MIGNON LEE-CHEUN LOH

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Mutations in CBL occur frequently in juvenile myelomonocytic leukemia
    Mignon L Loh
    Department of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, California, USA
    Blood 114:1859-63. 2009
  2. doi request reprint Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia
    Mignon L Loh
    Department of Pediatrics and the Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA
    Br J Haematol 152:677-87. 2011
  3. pmc Prospective analysis of TEL/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01
    Mignon L Loh
    Department of Pediatrics, Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Blood 107:4508-13. 2006
  4. doi request reprint Childhood myelodysplastic syndrome: focus on the approach to diagnosis and treatment of juvenile myelomonocytic leukemia
    Mignon L Loh
    Department of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Hematology Am Soc Hematol Educ Program 2010:357-62. 2010
  5. ncbi request reprint TEL/AML1-positive pediatric leukemia: prognostic significance and therapeutic approaches
    Mignon L Loh
    Department of Pediatric Hematology Oncology, University of California San Francisco, San Francisco, California 94143 0519, USA
    Curr Opin Hematol 9:345-52. 2002
  6. ncbi request reprint Treatment of infantile fibrosarcoma with chemotherapy and surgery: results from the Dana-Farber Cancer Institute and Children's Hospital, Boston
    Mignon L Loh
    Department of Pediatric Hematology Oncology, University of California San Francisco, San Francisco, CA 94143 0519, USA
    J Pediatr Hematol Oncol 24:722-6. 2002
  7. ncbi request reprint Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis
    Mignon L Loh
    Department of Pediatrics, University of California, Rm HSE 302 Box 0519, San Francisco, CA 94143, USA
    Blood 103:2325-31. 2004
  8. pmc Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells
    Suzanne Schubbert
    Department of Pediatrics, University of California at San Francisco, 513 Parnassus Ave, HSE 302, San Francisco, CA 94143, USA
    Blood 106:311-7. 2005
  9. pmc The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease
    Christian P Kratz
    University of California, Room HSE 302 Box 0519, San Francisco, CA 94143, USA
    Blood 106:2183-5. 2005
  10. ncbi request reprint Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia
    Mignon L Loh
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Leuk Res 29:459-62. 2005

