Research Topics
| Chad A LivasySummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Identification of a basal-like subtype of breast ductal carcinoma in situChad A Livasy
Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Hum Pathol 38:197-204. 2007..0001), p53 overexpression (P < .0001), and elevated Ki-67 index (P < .0001). These studies demonstrate the presence of a basal-like in situ carcinoma, a potential precursor lesion to invasive basal-like carcinoma...- Phenotypic evaluation of the basal-like subtype of invasive breast carcinomaChad A Livasy
Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Mod Pathol 19:264-71. 2006..These findings should further assist in the identification of basal-like carcinomas in clinical specimens, facilitating treatment and epidemiologic studies of this tumor subtype... - The clinical significance of a negative loop electrosurgical cone biopsy for high-grade dysplasiaChad A Livasy
Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7525, USA
Obstet Gynecol 104:250-4. 2004..We sought to estimate the incidence and clinical significance of a negative therapeutic loop electrosurgical excision procedure (LEEP) and to evaluate patient specimens for limiting histologic features associated with a negative LEEP... - Focal adhesion kinase overexpression in endometrial neoplasiaChad A Livasy
Department of Pathology, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Appl Immunohistochem Mol Morphol 12:342-5. 2004..FAK overexpression in endometrial carcinoma correlates with higher FIGO grade and p53 overexpression... - EGFR expression and HER2/neu overexpression/amplification in endometrial carcinosarcomaChad A Livasy
Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
Gynecol Oncol 100:101-6. 2006..The aim of this study was to evaluate for HER2 and EGFR expression in cases of endometrial carcinosarcoma... 
Local control following single-dose intraoperative radiotherapy prior to surgical excision of early-stage breast cancerRandall J Kimple
Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Ann Surg Oncol 18:939-45. 2011..This study details our completed, single-institution trial...- High focal adhesion kinase expression in invasive breast carcinomas is associated with an aggressive phenotypeAmy L Lark
Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Mod Pathol 18:1289-94. 2005..The presence of strong FAK expression in many high grade, estrogen- and progesterone-negative breast carcinomas indicates that FAK may be an attractive target for therapeutic intervention... - Race, breast cancer subtypes, and survival in the Carolina Breast Cancer StudyLisa A Carey
Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
JAMA 295:2492-502. 2006..Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B... 
Cosmetic outcomes for accelerated partial breast irradiation before surgical excision of early-stage breast cancer using single-dose intraoperative radiotherapyRandall J Kimple
Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Int J Radiat Oncol Biol Phys 79:400-7. 2011..Determine cosmetic outcome and toxicity profile of intraoperative radiation delivered before tumor excision for patients with early-stage breast cancer...- Upregulation of focal adhesion kinase (FAK) expression in ductal carcinoma in situ (DCIS) is an early event in breast tumorigenesisHarry M Lightfoot
Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Breast Cancer Res Treat 88:109-16. 2004..0001) and IDC (p = 0.02). We conclude that FAK overexpression in preinvasive, DCIS tumors precedes tumor cell invasion or metastasis, suggesting that FAK may function as a survival signal and be an early event in breast tumorigenesis... 
The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based studyKathleen Conway
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Breast Cancer Res 7:R871-80. 2005..This mutation was initially reported in one-third of hyperplastic benign breast lesions, although several recent studies failed to detect it in benign or malignant breast tissues...- Molecular characterization of human breast tumor vascular cellsRajendra Bhati
Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Pathol 172:1381-90. 2008..Therefore, these genetic markers may serve as potential targets for the development of angiogenesis inhibitors... - Methylation-dependent silencing of CST6 in primary human breast tumors and metastatic lesionsAshley G Rivenbark
Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
Exp Mol Pathol 83:188-97. 2007..Overall, the results of the current investigation suggest that methylation-dependent epigenetic silencing of CST6 represents an important mechanism for loss of CST6 during breast tumorigenesis and/or progression to metastasis... - Overexpression of the receptor tyrosine kinase Tie-1 intracellular domain in breast cancerXi-Hui Yang
Department of Surgery, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
Tumour Biol 24:61-9. 2003..CONCLUSIONS: We have shown that breast cancer cells overexpress a cleaved form of the Tie-1 protein. Our results implicate the intracellular domain of Tie-1, which includes the catalytic kinase domain, in breast cancer progression... - Use of the ThinPrep method in bile duct brushings: analysis of morphologic parameters associated with malignancy and determination of interobserver reliabilityMichael S Waugh
Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
Diagn Cytopathol 36:651-6. 2008..The relatively high proportion of benign cases thought to be diagnostic of malignancy by at least one reviewer argues for a consensus approach to this diagnosis... - Miliary pulmonary metastases from a clinically occult pleural mesotheliomaChad A Livasy
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, 27599-7525, USA
Ann Diagn Pathol 7:249-53. 2003..Metastatic mesothelioma is a consideration for metastatic pulmonary tumors of unknown origin... - Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analysesAmy L Lark
Department of Pathology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599-7210, USA
Clin Cancer Res 9:215-22. 2003..Furthermore, the majority of colorectal liver metastases demonstrated robust FAK expression equivalent to or greater than that in the primary colorectal tumor... - Feasibility of breast preserving therapy with single fraction in situ radiotherapy delivered intraoperativelyDavid W Ollila
Department of Surgery, UNC Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, 3010 Old Clinic Building, CB 7213, Chapel Hill, NC 27599 7213, USA
Ann Surg Oncol 14:660-9. 2007..We adapted the technique of Veronesi to deliver IORT prior to tumor excision to improve delivery to the region at risk and reduce the volume of normal tissue irradiated... - Effect of breast compression on lesion characteristic visibility with diffraction-enhanced imagingLaura S Faulconer
Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Acad Radiol 17:433-40. 2010..Because DEI possesses inherently superior contrast mechanisms, the current study assesses the effect of breast compression on lesion characteristic visibility with DEI imaging of breast specimens...