Research Topics
Genomes and Genes
| Youhua LiuSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin SignalingLili Zhou
Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261
J Am Soc Nephrol 24:771-85. 2013..Taken together, these results suggest that Klotho is an antagonist of endogenous Wnt/β-catenin activity; therefore, loss of Klotho may contribute to kidney injury by releasing the repression of pathogenic Wnt/β-catenin signaling...- Advanced oxidation protein products: a causative link between oxidative stress and podocyte depletionYouhua Liu
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 76:1125-7. 2009..This study for the first time establishes a causative link between oxidative stress and podocyte depletion and could have broad implications in our understanding of the pathogenic mechanism of proteinuria... 
Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of actionYouhua Liu
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Am J Physiol Renal Physiol 287:F7-16. 2004..This article reviews recent advances in our understanding of the cellular and molecular mechanisms underlying HGF inhibition of renal fibrosis...- Rapamycin and chronic kidney disease: beyond the inhibition of inflammationY Liu
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 69:1925-7. 2006..Besides its inhibition of renal inflammation, rapamycin is able to block tubular epithelial-mesenchymal transition, thereby shedding new light on the mechanism of its antifibrotic actions... - Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic interventionYouhua Liu
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Am Soc Nephrol 15:1-12. 2004..This article attempts to provide a comprehensive review of recent advances on understanding the pathologic significance, molecular mechanism, and therapeutic intervention of EMT in the setting of chronic renal fibrosis... - Renal fibrosis: new insights into the pathogenesis and therapeuticsYouhua Liu
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Kidney Int 69:213-7. 2006..This mini-review attempts to highlight the recent progress in our understanding of the cellular and molecular pathways leading to renal fibrosis, and discusses the challenges and opportunities in developing therapeutic strategies... - New insights into epithelial-mesenchymal transition in kidney fibrosisYouhua Liu
Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 21:212-22. 2010.... - Hepatocyte growth factor: new arsenal in the fights against renal fibrosis?Y Liu
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 70:238-40. 2006..Herrero-Fresneda et al. provide new evidence demonstrating that intramuscular injection of HGF gene reduces mortality, inflammation, and renal fibrosis in chronic allograft nephropathy... - Cellular and molecular mechanisms of renal fibrosisYouhua Liu
Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
Nat Rev Nephrol 7:684-96. 2011..This Review outlines our current understanding of the cellular and molecular mechanisms of renal fibrosis, which could offer novel insights into the development of new therapeutic strategies... - Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1Yingjian Li
Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 18:449-60. 2007.... - Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIFChunsun Dai
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop Sttreet, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 15:1402-12. 2004..These results suggest that HGF specifically antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF... 
Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signalingKebin Hu
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Clin Invest 117:3821-32. 2007..This study implicates tPA as a fibrogenic cytokine that promotes the progression of kidney fibrosis...- Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expressionKebin Hu
Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Biol Chem 281:2120-7. 2006.... - Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesisYingjian Li
Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, Pennsylvania 15261, USA
J Clin Invest 112:503-16. 2003..These findings suggest that ILK is a critical mediator for tubular EMT and likely plays a crucial role in the pathogenesis of chronic renal fibrosis... - Inhibition of integrin-linked kinase attenuates renal interstitial fibrosisYingjian Li
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 20:1907-18. 2009..These findings suggest that increased ILK activity mediates EMT and the progression of renal fibrosis. Pharmacologic inhibition of ILK signaling may hold therapeutic potential for fibrotic kidney diseases... - Molecular basis for the cell type specific induction of SnoN expression by hepatocyte growth factorRuoyun Tan
Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 18:2340-9. 2007..Collectively, these results suggest that CREB activation, in concert with Sp1, constitutes a molecular switch that confers the cell type-specific induction of SnoN in response to HGF stimulation... - Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cellsXiaoyan Wen
Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
Am J Pathol 167:947-57. 2005..Collectively, these results indicate that 9-cis-RA possesses anti-fibrotic ability by antagonizing TGF-beta1 in mesangial cells and that 9-cis-RA activity is likely mediated through a mechanism dependent on HGF/c-met receptor signaling... - PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinaseYingjian Li
