Zhi Liu

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Experimental models for the autoimmune and inflammatory blistering disease, Bullous pemphigoid
    Lisa Leighty
    Department of Dermatology, University of North Carolina School of Medicine, 3100 Thurston Bowles, Chapel Hill, NC 27599, USA
    Arch Dermatol Res 299:417-22. 2007
  2. ncbi request reprint Immunopathology of bullous pemphigoid, an autoimmune and inflammatory skin blistering disease
    Zhi Liu
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Keio J Med 52:128-33. 2003
  3. pmc Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid
    Zhi Liu
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Blood 107:1063-9. 2006
  4. pmc Synergy between a plasminogen cascade and MMP-9 in autoimmune disease
    Zhi Liu
    Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:879-87. 2005
  5. ncbi request reprint Inhibition of pemphigus vulgaris by targeting of the CD40-CD154 co-stimulatory pathway: a step toward antigen-specific therapy?
    Zhi Liu
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Invest Dermatol 126:11-3. 2006
  6. ncbi request reprint Bullous pemphigoid: using animal models to study the immunopathology
    Zhi Liu
    Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Investig Dermatol Symp Proc 9:41-6. 2004
  7. ncbi request reprint The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo
    Z Liu
    Department of Dermatology, University of North Carolina, Chapel Hill 27599, USA
    Cell 102:647-55. 2000
  8. pmc Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model
    Zhi Liu
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Autoimmun 31:331-8. 2008
  9. pmc Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases
    Ning Li
    Department of Dermatology, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:3440-50. 2005
  10. ncbi request reprint Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: macrophage-mediated neutrophil infiltration depends on mast cell activation
    Ruoyan Chen
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 169:3987-92. 2002

Research Grants

Collaborators

Detail Information

Publications55

  1. pmc Experimental models for the autoimmune and inflammatory blistering disease, Bullous pemphigoid
    Lisa Leighty
    Department of Dermatology, University of North Carolina School of Medicine, 3100 Thurston Bowles, Chapel Hill, NC 27599, USA
    Arch Dermatol Res 299:417-22. 2007
    ..The development of two novel humanized mouse models for the first time has enabled study of disease mechanisms caused by BP autoantibodies, and presents an ideal in vivo system to test novel therapeutic strategies for disease management...
  2. ncbi request reprint Immunopathology of bullous pemphigoid, an autoimmune and inflammatory skin blistering disease
    Zhi Liu
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Keio J Med 52:128-33. 2003
    ..The IgG passive transfer and active models of BP provide us with invaluable in vivo systems not only for dissecting cellular and humoral responses in BP but also for developing effective therapies for this disease...
  3. pmc Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid
    Zhi Liu
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Blood 107:1063-9. 2006
    ..These data suggest that beta2 integrins play differential roles in experimental BP: LFA-1 is required for neutrophil recruitment, while Mac-1 mediates late neutrophil accumulation and apoptosis of infiltrating neutrophils...
  4. pmc Synergy between a plasminogen cascade and MMP-9 in autoimmune disease
    Zhi Liu
    Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:879-87. 2005
    ..Thus, the Plg/plasmin system is epistatic to MMP-9 activation and subsequent dermal-epidermal separation in BP...
  5. ncbi request reprint Inhibition of pemphigus vulgaris by targeting of the CD40-CD154 co-stimulatory pathway: a step toward antigen-specific therapy?
    Zhi Liu
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Invest Dermatol 126:11-3. 2006
    ..Thus, blockade of this ligand-receptor interaction can prevent the development of antibody-mediated autoimmune diseases through different mechanisms...
  6. ncbi request reprint Bullous pemphigoid: using animal models to study the immunopathology
    Zhi Liu
    Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Investig Dermatol Symp Proc 9:41-6. 2004
    ....
  7. ncbi request reprint The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo
    Z Liu
    Department of Dermatology, University of North Carolina, Chapel Hill 27599, USA
    Cell 102:647-55. 2000
    ..Excess NE produces lesions in GB -/- mice without cleaving alpha1-PI. Excess alpha1-PI phenocopies GB and NE deficiency in wild-type mice...
  8. pmc Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model
    Zhi Liu
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Autoimmun 31:331-8. 2008
    ..The NC16A+/+ mice pretreated with mast cell activation blocker or depleted of complement or neutrophils become resistant to BP. These findings suggest that the humoral response in BP critically depends on innate immune system players...
