Vinata Lokeshwar

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. doi request reprint Targeting hyaluronic acid family for cancer chemoprevention and therapy
    Vinata B Lokeshwar
    Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA Department of Cell Biology, University of Miami Miller School of Medicine, Miami, Florida, USA Miami Clinical Translational Institute, University of Miami Miller School of Medicine, Miami, Florida, USA Electronic address
    Adv Cancer Res 123:35-65. 2014
  2. pmc Wee1-Hsp90 inhibitor combination treatment: Molecular therapy with potentially broad applicability
    Vinata B Lokeshwar
    Division of Urology Research Department of Urology and Cell Biology University of Miami Miller School of Medicine Miami, FL USA
    Cell Cycle 11:3722. 2012
  3. ncbi request reprint Urinary uronate and sulfated glycosaminoglycan levels: markers for interstitial cystitis severity
    Vinata B Lokeshwar
    Department of Urology, Sylvester Comprehensive Cancer Center, University of Miami School of, Miami, Florida, USA
    J Urol 174:344-9. 2005
  4. ncbi request reprint HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor
    Vinata B Lokeshwar
    Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    Cancer Res 65:7782-9. 2005
  5. ncbi request reprint Bladder tumor markers beyond cytology: International Consensus Panel on bladder tumor markers
    Vinata B Lokeshwar
    Department of Urology, University of Miami, Miami, Florida 33101, USA
    Urology 66:35-63. 2005
  6. ncbi request reprint Uronate peaks and urinary hyaluronic acid levels correlate with interstitial cystitis severity
    Vinata B Lokeshwar
    Department of Urology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Urol 176:1001-7. 2006
  7. ncbi request reprint Urinary bladder tumor markers
    Vinata B Lokeshwar
    Department of Urology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Urol Oncol 24:528-37. 2006
  8. ncbi request reprint HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer
    Vinata B Lokeshwar
    Department of Urology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Cancer Res 66:11219-27. 2006
  9. pmc Hyalurondiase: both a tumor promoter and suppressor
    Vinata B Lokeshwar
    Department of Urology, University of Miami, Miller School of Medicine, Miami, FL 33101, USA
    Semin Cancer Biol 18:281-7. 2008
  10. pmc Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter
    Vinata B Lokeshwar
    Department of Urology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 283:29215-27. 2008