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Am Soc Nephrol 18:2534-43. 2007..We conclude that PINCH-1, through its interaction with ILK, plays an important role in regulating TGF-beta1-mediated EMT and could be a potential future therapeutic target to prevent progression of renal disease... - A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transitionJunwei Yang
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 16:68-78. 2005.... - tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosisKebin Hu
Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 19:503-14. 2008..Together, these findings illustrate that tPA is a survival factor that prevents apoptosis of renal interstitial fibroblasts and myofibroblasts through an LRP-1-, Erk1/2-, p90RSK-, and Bad-dependent mechanism... - Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradationRuoyun Tan
Department of Pathology, University of Pittsburgh, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 17:2781-91. 2006..Preservation of SnoN by inhibiting its degradation may be a novel strategy for targeting hyperactive Smad signaling in renal fibrotic diseases... - Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuriaChunsun Dai
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Kidney Int 77:962-73. 2010..Collectively, these results indicate that HGF/c-met signaling has an important role in protecting podocytes from injury, thereby reducing proteinuria... - Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathyXiaoyue Tan
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 76:1248-57. 2009..Combination therapy had additive efficacy in retarding renal scar formation during obstructive nephropathy... - Transforming growth factor-beta (TGF-beta) activates cytosolic phospholipase A2alpha (cPLA2alpha)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-activated receptor-gamma (PPAR-gamma)/Smad signaling pathways in human liver cancer cells. AChang Han
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 279:44344-54. 2004.... - Both Sp1 and Smad participate in mediating TGF-beta1-induced HGF receptor expression in renal epithelial cellsXianghong Zhang
Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
Am J Physiol Renal Physiol 288:F16-26. 2005..These results suggest a novel regulatory mechanism controlling c-met expression by TGF-beta1 in renal epithelial cells, in which both Smad and Sp proteins participate and cooperate in activating c-met gene transcription... - hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonistsYingjian Li
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh, S-405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 17:54-65. 2006..Together, these findings suggest that HGF may act as a downstream effector that mediates the antifibrotic action of PPAR-gamma agonists... - Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signalingMyrto Giannopoulou
Department of Pathology, University of PittsburghSchool of Medicine, Pittsburgh, Pennsylvania 15261, USA
Am J Pathol 173:30-41. 2008..These observations suggest that HGF is a potent anti-inflammatory cytokine that inhibits renal inflammation by disrupting NF-kappaB signaling and may be a promising therapeutic agent for progressive renal diseases... - Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosisHong Ding
Department of Pathology, University of Pittsburgh School of Medicine, PA 15261, USA
J Am Soc Nephrol 23:801-13. 2012..We conclude that Shh/Gli1 signaling plays a critical role in promoting fibroblast activation, production of extracellular matrix, and development of renal interstitial fibrosis... - tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signalingSha Hao
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Am J Pathol 177:1164-75. 2010..These studies illustrate that tPA is a potent mitogen that promotes renal interstitial fibroblast proliferation through LDL receptor-related protein 1-mediated beta1 integrin and FAK signaling... - Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in miceDong Zhou
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Kidney Int 82:537-47. 2012..Hence, endogenous β-catenin is pivotal for renal tubular protection after AKI by promoting cell survival through multiple mechanisms... - Downregulation of Smad transcriptional corepressors SnoN and Ski in the fibrotic kidney: an amplification mechanism for TGF-beta1 signalingJunwei Yang
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Am Soc Nephrol 14:3167-77. 2003..Therefore, new strategy aimed to increase Smad transcriptional co-repressors expression may be effective in antagonizing TGF-beta1 signaling and thereby blocking the progression of chronic renal fibrosis... - 1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expressionYingjian Li
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 68:1500-10. 2005.... - Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/β-catenin activity in CKDWeichun He
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 23:294-304. 2012..In summary, levels of renal MMP-7 correlate with Wnt/β-catenin activity, and urinary MMP-7 may be a noninvasive biomarker of this profibrotic signaling in the kidney... - Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathyXiaoyue Tan
