Daniel J Lodge

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc A loss of hippocampal perineuronal nets produces deficits in dopamine system function: relevance to the positive symptoms of schizophrenia
    A Shah
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Transl Psychiatry 3:e215. 2013
  2. pmc Developmental pathology, dopamine, stress and schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7764, San Antonio, TX 78229, USA
    Int J Dev Neurosci 29:207-13. 2011
  3. pmc The medial prefrontal and orbitofrontal cortices differentially regulate dopamine system function
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Neuropsychopharmacology 36:1227-36. 2011
  4. pmc Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Int J Neuropsychopharmacol 16:1331-9. 2013
  5. pmc Aberrant dopamine D2-like receptor function in a rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology, Center for Biomedical Neuroscience, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7764, San Antonio, TX 78229, USA
    J Pharmacol Exp Ther 343:288-95. 2012
  6. pmc Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Trends Pharmacol Sci 32:507-13. 2011
  7. pmc An augmented dopamine system function is present prior to puberty in the methylazoxymethanol acetate rodent model of schizophrenia
    Li Chen
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas Department of Physiology, Medical School of Xi an Jiaotong University, Xi an, Shaanxi, China Department of Pathophysiology, Medical School of Xi an Jiaotong University, Xi an, Shaanxi, China
    Dev Neurobiol 74:907-17. 2014
  8. pmc Alterations in dopamine system function across the estrous cycle of the MAM rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Psychoneuroendocrinology 47:88-97. 2014
  9. pmc The lateral mesopontine tegmentum regulates both tonic and phasic activity of VTA dopamine neurons
    Li Chen
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas and
    J Neurophysiol 110:2287-94. 2013
  10. pmc The MAM rodent model of schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Curr Protoc Neurosci . 2013

Collaborators

  • A Shah
  • Stephanie M Perez
  • Li Chen
  • Amber Asher
  • Angela M Boley
  • Flávia R Carreño
  • Alan Frazer

Detail Information

Publications14

  1. pmc A loss of hippocampal perineuronal nets produces deficits in dopamine system function: relevance to the positive symptoms of schizophrenia
    A Shah
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Transl Psychiatry 3:e215. 2013
    ....
  2. pmc Developmental pathology, dopamine, stress and schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7764, San Antonio, TX 78229, USA
    Int J Dev Neurosci 29:207-13. 2011
    ..Such information is critical for our understanding into the pathology of psychiatric disease with the ultimate aim being the development of more effective therapeutics...
  3. pmc The medial prefrontal and orbitofrontal cortices differentially regulate dopamine system function
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Neuropsychopharmacology 36:1227-36. 2011
    ..Taken together, these data demonstrate that the mPFC and OFC differentially regulate dopamine neuron activity, and that the pattern of cortical activation is critical for determining dopamine system output...
  4. pmc Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Int J Neuropsychopharmacol 16:1331-9. 2013
    ..Therefore, we have provided initial preclinical evidence demonstrating the feasibility of hippocampal DBS as a potential novel approach for the treatment of schizophrenia...
  5. pmc Aberrant dopamine D2-like receptor function in a rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology, Center for Biomedical Neuroscience, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7764, San Antonio, TX 78229, USA
    J Pharmacol Exp Ther 343:288-95. 2012
    ....
  6. pmc Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Trends Pharmacol Sci 32:507-13. 2011
    ..Indeed, initial studies demonstrate that allosteric modulation of the α5GABA(A) receptor can decrease aberrant dopamine signaling and associated behaviors in a verified rodent model of psychosis...
  7. pmc An augmented dopamine system function is present prior to puberty in the methylazoxymethanol acetate rodent model of schizophrenia
    Li Chen
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas Department of Physiology, Medical School of Xi an Jiaotong University, Xi an, Shaanxi, China Department of Pathophysiology, Medical School of Xi an Jiaotong University, Xi an, Shaanxi, China
    Dev Neurobiol 74:907-17. 2014
    ..Thus, we posit that the pathological alterations underlying psychosis may be present prior to symptom onset and that the "normal" development of the postsynaptic side of the dopamine system may underlie the transition to psychosis...
  8. pmc Alterations in dopamine system function across the estrous cycle of the MAM rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Psychoneuroendocrinology 47:88-97. 2014
    ..Taken together, these data suggest that changes in dopamine system function occur across the estrous cycle in MAM-treated rats and may contribute to the differences in symptomatology between male and female schizophrenia patients. ..
  9. pmc The lateral mesopontine tegmentum regulates both tonic and phasic activity of VTA dopamine neurons
    Li Chen
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas and
    J Neurophysiol 110:2287-94. 2013
    ..Taken together, we provide further evidence that the mesopontine tegmentum regulates discrete dopamine neuron activity states that are relevant for the understanding of dopamine system function in both normal and disease states. ..
  10. pmc The MAM rodent model of schizophrenia
    Daniel J Lodge
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Curr Protoc Neurosci . 2013
    ..This unit describes the procedures required to safely induce the MAM phenotype in rats. In addition, we describe a simple behavioral procedure, amphetamine-induced hyperlocomotion, which can be utilized to verify the MAM phenotype...
  11. pmc Distinct prefrontal cortical regions negatively regulate evoked activity in nucleus accumbens subregions
    Amber Asher
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Int J Neuropsychopharmacol 15:1287-94. 2012
    ....
  12. pmc A fundamental role for hippocampal parvalbumin in the dopamine hyperfunction associated with schizophrenia
    Angela M Boley
    Department of Pharmacology, Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Schizophr Res 157:238-43. 2014
    ....
  13. pmc New approaches to the management of schizophrenia: focus on aberrant hippocampal drive of dopamine pathways
    Stephanie M Perez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center, San Antonio, TX, USA
    Drug Des Devel Ther 8:887-96. 2014
    ..By better understanding the underlying circuit level dysfunctions in schizophrenia, novel treatments can be advanced that may provide better efficacy and a superior side effect profile to conventional antipsychotic medications. ..
  14. pmc Vagal nerve stimulation reverses aberrant dopamine system function in the methylazoxymethanol acetate rodent model of schizophrenia
    Stephanie M Perez
    Department of Pharmacology and Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, and
    J Neurosci 34:9261-7. 2014
    ..These data provide the first preclinical evidence that VNS may be a possible alternative therapeutic approach for the treatment of schizophrenia. ..