Research Grants

Collaborators

Detail Information

Publications38

  1. doi request reprint Targeting hyaluronic acid family for cancer chemoprevention and therapy
    Vinata B Lokeshwar
    Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA Department of Cell Biology, University of Miami Miller School of Medicine, Miami, Florida, USA Miami Clinical Translational Institute, University of Miami Miller School of Medicine, Miami, Florida, USA Electronic address
    Adv Cancer Res 123:35-65. 2014
    ..This review discusses basic and clinical translational aspects of targeting each HA family member and respective treatment approaches that have been described in the literature. ..
  2. pmc Wee1-Hsp90 inhibitor combination treatment: Molecular therapy with potentially broad applicability
    Vinata B Lokeshwar
    Division of Urology Research Department of Urology and Cell Biology University of Miami Miller School of Medicine Miami, FL USA
    Cell Cycle 11:3722. 2012
    ..Comment on: Iwai A, et al. Cell Cycle 2012; 11:3649-55...
  3. ncbi request reprint Urinary uronate and sulfated glycosaminoglycan levels: markers for interstitial cystitis severity
    Vinata B Lokeshwar
    Department of Urology, Sylvester Comprehensive Cancer Center, University of Miami School of, Miami, Florida, USA
    J Urol 174:344-9. 2005
    ..We evaluated whether urinary uronate and sulfated GAG levels correlate with IC severity and we characterized urinary GAG species...
  4. ncbi request reprint HYAL1 hyaluronidase in prostate cancer: a tumor promoter and suppressor
    Vinata B Lokeshwar
    Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    Cancer Res 65:7782-9. 2005
    ..This study shows that, depending on the concentration, HYAL1 functions as a tumor promoter and as a suppressor and provides a basis for anti-hyaluronidase and high-hyaluronidase treatments for cancer...
  5. ncbi request reprint Bladder tumor markers beyond cytology: International Consensus Panel on bladder tumor markers
    Vinata B Lokeshwar
    Department of Urology, University of Miami, Miami, Florida 33101, USA
    Urology 66:35-63. 2005
    ..Therefore, use of bladder tumor markers in the management of patients with bladder cancer will require the willingness of both urologists and clinicians to accept them...
  6. ncbi request reprint Uronate peaks and urinary hyaluronic acid levels correlate with interstitial cystitis severity
    Vinata B Lokeshwar
    Department of Urology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Urol 176:1001-7. 2006
    ..In this study we examined the urinary glycosaminoglycan profile and correlated the profile and urinary hyaluronic acid (a glycosaminoglycan) levels with symptom severity...
  7. ncbi request reprint Urinary bladder tumor markers
    Vinata B Lokeshwar
    Department of Urology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Urol Oncol 24:528-37. 2006
    ..This review describes both new and well-studied bladder tumor markers...
  8. ncbi request reprint HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer
    Vinata B Lokeshwar
    Department of Urology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Cancer Res 66:11219-27. 2006
    ..Therefore, HYAL-v1 expression may negatively regulate bladder tumor growth, infiltration, and angiogenesis...
  9. pmc Hyalurondiase: both a tumor promoter and suppressor
    Vinata B Lokeshwar
    Department of Urology, University of Miami, Miller School of Medicine, Miami, FL 33101, USA
    Semin Cancer Biol 18:281-7. 2008
    ..In this part of the review, we will focus on the recent advances in our understanding of the role of HAases in cancer...
  10. pmc Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter
    Vinata B Lokeshwar
    Department of Urology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 283:29215-27. 2008
    ..Thus, HYAL-1 expression is epigenetically regulated by the binding of different transcription factors to the methylated and unmethylated HYAL-1 promoter...
  11. pmc Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells
    Vinata B Lokeshwar
    Division of Urology Research, Department of Urology M 800, University of Miami Miller School of Medicine, P O Box 016960, Miami, FL 33101, USA
    Cancer Res 70:2613-23. 2010
    ..Therefore, the anticancer effects of 4-MU, an orally bioavailable and relatively nontoxic agent, are primarily mediated by inhibition of HA signaling...
  12. ncbi request reprint HYAL1 hyaluronidase: a molecular determinant of bladder tumor growth and invasion
    Vinata B Lokeshwar
    Department of Urology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Cancer Res 65:2243-50. 2005
    ..5-fold higher than that in vector and HYAL1-AS tumors, respectively. These results show that HYAL1 expression in bladder cancer cells regulates tumor growth and progression and therefore serves as a marker for high-grade bladder cancer...
  13. ncbi request reprint Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells
    V B Lokeshwar
    Departments of Urology and Cell Biology and Anatomy, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 275:27641-9. 2000