Research Grants

Collaborators

Detail Information

Publications15

  1. pmc Mutations in CBL occur frequently in juvenile myelomonocytic leukemia
    Mignon L Loh
    Department of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, California, USA
    Blood 114:1859-63. 2009
    ..Moreover, the exclusivity of CBL mutations with respect to other Ras pathway-associated mutations indicates that CBL may have a role in deregulating this key pathway in JMML...
  2. doi request reprint Recent advances in the pathogenesis and treatment of juvenile myelomonocytic leukaemia
    Mignon L Loh
    Department of Pediatrics and the Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA
    Br J Haematol 152:677-87. 2011
    ..This review outlines our understanding of the genetic underpinnings of JMML with a recent update on the discovery of novel CBL mutations, as well as a brief review on current therapeutic approaches...
  3. pmc Prospective analysis of TEL/AML1-positive patients treated on Dana-Farber Cancer Institute Consortium Protocol 95-01
    Mignon L Loh
    Department of Pediatrics, Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Blood 107:4508-13. 2006
    ..However, factors such as age at diagnosis and presenting leukocyte count should be taken into consideration when treating this group of patients...
  4. doi request reprint Childhood myelodysplastic syndrome: focus on the approach to diagnosis and treatment of juvenile myelomonocytic leukemia
    Mignon L Loh
    Department of Pediatrics and the Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Hematology Am Soc Hematol Educ Program 2010:357-62. 2010
    ..This review is focused on the genetic abnormalities that occur in JMML, with particular attention to germ-line predisposition syndromes associated with the disorder. Current approaches to therapy are also discussed...
  5. ncbi request reprint TEL/AML1-positive pediatric leukemia: prognostic significance and therapeutic approaches
    Mignon L Loh
    Department of Pediatric Hematology Oncology, University of California San Francisco, San Francisco, California 94143 0519, USA
    Curr Opin Hematol 9:345-52. 2002
    ..Incorporating knowledge of this gene rearrangement into treatment decisions serves as a paradigm for translating molecular discoveries into clinically meaningful data to direct patient care and improve outcome...
  6. ncbi request reprint Treatment of infantile fibrosarcoma with chemotherapy and surgery: results from the Dana-Farber Cancer Institute and Children's Hospital, Boston
    Mignon L Loh
    Department of Pediatric Hematology Oncology, University of California San Francisco, San Francisco, CA 94143 0519, USA
    J Pediatr Hematol Oncol 24:722-6. 2002
    ..To retrospectively evaluate the treatment and outcome of patients diagnosed with infantile fibrosarcoma at the Dana-Farber Cancer Institute and Children's Hospital, Boston...
  7. ncbi request reprint Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis
    Mignon L Loh
    Department of Pediatrics, University of California, Rm HSE 302 Box 0519, San Francisco, CA 94143, USA
    Blood 103:2325-31. 2004
    ..We conclude that SHP-2 is an important cellular PTPase that is mutated in myeloid malignancies. Further investigation is required to clarify how these mutant proteins interact with Ras and other effectors to deregulate myeloid growth...
  8. pmc Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells
    Suzanne Schubbert
    Department of Pediatrics, University of California at San Francisco, 513 Parnassus Ave, HSE 302, San Francisco, CA 94143, USA
    Blood 106:311-7. 2005
    ..Mutant SHP-2 proteins induce aberrant growth in multiple hematopoietic compartments, which supports a primary role of hyperactive Ras in the pathogenesis of JMML...
  9. pmc The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease
    Christian P Kratz
    University of California, Room HSE 302 Box 0519, San Francisco, CA 94143, USA
    Blood 106:2183-5. 2005
    ..This supports the need to characterize the spectrum of hematologic abnormalities in individuals with NS and to better define the impact of the PTPN11 lesion on the disease course in patients with NS/MPD and JMML...
  10. ncbi request reprint Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia
    Mignon L Loh
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Leuk Res 29:459-62. 2005
    ..Here, we investigated contribution of PTPN11 mutations to adult MDS and CMML pathogenesis. Our results indicate that PTPN11 lesions might play a role in adult MDS/CMML pathogenesis but do not represent a major molecular event...
  11. doi request reprint Outcome for children treated for relapsed or refractory acute myelogenous leukemia (rAML): a Therapeutic Advances in Childhood Leukemia (TACL) Consortium study
    Matthew F Gorman
    Therapeutic Advances in Childhood Leukemia Consortium, USC CHLA Institute for Pediatric Clinical Research, Los Angeles, California, USA
    Pediatr Blood Cancer 55:421-9. 2010
    ..This report highlights efforts to assess the response rates and survival outcomes after first or greater relapse in children with AML...
  12. ncbi request reprint Inherited predispositions and hyperactive Ras in myeloid leukemogenesis
    Jennifer O Lauchle
    Department of Pediatrics and Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Pediatr Blood Cancer 46:579-85. 2006
    ..These strains model human disease features and provide an opportunity to investigate novel therapeutic strategies that may ultimately cure JMML and other myeloid malignancies characterized by hyperactive Ras...
  13. ncbi request reprint Congenital leukemia cutis with subsequent development of leukemia
    Inga Hofmann Zhang
    Department of Pediatrics, University of California San Francisco, California 94143 0519, USA
    J Am Acad Dermatol 54:S22-7. 2006
    ..The patient died of refractory leukemia and secondary fungal disease. This case report supports the observation that leukemia cutis with an 11q23 rearrangement should be treated aggressively...
  14. ncbi request reprint Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California
    Cliona M McHale
    School of Public Health, University of California, Berkeley 94720 7360, USA
    Genes Chromosomes Cancer 37:36-43. 2003
    ..Secondary changes were also similar to those described previously, with deletion of the second TEL allele being the most common. Other secondary changes included duplication of the fusion gene, trisomy 21, and monosomy X...
  15. pmc Outcome of patients treated for relapsed or refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium study
    Richard H Ko
    Therapeutic Advances in Childhood Leukemia Consortium, Institute for Pediatric Clinical Research and Childrens Center for Cancer and Blood Diseases, University of Southern California Childrens Hospital Los Angeles, Los Angeles, CA, USA
    J Clin Oncol 28:648-54. 2010
    ..We sought to define response rates and disease-free survival (DFS) rates in patients treated at TACL institutions, which could serve as a comparator for future studies...

Research Grants6

  1. FUSION GENES IN LEUKEMIA--DETERMINING SIGNIFICANCE
    Mignon Loh; Fiscal Year: 2003
    ..abstract_text> ..
  2. Ras Pathway Mutations in Human Leukemia
    Mignon Loh; Fiscal Year: 2007
    ....
  3. International Symposium on Juvenile Myelomonocytic Leukemia
    Mignon Loh; Fiscal Year: 2007
    ..A total of 50-60 participants are anticipated to attend. Special attention will be made to include junior investigators, post-doctoral fellows, and clinicians and scientists from underrepresented communities. ..