Richard Locksley

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment
    Helene Bour-Jordan
    UCSF Diabetes Center and Department of Medicine, University of California San Francisco, 94143, USA
    Nat Immunol 4:182-8. 2003
  2. pmc Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
    David Voehringer
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:1435-46. 2006
  3. pmc Cytokine-secreting follicular T cells shape the antibody repertoire
    R Lee Reinhardt
    Howard Hughes Medical Institute and Departments of Medicine and Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:385-93. 2009
  4. pmc Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function
    Daniel B Stetson
    University of California San Francisco, Box 0654, C 443, 521 Parnassus Avenue, San Francisco, CA 94143, USA
    J Exp Med 198:1069-76. 2003
  5. pmc Leishmania major LACK antigen is required for efficient vertebrate parasitization
    Ben L Kelly
    Howard Hughes Medical Institute, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 198:1689-98. 2003
  6. pmc Type 2 innate lymphoid cells control eosinophil homeostasis
    Jesse C Nussbaum
    Department of Medicine, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 502:245-8. 2013
  7. pmc Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity
    Hong Erh Liang
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, USA
    Nat Immunol 13:58-66. 2012
  8. pmc Marking and quantifying IL-17A-producing cells in vivo
    April E Price
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e39750. 2012
  9. pmc Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
    Ari B Molofsky
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco 94143, USA
    J Exp Med 210:535-49. 2013
  10. pmc Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung
    Jennifer K Bando
    1 UCSF, 513 Parnassus Ave, S 1004, San Francisco, CA 94143, USA
    J Leukoc Biol 94:877-84. 2013

Research Grants

  1. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2000
  2. Initiation of allergic immunity by parasites
    Richard M Locksley; Fiscal Year: 2010
  3. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 1991
  4. CD4+ T CELL RECEPTORS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2002
  5. Parasite Immunity Orchestrated by Th2 Cells
    Richard Locksley; Fiscal Year: 2007
  6. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2005
  7. CD4+ T CELL RECEPTORS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2007
  8. Initiation of allergic immunity by parasites
    Richard Locksley; Fiscal Year: 2009
  9. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 1993
  10. CD4+ T CELL RECEPTORS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 1993

