Research Topics
| Bernard LoSummaryAffiliation: University of California Country: USA Publications
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Publications
Ethical issues in stem cell researchBernard Lo
University of California San Francisco Program in Medical Ethics, San Francisco, California 94143, USA
Endocr Rev 30:204-13. 2009..This article provides a critical analysis of these issues and how they are addressed in current policies...
Importing human pluripotent stem cell lines derived at another institution: tailoring review to ethical concernsBernard Lo
Program in Medical Ethics, University of California San Francisco, San Francisco, CA 94143, USA
Cell Stem Cell 4:115-23. 2009..To maintain public trust, research institutions need to justify why they allow researchers to use lines whose derivation would not have been permitted locally...
Informed consent in human oocyte, embryo, and embryonic stem cell researchBernard Lo
Program in Medical Ethics and the Division of General Internal Medicine, Department of Medicine, University of California at San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0903, USA
Fertil Steril 82:559-63. 2004..Treating assisted reproduction technology physicians can help with the consent process, provided that they are not involved in the research...- Life support for patients without a surrogate decision maker: who decides?Douglas B White
University of California, San Francisco, and San Francisco General Hospital, San Francisco, California 94143 0903, USA
Ann Intern Med 147:34-40. 2007..Physicians in intensive care units have withdrawn life support in incapacitated patients who lack surrogate decision makers and advance directives, yet little is known about how often this occurs or under what circumstances... - Hope, truth, and preparing for death: perspectives of surrogate decision makersLatifat Apatira
University of California, San Francisco, and San Francisco General Hospital, San Francisco, California 94143, USA
Ann Intern Med 149:861-8. 2008..Although many physicians worry that openly discussing a poor prognosis will cause patients and families to lose hope, surrogate decision makers' perspectives on this topic are largely unknown... - Untapped potential: IRB guidance for the ethical research use of stored biological materialsLeslie E Wolf
Program in Medical Ethics, University of California-San Francisco, USA
IRB 26:1-8. 2004 - A new era in the ethics of human embryonic stem cell researchBernard Lo
Program in Medical Ethics and Division of General Internal Medicine, University of California San Francisco, San Francisco, California, USA
Stem Cells 23:1454-9. 2005..Lack of attention to the special ethical concerns raised by clinical trials of hESC transplantation and their implications for the derivation of new hESC lines may undermine or delay progress toward stem cell therapies... - The language of prognostication in intensive care unitsDouglas B White
Program in Medical Ethics, Department of Medicine, University of California, San Francisco, CA, USA
Med Decis Making 30:76-83. 2010..Rationale. Although misunderstandings about prognosis are common in intensive care units (ICUs), little is known about how physicians actually communicate prognostic information... - Who should receive life support during a public health emergency? Using ethical principles to improve allocation decisionsDouglas B White
Program in Medical Ethics, School of Medicine, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0903, USA
Ann Intern Med 150:132-8. 2009..We discuss strategies to engage the public in setting the priorities that will guide allocation of scarce life-sustaining treatments during a public health emergency... - Are physicians' recommendations to limit life support beneficial or burdensome? Bringing empirical data to the debateDouglas B White
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143, USA
Am J Respir Crit Care Med 180:320-5. 2009..Although there is a growing belief that physicians should routinely provide a recommendation to surrogates during deliberations about withdrawing life support, there is a paucity of empirical data on surrogates' perspectives on this topic... - Cloning mice and men: prohibiting the use of iPS cells for human reproductive cloningBernard Lo
Program in Medical Ethics, Department of Medicine, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
Cell Stem Cell 6:16-20. 2010..Professional standards and laws that ban human reproductive cloning by somatic cell nuclear transfer should be revised to also forbid it by other methods, such as iPSCs via tetraploid complementation... - Surrogate decision-makers' perspectives on discussing prognosis in the face of uncertaintyLeah R Evans
Division of Pulmonary and Critical Care Medicine, University of California School of Medicine, San Francisco, California 94143 0903, USA
Am J Respir Crit Care Med 179:48-53. 2009..Many physicians are reluctant to discuss a patient's prognosis when there is significant prognostic uncertainty... - Commentary: Conflict of interest policies: an opportunity for the medical profession to take the leadBernard Lo
Program in Medical Ethics, Division of General Internal Medicine, and Department of Medicine, University of California San Francisco, San Francisco, California 94143 0903, USA
Acad Med 85:9-11. 2010..The author concludes that these articles show that physician leaders, AHCs, and professional societies can continue to take the lead by developing, implementing, enforcing, evaluating, and improving thoughtful and effective COI policies... - Institutional review board guidance on pediatric research: missed opportunitiesLeslie E Wolf
Program in Medical Ethics, Center for AIDS Prevention Studies, San Francisco, CA 94143, USA
