Falk W Lohoff

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Serotonin receptor 2A (HTR2A) gene polymorphism predicts treatment response to venlafaxine XR in generalized anxiety disorder
    F W Lohoff
    Mood and Anxiety Disorders Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacogenomics J 13:21-6. 2013
  2. doi request reprint Association analysis of the pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) gene in bipolar disorder
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratory, Center for Neurobiology and Behavior, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 USA
    Psychiatr Genet 18:53-8. 2008
  3. ncbi request reprint Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychobiology 57:55-60. 2008
  4. pmc Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurosci Lett 440:280-3. 2008
  5. ncbi request reprint Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratories, University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
    J Neural Transm 115:1339-45. 2008
  6. ncbi request reprint Desvenlafaxine succinate for the treatment of major depressive disorder
    Falk W Lohoff
    University of Pennsylvania School of Medicine Mood and Anxiety Disorders Section, Department of Psychiatry, Center for Neurobiology and Behavior, Translational Research Laboratories, Philadelphia, PA 19104, USA
    Expert Opin Pharmacother 9:2129-36. 2008
  7. pmc Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratories, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:3078-84. 2008
  8. pmc Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 453:199-203. 2009
  9. pmc Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder
    Falk W Lohoff
    Translational Research Laboratory, Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 153:830-6. 2010
  10. ncbi request reprint Pharmacogenetic considerations in the treatment of psychiatric disorders
    Falk W Lohoff
    University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, Department of Psychiatry, Translational Research Laboratories, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
    Expert Opin Pharmacother 11:423-39. 2010

Research Grants

  1. VMAT1 in bipolar disorder and schizophrenia
    FALK LOHOFF; Fiscal Year: 2008

Detail Information

Publications61

  1. doi request reprint Serotonin receptor 2A (HTR2A) gene polymorphism predicts treatment response to venlafaxine XR in generalized anxiety disorder
    F W Lohoff
    Mood and Anxiety Disorders Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacogenomics J 13:21-6. 2013
    ..Future studies with larger sample sizes are necessary to further characterize this effect in treatment response to antidepressants in GAD...
  2. doi request reprint Association analysis of the pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) gene in bipolar disorder
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratory, Center for Neurobiology and Behavior, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104 USA
    Psychiatr Genet 18:53-8. 2008
    ..Animal models of PACAP mutations show remarkable behavioral defects, including hyperactivity and increased exploratory behavior...
  3. ncbi request reprint Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychobiology 57:55-60. 2008
    ..Further studies are necessary to confirm this effect, and to elucidate the role of VMAT1 in central nervous system physiology and possible involvement in the genetic origins of SZ...
  4. pmc Genetic variants in the cocaine- and amphetamine-regulated transcript gene (CARTPT) and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurosci Lett 440:280-3. 2008
    ....
  5. ncbi request reprint Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratories, University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
    J Neural Transm 115:1339-45. 2008
    ..Additional studies are necessary to confirm and elucidate the role of VAPA as a susceptibility gene for BPD on chromosome 18p...
  6. ncbi request reprint Desvenlafaxine succinate for the treatment of major depressive disorder
    Falk W Lohoff
    University of Pennsylvania School of Medicine Mood and Anxiety Disorders Section, Department of Psychiatry, Center for Neurobiology and Behavior, Translational Research Laboratories, Philadelphia, PA 19104, USA
    Expert Opin Pharmacother 9:2129-36. 2008
    ..Additional studies, in particular head-to-head comparison to other antidepressants and long-term treatment studies, will be necessary to comprehensively evaluate DVS safety and efficacy for clinical practice...
  7. pmc Association between the catechol-O-methyltransferase Val158Met polymorphism and cocaine dependence
    Falk W Lohoff
    Department of Psychiatry, Translational Research Laboratories, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:3078-84. 2008
    ..Additional studies are required to elucidate the role of COMT in the pathophysiology of substance use disorders...
  8. pmc Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 453:199-203. 2009
    ..However, additional studies using larger sample sizes, comprehensive SNP coverage, and clinically homogenous populations are necessary before confidently excluding CDNF as a significant genetic risk factor for cocaine dependence...
  9. pmc Association between polymorphisms in the metallophosphoesterase (MPPE1) gene and bipolar disorder
    Falk W Lohoff
    Translational Research Laboratory, Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 153:830-6. 2010
    ..Our results provide evidence of an association between a polymorphism in the MPPE1 gene and BPD. Additional studies are necessary to confirm and elucidate the role of MPPE1 as a susceptibility gene for BPD on chromosome 18p...