Collaborators

Detail Information

Publications53

  1. ncbi request reprint CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment
    Helene Bour-Jordan
    UCSF Diabetes Center and Department of Medicine, University of California San Francisco, 94143, USA
    Nat Immunol 4:182-8. 2003
    ..These results suggest that CTLA-4 has a critical role in T cell differentiation and that STAT6-dependent T(H)2 lineage commitment and stabilization can be bypassed by increasing the strength of signaling through the T cell receptor...
  2. pmc Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
    David Voehringer
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:1435-46. 2006
    ..Thus, components of type 2 immunity mediated by IL-4/IL-13 are partitioned between T cell-dependent IgE and an innate non-eosinophil tissue component, suggesting new strategies for interventions in allergic immunity...
  3. pmc Cytokine-secreting follicular T cells shape the antibody repertoire
    R Lee Reinhardt
    Howard Hughes Medical Institute and Departments of Medicine and Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:385-93. 2009
    ..Our findings support a model in which B cells compete for cytokines produced by follicular helper T cells that shape the affinity and isotype of the antibody response...
  4. pmc Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function
    Daniel B Stetson
    University of California San Francisco, Box 0654, C 443, 521 Parnassus Avenue, San Francisco, CA 94143, USA
    J Exp Med 198:1069-76. 2003
    ..Lineage-specific patterns of cytokine transcripts predate infection and suggest evolutionary selection for invariant but distinct types of effector responses among the earliest responding lymphocytes...
  5. pmc Leishmania major LACK antigen is required for efficient vertebrate parasitization
    Ben L Kelly
    Howard Hughes Medical Institute, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 198:1689-98. 2003
    ..These data suggest that LACK is critical for effective mammalian parasitization and thus represents a potential drug target for leishmaniasis...
  6. pmc Type 2 innate lymphoid cells control eosinophil homeostasis
    Jesse C Nussbaum
    Department of Medicine, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 502:245-8. 2013
    ....
  7. pmc Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity
    Hong Erh Liang
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, USA
    Nat Immunol 13:58-66. 2012
    ..The distinct localization and cellular expression of IL-4 and IL-13 explains their unique roles during allergic immunity...
  8. pmc Marking and quantifying IL-17A-producing cells in vivo
    April E Price
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e39750. 2012
    ....
  9. pmc Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
    Ari B Molofsky
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco 94143, USA
    J Exp Med 210:535-49. 2013
    ..Thus, ILC2s are resident in VAT and promote eosinophils and AAM implicated in metabolic homeostasis, and this axis is enhanced during Th2-associated immune stimulation...
  10. pmc Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung
    Jennifer K Bando
    1 UCSF, 513 Parnassus Ave, S 1004, San Francisco, CA 94143, USA
    J Leukoc Biol 94:877-84. 2013
    ..brasiliensis infection. Thus, ILC2s are a novel source of Arg1 in resting tissue and during allergic inflammation. ..
  11. doi request reprint Raggin' on T-bet
    Richard M Locksley
    HHMI and Departments of Medicine and Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143 0795, USA Electronic address
    Cell Metab 17:473-4. 2013
    ..2013) report in this issue that mice deficient in the T-box transcription factor, T-bet, display a dissociated phenotype with enhanced perigonadal adipose but enhanced insulin sensitivity...
  12. pmc Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease
    Steven J Van Dyken
    Departments of Medicine and Microbiology and Immunology, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    Annu Rev Immunol 31:317-43. 2013
    ....
  13. pmc Efficient generation of long-distance conditional alleles using recombineering and a dual selection strategy in replicate plates
    David Voehringer
    Howard Hughes Medical Institute, Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0795, USA
    BMC Biotechnol 9:69. 2009
    ..Therefore, we developed a new strategy to rapidly identify ES cells containing the desired allele...
  14. pmc Asthma and allergic inflammation
    Richard M Locksley
    Howard Hughes Medical Institute, University of California at San Francisco, 94143, USA
    Cell 140:777-83. 2010
    ..The similarities of these responses with mucosal responses to parasitic intestinal worms may reveal pathways relevant to the perplexing rise of these chronic inflammatory disorders...
  15. doi request reprint The Roaring Twenties
    Richard M Locksley
    Howard Hughes Medical Institute, Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143, USA
    Immunity 28:437-9. 2008
    ..New cell types and cytokines have emerged as key participants in the elaboration of and recovery from inflammation. A collection of reviews covers recent advances in our understanding of this crucial component of host defense...
  16. pmc Nine lives: plasticity among T helper cell subsets
    Richard M Locksley
    Department of Medicine, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 206:1643-6. 2009
    ..A deeper molecular context will be required to reconcile the ever-increasing complexity of effector T cells...
  17. ncbi request reprint Susceptibility to infectious diseases: Leishmania as a paradigm
    R M Locksley
    Howard Hughes Medical Institute, University of California, San Francisco 94143 0654, USA
    J Infect Dis 179:S305-8. 1999
    ..Similar paradigms could underlie susceptibility to other pathogenic organisms...
  18. ncbi request reprint Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection
    Jody L Baron
