Research Topics
Species | D J LodgeSummaryAffiliation: University of Pittsburgh Country: USA Publications
| Collaborators
|
Detail Information
Publications
Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophreniaDaniel J Lodge
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 27:11424-30. 2007..These data provide a direct link between hippocampal dysfunction and the hyper-responsivity of the DA system that is believed to underlie the augmented response to amphetamine in animal models and psychosis in schizophrenia patients...
Amphetamine activation of hippocampal drive of mesolimbic dopamine neurons: a mechanism of behavioral sensitizationDaniel J Lodge
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 28:7876-82. 2008....- Acute and chronic corticotropin-releasing factor 1 receptor blockade inhibits cocaine-induced dopamine release: correlation with dopamine neuron activityD J Lodge
Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260, USA
J Pharmacol Exp Ther 314:201-6. 2005.... - The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neuronsD J Lodge
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Proc Natl Acad Sci U S A 103:5167-72. 2006..These data show that the LDTg is critical to normal DA function, and thus, pathology within this region may lead to aberrant DA signaling... - Comparative analysis of hepatic ethanol metabolism in Fawn-Hooded and Wistar-Kyoto ratsDaniel J Lodge
Department of Pharmacology, Monash University, Box 13E, Clayton, Victoria 3800, Australia
Alcohol 30:75-9. 2003.... - The hippocampus modulates dopamine neuron responsivity by regulating the intensity of phasic neuron activationDaniel J Lodge
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neuropsychopharmacology 31:1356-61. 2006.... - Hippocampal dysfunction and disruption of dopamine system regulation in an animal model of schizophreniaDaniel J Lodge
Department of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neurotox Res 14:97-104. 2008..Moreover, this suggests an alternate pharmacotherapeutic approach based on the normalization of hippocampal activity in the treatment of schizophrenia in humans... - Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdalaJ Liu
Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Mol Psychiatry 16:1024-38. 2011..These findings suggest that Lepr signaling in midbrain dopamine neurons has a crucial role for the expression of anxiety and for the dopamine modulation of amygdala function... - A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophreniaDaniel J Lodge
Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 29:2344-54. 2009..Such information is central to gaining a better understanding of the disease pathophysiology and alternate pharmacotherapeutic approaches... - Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophreniaDaniel J Lodge
Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA
Behav Brain Res 204:306-12. 2009..Thus gestational MAM administration has been demonstrated to induce a pathodevelopmental process leading to neuroanatomical and behavioral phenotypes consistent with that observed in schizophrenia in humans... - Regulation of firing of dopaminergic neurons and control of goal-directed behaviorsAnthony A Grace
Departments of Neuroscience, Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Trends Neurosci 30:220-7. 2007.... - Aberrant striatal plasticity is specifically associated with dyskinesia following levodopa treatmentPauline Belujon
Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
Mov Disord 25:1568-76. 2010..Such information is critical for understanding the cellular mechanisms underlying one of the major caveats to L-dopa therapy... - Chronic corticotropin-releasing factor type 1 receptor antagonism with antalarmin regulates the dopaminergic system of Fawn-Hooded ratsA J Lawrence
Department of Pharmacology, Monash University, Clayton, Victoria, Australia
J Neurochem 94:1523-34. 2005..Thus, chronic antalarmin treatment modulates dopaminergic pathways and implies that chronic treatment with drugs of this class may ultimately alter postsynaptic signaling mechanisms within the basal ganglia... - Comparative analysis of the central CCK system in Fawn Hooded and Wistar Kyoto rats: extended localisation of CCK-A receptors throughout the rat brain using a novel radioligandD J Lodge
Department of Pharmacology, Monash University, Box 13E, Victoria 3800, Clayton, Australia
Regul Pept 99:191-201. 2001.... - Atypical behavioural responses to CCK-B receptor ligands in Fawn-Hooded ratsDaniel J Lodge
Department of Pharmacology, Monash University, Wellington Road, Box 13E, Clayton, Victoria 3800, Australia
Life Sci 74:1-12. 2003.... - The effect of isolation rearing on volitional ethanol consumption and central CCK/dopamine systems in Fawn-Hooded ratsDaniel J Lodge
Department of Pharmacology, Monash University, P O Box 13E, Clayton, VIC 3800, Australia
Behav Brain Res 141:113-22. 2003..In addition, isolation rearing induced a number of changes in central CCK/dopamine systems... - The CRF1 receptor antagonist antalarmin reduces volitional ethanol consumption in isolation-reared fawn-hooded ratsD J Lodge
Department of Pharmacology, Monash University, Box 13E, Clayton, Victoria 3800, Australia
Neuroscience 117:243-7. 2003..For these reasons, such drugs may provide a new therapeutic approach for the treatment of alcoholism; however, this requires further investigation... - The neurochemical effects of anxiolytic drugs are dependent on rearing conditions in Fawn-Hooded ratsDaniel J Lodge
Department of Pharmacology, Monash University, Box 13E, Clayton, Victoria 3800, Australia
Prog Neuropsychopharmacol Biol Psychiatry 27:451-8. 2003.... - The CRF1 receptor antagonist, antalarmin, reverses isolation-induced up-regulation of dopamine D2 receptors in the amygdala and nucleus accumbens of fawn-hooded ratsElvan Djouma
Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia
Eur J Neurosci 23:3319-27. 2006..Collectively, these findings demonstrate that multiple signalling systems are susceptible to modulation by social isolation and that antalarmin can reverse some, but not all, isolation-induced alterations in brain chemistry... - The effect of chronic CRF1 receptor blockade on the central CCK systems of Fawn-Hooded ratsDaniel J Lodge
Department of Pharmacology, Monash University, Box 13E, Clayton, Victoria 3800, Australia
Regul Pept 116:27-33. 2003..Therefore, these data provide clear evidence of the ability of chronic CRF(1) receptor blockade to significantly influence the central CCK systems of the rat...