  9. pmc Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases
    Ning Li
    Department of Dermatology, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    J Clin Invest 115:3440-50. 2005
    ..These data demonstrate that the therapeutic efficacy of HDIG treatment in the pemphigus and pemphigoid models is dependent on FcRn. Thus, FcRn is a promising therapeutic target for treating such IgG-mediated autoimmune diseases...
  10. ncbi request reprint Macrophages, but not T and B lymphocytes, are critical for subepidermal blister formation in experimental bullous pemphigoid: macrophage-mediated neutrophil infiltration depends on mast cell activation
    Ruoyan Chen
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 169:3987-92. 2002
    ..MCs play a major role in neutrophil recruitment into the dermis. Furthermore, Mphi-mediated neutrophil infiltration depends on MC activation/degranulation...
  11. ncbi request reprint Role of FcRs in animal model of autoimmune bullous pemphigoid
    Minglang Zhao
    Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    J Immunol 177:3398-405. 2006
    ..Results from this study establish that Fc gammaRIII plays a critical role in the activation of infiltrating neutrophils and the subsequent blistering in experimental BP...
  12. pmc The role of neutrophils in the induction of glomerulonephritis by anti-myeloperoxidase antibodies
    Hong Xiao
    Department of Pathology and Laboratory Medicine, University of North Carolina, 303 Brinkhous Bullitt Building, Chapel Hill, NC 27599 7525, USA
    Am J Pathol 167:39-45. 2005
    ..This raises the possibility that therapeutic strategies to reduce circulating neutrophils could be beneficial to patients with ANCA-induced NCGN...
  13. pmc Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid
    Lan Lin
    Dalian University of Technology, Dalian, Liaoning, P R China Department of Dermatology, University of North Carolina, Chapel Hill, NC, USA
    Matrix Biol 31:38-44. 2012
    ..These results demonstrate that (i) NE directly damages the extracellular matrix and (ii) NE degradation of mouse BP180 generates neutrophil chemotactic peptides that amplify disease severity at the early stage of the disease...
  14. pmc Role of different pathways of the complement cascade in experimental bullous pemphigoid
    Kelly C Nelson
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 116:2892-900. 2006
    ..These findings provide the first direct evidence to our knowledge that complement activation via the classical and alternative pathways is crucial in subepidermal blister formation in experimental BP...
  15. pmc Involvement of the apoptotic mechanism in pemphigus foliaceus autoimmune injury of the skin
    Ning Li
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 182:711-7. 2009
    ..Collectively, these findings show that biochemical events of apoptosis are provoked in the epidermis of mice injected with PF autoantibodies. Caspase activation may contribute to acantholytic blister formation in PF...
  16. pmc Autoantibodies in the autoimmune disease pemphigus foliaceus induce blistering via p38 mitogen-activated protein kinase-dependent signaling in the skin
    Paula Berkowitz
    Department of Dermatology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599 7287, USA
    Am J Pathol 173:1628-36. 2008
    ..Inhibition of p38 MAPK may be an effective strategy for the treatment of PF...
  17. pmc The C5a receptor on mast cells is critical for the autoimmune skin-blistering disease bullous pemphigoid
    Lisa Heimbach
    Department of Dermatology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:15003-9. 2011
    ..Taken together, these data demonstrate that C5a interacts with C5aR on MCs and that this C5a-C5aR interaction triggers activation of the p38 MAPK pathway, subsequent MC degranulation, and ultimately BP blistering...
  18. doi request reprint Complement and cutaneous autoimmune blistering diseases
    Elizabeth Lessey
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Immunol Res 41:223-32. 2008
    ....
  19. pmc p38MAPK inhibition prevents disease in pemphigus vulgaris mice
    Paula Berkowitz
    Department of Dermatology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7287, USA
    Proc Natl Acad Sci U S A 103:12855-60. 2006
    ..We now report that p38MAPK inhibitors prevented PV blistering disease in vivo. Targeting the end-organ by inhibiting keratinocyte desmosome signaling may be effective for treating desmosome autoimmune blistering disorders...
  20. pmc The Thomsen-Friedenreich antigen-binding lectin jacalin interacts with desmoglein-1 and abrogates the pathogenicity of pemphigus foliaceus autoantibodies in vivo
    Ning Li
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Invest Dermatol 130:2773-80. 2010
    ..TF-specific binding ligands may have a potential therapeutic value for PF...
