B London

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 95:2926-31. 1998
  2. ncbi request reprint Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongation
    B London
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Circ Res 88:940-6. 2001
  3. ncbi request reprint Cardiac arrhythmias: from (transgenic) mice to men
    B London
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania 15213 2582, USA
    J Cardiovasc Electrophysiol 12:1089-91. 2001
  4. ncbi request reprint Calcium-dependent arrhythmias in transgenic mice with heart failure
    Barry London
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 284:H431-41. 2003
  5. pmc The transient outward current in mice lacking the potassium channel gene Kv1.4
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Physiol 509:171-82. 1998
  6. ncbi request reprint Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, PA 15213 2582, USA
    Circ Res 81:870-8. 1997
  7. ncbi request reprint Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    D M McNamara
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Circulation 103:1644-8. 2001
  8. ncbi request reprint Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts
    C F McTiernan
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Gene Ther 14:1613-22. 2007
  9. ncbi request reprint Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop St, Room B535, Pittsburgh, PA 15213, USA
    Circulation 113:2880-7. 2006
  10. ncbi request reprint CaM kinase inhibition: apply directly to the heart?
    Barry London
    Circ Res 99:1027-8. 2006

Collaborators

Detail Information

Publications48

  1. pmc Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 95:2926-31. 1998
    ..These changes correlate with a marked decrease in the level of Kv1.5 polypeptide. Thus, overexpression of a truncated K+ channel in the heart alters native K+ channel expression and has profound effects on cardiac excitability...
  2. ncbi request reprint Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongation
    B London
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Circ Res 88:940-6. 2001
    ..1 may explain the phenotypic differences between SWAP mice and the previously described transgenic mice expressing a truncated dominant-negative Kv1.1 construct...
  3. ncbi request reprint Cardiac arrhythmias: from (transgenic) mice to men
    B London
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania 15213 2582, USA
    J Cardiovasc Electrophysiol 12:1089-91. 2001
    ..Despite its limitations, the mouse can provide a powerful tool to further our understanding of basic mechanisms that underlie human cardiac electrophysiology...
  4. ncbi request reprint Calcium-dependent arrhythmias in transgenic mice with heart failure
    Barry London
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 284:H431-41. 2003
    ....
  5. pmc The transient outward current in mice lacking the potassium channel gene Kv1.4
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Physiol 509:171-82. 1998
    ..6. Western blot analysis of heart membrane extracts showed no significant upregulation of the Kv4 subfamily of channels in the targeted mice. 7. Thus, Kv1.4 is not the molecular basis of Ito in adult murine ventricular myocytes...
  6. ncbi request reprint Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, PA 15213 2582, USA
    Circ Res 81:870-8. 1997
    ..This N-terminal Erg isoform may determine the properties of IKr and contribute to the pathogenesis of LQTS...
  7. ncbi request reprint Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    D M McNamara
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Circulation 103:1644-8. 2001
    ....
  8. ncbi request reprint Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts
    C F McTiernan
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Gene Ther 14:1613-22. 2007
    ..Thus, a cellular immune response to cardiac delivery of AAV encoding foreign proteins may be an important consideration for AAV-based cardiac gene therapy...
  9. ncbi request reprint Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop St, Room B535, Pittsburgh, PA 15213, USA
    Circulation 113:2880-7. 2006
    ..We examined continuous dynamics of repolarization in Holter electrocardiograms with spontaneous sustained (>30 seconds) VTA...
  10. ncbi request reprint CaM kinase inhibition: apply directly to the heart?
    Barry London
    Circ Res 99:1027-8. 2006
  11. ncbi request reprint Atrial contractile dysfunction, fibrosis, and arrhythmias in a mouse model of cardiomyopathy secondary to cardiac-specific overexpression of tumor necrosis factor-{alpha}
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop St, Scaife S572, Pittsburgh, PA 15213, USA
    Am J Physiol Heart Circ Physiol 289:H1456-67. 2005
    ..Thus abnormalities in action potential propagation and Ca(2+) handling contribute to the initiation of atrial arrhythmias in this mouse model of heart failure...
