SU LO

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc C-terminal tensin-like (CTEN): a promising biomarker and target for cancer
    Su Hao Lo
    Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, United States Electronic address
    Int J Biochem Cell Biol 51:150-4. 2014
  2. pmc The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1
    Yi Chun Liao
    Center for Tissue Regeneration and Repair, University of California, Davis, Sacramento, CA 95817, USA
    J Cell Biol 176:43-9. 2007
  3. pmc DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration
    Y Lin
    Department of Biochemistry and Molecular Medicine University of California Davis, Sacramento, CA 95817, USA
    Oncogene 29:3010-6. 2010
  4. pmc Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells
    Yi Ping Shih
    Center for Tissue Regeneration and Repair, University of California Davis, Sacramento, California 95817, USA
    Mol Cancer Res 10:34-9. 2012
  5. ncbi request reprint Reverse interactomics: from peptides to proteins and to functions
    Su Hao Lo
    Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, Cancer Center, University of California Davis, Sacramento, California 95817, USA
    ACS Chem Biol 2:93-5. 2007
  6. ncbi request reprint Focal adhesions: what's new inside
    Su Hao Lo
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery and Cancer Center, University of California Davis, Davis, Sacramento, CA 95817, USA
    Dev Biol 294:280-91. 2006
  7. ncbi request reprint Tensin
    Su Hao Lo
    Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, University of California Davis, 4635 Second Avenue, Room 2000, Sacramento, CA 95817, USA
    Int J Biochem Cell Biol 36:31-4. 2004
  8. ncbi request reprint Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer
    Su Hao Lo
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, The University of California Davis, Sacramento, California 95817, USA
    Cancer Res 62:4217-21. 2002
  9. ncbi request reprint Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3
    Yumin Cui
    Center for Tissue Regeneration and Repair, Department of Orthopedic Surgery, University of California Davis, Sacramento, California 95817, USA
    Mol Cancer Res 2:225-32. 2004
  10. pmc Regulation of tensin-promoted cell migration by its focal adhesion binding and Src homology domain 2
    Huaiyang Chen
    Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, University of California, Davis, Sacramento, CA 95817, USA
    Biochem J 370:1039-45. 2003

Research Grants

  1. The Promoter or A Prostate Specific Gene, Cten
    SU LO; Fiscal Year: 2004
  2. Role of Cten in Prostate Cancer
    Su Hao Lo; Fiscal Year: 2007
  3. Role of Cten in Prostate Cancer
    SU LO; Fiscal Year: 2004
  4. Role of Cten in Prostate Cancer
    SU LO; Fiscal Year: 2005
  5. Role of Cten in Prostate Cancer
    Su Hao Lo; Fiscal Year: 2006
  6. Mechanism of DLC1-mediated tumor suppression
    Su Hao Lo; Fiscal Year: 2010