    ..These results demonstrate that RHAMM is the functional HA receptor in primary human ECs. Heterogeneity exists among primary human ECs of different vascular origins, with respect to functional HA receptor expression and function...
  14. ncbi request reprint Bladder tumor markers for monitoring recurrence and screening comparison of hyaluronic acid-hyaluronidase and BTA-Stat tests
    Vinata B Lokeshwar
    Department of Urology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Cancer 95:61-72. 2002
    ..The authors examined the efficacy of the hyaluronic acid-hyaluronidase (HA-HAase) and BTA-Stat tests to detect and predict bladder carcinoma recurrence and tested their specificity for bladder carcinoma screening...
  15. ncbi request reprint Regulation of hyaluronidase activity by alternative mRNA splicing
    Vinata B Lokeshwar
    Department of Urology M 800, University of Miami School of Medicine, Miami, FL 33101, USA
    J Biol Chem 277:33654-63. 2002
    ..These results demonstrate that alternative mRNA splicing controls cellular expression of enzymatically active hyaluronidase and may explain the elevated hyaluronidase levels in bladder/prostate cancer...
  16. ncbi request reprint Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer
    V B Lokeshwar
    Department of Urology, Cell Biology and Anatomy, and Pathology, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Biol Chem 276:11922-32. 2001
    ..The stromal-epithelial HA and HYAL1 expression may promote angiogenesis in CaP and may serve as prognostic markers for CaP...
  17. doi request reprint Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44
    Roozbeh Golshani
    Department of Cell Biology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Cancer Res 68:483-91. 2008
    ..These results show that HAS1 regulates bladder cancer growth and progression by modulating HA synthesis and HA receptor levels...
  18. ncbi request reprint Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors
    Elizabeth J Franzmann
    Department of Otolaryngology, University of Miami School of Medicine, Miami, FL 33101, USA
    Int J Cancer 106:438-45. 2003
    ..Furthermore, HA and HAase may be sensitive and specific markers for detecting HNSCC and monitoring its recurrence. Further studies are needed to confirm these preliminary studies...
  19. pmc Hyaluronan and hyaluronidase in genitourinary tumors
    Melanie A Simpson
    Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, USA
    Front Biosci 13:5664-80. 2008
    ..Importantly, the major tumor-derived HAase enzyme, HYAL-1, either alone or together with HA, is an accurate diagnostic and prognostic marker for genitourinary tumors...
  20. pmc HYAL-1 hyaluronidase: a potential prognostic indicator for progression to muscle invasion and recurrence in bladder cancer
    Mario W Kramer
    Department of Urology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Eur Urol 57:86-93. 2010
    ..Hyaluronoglucosaminidase 1 (HYAL-1)-type hyaluronidase (HAase) promotes tumor growth, invasion, and angiogenesis. Urinary HA and HAase levels are diagnostic markers for BCa...
  21. ncbi request reprint Bladder cancer biomarkers: current developments and future implementation
    Alonso Alvarez
    Department of Urology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Curr Opin Urol 17:341-6. 2007
    ....
  22. ncbi request reprint Interleukin-8 is a molecular determinant of androgen independence and progression in prostate cancer
    Shinako Araki
    Department of Urology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Cancer Res 67:6854-62. 2007
    ..Therefore, IL-8 is a molecular determinant of androgen-independent prostate cancer growth and progression...
  23. ncbi request reprint Comparison of the prognostic potential of hyaluronic acid, hyaluronidase (HYAL-1), CD44v6 and microvessel density for prostate cancer
    Sinan Ekici
    Department of Urology, University of Miami School of Medicine, Miami, FL 33101, USA
    Int J Cancer 112:121-9. 2004
    ..In our retrospective study with 72- to 131-month follow-up, EPE, preoperative PSA and HYAL-1 either alone or together with HA (i.e., combined HA-HYAL-1) were independent prognostic indicators for PCa...
  24. pmc Osteopontin and interleukin-8 expression is independently associated with prostate cancer recurrence
    Daniel J Caruso
    Department of Urology, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Clin Cancer Res 14:4111-8. 2008
    ..The two inflammatory chemokines, osteopontin and interleukin-8 (IL-8), are associated with tumor angiogenesis and metastasis. We investigated whether osteopontin and IL-8 expression in prostate cancer correlates with disease progression...
  25. ncbi request reprint HAS1 expression in bladder cancer and its relation to urinary HA test
    Roozbeh Golshani
    Department of Cell Biology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Int J Cancer 120:1712-20. 2007
    ..05) and possibly disease progression (p = 0.058). Therefore, elevated HAS1 expression in bladder tumor tissues contributes to a positive HA urine test and may have some prognostic potential...