  12. pmc Dispersion of repolarization and refractoriness are determinants of arrhythmia phenotype in transgenic mice with long QT
    Barry London
    University of Pittsburgh, Cardiovascular Institute, Pittsburgh, PA 15213, USA
    J Physiol 578:115-29. 2007
    ..2DN mice. Thus, dispersion of repolarization (DR) appears to be an important determinant of arrhythmia vulnerability...
  13. pmc A sodium channel pore mutation causing Brugada syndrome
    Arnold E Pfahnl
    Division of Cardiology, Atlanta Veterans Affairs Medical Center and Emory University, Atlanta, Georgia 30033, USA
    Heart Rhythm 4:46-53. 2007
    ..Both male and female carriers are symptomatic at young ages, have typical Brugada-type electrocardiogram changes, and have relatively normal corrected QT intervals...
  14. ncbi request reprint A precondition for arrhythmias
    Barry London
    J Cardiovasc Electrophysiol 18:100-1. 2007
  15. ncbi request reprint Electrical remodeling of cardiac myocytes from mice with heart failure due to the overexpression of tumor necrosis factor-alpha
    Polina S Petkova-Kirova
    Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Physiol Heart Circ Physiol 290:H2098-107. 2006
    ..2, Kv4.3, and Kv1.5. Thus decreased K+ channel expression is largely responsible for the prolonged APD in the TNF mice and may, along with abnormalities in Ca2+ handling, contribute to arrhythmias...
  16. ncbi request reprint Omega-3 fatty acids and cardiac arrhythmias: prior studies and recommendations for future research: a report from the National Heart, Lung, and Blood Institute and Office Of Dietary Supplements Omega-3 Fatty Acids and their Role in Cardiac Arrhythmogenesi
    Barry London
    Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
    Circulation 116:e320-35. 2007
  17. pmc Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome
    David W Van Norstrand
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
    Circulation 116:2253-9. 2007
    ..We hypothesized that mutations in GPD1-L may be responsible for some cases of sudden unexplained death/sudden infant death syndrome...
  18. pmc Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias
    Barry London
    Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop St, Pittsburgh, PA 15213 2582, USA
    Circulation 116:2260-8. 2007
    ..We previously used positional cloning to identify a new locus on chromosome 3p24 in a large family with Brugada syndrome and excluded SCN5A as a candidate gene...
  19. ncbi request reprint Dual-dye optical mapping after myocardial infarction: does the site of ventricular stimulation alter the properties of electrical propagation?
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Cardiovasc Electrophysiol 19:197-202. 2008
    ..We investigated the effect of MI on the regional voltage and calcium (Ca) signals and their propagation properties, with special attention to the effect of the site of ventricular pacing on these properties...
  20. ncbi request reprint Amiodarone and atrial fibrillation
    Barry London
    J Cardiovasc Electrophysiol 18:1321-2. 2007
  21. pmc Prevention of adverse electrical and mechanical remodeling with biventricular pacing in a rabbit model of myocardial infarction
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Heart Rhythm 5:124-30. 2008
    ..Biventricular (BIV) pacing can improve cardiac function in heart failure (HF)...
  22. doi request reprint An irregularly irregular inheritance
    Barry London
    J Am Coll Cardiol 51:1090-1. 2008
  23. pmc Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, The Fred Saigh Distinguished Professor, Washington University, Campus Box 1097, Whitaker Hall Room 290B, One Brookings Dr, St Louis, MO 63130 4899, USA
    Circulation 118:1202-11. 2008
    ..The recommendations can be found on the NHLBI Web site at http://www.nhlbi.nih.gov/meetings/workshops/electro.htm...
