Russell Localio

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Relative risks and confidence intervals were easily computed indirectly from multivariable logistic regression
    A Russell Localio
    Division of Biostatistics, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 60:874-82. 2007
  2. pmc Shared decision making and behavioral impairment: a national study among children with special health care needs
    Alexander G Fiks
    The Pediatric Research Consortium PeRC, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    BMC Pediatr 12:153. 2012
  3. pmc Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma
    Melanie Rushefski
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, USA
    BMC Med Genet 12:77. 2011
  4. pmc Prevalence and risk factors for significant liver fibrosis among HIV-monoinfected patients
    Michelle DallaPiazza
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    BMC Infect Dis 10:116. 2010
  5. doi request reprint Increased risk of digoxin toxicity following hospitalization
    Kevin Haynes
    Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:28-35. 2009
  6. pmc Can we predict daily adherence to warfarin?: Results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Alec B Platt
    MSCE, University of Pennsylvania School of Medicine, 707 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Chest 137:883-9. 2010
  7. pmc Incidence of transaminitis among HIV-infected patients with occult hepatitis B
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Virol 43:32-6. 2008
  8. doi request reprint Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicity
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:328-35. 2008
  9. doi request reprint Impact of electronic health record-based alerts on influenza vaccination for children with asthma
    Alexander G Fiks
    Pediatric Generalist Research Group, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:159-69. 2009
  10. doi request reprint One-year results of the Think Health! study of weight management in primary care practices
    Shiriki K Kumanyika
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 20:1249-57. 2012

Collaborators

Detail Information

Publications93

  1. ncbi request reprint Relative risks and confidence intervals were easily computed indirectly from multivariable logistic regression
    A Russell Localio
    Division of Biostatistics, Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 60:874-82. 2007
    ..To assess alternative statistical methods for estimating relative risks and their confidence intervals from multivariable binary regression when outcomes are common...
  2. pmc Shared decision making and behavioral impairment: a national study among children with special health care needs
    Alexander G Fiks
    The Pediatric Research Consortium PeRC, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    BMC Pediatr 12:153. 2012
    ..This study examined the longitudinal association of SDM with behavioral impairment among children with special health care needs (CSHCN)...
  3. pmc Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma
    Melanie Rushefski
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, USA
    BMC Med Genet 12:77. 2011
    ..Little is known about genetic variation within the PRDX6 gene and its association with acute lung injury (ALI). In this study we sequenced the PRDX6 gene to uncover common variants, and tested association with ALI following major trauma...
  4. pmc Prevalence and risk factors for significant liver fibrosis among HIV-monoinfected patients
    Michelle DallaPiazza
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    BMC Infect Dis 10:116. 2010
    ..Since HIV-monoinfected patients do not routinely undergo liver biopsy, we evaluated the prevalence and risk factors of significant hepatic fibrosis in this group using the aspartate aminotransferase (AST)-to-platelet ratio index (APRI)...
  5. doi request reprint Increased risk of digoxin toxicity following hospitalization
    Kevin Haynes
    Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:28-35. 2009
    ..The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin...
  6. pmc Can we predict daily adherence to warfarin?: Results from the International Normalized Ratio Adherence and Genetics (IN-RANGE) Study
    Alec B Platt
    MSCE, University of Pennsylvania School of Medicine, 707 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Chest 137:883-9. 2010
    ..Currently, no comprehensive screening tool exists to help providers assess the risk of nonadherence at the time of initiation of warfarin therapy...
  7. pmc Incidence of transaminitis among HIV-infected patients with occult hepatitis B
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Virol 43:32-6. 2008
    ..This information is needed to determine the importance of detecting and treating occult HBV in this population...
  8. doi request reprint Moderate and high affinity serotonin reuptake inhibitors increase the risk of upper gastrointestinal toxicity
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:328-35. 2008
    ..This study examined the effect of medications that inhibit serotonin uptake on upper gastrointestinal toxicity...
