Richard M Locksley


Affiliation: University of California
Country: USA


  1. request reprint
    Locksley R, Killeen N, Lenardo M. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001;104:487-501 pubmed
  2. Van Dyken S, Locksley R. Chitins and chitinase activity in airway diseases. J Allergy Clin Immunol. 2018;142:364-369 pubmed publisher
    ..Here we review current advances in our understanding of how chitin-chitinase interactions affect mucosal immune feedback mechanisms essential to maintaining homeostasis and organ health. ..
  3. Molofsky A, Van Gool F, Liang H, Van Dyken S, Nussbaum J, Lee J, et al. Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 2015;43:161-74 pubmed publisher
  4. von Moltke J, Locksley R. I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis. Curr Opin Immunol. 2014;31:58-65 pubmed publisher
  5. Locksley R. Nine lives: plasticity among T helper cell subsets. J Exp Med. 2009;206:1643-6 pubmed publisher
    ..A deeper molecular context will be required to reconcile the ever-increasing complexity of effector T cells. ..
  6. Molofsky A, Savage A, Locksley R. Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity. 2015;42:1005-19 pubmed publisher
    ..Here, we highlight the regulation and function of IL-33 and ST2 and review their roles in homeostasis, damage, and inflammation, suggesting a conceptual framework for future studies. ..
  7. Voehringer D, WU D, Liang H, Locksley R. Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates. BMC Biotechnol. 2009;9:69 pubmed publisher
    ..This approach facilitates the generation of conditional knock-out mice when large parts of the genome are intended to be flanked by loxP sites. ..
  8. Locksley R. Asthma and allergic inflammation. Cell. 2010;140:777-83 pubmed publisher
    ..The similarities of these responses with mucosal responses to parasitic intestinal worms may reveal pathways relevant to the perplexing rise of these chronic inflammatory disorders...
  9. Bando J, Nussbaum J, Liang H, Locksley R. Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung. J Leukoc Biol. 2013;94:877-84 pubmed publisher
    ..brasiliensis infection. Thus, ILC2s are a novel source of Arg1 in resting tissue and during allergic inflammation. ..

More Information


  1. Van Dyken S, Mohapatra A, Nussbaum J, Molofsky A, Thornton E, Ziegler S, et al. Chitin activates parallel immune modules that direct distinct inflammatory responses via innate lymphoid type 2 and γδ T cells. Immunity. 2014;40:414-24 pubmed publisher
  2. Cheng L, Sullivan B, Retana L, Allen C, Liang H, Locksley R. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015;212:513-24 pubmed publisher
    ..Thus, basophils are gatekeepers that link adaptive immunity with innate effector programs by altering access to tissue sites by activation-induced interactions with the endothelium. ..