J Pediatr 147:84-9. 2005..To examine whether and how institutional review boards (IRBs) are using their web-sites to provide guidance to investigators conducting pediatric research... - Clinical trials in stem cell transplantation: guidelines for scientific and ethical reviewBernard Lo
Program in Medical Ethics and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0903, USA
Clin Trials 5:517-22. 2008..Transplantation of cells derived through the manipulation of pluripotent stem cells may involve great uncertainty and the possibility of serious risks... - Navigating language barriers under difficult circumstancesYael Schenker
University of California, San Francisco, California 94143, USA
Ann Intern Med 149:264-9. 2008..This conceptual and practical approach can help clinicians to improve the quality of care provided to patients with limited English proficiency... - Lessons from an HIV transmission pairFrederick M Hecht
Division of HIV/AIDS, Department of Medicine, University of California, San Francisco, CA 94110, USA
J Infect Dis 195:1239-41. 2007 - Prognostication during physician-family discussions about limiting life support in intensive care unitsDouglas B White
Division of Pulmonary and Critical Care Medicine, Program in Medical Ethics, Department of Medicine, University of California, San Francisco, USA
Crit Care Med 35:442-8. 2007.... - Human subjects issues and IRB review in practice-based researchLeslie E Wolf
University of California, San Francisco, San Francisco, California 94143 0903, USA
Ann Fam Med 3:S30-7. 2005..This article explores the challenges that practice-based research networks (PBRNs) face with respect to the regulatory requirements for institutional review board (IRB) review and the protection of human subjects in research... - The obligation to provide antiretroviral treatment in HIV prevention trialsBernard Lo
Program in Medical Ethics, Center for AIDS Prevention Studies and Division of General Internal Medicine, University of California San Francisco, San Francisco, CA, USA
AIDS 21:1229-31. 2007..Such an assurance should be done in a way that also improves access to ART for others in the country. US funds for ART in poor countries from the PEPFAR should be available to all countries that host HIV prevention and clinical trials... - The certificate of confidentiality application: a view from the NIH InstitutesLeslie E Wolf
Program in Medical Ethics, University of California-San Francisco, CA, USA
IRB 26:14-8. 2004 - HIPAA and patient care: the role for professional judgmentBernard Lo
Program in Medical Ethics and Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA 94143 0903, USA
JAMA 293:1766-71. 2005..Physicians should work with risk managers and practice administrators to develop policies that promote good communication in patient care, while taking appropriate steps to protect patient privacy... - Clinical trial design issues raised during recombinant DNA advisory committee review of gene transfer protocolsTiffany Scharschmidt
School of Medicine and Program in Medical Ethics, and Division of General Internal Medicine, University of California San Francisco, San Francisco, CA 94143-0903, USA
Hum Gene Ther 17:448-54. 2006..Such attention might help strengthen clinical trial protocols, shorten the protocol development process, and enhance the protection of research participants... - Medicine. Consent from donors for embryo and stem cell researchBernard Lo
Program in Medical Ethics, School of Medicine at the University of California, San Francisco, CA 94143, USA
Science 301:921. 2003..Some gamete donors who are willing to help women and couples bear children may object to the use of their genetic materials for certain types of research... - Decisions to limit life-sustaining treatment for critically ill patients who lack both decision-making capacity and surrogate decision-makersDouglas B White
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco School of Medicine, San Francisco, CA, USA
Crit Care Med 34:2053-9. 2006..Decisions to limit life support were generally made by physicians without judicial or institutional review. Further research and debate are needed to develop optimal decision-making strategies for these difficult cases... - Ethics and the practice of brain scienceBernard Lo
Program in Medical Ethics, University of California, San Francisco, CA, USA
Cerebrum 4:64-6. 2002 - Clinical decision making during public health emergencies: ethical considerationsBernard Lo
Division of General Internal Medicine, University of California, San Francisco, CA 94143 0903, USA
Ann Intern Med 143:493-8. 2005..Before an emergency occurs, physicians should think through how they will respond to foreseeable dilemmas arising when patients disagree with public health recommendations... - Historical perspective and evolving concerns for human researchBernard Lo
Program in Medical Ethics, Department of Medicine, University of California San Francisco San Francisco, California, USA
Cancer Treat Res 132:1-10. 2007 - Medical students' experiences with medical errors: an analysis of medical student essaysWilliam Martinez
University of California San Francisco Berkeley Joint Medical Program, San Francisco, California, USA
Med Educ 42:733-41. 2008..This study aimed to examine medical students' experiences with medical errors... - Legal barriers to implementing recommendations for universal, routine prenatal HIV testingLeslie E Wolf
Program in Medical Ethics, Center for AIDS Prevention Studies, Division of General Internal Medicine, University of California, San Francisco, USA
J Law Med Ethics 32:137-47. 2004 - Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trialSusan P Buchbinder
HIV Research Section, San Francisco Department of Public Health, San Francisco, CA, USA
Lancet 372:1881-93. 2008..The Step Study directly assessed the efficacy of a cell-mediated immunity vaccine to protect against HIV-1 infection or change in early plasma HIV-1 levels...