  9. doi request reprint Impact of electronic health record-based alerts on influenza vaccination for children with asthma
    Alexander G Fiks
    Pediatric Generalist Research Group, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:159-69. 2009
    ..The goal was to assess the impact of influenza vaccine clinical alerts on missed opportunities for vaccination and on overall influenza immunization rates for children and adolescents with asthma...
  10. doi request reprint One-year results of the Think Health! study of weight management in primary care practices
    Shiriki K Kumanyika
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 20:1249-57. 2012
    ..We conclude that the Basic Plus approach of moderate-intensity counseling by PCPs and their staff can facilitate modest weight loss, with clinically significant weight loss in high program attenders...
  11. pmc Impact of pulmonary artery pressure on exercise function in severe COPD
    Michael W Sims
    Department of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Chest 136:412-9. 2009
    ..Although pulmonary hypertension commonly complicates COPD, the functional consequences of increased pulmonary artery pressures in patients with this condition remain poorly defined...
  12. pmc Hormone therapy and fatal breast cancer
    Sandra A Norman
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 19:440-7. 2010
    ..Using a population-based case-control design, we estimated incidence rate ratios of fatal breast cancer in postmenopausal hormone therapy (HT) users compared to non-users by type, duration, and recency of HT use...
  13. pmc Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort study
    Vincent Lo Re
    University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Intern Med 155:353-60. 2011
    ..Adherence to therapy with pegylated interferon and ribavirin for hepatitis C virus (HCV) infection has been incompletely examined...
  14. pmc Risk factors for lymphedema after breast cancer treatment
    Sandra A Norman
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 19:2734-46. 2010
    ..As cancer treatments evolve, it is important to reevaluate their effect on lymphedema risk in breast cancer survivors...
  15. pmc Patient reported receipt of medication instructions for warfarin is associated with reduced risk of serious bleeding events
    Joshua P Metlay
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Gen Intern Med 23:1589-94. 2008
    ..Adverse drug events are an important cause of preventable hospitalizations...
  16. ncbi request reprint Benefit of screening mammography in reducing the rate of late-stage breast cancer diagnoses (United States)
    Sandra A Norman
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania, 801 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Cancer Causes Control 17:921-9. 2006
    ..We studied the benefit of modern mammography screening in community settings, evaluating age-related differences in rates of late-stage breast cancer detection...
  17. doi request reprint Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:561-71. 2008
    ..We sought to examine the validity of specific hospital discharge codes in identifying drug toxicity precipitating hospitalization, among elderly users of high-risk medications...
  18. ncbi request reprint Self-reported hepatitis B and C virus infections had low sensitivity among HIV-infected patients
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 60:294-9. 2007
    ..To determine the validity of self-reported hepatitis B virus (HBV) and hepatitis C virus (HCV) in HIV-infected injection drug users (IDUs) vs. nonIDUs...
  19. pmc Corticosteroids may improve clinical outcomes during hospitalization for Henoch-Schönlein purpura
    Pamela F Weiss
    Division of Rheumatology, Children s Hospital of Philadelphia, and Department of Pediatrics, Center for Clinical Epidemiology and Biostatistics, Leonard Davis Institute of Health Economics, University of Pennsylvania School of Medicine, Room 1539, North Campus, 3535 Market St, Philadelphia, PA 19104, USA
    Pediatrics 126:674-81. 2010
    ..To characterize the effect of corticosteroid exposure on clinical outcomes in children hospitalized with new-onset Henoch-Schönlein purpura (HSP)...
  20. ncbi request reprint Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugs
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 129:1865-74. 2005
    ..Less is known about over-the-counter (OTC) NANSAIDs, which are typically used at lower doses and for shorter durations. This study assessed the risk of toxicity with OTC NANSAIDs...
  21. ncbi request reprint Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes
    Muredach P Reilly
    Cardiovascular Division, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Clin Endocrinol Metab 89:3872-8. 2004
    ..Whether leptin signaling promotes atherosclerosis directly or represents a therapeutic target for the prevention of atherosclerotic cardiovascular disease remains to be explored...
