Research Topics
| J C LoSummaryAffiliation: University of California Country: USA Publications
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Publications
"Buffalo hump" in men with HIV-1 infectionJ C Lo
Division of Endocrinology, San Francisco General Hospital, CA 94110, USA
Lancet 351:867-70. 1998..Enlargement of the dorsocervical fat pad ("buffalo hump") has been reported in numerous HIV-1-infected patients. Some investigators have speculated that this finding is associated with protease-inhibitor treatment...- The effects of low-dose growth hormone in HIV-infected men with fat accumulation: a pilot studyJoan C Lo
Div of Endocrinology, General Clinical Research Center at San Francisco General Hospital, San Francisco, California 94110, USA
Clin Infect Dis 39:732-5. 2004..Visceral adipose tissue (VAT) levels did not change significantly for the group as a whole, although a reduction in the VAT level was seen in patients with a greater VAT level at baseline... - Normal female infants born of mothers with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiencyJ C Lo
Department of Medicine, University of California, San Francisco 94143, USA
J Clin Endocrinol Metab 84:930-6. 1999..Recommendations for the management of pregnancy and delivery in these patients are discussed... - Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney diseaseJoan C Lo
Divisions of Endocrinology and Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
Kidney Int 67:1047-52. 2005..Previous studies have suggested a higher prevalence of thyroid abnormalities in persons with end-stage renal disease. However, little is known regarding the epidemiology of thyroid disorders in persons with less severe kidney dysfunction... - The effects of recombinant human growth hormone on body composition and glucose metabolism in HIV-infected patients with fat accumulationJ C Lo
Division of Endocrinology, Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
J Clin Endocrinol Metab 86:3480-7. 2001..We also recommend a screening oral glucose tolerance test be performed to exclude subjects at risk for GH-induced hyperglycemia... - Altered fat distribution in HIV-positive men on nucleoside analog reverse transcriptase inhibitor therapyK Mulligan
Department of Medicine, University of California San Francisco, 94110, USA
J Acquir Immune Defic Syndr 26:443-8. 2001..Our results, which have been obtained retrospectively, are intended to provide the impetus for prospective, controlled studies of the interactions among drug and host factors in the development of fat distribution abnormalities... - Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infectionK Mulligan
Department of Medicine, University of California, San Francisco General Hospital, 94110, USA
J Acquir Immune Defic Syndr 23:35-43. 2000..However, at the moment, the risks associated with these metabolic effects do not appear to outweigh improvements in survival seen with PI therapy... - Metabolic effects of indinavir in healthy HIV-seronegative menM A Noor
Department of Medicine, University of California at San Francisco, California, USA
AIDS 15:F11-8. 2001..CONCLUSIONS: In the absence of HIV infection, treatment with indinavir for 4 weeks causes insulin resistance independent of increases in visceral adipose tissue or lipid and lipoprotein levels... - Pregnancy outcomes in women with congenital virilizing adrenal hyperplasiaJ C Lo
Department of Medicine, University of California, San Francisco, USA
Endocrinol Metab Clin North Am 30:207-29. 2001..In most cases, successful gestational management requires the close coordination of care between the obstetrician and endocrinologist... - Single-dose lopinavir-ritonavir acutely inhibits insulin-mediated glucose disposal in healthy volunteersGrace A Lee
Department of Medicine, University of California, San Francisco, California, USA
Clin Infect Dis 43:658-60. 2006..Insulin resistance from protease inhibitors may decrease with prolonged use; an increase in adiponectin levels may mediate this effect... - Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteersGrace A Lee
Department of Medicine, University of California, San Francisco, California, USA
AIDS 21:2183-90. 2007..Some HIV protease inhibitors (PIs) have been shown to induce insulin resistance in vitro but the degree to which specific PIs affect insulin sensitivity in humans is less well understood... - Indinavir increases glucose production in healthy HIV-negative menJean-Marc Schwarz
Department of Medicine, University of California, San Francisco, CA, USA
AIDS 18:1852-4. 2004..During the euglycemic hyperinsulinemic clamp, indinavir blunted the ability of insulin to suppress glucose production. Therefore, indinavir worsens hepatic insulin sensitivity, increasing endogenous glucose production... - The metabolic effects of lopinavir/ritonavir in HIV-negative menGrace A Lee
Metabolism Section 111F, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
AIDS 18:641-9. 2004..Therefore, we tested the effects of the PI combination lopinavir and ritonavir on glucose and lipid metabolism in HIV-negative subjects... - Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive studyKristine Yaffe
Department of Psychiatry, School of Medicine, University of California at San Francisco, San Francisco, California, USA
J Am Geriatr Soc 58:338-45. 2010.... - Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled studyMustafa A Noor
Department of Medicine, University of California, Berkeley, California, USA