  21. pmc Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid
    Z Liu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Exp Med 188:475-82. 1998
    ..These results implicate neutrophil-derived gelatinase B in the pathogenesis of experimental BP and might lead to novel therapeutic strategies for BP...
  22. pmc Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice
    Hong Xiao
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Clin Invest 110:955-63. 2002
    ..This animal model offers strong support for a direct pathogenic role for ANCA IgG in human glomerulonephritis and vasculitis...
  23. ncbi request reprint A subset of pemphigus foliaceus patients exhibits pathogenic autoantibodies against both desmoglein-1 and desmoglein-3
    Luis A Arteaga
    Department of Dermatology, University of North Carolina at Chapel Hill, 27599, USA
    J Invest Dermatol 118:806-11. 2002
    ..These results suggest that a subset of patients with pemphigus foliaceus and fogo selvagem have antibodies to desmoglein-3 that may be involved in the pathogenesis of their cutaneous disease...
  24. ncbi request reprint Are anti-BP180 IgG1 or IgG4 autoantibodies pathogenic?
    Zhi Liu
    Departments of Dermatology, Microbiology and Immunology, University of North Carolina, Chapel Hill, USA
    J Invest Dermatol 119:989-90. 2002
  25. pmc A critical role for neutrophil elastase in experimental bullous pemphigoid
    Z Liu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Clin Invest 105:113-23. 2000
    ..Finally, NE cleaved BP180 in vitro and in vivo. These results implicate NE directly in the dermal-epidermal cleavage induced by anti-BP180 antibodies in the experimental BP model...
  26. ncbi request reprint Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients
    David T Woodley
    Department of Dermatology, The Keck School of Medicine at the University of Southern California, Los Angeles, California, USA
    J Invest Dermatol 126:1323-30. 2006
    ..These passive transfer studies demonstrate that human EBA autoantibodies are pathogenic. This novel EBA mouse model can be used to further investigate EBA autoimmunity and to develop possible therapies...
  27. ncbi request reprint Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization
    Paula Berkowitz
    Department of Dermatology, University of North Carolina Chapel Hill School of Medicine, 27599, USA
    J Biol Chem 280:23778-84. 2005
    ..Targeting desmosome signaling via inhibition of p38MAPK and HSP27 phosphorylation may provide novel treatments for PV and other desmosome-associated blistering diseases...
  28. doi request reprint A dynamic micro-CT scanner based on a carbon nanotube field emission x-ray source
    G Cao
    Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC 27599, USA
    Phys Med Biol 54:2323-40. 2009
    ..2 lp mm(-1) at 10% system MTF. The high spatial and temporal resolutions of the micro-CT scanner make it well suited for high-resolution imaging of free-breathing small animals...
  29. pmc Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid
    R Chen
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Clin Invest 108:1151-8. 2001
    ..These findings provide the first direct evidence to our knowledge that MCs play an essential role in neutrophil recruitment during subepidermal blister formation in experimental BP...
  30. pmc A major role for neutrophils in experimental bullous pemphigoid
    Z Liu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Clin Invest 100:1256-63. 1997
    ....
  31. ncbi request reprint Molecular mapping of a pathogenically relevant BP180 epitope associated with experimentally induced murine bullous pemphigoid
    Z Liu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee 53226, USA
    J Immunol 155:5449-54. 1995
    ..These findings should help to elucidate the immunopathologic mechanisms responsible for human BP and HG and may have significant implications in the diagnosis and treatment of these autoimmune diseases...
  32. pmc Beta2-microglobulin-deficient mice are resistant to bullous pemphigoid
    Z Liu
    Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 43226, USA
    J Exp Med 186:777-83. 1997
    ..These data would indicate that autoantibody-mediated inflammation might be prevented or controlled by appropriate modulation of FcRn function...
  33. ncbi request reprint Bullous pemphigoid: end of the century overview
    Z Liu
    Department of Dermatology, University of North Carolina at Chapel Hill, 27599, USA
    J Dermatol 28:647-50. 2001
    ..After almost a half-century of studies, we have learned a great deal about IgG-mediated tissue injury and begin to understand the autoimmune responses leading to pathogenic IgG production in BP...
  34. pmc Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression
    William K Kaufmann
    Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    J Invest Dermatol 128:175-87. 2008
    ..The results suggest that defects in DNA damage checkpoints may be recognized in melanomas through analysis of gene expression...