  24. ncbi request reprint Fatty acid metabolism and arrhythmias
    Barry London
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    J Cardiovasc Electrophysiol 15:1317-8. 2004
  25. ncbi request reprint Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    Dennis M McNamara
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Am Coll Cardiol 44:2019-26. 2004
    ..We evaluated the interaction of angiotensin-converting enzyme (ACE) inhibitor therapy with the effect of the ACE D/I polymorphism on heart failure survival...
  26. ncbi request reprint Cardiac autonomic modulation by estrogen in female mice undergoing ambulatory monitoring and in vivo electrophysiologic testing
    Samir Saba
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213
    Ann Noninvasive Electrocardiol 9:142-8. 2004
    ..Estrogen is an important modulator of cardiovascular risk, but its mechanism of action is not fully understood. We investigated the effect of ovariectomy and its timing on the cardiac electrophysiology in mice...
  27. ncbi request reprint Detecting instabilities of cardiac rhythm
    Vladimir Shusterman
    University of Pittsburgh, PA 15213, USA
    J Electrocardiol 36:219-26. 2003
    ....
  28. ncbi request reprint A second ACE of hearts
    Barry London
    J Mol Cell Cardiol 35:1009-10. 2003
  29. ncbi request reprint Transgenic overexpression of caveolin-3 in the heart induces a cardiomyopathic phenotype
    Bharathi Aravamudan
    Department of Pharmacology, University of Pittsburgh School of Medicine, PA 15261, USA
    Hum Mol Genet 12:2777-88. 2003
    ..In addition, these findings suggest that caveolin-3 transgenic mice may represent a valid mouse model for studying the molecular mechanisms underlying cardiomyopathies associated with Duchenne muscular dystrophy...
  30. ncbi request reprint Autonomic blockade unmasks maturational differences in rate-dependent atrioventricular nodal conduction and facilitation in the mouse
    Samir Saba
    Division of Cardiac Electrophysiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Cardiovasc Electrophysiol 14:191-5. 2003
    ..In this study, we investigated whether the properties of AVN conduction and facilitation are altered by autonomic blockade in the mouse and whether this effect is age dependent...
  31. ncbi request reprint Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure
    Dennis M McNamara
    Heart Failure Section, Cardiovascular Institute, University of Pittsburgh Medical Center, 558 Scaife Hall, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Circulation 107:1598-602. 2003
    ..Given the importance of nitric oxide in the heart failure syndrome, we evaluated the effect of this variant on event-free survival in a population with systolic dysfunction...
  32. ncbi request reprint Presynaptic factors in the regulation of DSI expression in hippocampus
    Namita Varma
    University of Maryland School of Medicine, Department of Physiology, 655 W Baltimore St, 21201, USA
    Neuropharmacology 43:550-62. 2002
    ..Significant DSI of mIPSCs remained in omega-conotoxin, hence we infer that block of N-channels does not fully explain hippocampal DSI expression...
  33. ncbi request reprint Strain-specific patterns of autonomic nervous system activity and heart failure susceptibility in mice
    Vladimir Shusterman
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 282:H2076-83. 2002
    ..Strain-specific differences should be considered in selecting the strains of mice used for transgenic and gene targeting experiments...
  34. ncbi request reprint Genetic susceptibility to atrial fibrillation in patients with congestive heart failure
    Maninder Bedi
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania, USA
    Heart Rhythm 3:808-12. 2006
    ..Previous reports demonstrate an association between atrial fibrillation (AF) and certain polymorphisms in genes controlling the production of angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS)...
  35. ncbi request reprint Clinical and molecular heterogeneity in the Brugada syndrome: a novel gene locus on chromosome 3
    Raul Weiss
    Cardiovascular Institute, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213 2582, USA
    Circulation 105:707-13. 2002
    ..Mutations in other genes have not been identified, and it is not known if the efficacy of drug testing or the malignancy of arrhythmias correlates to the gene defect...
