Alessandra Livraghi

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways
    Alessandra Livraghi-Butrico
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, The University of North Carolina at Chapel Hill, 6029 Thurston Bowles Bldg, Chapel Hill, NC 25799 7248, USA
    Am J Physiol Lung Cell Mol Physiol 304:L469-80. 2013
  2. pmc Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation
    A Livraghi-Butrico
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Mucosal Immunol 5:397-408. 2012
  3. pmc Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction
    Alessandra Livraghi-Butrico
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Physiol Genomics 44:470-84. 2012
  4. pmc Modelling dysregulated Na+ absorption in airway epithelial cells with mucosal nystatin treatment
    Alessandra Livraghi
    University of North Carolina at Chapel Hill, Cystic Fibrosis Pulmonary Research and Treatment Center, CB 7248 Thurston Bowles Bldg, Room 6029, Chapel Hill, NC 27599, USA
    Am J Respir Cell Mol Biol 38:423-34. 2008
  5. pmc Airway and lung pathology due to mucosal surface dehydration in {beta}-epithelial Na+ channel-overexpressing mice: role of TNF-{alpha} and IL-4R{alpha} signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment
    Alessandra Livraghi
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599, USA
    J Immunol 182:4357-67. 2009
  6. ncbi request reprint Cystic fibrosis and other respiratory diseases of impaired mucus clearance
    Alessandra Livraghi
    Cystic Fibrosis Pulmonary Research and Treatment Center, Department of Medicine, The University of North Carolina at Chapel Hill, 27599, USA
    Toxicol Pathol 35:116-29. 2007
  7. pmc The mitochondrial barriers segregate agonist-induced calcium-dependent functions in human airway epithelia
    Carla M Pedrosa Ribeiro
    Cystic Fibrosis Pulmonary Research and Treatment Center and Department of Medicine, The University of North Carolina at Chapel Hill, NC 27599 7248, USA
    J Gen Physiol 122:377-87. 2003
  8. ncbi request reprint Inhibition of nonviral cationic liposome-mediated gene transfer into primary human respiratory cells by interferon-gamma
    Giovanna Sersale
    Institute for Experimental Treatment of Cystic Fibrosis, San Raffaele Scientific Institute, Via Olgettina 58, Milan 20132, Italy
    J Mol Med (Berl) 80:499-506. 2002
  9. pmc Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Am J Respir Crit Care Med 177:730-42. 2008

Collaborators

Detail Information

Publications9

  1. pmc Loss of Cftr function exacerbates the phenotype of Na(+) hyperabsorption in murine airways
    Alessandra Livraghi-Butrico
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, The University of North Carolina at Chapel Hill, 6029 Thurston Bowles Bldg, Chapel Hill, NC 25799 7248, USA
    Am J Physiol Lung Cell Mol Physiol 304:L469-80. 2013
    ....
  2. pmc Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation
    A Livraghi-Butrico
    Cystic Fibrosis Pulmonary Research and Treatment Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Mucosal Immunol 5:397-408. 2012
    ..Collectively, these data suggest that dehydration-induced mucus stasis promotes infection, compounds defects in other immune mechanisms, and alone is sufficient to trigger airway inflammation...
  3. pmc Genetically determined heterogeneity of lung disease in a mouse model of airway mucus obstruction
    Alessandra Livraghi-Butrico
    Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Physiol Genomics 44:470-84. 2012
    ..In summary, the genetic context and timing of airway innate immune dysfunction critically determines lung disease phenotype. These mouse strains may be useful to identify key modifier genes and pathways...
  4. pmc Modelling dysregulated Na+ absorption in airway epithelial cells with mucosal nystatin treatment
    Alessandra Livraghi
    University of North Carolina at Chapel Hill, Cystic Fibrosis Pulmonary Research and Treatment Center, CB 7248 Thurston Bowles Bldg, Room 6029, Chapel Hill, NC 27599, USA
    Am J Respir Cell Mol Biol 38:423-34. 2008
    ..We conclude that mucosal Nys treatment of HBEs provides a simple in vitro model to recapitulate the Na(+) and volume hyperabsorptive features of CF airway epithelia...
  5. pmc Airway and lung pathology due to mucosal surface dehydration in {beta}-epithelial Na+ channel-overexpressing mice: role of TNF-{alpha} and IL-4R{alpha} signaling, influence of neonatal development, and limited efficacy of glucocorticoid treatment
    Alessandra Livraghi
    Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, 27599, USA
    J Immunol 182:4357-67. 2009
    ..Thus, manipulation of multiple pathways will likely be required to treat the complex pathogenesis caused by airway surface dehydration...
  6. ncbi request reprint Cystic fibrosis and other respiratory diseases of impaired mucus clearance
    Alessandra Livraghi
    Cystic Fibrosis Pulmonary Research and Treatment Center, Department of Medicine, The University of North Carolina at Chapel Hill, 27599, USA
    Toxicol Pathol 35:116-29. 2007
    ..These models firmly establish the importance of mucus clearance for respiratory health, and will help elucidate disease mechanisms and therapeutic strategies in CF, PCD and COPD...
  7. pmc The mitochondrial barriers segregate agonist-induced calcium-dependent functions in human airway epithelia
    Carla M Pedrosa Ribeiro
    Cystic Fibrosis Pulmonary Research and Treatment Center and Department of Medicine, The University of North Carolina at Chapel Hill, NC 27599 7248, USA
    J Gen Physiol 122:377-87. 2003
    ....
  8. ncbi request reprint Inhibition of nonviral cationic liposome-mediated gene transfer into primary human respiratory cells by interferon-gamma
    Giovanna Sersale
    Institute for Experimental Treatment of Cystic Fibrosis, San Raffaele Scientific Institute, Via Olgettina 58, Milan 20132, Italy
    J Mol Med (Berl) 80:499-506. 2002
    ....
  9. pmc Development of chronic bronchitis and emphysema in beta-epithelial Na+ channel-overexpressing mice
    Marcus A Mall
    Pediatric Pulmonology and Cystic Fibrosis Center, Department of Pediatrics III, University of Heidelberg, Im Neuenheimer Feld 153, 69120 Heidelberg, Germany
    Am J Respir Crit Care Med 177:730-42. 2008
    ..Previous studies have shown that airway surface dehydration in beta-epithelial Na(+) channel (betaENaC)-overexpressing mice caused a chronic lung disease with high neonatal pulmonary mortality and chronic bronchitis in adult survivors...