  35. pmc Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity
    Janelle C Arthur
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Immunol 185:4515-9. 2010
    ..Both DCs and neutrophils fail to respond to chemokines in vitro. These findings indicate that NLRP12 is important in maintaining neutrophils and peripheral DCs in a migration-competent state...
  36. ncbi request reprint Experimental animal models of bullous pemphigoid
    L Heimbach
    Departments of Dermatology, Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    G Ital Dermatol Venereol 144:423-31. 2009
    ..In this review, we discuss the progress made in understanding the pathogenesis of BP, as well as the limits of using animal models to investigate human disease...
  37. ncbi request reprint Evidence that anti-type VII collagen antibodies are pathogenic and responsible for the clinical, histological, and immunological features of epidermolysis bullosa acquisita
    David T Woodley
    The Division of Dermatology, The Keck School of Medicine at the University of Southern California, Los Angeles, California 90033, USA
    J Invest Dermatol 124:958-64. 2005
    ....
  38. ncbi request reprint Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule
    Laurent Galibert
    Department of Molecular Sciences, Amgen Inc, 1201 Amgen Court, Seattle, WA 98119 3105, USA
    J Biol Chem 280:21955-64. 2005
    ..We propose that Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system...
  39. pmc Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus
    David M Koelle
    Department of Medicine, Department of Laboratory Medicine, and Department of Pathobiology, University of Washington, Seattle, Washington 98104, USA
    J Clin Invest 110:537-48. 2002
    ..The evaluation of vaccines for skin and mucosal pathogens should include study of the induction of appropriate tissue-specific homing molecules...
  40. pmc The effect of ecdysterone on cerebral vasospasm following experimental subarachnoid hemorrhage in vitro and in vivo
    Wei Hua Tang
    Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China
    Neurol Res 30:571-80. 2008
    ..Thus, we tested the hypothesis that ecdysterone could affect VAF characteristics and have an effect on SAH induced cerebral vasospasm...
  41. doi request reprint Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers
    Zhi Liu
    Division of Endocrinology and Metabolism, Department of Pathology, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 93:3106-16. 2008
    ....
  42. ncbi request reprint Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres
    Zhi Liu
    Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 2S2, Canada
    J Pharm Pharmacol 55:1063-73. 2003
    ..Controlled-release microsphere formulations of anticancer agents administered intratumorally were an efficient way to deliver high drug doses to the tumour with little systemic toxicity...
  43. ncbi request reprint Inhibitory effects of the mitogen-activated protein kinase kinase inhibitor CI-1040 on the proliferation and tumor growth of thyroid cancer cells with BRAF or RAS mutations
    Dingxie Liu
    Division of Endocrinology and Metabolism Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 92:4686-95. 2007
    ..Targeting MAPK kinase (MEK) in the MAPK pathway is a potentially effective therapeutic strategy for thyroid cancer...
  44. ncbi request reprint [The effect of body position changes on lung function, lung CT imaging and pathology in an oleic acid-induced acute lung injury model]
    Xin Ping Ji
    Department of Emergency, First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Jie He He Hu Xi Za Zhi 28:33-6. 2005
    ..To study the effect of body position changes on lung mechanics, oxygenation, CT images and pathology in an oleic acid-induced acute lung injury (ALI) model...
  45. ncbi request reprint Effects of hypercapnia on nuclear factor-kappaB and tumor necrosis factor-alpha in acute lung injury models
    Li Li Yang
    Department of Emergency Medicine, First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Chin Med J (Engl) 117:1859-61. 2004
  46. pmc Vibrio cholerae virulence regulator-coordinated evasion of host immunity
    Ansel Hsiao
    Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 103:14542-7. 2006
    ..cholerae is able to coordinate both virulence gene activation and repression to evade host defenses and successfully colonize intestines...
  47. ncbi request reprint Immunopathological mechanisms of acantholysis in pemphigus vulgaris: an explanation by ultrastructural observations
    Zhi Liu
    J Invest Dermatol 122:XIII-XIV. 2004
  48. ncbi request reprint The raphe magnus/pallidus regulates sweat secretion and skin vasodilation of the cat forepaw pad: a preliminary electrical stimulation study
    Masato Asahina
    Department of Neurology, Chiba University School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Neurosci Lett 415:283-7. 2007
    ..Stimulation of the mid to caudal raphe magnus/pallidus elicited an increase in both sweat secretion and SkBF. The raphe magnus/pallidus may play a crucial role in skin vasomotor and sudomotor responses in the cat footpad...