AIDS 16:F1-8. 2002..Our data are compatible with the hypothesis that an acute effect of indinavir on glucose disposal in humans is mediated by a direct blockade of GLUT-4 transporters... - Occult virilizing ovarian tumours in postmenopausal women: problems in evaluation with reference to a caseK C Loh
Department of Pathology, University of California, San Francisco, USA
Ann Acad Med Singapore 27:712-6. 1998..This approach avoids unnecessary investigations and delays in definitive management... - The metabolic syndrome and chronic kidney diseaseCarmen A Peralta
Department of Medicine, University of California San Francisco, CA 94118, USA
Curr Opin Nephrol Hypertens 15:361-5. 2006.... - The relationship between nucleoside analogue treatment duration, insulin resistance, and fasting arterialized lactate level in patients with HIV infectionJoan C Lo
Department of Medicine, University of California San Francisco, CA, USA
Clin Infect Dis 41:1335-40. 2005..We examined the association of NRTI treatment duration and lactate level in human immunodeficiency virus (HIV)-infected patients and assessed the relationship of treatment duration and lactate level with insulin resistance... - Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infectionPriscilla Y Hsue
Division of Cardiology, San Francisco General Hospital, and the Department of Medicine, University of California, San Francisco, CA 94110, USA
Circulation 109:1603-8. 2004..In HIV patients, carotid IMT is associated with classic coronary risk factors and with nadir CD4 count < or =200, suggesting that immunodeficiency and traditional coronary risk factors may contribute to atherosclerosis... - Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adultsManjula Kurella
University of California San Francisco, Department of Nephrology, Laurel Heights, 3333 California Street, Suite 430, San Francisco, CA 94118-1211, USA
J Am Soc Nephrol 16:2134-40. 2005..24 (95% CI, 1.01 to 1.51). The metabolic syndrome is independently associated with an increased risk for incident CKD in nondiabetic adults... - Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormoneLaura A Napolitano
Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
AIDS 16:1103-11. 2002..CONCLUSION: GH has significant effects on the human immune system, including the reversal of thymic atrophy in HIV-1-infected adults. De-novo T cell production may thus be inducible in immunodeficient adults... - Value of the sagittal abdominal diameter in coronary heart disease risk assessment: cohort study in a large, multiethnic populationCarlos Iribarren
Division of Research, Kaiser Permanente of Northern California, Oakland 94612, and Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco General Hospital, CA, USA
Am J Epidemiol 164:1150-9. 2006..In conclusion, standing sagittal abdominal diameter was a strong predictor of CHD independently of BMI and added incremental CHD risk prediction at each level of BMI... - The association of genetic polymorphisms in sex hormone biosynthesis and action with insulin sensitivity and diabetes mellitus in women at midlifeJoan C Lo
Division of Research, Kaiser Permanente Northern California, Oakland, California, USA
Am J Med 119:S69-78. 2006..The strong association of 17HSD and diabetes in Caucasian women has not been previously reported and should be further investigated... - Effects of recombinant human growth hormone on hepatic lipid and carbohydrate metabolism in HIV-infected patients with fat accumulationJean Marc Schwarz
Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California 94720 3104, USA
J Clin Endocrinol Metab 87:942. 2002..The combined implications of these positive and negative metabolic effects for cardiovascular disease risk remain unknown... - HIV protease inhibitors increase adiponectin levels in HIV-negative menGrace A Lee
J Acquir Immune Defic Syndr 36:645-7. 2004 - Epidemiology of non-dialysis-requiring chronic kidney disease and cardiovascular diseaseAlan S Go
Division of Research, Kaiser Permanente of Northern California, Oakland, CA 94612 2304, USA
Curr Opin Nephrol Hypertens 15:296-302. 2006..To review recent literature about the relationship between non-dialysis-requiring chronic kidney disease and cardiovascular disease as well as possible explanatory factors... - GFR, body mass index, and low high-density lipoprotein concentration in adults with and without CKDJoan C Lo
Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
Am J Kidney Dis 50:552-8. 2007..Low high-density lipoprotein (HDL) cholesterol level is common in patients with chronic kidney disease, but associations between severity of chronic kidney disease, obesity, and HDL level have not been well defined... - Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndromeJoan C Lo
Division of Research, Kaiser Permanente of Northern California, 2000 Broadway Street, 2nd Floor, Oakland, CA 94612 2304, USA
J Clin Endocrinol Metab 91:1357-63. 2006..Polycystic ovary syndrome (PCOS) is associated with menstrual and reproductive abnormalities, insulin resistance, and obesity... - Duration of lactation is associated with lower prevalence of the metabolic syndrome in midlife--SWAN, the study of women's health across the nationKavitha T Ram
Department of Obstetrics and Gynecology, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Am J Obstet Gynecol 198:268.e1-6. 2008..The objective of the study was to evaluate whether lactation duration is associated with lower prevalence of metabolic syndrome (MetSyn) in midlife, parous women...