Collaborators

Detail Information

Publications24

  1. pmc C-terminal tensin-like (CTEN): a promising biomarker and target for cancer
    Su Hao Lo
    Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, United States Electronic address
    Int J Biochem Cell Biol 51:150-4. 2014
    ..Up-regulated cten promotes cell motility, prolongs epidermal growth factor receptor signaling, and enhances tumorigenicity. Emerging findings suggest that cten is a promising biomarker and therapeutic target for various cancers. ..
  2. pmc The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1
    Yi Chun Liao
    Center for Tissue Regeneration and Repair, University of California, Davis, Sacramento, CA 95817, USA
    J Cell Biol 176:43-9. 2007
    ..These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity...
  3. pmc DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration
    Y Lin
    Department of Biochemistry and Molecular Medicine University of California Davis, Sacramento, CA 95817, USA
    Oncogene 29:3010-6. 2010
    ..These results indicate that DLC2 is not required for mouse development and normal vessel formation, but may protect mouse from unwanted angiogenesis induced by, for example, tumor cells...
  4. pmc Silencing of DLC1 upregulates PAI-1 expression and reduces migration in normal prostate cells
    Yi Ping Shih
    Center for Tissue Regeneration and Repair, University of California Davis, Sacramento, California 95817, USA
    Mol Cancer Res 10:34-9. 2012
    ....
  5. ncbi request reprint Reverse interactomics: from peptides to proteins and to functions
    Su Hao Lo
    Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, Cancer Center, University of California Davis, Sacramento, California 95817, USA
    ACS Chem Biol 2:93-5. 2007
    ..A paper in this issue shows how "reverse interactomics" can be exploited to identify binding partners of the SH2 domain of tensin...
  6. ncbi request reprint Focal adhesions: what's new inside
    Su Hao Lo
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery and Cancer Center, University of California Davis, Davis, Sacramento, CA 95817, USA
    Dev Biol 294:280-91. 2006
    ..Recent studies using genetic approaches in invertebrate and vertebrate systems have begun to reveal the structure and function of these complexes in vivo...
  7. ncbi request reprint Tensin
    Su Hao Lo
    Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, University of California Davis, 4635 Second Avenue, Room 2000, Sacramento, CA 95817, USA
    Int J Biochem Cell Biol 36:31-4. 2004
    ..Therefore, tensin and its downstream signaling molecules may be targets for therapeutic interventions in renal disease, wound healing and cancer...
  8. ncbi request reprint Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer
    Su Hao Lo
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, The University of California Davis, Sacramento, California 95817, USA
    Cancer Res 62:4217-21. 2002
    ..The evolutionary divergence has produced the first focal adhesion protein specifically expressed in the prostate and the placenta, which may be involved in preventing prostate tumor formation...
  9. ncbi request reprint Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3
    Yumin Cui
    Center for Tissue Regeneration and Repair, Department of Orthopedic Surgery, University of California Davis, Sacramento, California 95817, USA
    Mol Cancer Res 2:225-32. 2004
    ..Our results demonstrate that tensin3 may function as a platform for the disassembly of EGF-related signaling complexes at focal adhesions...
  10. pmc Regulation of tensin-promoted cell migration by its focal adhesion binding and Src homology domain 2
    Huaiyang Chen
    Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, University of California, Davis, Sacramento, CA 95817, USA
    Biochem J 370:1039-45. 2003
    ..These results have indicated that focal adhesion localization of tensin1 and the phosphotyrosine-binding activity are two critical factors in regulating tensin-mediated cell migration...
  11. pmc Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration
    Huaiyang Chen
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California at Davis, Sacramento, CA 95817, USA
    Proc Natl Acad Sci U S A 99:733-8. 2002
    ..Finally, functional analysis of tensin genes has demonstrated that expression of tensin genes is able to promote cell migration on fibronectin, indicating that the tensin family plays a role in regulating cell motility...
  12. pmc Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer through beta-catenin
    Yi Chun Liao
    Center for Tissue Regeneration and Repair, Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, California 95817, USA
    Cancer Res 69:4563-6. 2009
    ..Our studies have identified cten as a novel nuclear partner of beta-catenin, showed an oncogenic activity of cten in colon cancers, and revealed cten as a potential biomarker and target for colon cancers...
  13. ncbi request reprint Regulation of articular chondrocyte phenotype by bone morphogenetic protein 7, interleukin 1, and cellular context is dependent on the cytoskeleton
    Ruth L Vinall
    Center for Tissue Regeneration and Repair, University of California Davis, Sacramento, California 95817, USA
    Exp Cell Res 272:32-44. 2002
    ..Taken together these data demonstrate that cytoskeletal components play a critical role in the response to morphogens and cytokines in the regulation of chondrocyte phenotype. (c)2001 Elsevier Science...
  14. ncbi request reprint Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer
    Zongbing You
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California, Davis, Sacramento, California 95817, USA
    Cancer Res 66:175-83. 2006
    ..Thus, IL-17RL is a potential therapeutic target in the treatment of prostate cancer...
  15. pmc DLC1 negatively regulates angiogenesis in a paracrine fashion
    Yi Ping Shih
    Department of Biochemistry and Molecular Medicine, Center for Tissue Regeneration and Repair, University of California Davis, Sacramento, California 95817, USA
    Cancer Res 70:8270-5. 2010
    ..Thus, our results strongly suggest that loss of DLC1 may serve as a "second hit" in promoting angiogenesis in a paracrine fashion during tumorigenesis...
  16. pmc Mutations in the focal adhesion targeting region of deleted in liver cancer-1 attenuate their expression and function
    Yi Chun Liao
    Department of Biochemistry and Molecular Medicine, Center for Tissue Regeneration and Repair, University of California, Davis, Sacramento, California 95817, USA
    Cancer Res 68:7718-22. 2008
    ..Our studies have shown that mutations in DLC-1 may lead to loss of function and contribute to the tumorigenesis, and have revealed an allosteric regulation site for its RhoGAP activity...
  17. ncbi request reprint Inactivation of tensin3 in mice results in growth retardation and postnatal lethality
    Ming Ko Chiang
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California Davis, 4635 Second Avenue, Room 2000, Sacramento, CA 95817, USA
    Dev Biol 279:368-77. 2005
    ..About 10% of SRS cases have been linked to abnormality in chromosome 7p11.2-13, where human tensin3 gene is located, suggesting a potential link between tensin3 and SRS...
  18. doi request reprint Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation
    Shu Chen Hsieh
    Department of Biochemistry and Molecular Medicine, Center for Tissue Regeneration and Repair, University of California Davis, Sacramento, California 95817, USA
    Mol Carcinog 48:545-52. 2009
    ..Further analyses have suggested that the phenotypes of PTEN mutant likely attribute to PTEN's negatively regulating role in PI3K/Akt pathway...
  19. pmc Cell tracing dyes significantly change single cell mechanics
    Valentin Lulevich
    Department of Chemistry, University of California, Davis, California 95616, USA
    J Phys Chem B 113:6511-9. 2009
    ....
  20. ncbi request reprint The N-terminal half of talin2 is sufficient for mouse development and survival
    Nien Tsu Chen
    Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery and Cancer Center, University of California Davis, Sacramento, 95817, USA
    Biochem Biophys Res Commun 337:670-6. 2005
    ..Utilizing the expression of talin2(1-1295)/beta-galactosidase fusion protein, we have examined the distribution of talin2 in tissues. In contrast to talin1, talin2 expression is more restricted in tissues and cell types...
  21. pmc Deleted in liver cancer-1 (DLC-1): a tumor suppressor not just for liver
    Yi Chun Liao
    Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Biochemistry and Molecular Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Int J Biochem Cell Biol 40:843-7. 2008
    ..Therefore, the expression and subcellular localization of DLC-1 could be a useful molecular marker for cancer prognosis, whereas DLC-1 and its downstream signaling molecules might be therapeutic targets for the treatment of cancer...
  22. ncbi request reprint Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions
    Masumi Eto
    Center for Cell Signaling, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Biol Chem 282:17806-15. 2007
    ..Thus, the protein-tyrosine phosphatase domain of tensin exhibits isoform-specific association with PP1alpha in a restricted spatial region of adhesions that are formed during cell migration...
  23. ncbi request reprint Cleavage of cten by caspase-3 during apoptosis
    Su Shun Lo
    Division of General Surgery, Taipei Veterans General Hospital, National Yang Ming University, Taipei, Taiwan
    Oncogene 24:4311-4. 2005
    ..These results demonstrate that cten is a target of caspase-3 and the resultant fragments could further promote apoptosis...
  24. ncbi request reprint A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration
    Menachem Katz
    Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nat Cell Biol 9:961-9. 2007
    ..In conclusion, a transcriptional tensin-3-cten switch may contribute to the metastasis of mammary cancer...