  36. ncbi request reprint Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation
    Hsiao Huei Chen
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Circulation 110:2980-7. 2004
    ..In animal models of heart failure, cardiac alpha1-adrenergic signaling is constitutively activated. Here, we report the effects of constitutive activation of alpha1-adrenergic signaling on connexin phosphorylation and cardiac conduction...
  37. ncbi request reprint Interaction of implantable defibrillator therapy with angiotensin-converting enzyme deletion/insertion polymorphism
    Maninder S Bedi
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    J Cardiovasc Electrophysiol 15:1162-6. 2004
    ..If the ACE D genotype increases the risk of sudden death, implantable cardioverter defibrillator (ICD) therapy should diminish its negative impact. We sought to evaluate the effect of ICD therapy on ACE D genetic risk...
  38. ncbi request reprint Effect of the TNF-alpha-promoter polymorphism on cardiac allograft rejection
    Maninder Bedi
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Heart Lung Transplant 23:696-700. 2004
    ..We examined the effect of the TNFA2 allele on the risk of allograft rejection in adult cardiac transplant recipients...
  39. doi request reprint Design of a phase 1/2 trial of intracoronary administration of AAV1/SERCA2a in patients with heart failure
    Roger J Hajjar
    Mount Sinai School of Medicine, New York, New York 10029, USA
    J Card Fail 14:355-67. 2008
    ..Prior animal and human studies have documented decreased expression of SERCA2a, a major cardiac calcium cycling protein, as a major defect found in HF...
  40. ncbi request reprint What is the mechanism of this wide-complex tachycardia? More questions than answers
    Anca Iliescu
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Pacing Clin Electrophysiol 28:149-51. 2005
  41. ncbi request reprint Clinical importance of beta-adrenoceptor polymorphisms in cardiovascular disease
    Dennis M McNamara
    Department of Medicine, Heart Failure Section, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 2582, USA
    Am J Pharmacogenomics 2:73-8. 2002
    ..Importantly, the pharmacogenetic impact of these variants on the effectiveness of beta-adrenergic blockade remains unknown...
  42. ncbi request reprint Renal insufficiency predicts the time to first appropriate defibrillator shock
    Haitham Hreybe
    University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am Heart J 151:852-6. 2006
    ..We investigated the effect of renal function on the incidence and time to first appropriate ICD shock...
  43. ncbi request reprint Utilization of implantable cardioverter-defibrillators in survivors of cardiac arrest in the United States from 1996 to 2001
    Andrew Voigt
    Cardiovascular Institute, University of Pittsburgh, Pennsylvania, USA
    J Am Coll Cardiol 44:855-8. 2004
    ..We analyzed the incidence of implantable cardioverter-defibrillator (ICD) therapy in survivors of cardiac arrest (CA) in the U.S. from 1996 through 2001...
  44. ncbi request reprint Natriuretic peptides and cardiac hypertrophy
    Barry London
    J Am Coll Cardiol 48:506-7. 2006
  45. ncbi request reprint Knockin animal models of inherited arrhythmogenic diseases: what have we learned from them?
    Kathy M Nilles
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Cardiovasc Electrophysiol 18:1117-25. 2007
    ..Our goal is to provide the reader with a general understanding of studies done on knockin mouse models of inherited arrhythmias as well as ideas for future directions...
  46. pmc Mouse models of long QT syndrome
    Guy Salama
    Cardiovascular Institute, University of Pittsburgh Medical Center, Scaife S 572, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Physiol 578:43-53. 2007
    ..Our goal is to provide the reader with a comprehensive overview of mouse models with long QT syndrome and to emphasize the advantages and limitations of these models...
  47. ncbi request reprint Staying connected without connexin43: can you hear me now?
    Barry London
    Circ Res 95:120-1. 2004
  48. ncbi request reprint Epidemiology and determinants of outcome of admissions for atrial fibrillation in the United States from 1996 to 2001
    Farhat Khairallah
    Cardiovascular Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Am J Cardiol 94:500-4. 2004
    ....