  22. ncbi request reprint The impact of emergency department crowding measures on time to antibiotics for patients with community-acquired pneumonia
    Jesse M Pines
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Emerg Med 50:510-6. 2007
    ..We seek to determine the impact of emergency department (ED) crowding on delays in antibiotic administration for patients with community-acquired pneumonia...
  23. ncbi request reprint Coronary artery calcification and cardiovascular risk factors: impact of the analytic approach
    Muredach P Reilly
    Cardiovascular Division, Department of Medicine, Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19004 6160, USA
    Atherosclerosis 173:69-78. 2004
    ..We present analytic approaches that are likely to provide consistent results and recommend the use of at least two distinct multivariable methods...
  24. doi request reprint Epidemiologic features of the presentation of critical congenital heart disease: implications for screening
    Amy H Schultz
    Department of, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatrics 121:751-7. 2008
    ..These descriptive parameters must be defined to evaluate the impact and feasibility of any proposed screening strategy...
  25. pmc Adherence to hepatitis C virus therapy and early virologic outcomes
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Dr, Philadelphia, PA 19104 6021, USA
    Clin Infect Dis 48:186-93. 2009
    ..We examined the relationship between adherence to pegylated interferon and ribavirin therapy, measured by pharmacy refill, and HCV suppression during the initial 12 weeks of therapy...
  26. pmc Risk factors for nonadherence to warfarin: results from the IN-RANGE study
    Alec B Platt
    Department of Medicine, University of Pennsylvania School of Medicine, PA, USA
    Pharmacoepidemiol Drug Saf 17:853-60. 2008
    ..Warfarin is widely used to prevent stroke and venous thromboembolism despite its narrow therapeutic window. Warfarin nonadherence is a substantial problem, but risk factors have not been well elucidated...
  27. pmc Construct validity of the definition of primary graft dysfunction after lung transplantation
    Jason D Christie
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Heart Lung Transplant 29:1231-9. 2010
    ..This study tested the discriminant validity of International Society for Heart and Lung Transplantation (ISHLT) primary graft dysfunction (PGD) grades with lung injury biomarker profiles and survival...
  28. pmc Risk factors and predictors for candidemia in pediatric intensive care unit patients: implications for prevention
    Theoklis E Zaoutis
    Division of Infectious Diseases, Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Clin Infect Dis 51:e38-45. 2010
    ..Few data exist on risk factors for candidemia in pediatric intensive care unit (PICU) patients...
  29. ncbi request reprint Intercellular adhesion molecule 1 (ICAM-1) gene variant is associated with coronary artery calcification independent of soluble ICAM-1 levels
    Muredach P Reilly
    Cardiovascular Division, Department of Medicine, The Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Investig Med 52:515-22. 2004
    ....
  30. pmc Shared decision-making in pediatrics: a national perspective
    Alexander G Fiks
    ediatric Research Consortium, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatrics 126:306-14. 2010
    ....
  31. ncbi request reprint Neither panacea nor black box: responding to three Journal of Biomedical Informatics papers on computerized physician order entry systems
    Ross Koppel
    Department of Sociology and Center for Clinical Epidemiology and Biostatistics of the School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Biomed Inform 38:267-9. 2005
  32. doi request reprint Variation in occult injury screening for children with suspected abuse in selected US children's hospitals
    Joanne N Wood
    Division of General Pediatrics and PolicyLab, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 130:853-60. 2012
    ....
  33. doi request reprint Risk factors for renal failure in pediatric patients with acute myeloid leukemia: a retrospective cohort study
    Brian T Fisher
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatr Blood Cancer 55:655-61. 2010
    ..This study aims to evaluate the rate of ARF in AML patients and to delineate the impact of age, race, various co-morbid conditions and antimicrobial agents on the development of ARF...
  34. ncbi request reprint Evaluating bias due to population stratification in epidemiologic studies of gene-gene or gene-environment interactions
    Yiting Wang
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, 904 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Cancer Epidemiol Biomarkers Prev 15:124-32. 2006
    ..However, when linkage disequilibrium among genes or correlations among genes and environments were small, biases to main effects or interaction odds ratios were small to nonexistent...