Research Grants7

  1. The Promoter or A Prostate Specific Gene, Cten
    SU LO; Fiscal Year: 2004
    ....
  2. Role of Cten in Prostate Cancer
    Su Hao Lo; Fiscal Year: 2007
    ..Aim 3. To determine the function of cten in prostate physiology and carcinogenesis, using in vivo models of transgenic mice expressing wild-type or mutated human cten. ..
  3. Role of Cten in Prostate Cancer
    SU LO; Fiscal Year: 2004
    ..Aim 3. To determine the function of cten in prostate physiology and carcinogenesis, using in vivo models of transgenic mice expressing wild-type or mutated human cten. ..
  4. Role of Cten in Prostate Cancer
    SU LO; Fiscal Year: 2005
    ..Aim 3. To determine the function of cten in prostate physiology and carcinogenesis, using in vivo models of transgenic mice expressing wild-type or mutated human cten. ..
  5. Role of Cten in Prostate Cancer
    Su Hao Lo; Fiscal Year: 2006
    ..Aim 3. To determine the function of cten in prostate physiology and carcinogenesis, using in vivo models of transgenic mice expressing wild-type or mutated human cten. ..
  6. Mechanism of DLC1-mediated tumor suppression
    Su Hao Lo; Fiscal Year: 2010
    ..The knowledge may apply to other cancers, since loss of DLC1 is associated with a variety of cancer types. ..