  10. ncbi request reprint Pharmacogenetic considerations in the treatment of psychiatric disorders
    Falk W Lohoff
    University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, Department of Psychiatry, Translational Research Laboratories, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
    Expert Opin Pharmacother 11:423-39. 2010
    ..In addition to clinical heterogeneity, diagnostic uncertainty, environmental, social factors, and genetic factors have been identified as playing an important role in the interindividual differences in therapeutic and toxic drug effects...
  11. doi request reprint Association analysis between polymorphisms in the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes with cocaine dependence
    Falk W Lohoff
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 473:87-91. 2010
    ..However, additional studies using larger sample sizes and clinically homogenous populations are necessary before confidently excluding these variants as contributing genetic risk factors for CD...
  12. ncbi request reprint Ziprasidone treatment of refractory generalized anxiety disorder: a placebo-controlled, double-blind study
    Falk W Lohoff
    Mood and Anxiety Disorders Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 30:185-9. 2010
    ....
  13. pmc Overview of the genetics of major depressive disorder
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, Philadelphia, 19104, USA
    Curr Psychiatry Rep 12:539-46. 2010
    ..Future large-scale studies are needed to dissect this complex phenotype and to identify pathways involved in the etiology of MDD...
  14. doi request reprint Association between variation in the vesicular monoamine transporter 1 gene on chromosome 8p and anxiety-related personality traits
    Falk W Lohoff
    Center for Neurobiology and Behavior, University of Pennsylvania, USA
    Neurosci Lett 434:41-5. 2008
    ..408, p=0.0004; STAI trait: Thr/Ile vs. Ile/Ile: T=3.074, p=0.009) but not in the male group. Our findings support the hypothesis that anxiety-related personality traits are associated with variation in the VMAT1/SLC18A1 gene...
  15. pmc Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 31:2739-47. 2006
    ..Additional studies are necessary to confirm this effect and to elucidate the role of VMAT1 in central nervous system physiology...
  16. ncbi request reprint No association between common variations in the human alpha 2 subunit gene (ATP1A2) of the sodium-potassium-transporting ATPase and idiopathic generalized epilepsy
    Falk W Lohoff
    Department of Psychiatry, University of Pennsylvania School of Medicine, Center for Neurobiology and Behavior, 3535 Market Street, 2nd Floor, R2070, Philadelphia, PA 19104, USA
    Neurosci Lett 382:33-8. 2005
    ..Linkage disequilibrium was demonstrated throughout the gene. Results suggest that the polymorphisms we studied in the ATP1A2 gene do not represent major susceptibility factors for common forms of IGE...
  17. ncbi request reprint No association between common variations in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) and bipolar I disorder
    Falk W Lohoff
    School of Medicine Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Clinical Research Building, Room 135a, 415 Curie Boulevard, Philadelphia, PA 19104 6140, USA
    Psychiatry Res 135:171-7. 2005
    ..Our results suggest that common variations in the CHRNA2 gene are unlikely to confer susceptibility to BPD in this sample. Further studies are required to elucidate the susceptibility locus for BPD on chromosome 8p21-22...
  18. ncbi request reprint Lack of association between variations in the brain-derived neurotrophic factor (BDNF) gene and temporal lobe epilepsy
    Falk W Lohoff
    Department of Psychiatry, Center for Neurobiology and Behaviour, University of Pennsylvania School of Medicine, 3535 Market Street, 2nd Floor, R2070, Philadelphia, PA 19104, USA
    Epilepsy Res 66:59-62. 2005
    ..Results suggest that neither of the studied polymorphisms are strong susceptibility factors for TLE in this sample of individuals of European ancestry...
  19. ncbi request reprint Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder
    F W Lohoff
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 6140, USA
    Am J Med Genet B Neuropsychiatr Genet 139:51-3. 2005
    ..02-1.47). Results confirm previous findings and suggest that the Val allele increases risk for BPI in patients of European descent. Further studies are necessary to elucidate the involvement of the BDNF gene in the pathophysiology of BPD...
  20. ncbi request reprint Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder
    Falk W Lohoff
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, 19104 6140, USA
    Psychiatr Genet 15:255-8. 2005
    ..We tested the hypothesis that the potential functional variation Phe209Leu confers susceptibility to bipolar disorder in a case-control study...