  35. pmc Variation in inpatient therapy and diagnostic evaluation of children with Henoch Schönlein purpura
    Pamela F Weiss
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Pediatr 155:812-818.e1. 2009
    ..To describe variation regarding inpatient therapy and evaluation of children with Henoch Schönlein purpura (HSP) admitted to children's hospitals across the United States...
  36. ncbi request reprint Bias correction with a single null marker for population stratification in candidate gene association studies
    Yiting Wang
    Department of Biostatistics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Hum Hered 59:165-75. 2005
    ..Our results suggested that marker choice and the specific treatment of that marker in analysis greatly influenced bias correction...
  37. doi request reprint Variation in pregnancy outcomes following statewide implementation of a prenatal home visitation program
    David M Rubin
    Division of General Pediatrics, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104 4399, USA
    Arch Pediatr Adolesc Med 165:198-204. 2011
    ..To examine, following statewide dissemination, the influence of an evidence-based home visitation program for first-time mothers on reductions of subsequent pregnancies across time and different locations...
  38. doi request reprint Prioritization of comparative effectiveness research topics in hospital pediatrics
    Ron Keren
    Division of General Pediatrics, Center for Pediatric Clinical Effectiveness, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 166:1155-64. 2012
    ..To use information about prevalence, cost, and variation in resource utilization to prioritize comparative effectiveness research topics in hospital pediatrics...
  39. ncbi request reprint Outcomes attributable to neonatal candidiasis
    Theoklis E Zaoutis
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Clin Infect Dis 44:1187-93. 2007
    ..The incidence of candidiasis has increased in neonatal intensive care units, and invasive candidiasis is associated with significant morbidity and mortality. However, few data exist on outcomes directly attributable to neonatal candidiasis...
  40. pmc Oseltamivir shortens hospital stays of critically ill children hospitalized with seasonal influenza: a retrospective cohort study
    Susan E Coffin
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 30:962-6. 2011
    ..The effect of oseltamivir on outcomes of hospitalized children is unknown. The primary objective of this study was to determine whether oseltamivir improves outcomes of critically ill children hospitalized with influenza...
  41. pmc Identifying and quantifying medication errors: evaluation of rapidly discontinued medication orders submitted to a computerized physician order entry system
    Ross Koppel
    Department of Sociology, University of Pennsylvania, Philadelphia, PA, USA
    J Am Med Inform Assoc 15:461-5. 2008
    ..This measure offers a rapid, constant, inexpensive, and objective method to identify medication orders with a high probability of error. It may also serve as a screening and teaching mechanism for physicians-in-training...
  42. pmc Electronic medical record use in pediatric primary care
    Alexander G Fiks
    The Pediatric Research Consortium PeRC, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Am Med Inform Assoc 18:38-44. 2011
    ..To characterize patterns of electronic medical record (EMR) use at pediatric primary care acute visits...
  43. pmc Validity of The Health Improvement Network (THIN) for epidemiologic studies of hepatitis C virus infection
    Vincent Lo Re
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:807-14. 2009
    ..We determined the accuracy of HCV diagnostic codes within The Health Improvement Network (THIN), an electronic database containing medical record data from general medical practices in the United Kingdom...
  44. pmc The effect of cardiac troponin testing on clinical care in a veterans population: a randomized controlled trial
    Michael Berkwits
    Philadelphia VA Medical Center and the Division of General Internal Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA
    J Gen Intern Med 20:584-92. 2005
    ..Cardiac troponin is more accurate than creatine kinase (CK) testing for detecting myocardial injury in patients with acute coronary syndromes (ACS), but its effects on clinical care compared with CK testing alone is open to question...
  45. pmc Lymphedema in breast cancer survivors: incidence, degree, time course, treatment, and symptoms
    Sandra A Norman
    Department of Medicine, Division of Hematology Oncology, Center for Clinical Epidemiologyand Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Oncol 27:390-7. 2009
    ..To examine the incidence, degree, time course, treatment, and symptoms of lymphedema in breast cancer survivors...
