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Genomes and Genes | B LondonSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channelB London
Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 95:2926-31. 1998..These changes correlate with a marked decrease in the level of Kv1.5 polypeptide. Thus, overexpression of a truncated K+ channel in the heart alters native K+ channel expression and has profound effects on cardiac excitability...
Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongationB London
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
Circ Res 88:940-6. 2001..1 may explain the phenotypic differences between SWAP mice and the previously described transgenic mice expressing a truncated dominant-negative Kv1.1 construct...- Cardiac arrhythmias: from (transgenic) mice to menB London
Cardiovascular Institute, University of Pittsburgh, Pennsylvania 15213 2582, USA
J Cardiovasc Electrophysiol 12:1089-91. 2001..Despite its limitations, the mouse can provide a powerful tool to further our understanding of basic mechanisms that underlie human cardiac electrophysiology... - Calcium-dependent arrhythmias in transgenic mice with heart failureBarry London
Cardiovascular Institute, University of Pittsburgh, Pennsylvania 15213, USA
Am J Physiol Heart Circ Physiol 284:H431-41. 2003.... - The transient outward current in mice lacking the potassium channel gene Kv1.4B London
Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Physiol 509:171-82. 1998..6. Western blot analysis of heart membrane extracts showed no significant upregulation of the Kv4 subfamily of channels in the targeted mice. 7. Thus, Kv1.4 is not the molecular basis of Ito in adult murine ventricular myocytes... - Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ currentB London
Division of Cardiology, University of Pittsburgh Medical Center, PA 15213 2582, USA
Circ Res 81:870-8. 1997..This N-terminal Erg isoform may determine the properties of IKr and contribute to the pathogenesis of LQTS... - Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failureD M McNamara
Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Circulation 103:1644-8. 2001.... - Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon heartsC F McTiernan
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
Gene Ther 14:1613-22. 2007..Thus, a cellular immune response to cardiac delivery of AAV encoding foreign proteins may be an important consideration for AAV-based cardiac gene therapy... - Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humansVladimir Shusterman
Cardiovascular Institute, University of Pittsburgh, 200 Lothrop St, Room B535, Pittsburgh, PA 15213, USA
Circulation 113:2880-7. 2006..We examined continuous dynamics of repolarization in Holter electrocardiograms with spontaneous sustained (>30 seconds) VTA... - CaM kinase inhibition: apply directly to the heart?Barry London
Circ Res 99:1027-8. 2006 - Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of tumor necrosis factor-{alpha}Samir Saba
Cardiovascular Institute, University of Pittsburgh, 200 Lothrop St, Scaife S572, Pittsburgh, PA 15213, USA
Am J Physiol Heart Circ Physiol 289:H1456-67. 2005..Thus abnormalities in action potential propagation and Ca(2+) handling contribute to the initiation of atrial arrhythmias in this mouse model of heart failure... - Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QTBarry London
University of Pittsburgh, Cardiovascular Institute, Pittsburgh, PA 15213, USA
J Physiol 578:115-29. 2007..2DN mice. Thus, dispersion of repolarization (DR) appears to be an important determinant of arrhythmia vulnerability... - A sodium channel pore mutation causing Brugada syndromeArnold E Pfahnl
Division of Cardiology, Atlanta Veterans Affairs Medical Center and Emory University, Atlanta, Georgia 30033, USA
Heart Rhythm 4:46-53. 2007..Both male and female carriers are symptomatic at young ages, have typical Brugada-type electrocardiogram changes, and have relatively normal corrected QT intervals... - A precondition for arrhythmiasBarry London
J Cardiovasc Electrophysiol 18:100-1. 2007 - Electrical remodeling of cardiac myocytes from mice with heart failure due to the overexpression of tumor necrosis factor-alphaPolina S Petkova-Kirova
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Am J Physiol Heart Circ Physiol 290:H2098-107. 2006..2, Kv4.3, and Kv1.5. Thus decreased K+ channel expression is largely responsible for the prolonged APD in the TNF mice and may, along with abnormalities in Ca2+ handling, contribute to arrhythmias... - Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac ArrhythmogenesiBarry London
Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S-572, 200 Lothrop St, Pittsburgh, PA 15213-2582, USA
Circulation 116:e320-35. 2007 - Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndromeDavid W Van Norstrand
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