  21. pmc Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis
    Toni Kim Clarke
    Psychiatric Pharmacogenetics Laboratory Center for Neurobiology and Behavior Treatment Research Center Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Biol 18:702-8. 2013
    ..Furthermore, as this population consists of American individuals of African descent, the possibility of population stratification should not be excluded...
  22. doi request reprint Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains
    Glenn A Doyle
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 33:2801-9. 2008
    ..10 (which harbors Oprm1) between the acromere and Stxbp5, as well as on distal Chr. 6 between marker D6Mit10 and the telomere...
  23. ncbi request reprint Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
  24. ncbi request reprint No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence
    Andrew E Weller
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychiatr Genet 16:193-6. 2006
    ..The aim of this study is to investigate whether polymorphisms in the human Par-4 gene contribute to the etiology of cocaine dependence...
  25. pmc The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction
    Toni Kim Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA
    Ann Hum Genet 78:33-9. 2014
    ..No association was found with cocaine dependence. These data demonstrate the importance of dopamine gene variants in the risk for opioid dependence and highlight a functional polymorphism that warrants further study. ..
  26. pmc Case-control association study of WLS variants in opioid and cocaine addicted populations
    Richard C Crist
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA
    Psychiatry Res 208:62-6. 2013
    ..However, this study does not exclude the possibilities that rare variants in WLS may affect susceptibility to drug addiction, or that common variants with small effect size may fall below the detection level of our analysis...
  27. pmc Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine
    Toni Kim Clarke
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
    Neurosci Lett 542:71-5. 2013
    ..02; 95% C.I. 0.47 [0.24-0.92]). This study suggests a potential role for rare OPRM1 variants in addiction disorders and highlights an area worthy of future study...
  28. ncbi request reprint Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer
    Thomas N Ferraro
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3404, USA
    Epilepsia 48:1667-77. 2007
    ....
  29. pmc Dopamine transporter genotype modulation of neural responses to smoking cues: confirmation in a new cohort
    Teresa R Franklin
    Research Assistant Professor of Neuroscience, Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Addict Biol 16:308-22. 2011
    ..Despite heterogeneity introduced by a host of factors, including variance in other genes involved in smoking behavior, we confirm that DAT genotype predicts the direction and location of neural responses to SCs...
  30. pmc Neuronal calcium sensor-1 and cocaine addiction: a genetic association study in African-Americans and European Americans
    Pushpinder K Multani
    Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, Philadelphia, PA, USA
    Neurosci Lett 531:46-51. 2012
    ..0001, allelic p = 0.002) with a gender specific effect for males (allelic p = 0.005, genotypic p = 0.0003). Our data suggest that genetic variants in the NCS-1 gene contribute to susceptibility of CA in individuals of African descent...
  31. ncbi request reprint Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, PA 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 139:106-8. 2005
    ....
  32. doi request reprint Association analysis between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and treatment response to venlafaxine XR in generalized anxiety disorder
    Sneha Narasimhan
    Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, United States
    Neurosci Lett 503:200-2. 2011
    ..Future studies in larger populations will need to be conducted to further elucidate the pharmacogenetic role of this variant in anxiety disorders...
  33. ncbi request reprint Quantitative trait locus for seizure susceptibility on mouse chromosome 5 confirmed with reciprocal congenic strains
    Thomas N Ferraro
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 3404, USA
    Physiol Genomics 31:458-62. 2007
    ....
  34. ncbi request reprint Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population
    John P Dahl
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, 19104, USA
    Psychiatr Genet 15:277-83. 2005
    ..The purpose of this study is to determine whether single-nucleotide polymorphisms in the Homer1 and Homer2 genes associate with the cocaine-dependent phenotype in an African American population...
  35. ncbi request reprint Lack of association between single nucleotide polymorphisms in the corticotropin releasing hormone receptor 1 (CRHR1) gene and alcohol dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Psychiatr Res 39:475-9. 2005
    ..The results of this study suggest that polymorphisms in the CRHR 1 gene are not major risk factors for the development of alcohol dependence in persons of European ancestry...
  36. doi request reprint Remission of generalized anxiety disorder after 6 months of open-label treatment with venlafaxine XR
    Karl Rickels
    Mood and Anxiety Disorders Section, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Psychother Psychosom 82:363-71. 2013
    ....
  37. doi request reprint Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder
    Paul J Bloch
    Psychiatric Pharmacogenetics Laboratory, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:1515-9. 2010
    ....
