M W Logue
Affiliation: University of Iowa
- Calculation of multipoint likelihoods using flanking marker data: a simulation studyAndrew W George
Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, Iowa, USA
BMC Genet 6:S44. 2005..The flanking marker procedure performs well, even when missing data and genotyping errors are introduced...
- Bayesian analysis of a previously published genome screen for panic disorder reveals new and compelling evidence for linkage to chromosome 7Mark W Logue
Division of Statistical Genetics, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA
Am J Med Genet B Neuropsychiatr Genet 121:95-9. 2003..The results for the remainder of the genome are consistently low. The two loci identified here are also supported by independent evidence from other studies...
- A model-integrated multipoint Bayesian analysis of hypertension in the Framingham Heart Study data finds little evidence of linkageMark W Logue
Division of Statistical Genetics, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA
BMC Genet 4:S75. 2003..While the PPL analysis of this data remains inconclusive, Bayesian methodology gives us a clear mechanism for using the information gained here in further studies...
- A posterior probability of linkage-based re-analysis of schizophrenia data yields evidence of linkage to chromosomes 1 and 17M W Logue
Program for Public Health Genetics, Center for Statistical Genetics Research, Iowa City, IA 52242, USA
Hum Hered 62:47-54. 2006..8 [Brzustowicz et al. 2000]. In the current study, we revisited this data set using a Bayesian linkage analysis technique, namely the posterior probability of linkage (PPL)...
- A new method for computing the multipoint posterior probability of linkageMark W Logue
Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
Hum Hered 57:90-9. 2004..This version, which we call the imputed PPL, is shown to be superior to previously developed versions...
- The incorporation of prior genomic information does not necessarily improve the performance of Bayesian linkage methods: an example involving sex-specific recombination and the two-point PPLMark W Logue
Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA
Hum Hered 60:196-205. 2005..We present a two-point PPL allowing for unequal male and female recombination fractions, thetaM and thetaF, and consider alternative priors on thetaM, thetaF...
- Performance comparison of two-point linkage methods using microsatellite markers flanking known disease locationsMark W Logue
Center for Statistical Genetics Research, College of Public Health, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, USA
BMC Genet 6:S141. 2005..The pooling of the four datasets in each replicate (n = 350 pedigrees) greatly improved the chance of detecting the major genes using all five methods, but failed to increase the chance to detect D5 and D6...
- A major susceptibility locus for specific language impairment is located on 13q21Christopher W Bartlett
Center for Molecular and Behavioral Neuroscience, Rutgers University, Piscataway, NJ 08854 8095, USA
Am J Hum Genet 71:45-55. 2002..86, genomic P value <.06 under the recessive language impairment model). Our findings underscore the utility of traditional LOD-score-based methods in finding genes for complex diseases, specifically, SLI...
- The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a markerXinqun Yang
Center for Statistical Genetics Research, The University of Iowa, Iowa City, Iowa 52242, USA
Hum Hered 59:210-9. 2005..The estimate of D' also behaves well even in relatively small, heterogeneous samples...
- Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairmentChristopher W Bartlett
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA
Hum Hered 57:10-20. 2004..2003). Our results indicate that using samples selected for components of the autism phenotype may be a useful adjunct to autism genetics...
- Model selection and Bayesian methods in statistical genetics: summary of group 11 contributions to Genetic Analysis Workshop 15Michael D Swartz
Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
Genet Epidemiol 31:S96-102. 2007..These group contributions exhibit the value of framing genetic problems in terms of model selection, and highlight the impact of variable selection for gene mapping...