  49. ncbi request reprint BRAF V600E maintains proliferation, transformation, and tumorigenicity of BRAF-mutant papillary thyroid cancer cells
    Dingxie Liu
    Division of Endocrinology and Metabolism, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Clin Endocrinol Metab 92:2264-71. 2007
    ..Although the BRAF V600E mutant can initiate the formation of papillary thyroid cancer (PTC), it is unclear whether it is required to maintain cell proliferation, transformation, and tumor growth of BRAF mutation-harboring PTC...
  50. ncbi request reprint D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid
    Jiangang Long
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
    Biogerontology 8:373-81. 2007
    ..These results suggest LA is effective in delaying D-gal toxicity by ameliorating mitochondrial dysfunction...
  51. ncbi request reprint SIS with tissue-cultured allogenic cartilages patch tracheoplasty in a rabbit model for tracheal defect
    Longfang Zhang
    Department of Otolaryngology, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Acta Otolaryngol 127:631-6. 2007
    ..SIS appears to be a safe and promising means of facilitating neovascularization and tissue regeneration. The long-term use of SIS and tissue-cultured allogenic cartilages warrants further investigation...
  52. ncbi request reprint Angiotensin-converting enzyme inhibitor captopril prevents oleic acid-induced severe acute lung injury in rats
    Xiaolin He
    Department of Emergency and Institute of Respiratory Disease, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China
    Shock 28:106-11. 2007
    ..Thus, our data suggest that the inhibition of ACE with its clinically used inhibitor offers protective effects on ALI/ARDS, implying the potential for therapeutic option...
  53. ncbi request reprint Action-potential-independent GABAergic tone mediated by nicotinic stimulation of immature striatal miniature synaptic transmission
    Zhi Liu
    Kinsmen Laboratory and Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurophysiol 98:581-93. 2007
    ..Current-clamp recordings confirmed a direct depolarizing action of nicotine that could dampen eIPSC activity leading to a switch to striatal inhibitory synaptic transmission mediated by tonic mIPSCs...
  54. pmc Immunodominance among herpes simplex virus-specific CD8 T cells expressing a tissue-specific homing receptor
    David M Koelle
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 100:12899-904. 2003
    ..We conclude that among circulating cells expressing a homing-associated receptor, during chronic herpes type 2 infection, the CD8 T cell response becomes quite focused despite the presence of many potential antigenic peptides...
  55. doi request reprint Hypermethylation of the DNA mismatch repair gene hMLH1 and its association with lymph node metastasis and T1799A BRAF mutation in patients with papillary thyroid cancer
    Haixia Guan
    Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Cancer 113:247-55. 2008
    ..It remains to be investigated whether the aberrant methylation of DNA repair genes plays a pathogenic role in BRAF mutation-promoted tumorigenesis of papillary thyroid cancer (PTC)...

Research Grants12

  1. IMMUNOPATHOGENESIS OF BULLOUS PEMPHIGOID
    Zhi Liu; Fiscal Year: 2010
    ..Bullous pemphigoid (BP) is the most common and potentially fatal autoimmune blistering disease. Better understanding of the disease process will lead to more effective therapies. ..
  2. IMMUNOPATHOGENESIS OF BULLOUS PEMPHIGOID
    Zhi Liu; Fiscal Year: 2009
    ..Bullous pemphigoid (BP) is the most common and potentially fatal autoimmune blistering disease. Better understanding of the disease process will lead to more effective therapies. ..
  3. The Mechanism of IVIG Action in Pemphigus
    Zhi Liu; Fiscal Year: 2006
    ..The overall goal of this project is to study the mechanisms of WIG action in autoantibody-mediated diseases and develop novel therapies to replace current immunosuppressive treatments, which confer severe side effects. ..
  4. IMMUNOPATHOGENESIS OF BULLOUS PEMPHIGOID
    Zhi Liu; Fiscal Year: 2005
    ..The results from these studies will have profound clinical implications in the care of patients with BP and HG and other related diseases. ..
  5. Innate Immunity in Bullous Pemphigoid
    Zhi Liu; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Bullous pemphigoid (BP) is the most common and potentially fatal autoimmune blistering disease. We will study the process of the disease development and identify new targets for more effective therapies. ..