James Lohr

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The Peritraumatic Behavior Questionnaire: development and initial validation of a new measure for combat-related peritraumatic reactions
    Agorastos Agorastos
    Veterans Affairs Center of Excellence for Stress and Mental Health, VA San Diego, CA, USA
    BMC Psychiatry 13:9. 2013
  2. doi request reprint Quantitative assessment of motor abnormalities in untreated patients with major depressive disorder
    James B Lohr
    Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA
    J Affect Disord 146:84-90. 2013
  3. ncbi request reprint Treatment predictors of extrapyramidal side effects in patients with tardive dyskinesia: results from Veterans Affairs Cooperative Study 394
    James B Lohr
    Psychiatry Service, San Diego Department of Veterans Affairs Medical Center, California 92161, USA
    J Clin Psychopharmacol 22:196-200. 2002
  4. ncbi request reprint Oxidative mechanisms and tardive dyskinesia
    James B Lohr
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    CNS Drugs 17:47-62. 2003
  5. ncbi request reprint Performance of schizophrenia and bipolar patients on verbal and figural working memory tasks
    Gregory G Brown
    Psychology Service, Veterans Affairs San Diego Healthcare System, University of California, San Diego, CA, USA
    J Abnorm Psychol 116:741-53. 2007
  6. ncbi request reprint An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder
    Michael P Caligiuri
    Movement Disorders Laboratory, Department of Psychiatry 0603, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Psychiatry Res 123:171-82. 2003
  7. pmc Handwriting movement kinematics for quantifying extrapyramidal side effects in patients treated with atypical antipsychotics
    Michael P Caligiuri
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Psychiatry Res 177:77-83. 2010
  8. ncbi request reprint Quantitative measurement of handwriting in the assessment of drug-induced parkinsonism
    Michael P Caligiuri
    University of California, Department of Psychiatry, 9500 Gilman Drive, La Jolla, CA 29093, USA
    Hum Mov Sci 25:510-22. 2006
  9. ncbi request reprint Striatopallidal regulation of affect in bipolar disorder
    Michael P Caligiuri
    Department of Psychiatry, University of California at San Diego, USA
    J Affect Disord 91:235-42. 2006
  10. ncbi request reprint Abnormalities in motor physiology in bipolar disorder
    James B Lohr
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Neuropsychiatry Clin Neurosci 18:342-9. 2006

