Affiliation: University of Pennsylvania
- Mechanisms of FUS1/TUSC2 deficiency in mesothelioma and its tumorigenic transcriptional effectsAlla V Ivanova
Hematology Oncology Division, Vanderbilt Medical Center, Nashville, TN, USA
Mol Cancer 8:91. 2009..The goal of this study was to analyze possible involvement of TUSC2 in malignant pleural mesothelioma (MPM) - an aggressive inflammatory cancer associated with exposure to asbestos...
- Sequence space coverage, entropy of genomes and the potential to detect non-human DNA in human samplesZhandong Liu
Genomics and Computational Biology Graduate Group, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
BMC Genomics 9:509. 2008..Genomes store information for building and maintaining organisms. Complete sequencing of many genomes provides the opportunity to study and compare global information properties of those genomes...
- Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivoZhandong Liu
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Blvd, BRB II III 616, Philadelphia, PA 19104, USA
Genome Biol 9:R180. 2008..Our findings demonstrate that this approach is sufficiently sensitive to detect the secondary activation of endogenous signaling pathways as it occurs through crosstalk following ectopic activation of a primary pathway...
- The Snf1-related kinase, Hunk, is essential for mammary tumor metastasisGerald B W Wertheim
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
Proc Natl Acad Sci U S A 106:15855-60. 2009..These findings identify a direct role for Hunk kinase activity in metastasis and establish an in vivo function for this kinase...