Daniel J Lodge

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc A loss of hippocampal perineuronal nets produces deficits in dopamine system function: relevance to the positive symptoms of schizophrenia
    A Shah
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Transl Psychiatry 3:e215. 2013
  2. pmc Developmental pathology, dopamine, stress and schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7764, San Antonio, TX 78229, USA
    Int J Dev Neurosci 29:207-13. 2011
  3. pmc The medial prefrontal and orbitofrontal cortices differentially regulate dopamine system function
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Neuropsychopharmacology 36:1227-36. 2011
  4. pmc Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Int J Neuropsychopharmacol 16:1331-9. 2013
  5. pmc Aberrant dopamine D2-like receptor function in a rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology, Center for Biomedical Neuroscience, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7764, San Antonio, TX 78229, USA
    J Pharmacol Exp Ther 343:288-95. 2012
  6. pmc Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Trends Pharmacol Sci 32:507-13. 2011
  7. pmc The lateral mesopontine tegmentum regulates both tonic and phasic activity of VTA dopamine neurons
    Li Chen
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas and
    J Neurophysiol 110:2287-94. 2013
  8. ncbi request reprint Alterations in dopamine system function across the estrous cycle of the MAM rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Psychoneuroendocrinology 47:88-97. 2014
  9. pmc The MAM rodent model of schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Curr Protoc Neurosci . 2013
  10. pmc Distinct prefrontal cortical regions negatively regulate evoked activity in nucleus accumbens subregions
    Amber Asher
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Int J Neuropsychopharmacol 15:1287-94. 2012

Research Grants

  1. Regulation of ventral hippocampal system function
    Daniel J Lodge; Fiscal Year: 2010

Collaborators

  • A Shah
  • Stephanie M Perez
  • Li Chen
  • Amber Asher
  • Flávia R Carreño
  • Alan Frazer

Detail Information

Publications11

  1. pmc A loss of hippocampal perineuronal nets produces deficits in dopamine system function: relevance to the positive symptoms of schizophrenia
    A Shah
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Transl Psychiatry 3:e215. 2013
    ....
  2. pmc Developmental pathology, dopamine, stress and schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7764, San Antonio, TX 78229, USA
    Int J Dev Neurosci 29:207-13. 2011
    ..Such information is critical for our understanding into the pathology of psychiatric disease with the ultimate aim being the development of more effective therapeutics...
  3. pmc The medial prefrontal and orbitofrontal cortices differentially regulate dopamine system function
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Neuropsychopharmacology 36:1227-36. 2011
    ..Taken together, these data demonstrate that the mPFC and OFC differentially regulate dopamine neuron activity, and that the pattern of cortical activation is critical for determining dopamine system output...
  4. pmc Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Int J Neuropsychopharmacol 16:1331-9. 2013
    ..Therefore, we have provided initial preclinical evidence demonstrating the feasibility of hippocampal DBS as a potential novel approach for the treatment of schizophrenia...
  5. pmc Aberrant dopamine D2-like receptor function in a rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology, Center for Biomedical Neuroscience, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7764, San Antonio, TX 78229, USA
    J Pharmacol Exp Ther 343:288-95. 2012
    ....
  6. pmc Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Trends Pharmacol Sci 32:507-13. 2011
    ..Indeed, initial studies demonstrate that allosteric modulation of the α5GABA(A) receptor can decrease aberrant dopamine signaling and associated behaviors in a verified rodent model of psychosis...
  7. pmc The lateral mesopontine tegmentum regulates both tonic and phasic activity of VTA dopamine neurons
    Li Chen
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas and
    J Neurophysiol 110:2287-94. 2013
    ..Taken together, we provide further evidence that the mesopontine tegmentum regulates discrete dopamine neuron activity states that are relevant for the understanding of dopamine system function in both normal and disease states. ..
  8. ncbi request reprint Alterations in dopamine system function across the estrous cycle of the MAM rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Psychoneuroendocrinology 47:88-97. 2014
    ..Taken together, these data suggest that changes in dopamine system function occur across the estrous cycle in MAM-treated rats and may contribute to the differences in symptomatology between male and female schizophrenia patients. ..
  9. pmc The MAM rodent model of schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Curr Protoc Neurosci . 2013
    ..This unit describes the procedures required to safely induce the MAM phenotype in rats. In addition, we describe a simple behavioral procedure, amphetamine-induced hyperlocomotion, which can be utilized to verify the MAM phenotype...
  10. pmc Distinct prefrontal cortical regions negatively regulate evoked activity in nucleus accumbens subregions
    Amber Asher
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Int J Neuropsychopharmacol 15:1287-94. 2012
    ....
  11. ncbi request reprint Vagal nerve stimulation reverses aberrant dopamine system function in the methylazoxymethanol acetate rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, and
    J Neurosci 34:9261-7. 2014
    ..These data provide the first preclinical evidence that VNS may be a possible alternative therapeutic approach for the treatment of schizophrenia. ..

Research Grants1

  1. Regulation of ventral hippocampal system function
    Daniel J Lodge; Fiscal Year: 2010
    ..abstract_text> ..