Circulation 116:2253-9. 2007..We hypothesized that mutations in GPD1-L may be responsible for some cases of sudden unexplained death/sudden infant death syndrome... - Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmiasBarry London
Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
Circulation 116:2260-8. 2007..We previously used positional cloning to identify a new locus on chromosome 3p24 in a large family with Brugada syndrome and excluded SCN5A as a candidate gene... - Dual-dye optical mapping after myocardial infarction: does the site of ventricular stimulation alter the properties of electrical propagation?Samir Saba
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Cardiovasc Electrophysiol 19:197-202. 2008..We investigated the effect of MI on the regional voltage and calcium (Ca) signals and their propagation properties, with special attention to the effect of the site of ventricular pacing on these properties... - Amiodarone and atrial fibrillationBarry London
J Cardiovasc Electrophysiol 18:1321-2. 2007 - Prevention of adverse electrical and mechanical remodeling with biventricular pacing in a rabbit model of myocardial infarctionSamir Saba
Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Heart Rhythm 5:124-30. 2008..Biventricular (BIV) pacing can improve cardiac function in heart failure (HF)... - An irregularly irregular inheritanceBarry London
J Am Coll Cardiol 51:1090-1. 2008 - Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summaryYoram Rudy
Cardiac Bioelectricity and Arrhythmia Center, The Fred Saigh Distinguished Professor, Washington University, Campus Box 1097, Whitaker Hall Room 290B, One Brookings Dr, St Louis, MO 63130 4899, USA
Circulation 118:1202-11. 2008..The recommendations can be found on the NHLBI Web site at http://www.nhlbi.nih.gov/meetings/workshops/electro.htm... - Fatty acid metabolism and arrhythmiasBarry London
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2582, USA
J Cardiovasc Electrophysiol 15:1317-8. 2004 - Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failureDennis M McNamara
Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Am Coll Cardiol 44:2019-26. 2004..We evaluated the interaction of angiotensin-converting enzyme (ACE) inhibitor therapy with the effect of the ACE D/I polymorphism on heart failure survival... - Cardiac autonomic modulation by estrogen in female mice undergoing ambulatory monitoring and in vivo electrophysiologic testingSamir Saba
Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213
Ann Noninvasive Electrocardiol 9:142-8. 2004..Estrogen is an important modulator of cardiovascular risk, but its mechanism of action is not fully understood. We investigated the effect of ovariectomy and its timing on the cardiac electrophysiology in mice... - Detecting instabilities of cardiac rhythmVladimir Shusterman
University of Pittsburgh, PA 15213, USA
J Electrocardiol 36:219-26. 2003.... - A second ACE of heartsBarry London
J Mol Cell Cardiol 35:1009-10. 2003 - Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotypeBharathi Aravamudan
Department of Pharmacology, University of Pittsburgh School of Medicine, PA 15261, USA
Hum Mol Genet 12:2777-88. 2003..In addition, these findings suggest that caveolin-3 transgenic mice may represent a valid mouse model for studying the molecular mechanisms underlying cardiomyopathies associated with Duchenne muscular dystrophy... - Autonomic blockade unmasks maturational differences in rate-dependent atrioventricular nodal conduction and facilitation in the mouseSamir Saba
Division of Cardiac Electrophysiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Cardiovasc Electrophysiol 14:191-5. 2003..In this study, we investigated whether the properties of AVN conduction and facilitation are altered by autonomic blockade in the mouse and whether this effect is age dependent... - Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failureDennis M McNamara
Heart Failure Section, Cardiovascular Institute, University of Pittsburgh Medical Center, 558 Scaife Hall, 200 Lothrop St, Pittsburgh, PA 15213, USA
Circulation 107:1598-602. 2003..Given the importance of nitric oxide in the heart failure syndrome, we evaluated the effect of this variant on event-free survival in a population with systolic dysfunction... - Presynaptic factors in the regulation of DSI expression in hippocampusNamita Varma
University of Maryland School of Medicine, Department of Physiology, 655 W. Baltimore St, 21201, USA
Neuropharmacology 43:550-62. 2002..Significant DSI of mIPSCs remained in omega-conotoxin, hence we infer that block of N-channels does not fully explain hippocampal DSI expression... - Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in miceVladimir Shusterman
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Am J Physiol Heart Circ Physiol 282:H2076-83. 2002..Strain-specific differences should be considered in selecting the strains of mice used for transgenic and gene targeting experiments... - Genetic susceptibility to atrial fibrillation in patients with congestive heart failureManinder Bedi