  26. ncbi request reprint Evaluation of the prognostic potential of hyaluronic acid and hyaluronidase (HYAL1) for prostate cancer
    J Timothy Posey
    Department of Urology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Cancer Res 63:2638-44. 2003
    ..42; P = 0.009), HA-HYAL1 (OR = 18.048; P = 0.0033), and margin (OR = 26.948; P = 0.006)] were significant. Thus, in this 5-year follow-up study, HYAL1, together with EPE and margin, was found to be an independent prognostic indicator...
  27. pmc Hyaluronic acid and HYAL-1 in prostate biopsy specimens: predictors of biochemical recurrence
    Christopher S Gomez
    Department of Urology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    J Urol 182:1350-6. 2009
    ..We examined whether hyaluronic acid and HYAL-1 staining in biopsy specimens predicts biochemical recurrence and correlates with staining in matched prostatectomy specimens...
  28. ncbi request reprint Immunocyt and the HA-HAase urine tests for the detection of bladder cancer: a side-by-side comparison
    Stefan Hautmann
    Department of Urology, University Hospital, University of Kiel, Arnold Heller Str 7, 24105 Kiel, Germany
    Eur Urol 46:466-71. 2004
    ..With the HA-HAase urine test the level of hyaluronic acid (HA) and its degrading enzyme hyaluronidase (HAase) are measured in an ELISA-like test...
  29. ncbi request reprint An orally active Amazonian plant extract (BIRM) inhibits prostate cancer growth and metastasis
    Devendra S Dandekar
    Department of Urology, McKnight Vision Research Building, University of Miami School of Medicine, Miami, Florida 33101, USA
    Cancer Chemother Pharmacol 52:59-66. 2003
    ....
  30. pmc Potential new urinary markers in the early detection of bladder cancer
    Samir P Shirodkar
    Departments of Urology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
    Curr Opin Urol 19:488-93. 2009
    ..We aim to provide a critical appraisal of newer markers and the current state of research...
  31. ncbi request reprint Cyclooxygenase-2 (COX-2) expression is an independent predictor of prostate cancer recurrence
    Brian L Cohen
    Department of Urology, Miller School of Medicine, University of Miami, FL 33101, USA
    Int J Cancer 119:1082-7. 2006
    ..COX-2 expression is an independent predictor of prostate cancer progression following RP and underscores the significance of inflammatory factors in this process...
  32. ncbi request reprint Differential selectivity of hyaluronidase inhibitors toward acidic and basic hyaluronidases
    Tadahiro Isoyama
    Department of Urology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Glycobiology 16:11-21. 2006
    ..These results demonstrate that HAase inhibitors show selectivity toward the different types of HAases, which could be exploited to inhibit specific HAases involved in a variety of pathophysiologic conditions...
  33. ncbi request reprint Prognostic markers for bladder cancer: International Consensus Panel on bladder tumor markers
    Tomonori Habuchi
    Department of Urology, Kyoto University, Kyoto, Japan
    Urology 66:64-74. 2005
    ....
  34. ncbi request reprint Are there molecular signatures for predicting bladder cancer prognosis?
    Vinata B Lokeshwar
    J Urol 176:2347-8. 2006
  35. ncbi request reprint Re: Urine based markers of urological malignancy
    Vinata B Lokeshwar
    J Urol 167:1406-7. 2002
  36. ncbi request reprint A side by side comparison of cytology and biomarkers for bladder cancer detection
    Grethchen L Schroeder
    Department of Urology, University of Miami School of Medicine, Miami, FL 33101, USA
    J Urol 172:1123-6. 2004
    ....
  37. doi request reprint Bladder tumor markers: from hematuria to molecular diagnostics--where do we stand?
    Samir P Shirodkar
    Department of Urology M 800, Miller School of Medicine University of Miami, P O Box 016960, Miami, Florida 33101, USA
    Expert Rev Anticancer Ther 8:1111-23. 2008
    ..Studies continue to refine the role of these markers in clinical practice, but their ultimate efficacy will need to be borne out in large-scale clinical trials in a multitude of settings...
  38. ncbi request reprint Current bladder cancer tests: unnecessary or beneficial?
    Michael A Simon
    Scott Department of Urology, Baylor College of Medicine, 6560 Fannin Street, Suite 2100, Houston, TX 77030 2769, USA
    Crit Rev Oncol Hematol 47:91-107. 2003
    ..An ideal bladder cancer test would be non-invasive, highly sensitive and specific, inexpensive, easy to perform, and yield highly reproducible results. Many of the tests reviewed meet some, but not all, of these criteria...

Research Grants2

  1. Glycosaminoglycans For IC Pathophysiology and Prognosis
    Vinata Lokeshwar; Fiscal Year: 2005
    ..Furthermore, it might yield a test or a combination of tests that can be used in the follow-up of IC patients and for monitoring 9 treatment responses. ..
  2. Glycosaminoglycan-based inhibitors for treatment of prostate cancer
    Vinata B Lokeshwar; Fiscal Year: 2010
    ..If proven efficacious, sHA compounds and 4-MU will be a novel class of glycosaminoglycan-based target-specific anti-tumor drugs. ..