  38. doi request reprint Association analysis between the A118G polymorphism in the OPRM1 gene and treatment response to venlafaxine XR in generalized anxiety disorder
    Alissa J Cooper
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Hum Psychopharmacol 28:258-62. 2013
    ....
  39. doi request reprint Variation in the catechol-O-methyltransferase (COMT) gene and treatment response to venlafaxine XR in generalized anxiety disorder
    Sneha Narasimhan
    Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Psychiatry Res 198:112-5. 2012
    ..Further studies in a larger population are needed to confirm this effect...
  40. pmc An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans
    Richard C Crist
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 38:2003-10. 2013
    ..This observation requires confirmation in an independent population...
  41. ncbi request reprint Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder
    Andrew E Weller
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Psychiatr Genet 16:3-8. 2006
    ..The purpose of this study is to investigate whether polymorphisms in the human NAPG gene contribute to the etiology of bipolar disorder...
  42. doi request reprint Genetic variants in the vesicular monoamine transporter 1 (VMAT1/SLC18A1) and neuropsychiatric disorders
    Falk W Lohoff
    Translational Research Laboratories, Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Methods Mol Biol 637:165-80. 2010
    ..This chapter describes methods for genotyping three missense polymorphisms implicated in neuropsychiatric disorders (Thr4Pro, Thr98Ser, Thr136Ile) using TaqMan-based PCR and standard PCR approaches...
  43. doi request reprint Evidence for the use of vilazodone in the treatment of major depressive disorder
    Jennifer A Reinhold
    University of the Sciences, Philadelphia College of Pharmacy, Department of Pharmacy Practice, Administration, PA, USA
    Expert Opin Pharmacother 13:2215-24. 2012
    ..This often translates into relapse of symptoms or recurrence of the depressive episode. The delay to therapeutic response also has a meaningful implication for treatment adherence...
  44. pmc DAT genotype modulates brain and behavioral responses elicited by cigarette cues
    Teresa R Franklin
    Department of Psychiatry, Addiction Treatment Research Center, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 34:717-28. 2009
    ..These results provide evidence that genetic variation in the DAT gene contributes to the neural and behavioral responses elicited by smoking cues...
  45. doi request reprint Time to relapse after 6 and 12 months' treatment of generalized anxiety disorder with venlafaxine extended release
    Karl Rickels
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Arch Gen Psychiatry 67:1274-81. 2010
    ..Generalized anxiety disorder (GAD) is a chronic disorder in need of reliable data to guide long-term treatment...
  46. doi request reprint Pharmacogenetics of antidepressant drugs: current clinical practice and future directions
    Sneha Narasimhan
    University of Pennsylvania School of Medicine, Department of Psychiatry, Center for Neurobiology and Behavior, Translational Research Laboratories, 125 South 31st Street, Room 2213, Philadelphia, PA 19104, USA
    Pharmacogenomics 13:441-64. 2012
    ..Ultimately, these studies should lead to the use of genetic testing to guide the use of antidepressants in clinical practice...
  47. doi request reprint Double dissociation of dopamine genes and timing in humans
    Martin Wiener
    University of Pennsylvania, Philadelphia, PA 19104 6241, USA
    J Cogn Neurosci 23:2811-21. 2011
    ..These data provide a potential biological basis for the distinctions between sub- and supra-second timing and suggest that BG are integral for the former whereas pFC is implicated in the latter...
  48. doi request reprint Pharmacological treatment of generalized anxiety disorder
    Jennifer A Reinhold
    University of the Sciences, Philadelphia College of Pharmacy, Department of Pharmacy Practice Pharmacy Administration, PA, USA
    Expert Opin Pharmacother 12:2457-67. 2011
    ..While there are clear data for the efficacy of short-term acute treatment, long-term treatment and treatment-resistant GAD remain challenging...
  49. ncbi request reprint Fine mapping of a seizure susceptibility locus on mouse Chromosome 1: nomination of Kcnj10 as a causative gene
    Thomas N Ferraro
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 15:239-51. 2004
    ..The critical interval contains several candidate genes, one of which, Kcnj10, exhibits a potentially important polymorphism with regard to fundamental aspects of seizure susceptibility...
  50. ncbi request reprint Quantitative genetic study of maximal electroshock seizure threshold in mice: evidence for a major seizure susceptibility locus on distal chromosome 1
    T N Ferraro
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genomics 75:35-42. 2001
    ..These results support the hypothesis that the distal portion of chromosome 1 harbors a gene(s) that has a fundamental role in regulating seizure susceptibility...