Cardiovascular Institute, University of Pittsburgh, Pennsylvania, USA
Heart Rhythm 3:808-12. 2006..Previous reports demonstrate an association between atrial fibrillation (AF) and certain polymorphisms in genes controlling the production of angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS)... - Clinical and molecular heterogeneity in the Brugada syndrome: a novel gene locus on chromosome 3Raul Weiss
Cardiovascular Institute, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213-2582, USA
Circulation 105:707-13. 2002..CONCLUSIONS: A Brugada syndrome locus distinct from SCN5A is associated with progressive conduction disease, a low sensitivity to procainamide testing, and a relatively good prognosis in a single large pedigree... - Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylationHsiao Huei Chen
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
Circulation 110:2980-7. 2004..In animal models of heart failure, cardiac alpha1-adrenergic signaling is constitutively activated. Here, we report the effects of constitutive activation of alpha1-adrenergic signaling on connexin phosphorylation and cardiac conduction... - Interaction of implantable defibrillator therapy with angiotensin-converting enzyme deletion/insertion polymorphismManinder S Bedi
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2582, USA
J Cardiovasc Electrophysiol 15:1162-6. 2004..This finding suggests that mortality in this high-risk genetic subset of patients is due to progression of heart failure rather than arrhythmic sudden death... - Effect of the TNF-alpha-promoter polymorphism on cardiac allograft rejectionManinder Bedi
Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Heart Lung Transplant 23:696-700. 2004..We examined the effect of the TNFA2 allele on the risk of allograft rejection in adult cardiac transplant recipients... 
Design of a phase 1/2 trial of intracoronary administration of AAV1/SERCA2a in patients with heart failureRoger J Hajjar
Mount Sinai School of Medicine, New York, New York 10029, USA
J Card Fail 14:355-67. 2008..Prior animal and human studies have documented decreased expression of SERCA2a, a major cardiac calcium cycling protein, as a major defect found in HF...- What is the mechanism of this wide-complex tachycardia? More questions than answersAnca Iliescu
Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Pacing Clin Electrophysiol 28:149-51. 2005 - Clinical importance of beta-adrenoceptor polymorphisms in cardiovascular diseaseDennis M McNamara
Department of Medicine, Heart Failure Section, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
Am J Pharmacogenomics 2:73-8. 2002..Importantly, the pharmacogenetic impact of these variants on the effectiveness of beta-adrenergic blockade remains unknown... - Renal insufficiency predicts the time to first appropriate defibrillator shockHaitham Hreybe
University of Pittsburgh, Pittsburgh, PA 15213, USA
Am Heart J 151:852-6. 2006..Defibrillator therapy should therefore not be withheld based on the presence of this comorbidity. The mechanisms underlying the relationship between renal function and ventricular arrhythmias deserve further investigation... - Utilization of implantable cardioverter-defibrillators in survivors of cardiac arrest in the United States from 1996 to 2001Andrew Voigt
Cardiovascular Institute, University of Pittsburgh, Pennsylvania, USA
J Am Coll Cardiol 44:855-8. 2004..There are gross discrepancies by race. At a time when newer indications for ICD implantation are emerging, efforts should be focused on identifying the causes of this underutilization and discrepancies in survivors of CA... - Natriuretic peptides and cardiac hypertrophyBarry London
J Am Coll Cardiol 48:506-7. 2006 - Knockin animal models of inherited arrhythmogenic diseases: what have we learned from them?Kathy M Nilles
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Cardiovasc Electrophysiol 18:1117-25. 2007..Our goal is to provide the reader with a general understanding of studies done on knockin mouse models of inherited arrhythmias as well as ideas for future directions... - Mouse models of long QT syndromeGuy Salama
Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop Street, Pittsburgh, PA 15213, USA
J Physiol 578:43-53. 2007..Our goal is to provide the reader with a comprehensive overview of mouse models with long QT syndrome and to emphasize the advantages and limitations of these models... - Staying connected without connexin43: can you hear me now?Barry London
Circ Res 95:120-1. 2004 - Epidemiology and determinants of outcome of admissions for atrial fibrillation in the United States from 1996 to 2001Farhat Khairallah
Cardiovascular Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Am J Cardiol 94:500-4. 2004....