    Department of Microbiology Immunology, Howard Hughes Medical Institute, University of California Medical Center, San Francisco, CA 94143, USA
    Immunity 16:583-94. 2002
    ..Our results document the first in vivo function for such nonclassical NKT cells and suggest a role for these cells in the host response to HBV infection...
  19. ncbi request reprint Stat signals release activated naive Th cells from an anergic checkpoint
    Markus Mohrs
    Howard Hughes Medical Institute and Department of Medicine, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0654, USA
    J Immunol 170:1870-6. 2003
    ....
  20. pmc Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung
    Emily E Thornton
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 209:1183-99. 2012
    ....
  21. ncbi request reprint T helper cell differentiation: on again, off again
    Jane L Grogan
    Howard Hughes Medical Institute, University of California San Francisco, 521 Parnassus Avenue, C 443, San Francisco, CA 94143 0654, USA
    Curr Opin Immunol 14:366-72. 2002
    ....
  22. pmc Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo
    Jennifer L Matsuda
    La Jolla Institute for Allergy and Immunology, and Division of Biological Sciences, University of California, San Diego, CA, USA
    Proc Natl Acad Sci U S A 100:8395-400. 2003
    ....
  23. ncbi request reprint Basal chromatin modification at the IL-4 gene in helper T cells
    Jane L Grogan
    Howard Hughes Medical Institute, Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143 0654, USA
    J Immunol 171:6672-9. 2003
    ..Hyperacetylation of nonexpressed genes may serve to mark lineage-specific loci for rapid expression and further modification...
  24. ncbi request reprint T helper cell effector fates--who, how and where?
    R Lee Reinhardt
    University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0795, USA
    Curr Opin Immunol 18:271-7. 2006
    ..Finally, the role of innate cells in influencing these processes has become increasingly realized...
  25. ncbi request reprint Th2 cells: orchestrating barrier immunity
    Daniel B Stetson
    Howard Hughes Medical Institute, University of California San Francisco, 94143, USA
    Adv Immunol 83:163-89. 2004
  26. pmc Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    April E Price
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, CA 94143 0795, USA
    Proc Natl Acad Sci U S A 107:11489-94. 2010
    ..Widely dispersed innate type 2 helper cells, which we designate Ih2 cells, play an integral role in type 2 immune responses...
  27. ncbi request reprint Helper T cells regulate type-2 innate immunity in vivo
    Kanade Shinkai
    Howard Hughes Medical Institute, Department of Medicine and Microbiology, University of California San Francisco, 94143 0654, USA
    Nature 420:825-9. 2002
    ..Helper T cells confer antigen specificity on eosinophil cytotoxicity, but not cytokine responses, so defining a novel mechanism that focuses tissue injury at sites of immune challenge...
  28. pmc Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells
    Alusha A Mamchak
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 181:5374-85. 2008
    ..These data demonstrate that ablation of Fyn expression does not alter most Ag-driven CD4(+) T cell responses, with the exception of cytokine production, which under some circumstances is enhanced in Fyn-deficient CD4(+) T cells...
  29. ncbi request reprint Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production
    David Voehringer
    Howard Hughes Medical Institute, Department of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA
    Immunity 20:267-77. 2004
    ..Primary type 2 immune responses in the lung represent the focal recruitment and activation of discrete cell populations from the blood that have previously committed to express IL-4...
  30. ncbi request reprint Lung CD25 CD4 regulatory T cells suppress type 2 immune responses but not bronchial hyperreactivity
    Husein Hadeiba
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 170:5502-10. 2003
    ..Despite their ability to suppress allergic type 2 immunity in the airways, however, CD25(+) CD4 regulatory T cells had no effect on the development of bronchial hyperreactivity...
  31. ncbi request reprint Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages
    David Voehringer
    Howard Hughes Medical Institute, Department of Medicine, University of California San Francisco, San Francisco, California, USA
    J Leukoc Biol 81:1434-44. 2007
    ..Alternatively activated macrophages contributed substantially to tissue recruitment of eosinophils, providing a novel basis for development of therapeutic approaches to lower tissue eosinophilia...
  32. ncbi request reprint A failure to launch: fuelling cytokine secretion in iNKT cells
    Richard M Locksley
    Howard Hughes Medical Institute, Department of Medicine and Microbiology Immunology, University of California, San Francisco, San Francisco, California 94143 0795, USA
    Immunity 25:393-5. 2006
    ..2006) uncover an unsuspected role for the cytokine GM-CSF in the thymic development of invariant NKT cells, a role that licenses these cells to secrete effector cytokines upon activation in the periphery...
  33. ncbi request reprint Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation
    R Lee Reinhardt
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 177:1618-27. 2006
    ....
  34. ncbi request reprint Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo
    Daniel B Stetson
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, 94143, USA
    Immunity 17:191-200. 2002
    ..CD4 subset polarization in this highly characterized model occurs independently from IL-4 expression by naive T cells, which is activated indiscriminately after parasitism...
  35. pmc Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice
    Qizhi Tang
    Diabetes Center, Department of Medicine, University of California, San Francisco 94143, USA
    Nat Immunol 7:83-92. 2006
    ..Such persistent T(reg) cell-dendritic cell contacts preceded the inhibition of T(H) cell activation by dendritic cells, supporting the idea that dendritic cells are central to T(reg) cell function in vivo...