  46. doi request reprint Women of child-bearing age have better inhospital cardiac arrest survival outcomes than do equal-aged men
    Alexis A Topjian
    Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 38:1254-60. 2010
    ..Our objective was to determine whether women of child-bearing age are more likely than men to survive to hospital discharge after in-hospital cardiac arrest...
  47. pmc Extrinsic risk factors for pressure ulcers early in the hospital stay: a nested case-control study
    Mona Baumgarten
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Gerontol A Biol Sci Med Sci 63:408-13. 2008
    ....
  48. ncbi request reprint Predictors of recall of over-the-counter and prescription non-steroidal anti-inflammatory drug exposure
    James D Lewis
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 15:39-45. 2006
    ..Because of the difficulty in establishing a gold standard, data on accuracy of recall of over-the-counter (OTC) medication use are sparse...
  49. ncbi request reprint The association between emergency department crowding and hospital performance on antibiotic timing for pneumonia and percutaneous intervention for myocardial infarction
    Jesse M Pines
    Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Acad Emerg Med 13:873-8. 2006
    ..Antibiotics within four hours of arrival for patients with pneumonia and percutaneous intervention (PCI) within two hours for patients with acute myocardial infarction (AMI) are standard measures of emergency department (ED) quality...
  50. ncbi request reprint Characterization of interpersonal violence events involving young adolescent girls vs events involving young adolescent boys
    Cynthia J Mollen
    Department of Pediatrics, Division of Emergency Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Arch Pediatr Adolesc Med 158:545-50. 2004
    ..Multiple studies have demonstrated that girls are engaging in interpersonal violence. However, little is known about the potentially unique aspects of violent events involving girls...
  51. ncbi request reprint Impact of clinical alerts within an electronic health record on routine childhood immunization in an urban pediatric population
    Alexander G Fiks
    Pediatric Research Consortium, Children s Hospital of Philadelphia, 3535 Market St, Room 1546, Philadelphia, PA 19104, USA
    Pediatrics 120:707-14. 2007
    ....
  52. ncbi request reprint Longitudinal and repeated cross-sectional cluster-randomization designs using mixed effects regression for binary outcomes: bias and coverage of frequentist and Bayesian methods
    A Russell Localio
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Stat Med 25:2720-36. 2006
    ..The performance of common statistical tools for the analysis of cluster randomization designs depends heavily on the precise design, the number of clusters, and the variability of baseline outcomes and treatment effects across centres...
  53. ncbi request reprint Validation of self-reported screening mammography histories among women with and without breast cancer
    Sandra A Norman
    Center for Clinical Epidemiology and Biostatistics and Department of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia 19104 6021, USA
    Am J Epidemiol 158:264-71. 2003
    ..Therefore, odds ratios will likely be biased toward the null, underestimating screening efficacy...
  54. pmc The association of early transfusion with acute lung injury in patients with severe injury
    Daniel N Holena
    Division of Traumatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Trauma Acute Care Surg 73:825-31. 2012
    ..We hypothesized that the relationship between PRBC delivery and ALI risk varies through time after injury...
  55. pmc Home visitation program effectiveness and the influence of community behavioral norms: a propensity score matched analysis of prenatal smoking cessation
    Meredith Matone
    PolicyLab, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    BMC Public Health 12:1016. 2012
    ....
  56. doi request reprint The use of palliative chemotherapy in pediatric oncology patients: a national survey of pediatric oncologists
    Tammy I Kang
    The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Blood Cancer 60:88-94. 2013
    ..One factor that influences parental decisions to pursue medical therapies is physician preference. To date, no studies have described pediatric oncologists' perspectives and practices regarding palliative chemotherapy (PC)...
  57. doi request reprint Improving adherence to otitis media guidelines with clinical decision support and physician feedback
    Christopher B Forrest
    Department of Pediatrics, Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Pediatrics 131:e1071-81. 2013
    ..To assess the effects of electronic health record-based clinical decision support (CDS) and physician performance feedback on adherence to guidelines for acute otitis media (AOM) and otitis media with effusion (OME)...