  51. pmc Confirmation of multiple seizure susceptibility QTLs on chromosome 15 in C57BL/6J and DBA/2J inbred mice
    T N Ferraro
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
    Physiol Genomics 42:1-7. 2010
    ..It harbors 83 genes in highly polymorphic areas, 310 genes in all. Complete dissection of these loci will lead to identification of genetic variants that influence SZS in mice and provide a better understanding of seizure biology...
  52. ncbi request reprint Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility
    R J Buono
    Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, 415 Curie Boulevard, CRB 120, Philadelphia, PA 19104 6140, USA
    Epilepsy Res 58:175-83. 2004
    ..The purpose of this work was to translate these animal model data to a human genetic association study...
  53. ncbi request reprint Lack of association between an interleukin 1 beta (IL-1beta) gene variation and refractory temporal lobe epilepsy
    R J Buono
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104 6140, U S A
    Epilepsia 42:782-4. 2001
    ..that demonstrated a positive association (p < 0.017) between a polymorphism in the promoter region of the interleukin 1-beta (IL-1beta) gene and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS)...
  54. doi request reprint Genetic polymorphisms in the PACAP and PAC1 receptor genes and treatment response to venlafaxine XR in generalized anxiety disorder
    Alissa J Cooper
    Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, United States
    Psychiatry Res 210:1299-300. 2013
    ..Genotypes for PACAP/PAC1 were examined for effects on treatment response to venlafaxine XR in generalized anxiety disorder. The Asp54Gly (rs2856966) variant in the PACAP gene was associated with better treatment outcome. ..
  55. pmc Association study of the β-arrestin 2 gene (ARRB2) with opioid and cocaine dependence in a European-American population
    Lisa M Ambrose-Lanci
    Translational Research Laboratory, Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, 125 S 31st St, School of Medicine, Rm 2109, Philadelphia, PA 19104, USA
    Psychiatr Genet 22:141-5. 2012
    ....
  56. ncbi request reprint Lack of influence of DAT1 and DRD2 gene variants on antidepressant response in generalized anxiety disorder
    Wint Thu Saung
    Psychiatric Pharmacogenetics Laboratory, Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Hum Psychopharmacol 29:316-21. 2014
    ..In our study, we investigated whether functional genetic polymorphisms in the dopamine active transporter 1 (DAT1) and dopamine receptor D2 (DRD2) may play a role in antidepressant treatment response in GAD...
  57. pmc Individual differences in the morphometry and activation of time perception networks are influenced by dopamine genotype
    Martin Wiener
    Dept of Neurology, University of Pennsylvania, USA Center for Cognitive Neuroscience, University of Pennsylvania, USA Electronic address
    Neuroimage 89:10-22. 2014
    ..These results point to the neural bases for heterogeneous timing performance in humans, and suggest that differences in performance on a temporal discrimination task are, in part, attributable to the DRD2/ANKK1 genotype. ..
  58. pmc Identification of CHRNA5 rare variants in African-American heavy smokers
    Glenn A Doyle
    Department of Psychiatry, Perelman School of Medicine, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Psychiatr Genet 24:102-9. 2014
    ....
  59. pmc Neural correlates of attentional bias for smoking cues: modulation by variance in the dopamine transporter gene
    Reagan R Wetherill
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Addict Biol 19:294-304. 2014
    ..Findings suggest that genetic variation in the DAT gene influences brain responses associated with attentional bias; thus, providing additional support for a SC-vulnerable endophenotype. ..
  60. ncbi request reprint Association of the met66 allele of brain-derived neurotrophic factor (BDNF) with smoking
    Undine E Lang
    Department of Psychiatry and Psychotherapy, University of Dresden, Fetscherstr 74, 01307, Dresden, Germany
    Psychopharmacology (Berl) 190:433-9. 2007
    ..In this study, we addressed the question if a common BDNF missense variation (Val66Met) influences the risk for smoking behavior in otherwise healthy human volunteers...

Research Grants1

  1. VMAT1 in bipolar disorder and schizophrenia
    FALK LOHOFF; Fiscal Year: 2008
    ..Relevance: BPD and SZ are chronic disabling psychiatric disorders with strong genetic components to their etiologies. Identifying genetic risk factors will lead to better diagnosis and improved treatment of the disorders. ..