B London

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, PA 15213 2582, USA
    Circ Res 81:870-8. 1997
  2. pmc The transient outward current in mice lacking the potassium channel gene Kv1.4
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Physiol 509:171-82. 1998
  3. ncbi request reprint Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongation
    B London
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Circ Res 88:940-6. 2001
  4. pmc Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 95:2926-31. 1998
  5. ncbi request reprint N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator
    A D Wickenden
    Icagen, Inc, 4222 Emperor Blvd, Durham, NC 27703, USA
    Mol Pharmacol 73:977-86. 2008
  6. ncbi request reprint Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts
    C F McTiernan
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Gene Ther 14:1613-22. 2007
  7. ncbi request reprint Cardiovascular tissues contain independent circadian clocks
    A J Davidson
    Department of Biology, University of Virginia, Charlottesville, Virginia 22904 4328, USA
    Clin Exp Hypertens 27:307-11. 2005
  8. ncbi request reprint Dominant-negative subunits reveal potassium channel families that contribute to M-like potassium currents
    A A Selyanko
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 22:RC212. 2002
  9. ncbi request reprint Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5
    S L Archer
    Vascular Biology Group, Department of Medicine, Division of Cardiology, University of Alberta, Alberta, Canada
    FASEB J 15:1801-3. 2001
  10. ncbi request reprint Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    D M McNamara
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Circulation 103:1644-8. 2001

Detail Information

Publications14

  1. ncbi request reprint Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, PA 15213 2582, USA
    Circ Res 81:870-8. 1997
    ..This N-terminal Erg isoform may determine the properties of IKr and contribute to the pathogenesis of LQTS...
  2. pmc The transient outward current in mice lacking the potassium channel gene Kv1.4
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Physiol 509:171-82. 1998
    ..6. Western blot analysis of heart membrane extracts showed no significant upregulation of the Kv4 subfamily of channels in the targeted mice. 7. Thus, Kv1.4 is not the molecular basis of Ito in adult murine ventricular myocytes...
  3. ncbi request reprint Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K,slow) and resistance to drug-induced qt prolongation
    B London
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Circ Res 88:940-6. 2001
    ..1 may explain the phenotypic differences between SWAP mice and the previously described transgenic mice expressing a truncated dominant-negative Kv1.1 construct...
  4. pmc Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel
    B London
    Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 95:2926-31. 1998
    ..These changes correlate with a marked decrease in the level of Kv1.5 polypeptide. Thus, overexpression of a truncated K+ channel in the heart alters native K+ channel expression and has profound effects on cardiac excitability...
  5. ncbi request reprint N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator
    A D Wickenden
    Icagen, Inc, 4222 Emperor Blvd, Durham, NC 27703, USA
    Mol Pharmacol 73:977-86. 2008
    ..In conclusion, ICA-27243 represents the first member of a novel chemical class of selective KCNQ2/Q3 activators with anticonvulsant-like activity in experimental models of epilepsy...
  6. ncbi request reprint Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts
    C F McTiernan
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Gene Ther 14:1613-22. 2007
    ..Thus, a cellular immune response to cardiac delivery of AAV encoding foreign proteins may be an important consideration for AAV-based cardiac gene therapy...
  7. ncbi request reprint Cardiovascular tissues contain independent circadian clocks
    A J Davidson
    Department of Biology, University of Virginia, Charlottesville, Virginia 22904 4328, USA
    Clin Exp Hypertens 27:307-11. 2005
    ..However, phase relationships among tissues were consistent across culture times; this suggests diversity in circadian regulation among components of the cardiovascular system...
  8. ncbi request reprint Dominant-negative subunits reveal potassium channel families that contribute to M-like potassium currents
    A A Selyanko
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 22:RC212. 2002
    ..This experimental approach should therefore be useful in delineating the contributions of members of these two gene families to K+ currents in other cells...
  9. ncbi request reprint Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5
    S L Archer
    Vascular Biology Group, Department of Medicine, Division of Cardiology, University of Alberta, Alberta, Canada
    FASEB J 15:1801-3. 2001
  10. ncbi request reprint Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure
    D M McNamara
    Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Circulation 103:1644-8. 2001
    ....
  11. ncbi request reprint Inducible polymorphic ventricular tachyarrhythmias in a transgenic mouse model with a long Q-T phenotype
    A Jeron
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 278:H1891-8. 2000
    ....
  12. pmc Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes
    W Guo
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Physiol 521:587-99. 1999
    ..4 protein expression, suggesting that the upregulation of Kv1.4 underlies the observed electrical remodeling in Kv4.2W362F-expressing transgenics...
  13. ncbi request reprint Two types of K(+) channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell
    A A Selyanko
    Department of Pharmacology, University College London, London, WC1E 6BT, United Kingdom
    J Neurosci 19:7742-56. 1999
    ..Thus, the channels generating M-like currents in different cells may be heterogeneous in molecular composition...
  14. ncbi request reprint Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart
    M L Ruiz
    Department of Cell Biology, Harvard Medical School, USA
    J Mol Cell Cardiol 28:1453-61. 1996
    ..Part of this work was presented in abstract form...