  58. pmc The relationship between mental health diagnosis and treatment with second-generation antipsychotics over time: a national study of U.S. Medicaid-enrolled children
    Meredith Matone
    PolicyLab, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Health Serv Res 47:1836-60. 2012
    ..To describe the relationship between mental health diagnosis and treatment with antipsychotics among U.S. Medicaid-enrolled children over time...
  59. ncbi request reprint Incidence, complications, and risk factors for prolonged stay in children hospitalized with community-acquired influenza
    Susan E Coffin
    Division of General Pediatrics, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 119:740-8. 2007
    ....
  60. pmc Multimodality screening of high-risk women: a prospective cohort study
    Susan P Weinstein
    University of Pennsylvania Health System, Radiology, 1 Silverstein Bldg, 3400 Spruce St, Philadelphia, PA, USA
    J Clin Oncol 27:6124-8. 2009
    ....
  61. ncbi request reprint Modifiable risk factors for breast cancer recurrence: what can we tell survivors?
    Sandra A Norman
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    J Womens Health (Larchmt) 16:177-90. 2007
    ....
  62. pmc Prolonged intravenous therapy versus early transition to oral antimicrobial therapy for acute osteomyelitis in children
    Theoklis Zaoutis
    Division of Infectious Diseases, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, CHOP North, Suite 1527, Philadelphia, PA 19104, USA
    Pediatrics 123:636-42. 2009
    ..We sought to compare the effectiveness of early transition from intravenous to oral antimicrobial therapy versus prolonged intravenous antimicrobial therapy for the treatment of children with acute osteomyelitis...
  63. doi request reprint Impact of immunization at sick visits on well-child care
    Alexander G Fiks
    Pediatric Research Consortium, Children s Hospital of Philadelphia, 3535 Market St, Philadelphia, PA 19104, USA
    Pediatrics 121:898-905. 2008
    ..We assessed the impact of immunization at sick visits on subsequent and overall well-child care...
  64. doi request reprint Local macroeconomic trends and hospital admissions for child abuse, 2000-2009
    Joanne N Wood
    PolicyLab and General Pediatrics, The Children s Hospital of Philadelphia 3535 Market St, Room 1517, Philadelphia, PA 19104, USA
    Pediatrics 130:e358-64. 2012
    ..To examine the relationship between local macroeconomic indicators and physical abuse admission rates to pediatric hospitals over time...
  65. pmc State variation in psychotropic medication use by foster care children with autism spectrum disorder
    David M Rubin
    Division of General Pediatrics, Children s Hospital of Philadelphia, PolicyLab, Center to Bridge Research, Practice, and Policy, Safe Place, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:e305-12. 2009
    ....
  66. doi request reprint Cefepime and mortality in pediatric acute myelogenous leukemia: a retrospective cohort study
    Brian T Fisher
    Division of Infectious Diseases, The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pediatr Infect Dis J 28:971-5. 2009
    ..We evaluated the association of cefepime and other beta-lactam antibiotic exposures with all cause in-hospital mortality in pediatric AML patients...
  67. ncbi request reprint Survival associated with treatment vs observation of localized prostate cancer in elderly men
    Yu Ning Wong
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    JAMA 296:2683-93. 2006
    ..Prostate-specific antigen screening has led to an increase in the diagnosis and treatment of localized prostate cancer. However, the role of active treatment of low- and intermediate-risk disease in elderly men is controversial...
  68. ncbi request reprint Role of computerized physician order entry systems in facilitating medication errors
    Ross Koppel
    Department of Sociology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia 19104 USA
    JAMA 293:1197-203. 2005
    ..Published studies report that CPOE reduces medication errors up to 81%. Few researchers, however, have focused on the existence or types of medication errors facilitated by CPOE...
  69. pmc The impact of placement stability on behavioral well-being for children in foster care
    David M Rubin
    Pediatric Generalist Research Group, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 119:336-44. 2007
    ..This study sought to disentangle this cascading relationship in order to identify the independent impact of placement stability on behavioral outcomes downstream...
  70. pmc The implementation and acceptability of an HPV vaccination decision support system directed at both clinicians and families
    Stephanie Mayne
    Center for Pediatric Clinical Effectiveness, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    AMIA Annu Symp Proc 2012:616-24. 2012
    ..The results of this study demonstrate the acceptability and potential impact on clinical care of a comprehensive decision support system directed at both clinicians and families...
