James O Lloyd-Smith

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Autonomous targeting of infectious superspreaders using engineered transmissible therapies
    Vincent T Metzger
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America
    PLoS Comput Biol 7:e1002015. 2011
  2. pmc Vacated niches, competitive release and the community ecology of pathogen eradication
    James O Lloyd-Smith
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, 610 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120150. 2013
  3. pmc Epidemic dynamics at the human-animal interface
    James O Lloyd-Smith
    Department of Ecology and Evolutionary Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 326:1362-7. 2009
  4. doi request reprint Modeling density dependence in heterogeneous landscapes: dispersal as a case study
    James O Lloyd-Smith
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA
    J Theor Biol 265:160-6. 2010
  5. pmc Pathogen-host associations and predicted range shifts of human monkeypox in response to climate change in central Africa
    Henri A Thomassen
    Center for Tropical Research, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 8:e66071. 2013
  6. doi request reprint Incongruent HIV and tuberculosis co-dynamics in Kenya: interacting epidemics monitor each other
    Maria S Sanchez
    Department of Environmental Science, Policy and Management, University of California, 137 Mulford Hall, Berkeley, CA 94720 3112, USA
    Epidemics 1:14-20. 2009
  7. pmc Multiple scales of selection influence the evolutionary emergence of novel pathogens
    Miran Park
    Department of Ecology and Evolutionary Biology, University of California, 610 Charles E Young Dr South, Los Angeles, CA 90095, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120333. 2013
  8. ncbi request reprint A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity
    Hangfei Qi
    Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Pathog 10:e1004064. 2014
  9. pmc Monitoring linked epidemics: the case of tuberculosis and HIV
    Maria S Sanchez
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California, United States of America
    PLoS ONE 5:e8796. 2010
  10. ncbi request reprint Dynamics and management of infectious disease in colonizing populations
    Shirli Bar-David
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    Ecology 87:1215-24. 2006