Research Grants

Detail Information

Publications22

  1. pmc The Peritraumatic Behavior Questionnaire: development and initial validation of a new measure for combat-related peritraumatic reactions
    Agorastos Agorastos
    Veterans Affairs Center of Excellence for Stress and Mental Health, VA San Diego, CA, USA
    BMC Psychiatry 13:9. 2013
    ..This study describes the development of the PBQ and reports on the psychometric properties of its self-rated version (PBQ-SR)...
  2. doi request reprint Quantitative assessment of motor abnormalities in untreated patients with major depressive disorder
    James B Lohr
    Psychiatry Service, VA San Diego Healthcare System, San Diego, CA, USA
    J Affect Disord 146:84-90. 2013
    ..The finding of impaired movement time and velocity scaling in the presence of normal reaction time suggests a neuromotor or parkinsonian pathophysiology for slowness in depression...
  3. ncbi request reprint Treatment predictors of extrapyramidal side effects in patients with tardive dyskinesia: results from Veterans Affairs Cooperative Study 394
    James B Lohr
    Psychiatry Service, San Diego Department of Veterans Affairs Medical Center, California 92161, USA
    J Clin Psychopharmacol 22:196-200. 2002
    ..These findings indicate that clinician-modifiable factors related to medication usage can influence the outcome of TD and EPS in patients with persistent TD...
  4. ncbi request reprint Oxidative mechanisms and tardive dyskinesia
    James B Lohr
    Department of Psychiatry, University of California San Diego, San Diego, California, USA
    CNS Drugs 17:47-62. 2003
    ..These approaches may include the use of antioxidants as a preventive measure for tardive dyskinesia or the use of other antioxidants or neuroprotective drugs, such as melatonin, for established tardive dyskinesia...
  5. ncbi request reprint Performance of schizophrenia and bipolar patients on verbal and figural working memory tasks
    Gregory G Brown
    Psychology Service, Veterans Affairs San Diego Healthcare System, University of California, San Diego, CA, USA
    J Abnorm Psychol 116:741-53. 2007
    ....
  6. ncbi request reprint An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder
    Michael P Caligiuri
    Movement Disorders Laboratory, Department of Psychiatry 0603, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Psychiatry Res 123:171-82. 2003
    ....
  7. pmc Handwriting movement kinematics for quantifying extrapyramidal side effects in patients treated with atypical antipsychotics
    Michael P Caligiuri
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Psychiatry Res 177:77-83. 2010
    ..These findings support the ecological validity of handwriting movement analysis as an objective behavioral biomarker for quantifying the effects of antipsychotic medication and dose on the motor system...
  8. ncbi request reprint Quantitative measurement of handwriting in the assessment of drug-induced parkinsonism
    Michael P Caligiuri
    University of California, Department of Psychiatry, 9500 Gilman Drive, La Jolla, CA 29093, USA
    Hum Mov Sci 25:510-22. 2006
    ..This study demonstrates that kinematic analyses of pen movements during handwriting may be useful in detecting and monitoring subtle changes in motor control related to the adverse effects of psychotropic medications...
  9. ncbi request reprint Striatopallidal regulation of affect in bipolar disorder
    Michael P Caligiuri
    Department of Psychiatry, University of California at San Diego, USA
    J Affect Disord 91:235-42. 2006
    ..The aim of this study was to increase our understanding of the functional role of the basal ganglia and thalamus in relation to change in affect in patients with bipolar disorder...
  10. ncbi request reprint Abnormalities in motor physiology in bipolar disorder
    James B Lohr
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Neuropsychiatry Clin Neurosci 18:342-9. 2006
    ..This study demonstrates that motor abnormalities suggestive of basal ganglia dysfunction occur in many patients with bipolar disorder...
  11. ncbi request reprint Lateralized cognitive dysfunction and psychotic symptoms in schizophrenia
    Michael P Caligiuri
    University of California, San Diego, San Diego, CA, USA
    Schizophr Res 80:151-61. 2005
    ....
  12. ncbi request reprint Functional brain asymmetries during visuomotor tracking
    Gregory G Brown
    Psychology Service 116B, VA San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    J Clin Exp Neuropsychol 26:356-68. 2004
    ..The VM task used in this study activated asymmetrical neural activity in the vertically organized skelotomotor system and in sensory systems involving visual attention or proprioception...
  13. ncbi request reprint A functional magnetic resonance imaging study of cortical asymmetry in bipolar disorder
    Michael P Caligiuri
    Department of Psychiatry, University of California at San Diego, and VISN 22 Mental Illness Research, Education, and Clinical Center, VA San Diego Healthcare System, USA
    Bipolar Disord 6:183-96. 2004
    ..A secondary goal of the study was to examine effects of psychotropic medications on blood volume changes in the motor cortices...
  14. pmc Voxel-based morphometry of patients with schizophrenia or bipolar I disorder: a matched control study
    Gregory G Brown
    VA San Diego Healthcare System, San Diego, CA, USA
    Psychiatry Res 194:149-56. 2011
    ..The hippocampal and amygdala findings confirm predictions derived from recent meta-analyses. These structural abnormalities may be important factors in the differential manifestations of these two functional psychotic disorders...
  15. ncbi request reprint Impaired hemispheric communication in schizophrenia: a study using the consonant-vowel-consonant task
    James B Lohr
    Department of Psychiatry, San Diego VA Healthcare System, University of California at San Diego, USA
    Schizophr Res 87:279-88. 2006
    ....
  16. pmc Handwriting movement analyses for monitoring drug-induced motor side effects in schizophrenia patients treated with risperidone
    Michael P Caligiuri
    Department of Psychiatry 0603, University of California, La Jolla, CA 92093, USA
    Hum Mov Sci 28:633-42. 2009
    ..In contrast, we found no association between observer-based EPS severity ratings and medication dose. These findings support the importance of handwriting-based measures to monitor EPS in medicated schizophrenia patients...
  17. doi request reprint Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood
    Chad A Bousman
    Department of Psychiatry, University of California, San Diego, California, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1336-41. 2010
    ..Our findings suggest that dysregulation of the UPS, specifically ubiquitin conjugation and deubiquitination, may point to a possible underlying biological mechanism for severity of positive but not negative symptoms...
  18. doi request reprint Preliminary evidence of ubiquitin proteasome system dysregulation in schizophrenia and bipolar disorder: convergent pathway analysis findings from two independent samples
    Chad A Bousman
    Center for Behavioral Genomics, Department of Psychiatry, University of California, San Diego, La Jolla, CA 92039, USA
    Am J Med Genet B Neuropsychiatr Genet 153:494-502. 2010
    ..Findings provide preliminary evidence of UPS dysregulation in BPD and psychosis as well as support further investigation of the UPS and other molecular and cellular pathways for potential biomarkers for SCZ, BPD, and/or psychosis...
  19. ncbi request reprint A randomized trial of short-term acute residential treatment for veterans
    William B Hawthorne
    Department of Psychiatry, University of California, San Diego, and San Diego County Mental Health Services 92161, USA
    Psychiatr Serv 56:1379-86. 2005
    ..This study compared outcomes, patient satisfaction, and episode costs for a sample of 99 veterans who received acute care either at an inpatient unit at a Department of Veterans Affairs (VA) hospital or at a START facility...
  20. ncbi request reprint Pharmacogenetics for off-patent antipsychotics: reframing the risk for tardive dyskinesia and access to essential medicines
    Vural Ozdemir
    VA Long Beach Healthcare System, Southern California Institute for Research and Education, Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, Long Beach, CA 90822, USA
    Expert Opin Pharmacother 7:119-33. 2006
    ..This review discusses pharmacogenetic associations of tardive dyskinesia that are in part supported by meta-analyses and the oxidative stress-neuronal degeneration hypothesis...
  21. ncbi request reprint The value of referring to recently introduced antipsychotics as "second generation"
    James B Lohr
    Am J Psychiatry 160:1371-2. 2003
  22. ncbi request reprint PhenoChipping of psychotic disorders: a novel approach for deconstructing and quantitating psychiatric phenotypes
    Alexander B Niculescu
    Laboratory of Neurophenomics, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Am J Med Genet B Neuropsychiatr Genet 141:653-62. 2006
    ..Empirically derived clusterings of (endo)phenotypes and of patients will better serve genetic, pharmacological, and imaging research, as well as clinical practice...

Research Grants5

  1. MOTOR/COGNITIVE ASYMMETRY IN OLDER PSYCHOTIC PATIENTS
    James Lohr; Fiscal Year: 2002
    ..We hope these studies will provide insights into the localization of pathology in schizophrenia and bipolar disorder, as well as their relationship to each other. ..