  36. ncbi request reprint Activation of the integrated stress response during T helper cell differentiation
    Stefanie Scheu
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143, USA
    Nat Immunol 7:644-51. 2006
    ..Therefore, T lymphocytes require components of the integrated stress response to uncouple differentiation from the execution of effector functions...
  37. pmc IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway
    Kelly M Kroeger
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California, USA
    J Leukoc Biol 86:769-78. 2009
    ..In addition, basophil survival increased in the presence of IL-18 or IL-33 as a result of increased Akt activation. Studies in vivo confirmed the potency of IL-18 and IL-33 in activating cytokine release from mouse basophils...
  38. pmc Nippostrongylus brasiliensis: identification of intelectin-1 and -2 as Stat6-dependent genes expressed in lung and intestine during infection
    David Voehringer
    Department of Medicine and Microbiology, University of California San Francisco, San Francisco, CA 94143, USA
    Exp Parasitol 116:458-66. 2007
    ..Further, no significant modulation of the immune response in lung or lymph nodes was observed. Thus, under these conditions, intelectins did not enhance pathogen clearance...
  39. pmc Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein
    Max A Seibold
    Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:19650-8. 2009
    ..The structural, kinetic, and genetic data regarding the AMCase isoforms are consistent with the Th2-priming effects of environmental chitin and a role for AMCase in negatively regulating this stimulus...
  40. pmc The Leishmania major LACK antigen with an immunodominant epitope at amino acids 156 to 173 is not required for early Th2 development in BALB/c mice
    Ben L Kelly
    Departmrnt of Medicine, Howard Hughes Medical Institute, University of California San Francisco, UCSF Medical Center, Room C 443, 521 Parnassus Avenue, San Francisco, CA 94143 0654, USA
    Infect Immun 72:6924-31. 2004
    ..Mice inoculated with mutant parasites were not protected against subsequent infection with wild-type L. major...
  41. pmc Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
    P ng Loke
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:9872-7. 2005
    ..The primary role of ICOS in a chronic helminth infection could be to drive antibodies toward type 2 isotypes. T-independent antibody response to the parasite could be enhanced in the absence of costimulation and T cell help...
  42. pmc Innate immune responses in peptidoglycan recognition protein L-deficient mice
    Min Xu
    Howard Hughes Medical Institute, Department of Medicine, University of California San Francisco, 94143 0654, USA
    Mol Cell Biol 24:7949-57. 2004
    ..In contrast to its critical role in immunity in flies, PGRP-L is largely dispensable for mammalian immunity against bacteria and fungi...
  43. ncbi request reprint Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the onset of infection with Leishmania major instructs Th2 cell development, resulting in non
    Pascal Launois
    World Health Organization Immunology Research and Training Center, Institute of Biochemistry, University of Lausanne, Lausanne, Switzerland
    J Immunol 168:4628-35. 2002
    ..Together these results suggest that a deficiency in mechanisms capable of down-regulating the early IL-4 response to L. major contributes to the exquisite susceptibility of BALB/c mice to L. major...
  44. ncbi request reprint Interleukin-4 can be a key positive regulator of inflammatory arthritis
    Koichiro Ohmura
    Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Arthritis Rheum 52:1866-75. 2005
    ..This study was undertaken to determine whether this strong autoantibody response depends on T cell differentiation to the Th1 or Th2 phenotype...
  45. ncbi request reprint TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Immunity 24:179-89. 2006
    ..Our data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation of IL-17-producing T cells...
  46. ncbi request reprint Replication initiation from a novel origin identified in the Th2 cytokine cluster locus requires a distant conserved noncoding sequence
    Toshiro Hayashida
    Cytokine Project, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Bunkyo ku, 113 8613 Tokyo, Japan
    J Immunol 176:5446-54. 2006
    ....
  47. ncbi request reprint LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major
    Alain Gumy
    World Health Organization Immunology Research and Training Centre, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 36:1465-73. 2006
    ..Thus, in C57BL/6 mice, the inability of LACK-reactive CD4(+) T cells to express early IL-4 mRNA transcription, important for disease progression, appears due to an incapacity of these cells to produce IL-2...
  48. ncbi request reprint IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
    ....
  49. pmc A two-step process for cytokine production revealed by IL-4 dual-reporter mice
    Katja Mohrs
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Immunity 23:419-29. 2005
    ..These data reveal a two-step process for cytokine production: the first generating poised cells that disseminate systemically and the second inducing the rapid production of the cytokine in response to local stimulation...
  50. ncbi request reprint Regulation of homeostatic chemokine expression and cell trafficking during immune responses
    Scott N Mueller
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Science 317:670-4. 2007
    ..We propose that this transient chemokine modulation may help orchestrate local cellularity, thus minimizing competition for space and resources in activated lymphoid tissues...
  51. pmc Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma
    Kirk D C Jensen
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Immunity 29:90-100. 2008
    ..The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens...