Detail Information

Publications24

  1. pmc Autonomous targeting of infectious superspreaders using engineered transmissible therapies
    Vincent T Metzger
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America
    PLoS Comput Biol 7:e1002015. 2011
    ..While demonstrated here for HIV, the TIP concept could apply broadly to many viral infectious diseases and would represent a new paradigm for disease control, away from pathogen eradication but toward robust disease suppression...
  2. pmc Vacated niches, competitive release and the community ecology of pathogen eradication
    James O Lloyd-Smith
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, 610 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120150. 2013
    ..I focus on the case study of human monkeypox and its rise following smallpox eradication, but also survey how these ideas apply to other pathogens and discuss implications for eradication policy. ..
  3. pmc Epidemic dynamics at the human-animal interface
    James O Lloyd-Smith
    Department of Ecology and Evolutionary Biology, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 326:1362-7. 2009
    ..Progress in understanding and combating zoonoses requires a new generation of models that addresses a broader set of pathogen life histories and integrates across host species and scientific disciplines...
  4. doi request reprint Modeling density dependence in heterogeneous landscapes: dispersal as a case study
    James O Lloyd-Smith
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA
    J Theor Biol 265:160-6. 2010
    ..Other circumstances may require different formulations, but modelers must ensure that these have appropriate scaling and non-equilibrium behavior...
  5. pmc Pathogen-host associations and predicted range shifts of human monkeypox in response to climate change in central Africa
    Henri A Thomassen
    Center for Tropical Research, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 8:e66071. 2013
    ....
  6. doi request reprint Incongruent HIV and tuberculosis co-dynamics in Kenya: interacting epidemics monitor each other
    Maria S Sanchez
    Department of Environmental Science, Policy and Management, University of California, 137 Mulford Hall, Berkeley, CA 94720 3112, USA
    Epidemics 1:14-20. 2009
    ..Kenya is heralded as an example of declining HIV in Africa, while its tuberculosis (TB) numbers continue rising. We conducted a comparative investigation of TB-HIV co-dynamics in Africa to determine the likelihood of reported trends...
  7. pmc Multiple scales of selection influence the evolutionary emergence of novel pathogens
    Miran Park
    Department of Ecology and Evolutionary Biology, University of California, 610 Charles E Young Dr South, Los Angeles, CA 90095, USA
    Philos Trans R Soc Lond B Biol Sci 368:20120333. 2013
    ..Our cross-scale model represents a step towards integrating laboratory experiments with field surveillance data to create a rational framework to assess emergence risk...
  8. ncbi request reprint A quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivity
    Hangfei Qi
    Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Pathog 10:e1004064. 2014
    ....
  9. pmc Monitoring linked epidemics: the case of tuberculosis and HIV
    Maria S Sanchez
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California, United States of America
    PLoS ONE 5:e8796. 2010
    ..The tight epidemiological coupling between HIV and its associated opportunistic infections leads to challenges and opportunities for disease surveillance...
  10. ncbi request reprint Dynamics and management of infectious disease in colonizing populations
    Shirli Bar-David
    Department of Environmental Science, Policy and Management, University of California, Berkeley 94720 3112, USA
    Ecology 87:1215-24. 2006
    ..Recognizing which of our three general cases best describes a particular outbreak will aid in planning an efficient strategy to contain the disease...
  11. pmc Intergenerational phenotypic mixing in viral evolution
    Claude Loverdo
    Department of Ecology and Evolutionary Biology, University of California Los Angeles, CA 90095, USA
    Evolution 67:1815-22. 2013
    ..Modeling the dynamics of viral evolution in these contexts thus requires attention to the mutational mechanism and the determinants of fitness...
  12. pmc Curtailing transmission of severe acute respiratory syndrome within a community and its hospital
    James O Lloyd-Smith
    Biophysics Graduate Group, University of California, Berkeley, CA 94720, USA
    Proc Biol Sci 270:1979-89. 2003
    ..The implications of our results for future emerging pathogens are discussed...
  13. pmc Potential impact of vaccination on the hepatitis C virus epidemic in injection drug users
    Judith A Hahn
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0811, USA
    Epidemics 1:47-57. 2009
    ....
  14. pmc Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo
    Anne W Rimoin
    University of California, Los Angeles School of Public Health, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:16262-7. 2010
    ..Improved surveillance and epidemiological analysis is needed to better assess the public health burden and develop strategies for reducing the risk of wider spread of infection...
  15. pmc Using remote sensing to map the risk of human monkeypox virus in the Congo Basin
    Trevon Fuller
    Center for Tropical Research, Institute of the Environment, University of California, Los Angeles, 619 Charles E Young Dr East, Los Angeles, CA 90095 1496, USA
    Ecohealth 8:14-25. 2011
    ..32; 95% CI 1.08-1.63). We recommend that semi-deciduous rainforests with oil-palm, the rope squirrel's main food source, be prioritized for monitoring...
  16. pmc Phylodynamic analysis of the emergence and epidemiological impact of transmissible defective dengue viruses
    Ruian Ke
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California, United States of America
    PLoS Pathog 9:e1003193. 2013
    ..They also demonstrate that interactions between viral variants, such as complementation, can open new pathways to viral emergence...
  17. pmc Evolutionary analysis of human immunodeficiency virus type 1 therapies based on conditionally replicating vectors
    Ruian Ke
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, California, USA
    PLoS Comput Biol 8:e1002744. 2012
    ....
  18. doi request reprint Invasion dynamics in spatially heterogeneous environments
    Sebastian J Schreiber
    Department of Evolution and Ecology and Center for Population Biology, University of California, Davis, California 95616, USA
    Am Nat 174:490-505. 2009
    ..Sensitivity analysis of our models provides guidance for control efforts...
  19. ncbi request reprint The effect of treatment on pathogen virulence
    Travis C Porco
    San Francisco Department of Public Health, 101 Grove St, Suite 204, San Francisco, CA, USA
    J Theor Biol 233:91-102. 2005
    ..Thus we show that conflict can arise between the epidemiological benefits of treatment and the evolutionary risks of heightened virulence...
  20. doi request reprint Modelling clinical data shows active tissue concentration of daclatasvir is 10-fold lower than its plasma concentration
    Ruian Ke
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, USA
    J Antimicrob Chemother 69:724-7. 2014
    ..Daclatasvir is a highly potent inhibitor of hepatitis C virus. We estimated the active tissue concentration of daclatasvir in vivo...
  21. doi request reprint Impact of HIV on novel therapies for tuberculosis control
    Maria S Sanchez
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3114, USA
    AIDS 22:963-72. 2008
    ..We investigated how tuberculosis is impacted by reducing treatment duration alone or combined with enhanced case detection and/or cure under different HIV prevalence levels...
  22. pmc Evolutionary invasion and escape in the presence of deleterious mutations
    Claude Loverdo
    Department of Ecology and Evolutionary Biology, University of California Los Angeles, Los Angeles, California, USA
    PLoS ONE 8:e68179. 2013
    ..These conclusions are robust for more realistic or mechanistic depictions of the fitness landscapes such as a more detailed viral life history, or non-lethal deleterious mutations. ..
  23. doi request reprint Influence of viral replication mechanisms on within-host evolutionary dynamics
    Claude Loverdo
    Department of Ecology and Evolutionary Biology, University of California, Los Angeles, California 90095, USA
    Evolution 66:3462-71. 2012
    ....
  24. ncbi request reprint Likelihood ridges and multimodality in population growth rate models
    Leo Polansky
    Department of Environmental Science, Policy, and Management, University of California, 137 Mulford Hall, Berkeley, California 94720 3112, USA
    Ecology 90:2313-20. 2009
    ....