterans Affairs Medical Center and Emory University, Atlanta, Georgia 30033, USA
    Heart Rhythm 4:46-53. 2007
    ..Both male and female carriers are symptomatic at young ages, have typical Brugada-type electrocardiogram changes, and have relatively normal corrected QT intervals...
  45. ncbi request reprint A precondition for arrhythmias
    Barry London
    J Cardiovasc Electrophysiol 18:100-1. 2007
  46. pmc Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome
    David W Van Norstrand
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 116:2253-9. 2007
    ..We hypothesized that mutations in GPD1-L may be responsible for some cases of sudden unexplained death/sudden infant death syndrome...
  47. pmc Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, The Fred Saigh Distinguished Professor, Washington University, Campus Box 1097, Whitaker Hall Room 290B, One Brookings Dr, St Louis, MO 63130 4899, USA
    Circulation 118:1202-11. 2008
    ..The recommendations can be found on the NHLBI Web site at http://www.nhlbi.nih.gov/meetings/workshops/electro.htm...
  48. ncbi request reprint Amiodarone and atrial fibrillation
    Barry London
    J Cardiovasc Electrophysiol 18:1321-2. 2007
  49. doi request reprint An irregularly irregular inheritance
    Barry London
    J Am Coll Cardiol 51:1090-1. 2008
  50. ncbi request reprint Staying connected without connexin43: can you hear me now?
    Barry London
    Circ Res 95:120-1. 2004
  51. doi request reprint Design of a phase 1/2 trial of intracoronary administration of AAV1/SERCA2a in patients with heart failure
    Roger J Hajjar
    Mount Sinai School of Medicine, New York, New York 10029, USA
    J Card Fail 14:355-67. 2008
    ..Prior animal and human studies have documented decreased expression of SERCA2a, a major cardiac calcium cycling protein, as a major defect found in HF...
  52. ncbi request reprint Natriuretic peptides and cardiac hypertrophy
    Barry London
    J Am Coll Cardiol 48:506-7. 2006
  53. ncbi request reprint Presynaptic factors in the regulation of DSI expression in hippocampus
    Namita Varma
    University of Maryland School of Medicine, Department of Physiology, 655 W Baltimore St, 21201, USA
    Neuropharmacology 43:550-62. 2002
    ..Significant DSI of mIPSCs remained in omega-conotoxin, hence we infer that block of N-channels does not fully explain hippocampal DSI expression...

Research Grants24

  1. CLINICAL AND MOLECULAR ANALYSIS OF THE BRUGADA SYNDROME
    Barry London; Fiscal Year: 1999
    ..abstract_text> ..
  2. A Clinical & Molecular Analysis of the Brugada Syndrome
    Barry London; Fiscal Year: 2003
    ....
  3. Genetic Modulators of Sudden Death
    Barry London; Fiscal Year: 2004
    ..We hope to identify genetic predictors for the common forms of sudden cardiac death. This would allow the identification of a subpopulation of heart failure patients that would benefit most from ICD placement. ..
  4. A Clinical & Molecular Analysis of the Brugada Syndrome
    Barry London; Fiscal Year: 2005
    ..abstract_text> ..
  5. Genetic Modulators of Sudden Death
    Barry London; Fiscal Year: 2005
    ..We hope to identify genetic predictors for the common forms of sudden cardiac death. This would allow the identification of a subpopulation of heart failure patients that would benefit most from ICD placement. ..
  6. Genetic Modulators of Sudden Death
    Barry London; Fiscal Year: 2006
    ..We hope to identify genetic predictors for the common forms of sudden cardiac death. This would allow the identification of a subpopulation of heart failure patients that would benefit most from ICD placement. ..
  7. Genetic Modulators of Sudden Death
    Barry London; Fiscal Year: 2007
    ..We hope to identify genetic predictors for the common forms of sudden cardiac death. This would allow the identification of a subpopulation of heart failure patients that would benefit most from ICD placement. ..
  8. A Clinical and Molecular Analysis of the Brugada Syndrome
    Barry London; Fiscal Year: 2009
    ..In this proposal, we will study a family with an inherited genetic form of sudden death with the hope that we can develop new treatments for the more common causes of this devastating and unpredictable condition. ..
  9. A Clinical & Molecular Analysis of the Brugada Syndrome
    Barry London; Fiscal Year: 2004
    ..abstract_text> ..
  10. CYTOKINE-INDUCED ARRHYTHMIAS IN CONGESTIVE HEART FAILURE
    Barry London; Fiscal Year: 2004
    ....
  11. TARGETING HERG: A MOUSE MODEL OF THE LONG QT SYNDROME
    Barry London; Fiscal Year: 1999
    ..Information gained from these studies may help to clarify the mechanisms of the more common arrhythmias that cause sudden death. ..
  12. TARGETING HERG: A MOUSE MODEL OF THE LONG QT SYNDROME
    Barry London; Fiscal Year: 2000
    ..Information gained from these studies may help to clarify the mechanisms of the more common arrhythmias that cause sudden death. ..
  13. CLINICAL AND MOLECULAR ANALYSIS OF THE BRUGADA SYNDROME
    Barry London; Fiscal Year: 2000
    ..abstract_text> ..
  14. CYTOKINE-INDUCED ARRHYTHMIAS IN CONGESTIVE HEART FAILURE
    Barry London; Fiscal Year: 2001
    ....
  15. TARGETING HERG: A MOUSE MODEL OF THE LONG QT SYNDROME
    Barry London; Fiscal Year: 2001
    ..Information gained from these studies may help to clarify the mechanisms of the more common arrhythmias that cause sudden death. ..
  16. CLINICAL AND MOLECULAR ANALYSIS OF THE BRUGADA SYNDROME
    Barry London; Fiscal Year: 2001
    ..abstract_text> ..
  17. TARGETING HERG: A MOUSE MODEL OF THE LONG QT SYNDROME
    Barry London; Fiscal Year: 2002
    ..Information gained from these studies may help to clarify the mechanisms of the more common arrhythmias that cause sudden death. ..
  18. CYTOKINE-INDUCED ARRHYTHMIAS IN CONGESTIVE HEART FAILURE
    Barry London; Fiscal Year: 2002
    ....
  19. CYTOKINE-INDUCED ARRHYTHMIAS IN CONGESTIVE HEART FAILURE
    Barry London; Fiscal Year: 2003
    ....
  20. A Clinical & Molecular Analysis of the Brugada Syndrome
    Barry London; Fiscal Year: 2003
    ..abstract_text> ..
  21. A Clinical and Molecular Analysis of the Brugada Syndrome
    Barry London; Fiscal Year: 2010
    ..In this proposal, we will study a family with an inherited genetic form of sudden death with the hope that we can develop new treatments for the more common causes of this devastating and unpredictable condition. ..