Affiliation: University of Kansas Medical Center
- Antigen expression kinetics and immune responses of mice immunized with noninfectious simian-human immunodeficiency virus DNARamakrishna Hegde
Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City 66160, USA
J Virol 79:14688-97. 2005..Since new waves of viral antigen production could be induced with each boosting injection of the vaccine DNA, this DNA could be a safe and efficient agent to induce long-term protection against HIV...
- Immunoprophylaxis against AIDS in macaques with a lentiviral DNA vaccineZhenqian Liu
Marion Merrell Dow Laboratory of Viral Pathogenesis, Department of Microbiology, Molecular Genetics and Immunology, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Virology 351:444-54. 2006..The DNA vaccine induced broad-based protection without using viral proteins to boost the immunity...
- A noninfectious simian/human immunodeficiency virus DNA vaccine that protects macaques against AIDSDinesh K Singh
Marion Merrell Dow Laboratory of Viral Pathogenesis, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
J Virol 79:3419-28. 2005....
- Protection of macaques against AIDS with a live attenuated SHIV vaccine is of finite durationAnil Kumar
Division of Pharmacology, School of Pharmacy, University of Missouri, Kansas City, MO 64108, USA
Virology 371:238-45. 2008..All 8 animals succumbed to disease when challenged with pathogenic viruses...
- Protection against late-onset AIDS in macaques prophylactically immunized with a live simian HIV vaccine was dependent on persistence of the vaccine virusGlenn A Mackay
Marion Merrell Dow Laboratory of Viral Pathogenesis, Division of Infectious Diseases, Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Immunol 173:4100-7. 2004..The two others harboring SHIV(KU-1) remain at risk for developing late-onset disease. The primary correlate against AIDS was persistence of the vaccine virus...
- Comparison of the replication and persistence of simian-human immunodeficiency viruses expressing Vif proteins with mutation of the SLQYLA or HCCH domains in macaquesKimberly Schmitt
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
Virology 404:187-203. 2010..Our results show that while the presence of HCCH and SLQYLA domains are critical in vivo, there may exist APOBEC3 negative reservoirs that allow for low levels of viral replication and persistence but not disease...
- Microarray analysis of cytokine and chemokine genes in the brains of macaques with SHIV-encephalitisYongjun Sui
Department of Microbiology, Immunology and Molecular Genetics, Marion Merrell Dow Laboratory of Viral Pathogenesis, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Med Primatol 32:229-39. 2003..These data provide a comprehensive spectrum of gene expression that underscores the two major clinical manifestations of this unique syndrome: enhanced virus replication in brain macrophages and dystrophic changes in neurons...
- Immunization of macaques with live simian human immunodeficiency virus (SHIV) vaccines conferred protection against AIDS induced by homologous and heterologous SHIVs and simian immunodeficiency virusAnil Kumar
University of Kansas Medical Center, Department of Microbiology, Molecular Genetics and Immunology, Kansas City 66160, USA
Virology 301:189-205. 2002..The study is still in progress and at this time DNA of SIV has become undetectable in lymph nodes of six of the seven vaccinates, SHIV(89.6)P in five of the seven, and SHIV(KU) in three of the seven animals...