  71. ncbi request reprint Evaluating bias due to population stratification in case-control association studies of admixed populations
    Yiting Wang
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Genet Epidemiol 27:14-20. 2004
    ..Therefore, bias due to PS alone may be small when baseline risk differences are small within major categories of admixed ethnicity, such as African Americans...
  72. ncbi request reprint Statistical characteristics of area under the receiver operating characteristic curve for a simple prognostic model using traditional and bootstrapped approaches
    David J Margolis
    Department of Dermatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19004, USA
    J Clin Epidemiol 55:518-24. 2002
    ..We further show that for our simple prognostic model a bootstrap z-statistic approach is preferred over the trapezoidal method when comparing the AROCs of two related models...
  73. pmc Decreased post-transplant survival among heart transplant recipients with pre-transplant hepatitis C virus positivity
    Ingi Lee
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Heart Lung Transplant 30:1266-74. 2011
    ..However, there have been few studies examining whether HCV infection reduces survival after heart transplantation...
  74. pmc Design, recruitment and start up of a primary care weight loss trial targeting African American and Hispanic adults
    Shiriki Kumanyika
    Center for Clinical Epidemiology and Biostatistics, 8th Floor Blockley Hall, 423 Guardian Drive, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Contemp Clin Trials 32:215-24. 2011
    ..The study will have particular relevance to African Americans and women...
  75. ncbi request reprint Clinicians required very high sensitivity of a bacteremia prediction rule
    Ebbing Lautenbach
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 57:1104-6. 2004
    ..However, no such models have been accepted into general clinical use. The goal of this study was to determine physicians' criteria for acceptability of a bacteremia clinical prediction rule...
  76. ncbi request reprint Gliomatosis cerebri: 20 years of experience at the Children's Hospital of Philadelphia
    Gregory T Armstrong
    Division of Oncology, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Cancer 107:1597-606. 2006
    ..In this report, the authors describe the largest cohort of children to date with GC and explore relations between potential prognostic factors, treatment, and survival...
  77. ncbi request reprint Hepatitis C virus seropositivity in organ donors and survival in heart transplant recipients
    Leanne B Gasink
    Division of Infectious Diseases of the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    JAMA 296:1843-50. 2006
    ..Little is known about the effect of donor HCV positivity on survival in cardiac transplantation...
  78. ncbi request reprint Prevalence, risk factors, and outcomes for occult hepatitis B virus infection among HIV-infected patients
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA
    J Acquir Immune Defic Syndr 44:315-20. 2007
    ..The prevalence of occult HBV in HIV-infected patients remains controversial, and the risk factors and clinical significance are unknown...
  79. pmc An alternative method of acute lung injury classification for use in observational studies
    Chirag V Shah
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Blockley Hall, 423 Guardian Dr, Philadelphia, PA, USA
    Chest 138:1054-61. 2010
    ..We assessed the impact of excluding patients with difficult-to-classify or equivocal ALI diagnosis on clinical and genetic risk factor associations for ALI after trauma...
  80. ncbi request reprint Relationship between coronary angioplasty laboratory volume and outcomes after hospital discharge
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics and the Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Am Heart J 143:833-40. 2002
    ....
  81. ncbi request reprint Placement changes and emergency department visits in the first year of foster care
    David M Rubin
    Division of General Pediatrics, Pediatric Generalist Research Group, Safe Place Center for Child Protection and Health, Philadelphia, PA, USA
    Pediatrics 114:e354-60. 2004
    ..The secondary aim was to compare ED visit rates with rates of visits to other ambulatory care settings among children in foster care and other Medicaid-eligible children not in foster care...
  82. pmc Validation of a Pediatric Primary Care Network in a US Metropolitan Region as a Community-Based Infectious Disease Surveillance System
    Kristen A Feemster
    Division of Infectious Diseases, Department of Pediatrics, The Children s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Interdiscip Perspect Infect Dis 2011:219859. 2011
    ..Observed population rates of an infectious disease did not significantly differ suggesting that the network can potentially provide valid disease estimates for the community population...