Research Grants40

  1. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2000
    ..major such that human homologs might be found. ..
  2. Initiation of allergic immunity by parasites
    Richard M Locksley; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Helminths infect over 2.9 billion humans and are estimated to cause morbidity approaching those of diabetes and lung cancer. New insights regarding the pathogenesis of these infections are greatly needed. ..
  3. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 1991
    ..The long term goal will be to use these discrete populations of cloned T cells to screen Leishmania antigens that could function as candidate vaccines or that mediate the immunosuppression of progressive disease...
  4. CD4+ T CELL RECEPTORS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2002
    ..Further, targeting this pool by either understanding its fine specificity or the requirements for Th development can overcome genetic tendencies and provide protection from otherwise fatal infection. ..
  5. Parasite Immunity Orchestrated by Th2 Cells
    Richard Locksley; Fiscal Year: 2007
    ....
  6. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2005
    ..The use of a parasite model in which the outcome has been so clearly tied to this decision offers an opportunity for important insights into disease susceptibility and effective vaccine strategy. ..
  7. CD4+ T CELL RECEPTORS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2007
    ..abstract_text> ..
  8. Initiation of allergic immunity by parasites
    Richard Locksley; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Helminths infect over 2.9 billion humans and are estimated to cause morbidity approaching those of diabetes and lung cancer. New insights regarding the pathogenesis of these infections are greatly needed. ..
  9. HELPER T CELL SUBSETS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 1993
    ..These studies should provide important insights towards the understanding of Th1 and Th2 cell subset maturation and the characteristics of critical parasite antigens involved in this process...
  10. CD4+ T CELL RECEPTORS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 1993
    ....
  11. CD4+ T CELL RECEPTORS IN LEISHMANIASIS
    Richard Locksley; Fiscal Year: 2006
    ..abstract_text> ..