  83. ncbi request reprint C-reactive protein and coronary artery calcification: The Study of Inherited Risk of Coronary Atherosclerosis (SIRCA)
    Muredach P Reilly
    Cardiovascular Division, University of Pennsylvania School of Medicine, Philadelphia, USA
    Arterioscler Thromb Vasc Biol 23:1851-6. 2003
    ..In the largest study to date, we examined the association of plasma CRP with coronary artery calcification (CAC) in 914 asymptomatic subjects in the Study of Inherited Risk of Coronary Atherosclerosis (SIRCA)...
  84. ncbi request reprint Measuring screening intensity in case-control studies of the efficacy of mammography
    A Russell Localio
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, 19104 6021, USA
    Am J Epidemiol 164:272-81. 2006
    ..Assessing the effect of screening intensity in case-control studies of mammography is possible if principles and methods for misclassification and measurement error guide the analysis...
  85. ncbi request reprint Initial evaluation of rectal bleeding in young persons: a cost-effectiveness analysis
    James D Lewis
    Center for Clinical Epidemiology and Biostatistics, Blockley Hall, 9th Floor, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Ann Intern Med 136:99-110. 2002
    ..Evaluation of rectal bleeding in young patients is a frequent diagnostic challenge...
  86. ncbi request reprint Placement stability and mental health costs for children in foster care
    David M Rubin
    Pediatric Generalist Research Group, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 113:1336-41. 2004
    ..The secondary aim is to test the hypothesis that foster care children are also more likely to generate high costs for mental health services if they generate higher costs for non-mental health claims...
  87. pmc Molecular analysis of nondisjunction in mice heterozygous for a Robertsonian translocation
    Lara A Underkoffler
    Division of Human Genetics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Genetics 161:1219-24. 2002
    ..These results show that molecular genotyping provides a valuable tool for understanding factors influencing meiotic nondisjunction in mammals...
  88. ncbi request reprint Association between primary care practice characteristics and emergency department use in a medicaid managed care organization
    Robert A Lowe
    Center for Policy and Research in Emergency Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA
    Med Care 43:792-800. 2005
    ..Many patients use emergency departments (EDs) for primary care. Previous studies have found that patient characteristics affect ED utilization. However, such studies have led to few policy changes...
  89. ncbi request reprint Rosiglitazone: a thunderstorm from scarce and fragile data
    Cynthia D Mulrow
    Ann Intern Med 147:585-7. 2007
  90. ncbi request reprint Trends in operative management of pediatric splenic injury in a regional trauma system
    Daniela H Davis
    Naval Medical Center Portsmouth, Portsmouth, Virginia, USA
    Pediatrics 115:89-94. 2005
    ....
  91. ncbi request reprint Pressure ulcers among elderly patients early in the hospital stay
    Mona Baumgarten
    Department of Epidemiology and Preventive Medicine, Division of Gerontology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 61:749-54. 2006
    ..The goals of this study were to estimate the incidence of hospital-acquired pressure ulcers in the first 2 days of the hospital stay and to identify patient characteristics associated with higher incidence...
  92. doi request reprint Health care use of children whose female caregivers have intimate partner violence histories
    Megan H Bair-Merritt
    Division of General Pediatrics and Adolescent Medicine, Johns Hopkins School of Medicine, 200 N Wolfe St, Office 2021, Baltimore, MD 21287, USA
    Arch Pediatr Adolesc Med 162:134-9. 2008
    ..To determine whether prior exposure to intimate partner violence (IPV) is associated with children's subsequent emergency department (ED) visits and hospitalizations...
  93. ncbi request reprint Attitudes and beliefs concerning prostate cancer genetic screening
    David J Doukas
    Department of Family and Geriatric Medicine, Institute of Bioethics, Public Policy and Law, University of Louisville, KY 40202, USA
    Clin Genet 66:445-51. 2004
    ..The relationship of men to others, family and society, require further investigation in this and other aspects of genetic testing...