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 17:3382-93. 2006..These studies suggest that paricalcitol is able to ameliorate renal interstitial fibrosis in obstructive nephropathy, possibly by preserving tubular epithelial integrity through suppression of EMT... - Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuriaChunsun Dai
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 20:1997-2008. 2009..These results suggest that targeting hyperactive Wnt/beta-catenin signaling may represent a novel therapeutic strategy for proteinuric kidney diseases... - Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in miceJunwei Yang
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Am Soc Nephrol 13:2464-77. 2002..These findings may provide the basis for designing future therapeutic regimens for blocking progressive renal fibrosis in patients... - Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transductionJunwei Yang
Department of Pathology, Division of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Am J Pathol 163:621-32. 2003..Therefore, HGF suppresses TGF-beta1-mediated renal interstitial myofibroblastic activation; and this action of HGF is likely related to a mitogen-activated protein kinase-dependent blockade of Smad nuclear translocation... - Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuriaYoung Sun Kang
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Kidney Int 78:363-73. 2010..Our results show that upregulation of ILK is a convergent pathway leading to podocyte EMT, migration, and dysfunction. ILK may be an attractive target for therapeutic intervention of proteinuric kidney diseases... - Delayed administration of hepatocyte growth factor reduces renal fibrosis in obstructive nephropathyJunwei Yang
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Am J Physiol Renal Physiol 284:F349-57. 2003..These results suggest that exogenous HGF exhibits potent therapeutic effects on retarding the progression of an established renal fibrosis... - Intravenous administration of hepatocyte growth factor gene ameliorates diabetic nephropathy in miceChunsun Dai
Department of Pathology, University of Pittsburgh School of Medicine, 200 Lothrop Street, PA 15261, USA
J Am Soc Nephrol 15:2637-47. 2004..Therefore, despite the effects of HGF on diabetic nephropathy being controversial, these observations suggest that supplementation of HGF is beneficial in ameliorating diabetic renal insufficiency in mice... - Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intoleranceChunsun Dai
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Am J Pathol 167:429-36. 2005..Therefore, HGF/c-met signaling plays an imperative role in controlling islet growth, in regulating beta-cell function, and in maintaining glucose homeostasis... - Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligationJing Lin Xia
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Am J Pathol 168:1500-12. 2006..HGF abolished the phenotypic conversion of biliary epithelial cells induced by TGF-beta1. These results suggest that HGF ameliorates hepatic biliary fibrosis in part by blocking bile duct epithelial to mesenchymal transition... - Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosisJunwei Yang
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Am Soc Nephrol 13:96-107. 2002.... - Wnt/beta-catenin signaling promotes renal interstitial fibrosisWeichun He
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
J Am Soc Nephrol 20:765-76. 2009..In summary, these results establish a role for Wnt/beta-catenin signaling in the pathogenesis of renal fibrosis and identify this pathway as a potential therapeutic target... - Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidneyXianghong Zhang
Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
Am J Physiol Renal Physiol 284:F82-94. 2003..Our findings suggest that HGF may have a broader spectrum of target cells and possess wider implications in kidney structure and function than originally thought... - Therapeutic role and potential mechanisms of active Vitamin D in renal interstitial fibrosisXiaoyue Tan
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Steroid Biochem Mol Biol 103:491-6. 2007..Thus, supplementation of active Vitamin D could be a rational strategy for the therapeutics of chronic kidney diseases... - Hepatocyte growth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic miceChunsun Dai
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 278:27080-7. 2003..These findings suggest that supplementation of HGF to prevent beta cells from destructive depletion and to promote their proliferation might be an effective strategy for ameliorating type I diabetes... - Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuriaYingjian Li
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Am J Pathol 172:299-308. 2008..These results suggest that podocyte dedifferentiation and mesenchymal transition could be a potential pathway leading to their dysfunction, thereby playing a role in the genesis of proteinuria... - Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signalingXiaoyue Tan
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Am Soc Nephrol 19:1741-52. 2008..These results suggest that paricalcitol inhibits renal inflammatory infiltration and RANTES expression by promoting VDR-mediated sequestration of NF-kappaB signaling... - Opposite action of peroxisome proliferator-activated receptor-gamma in regulating renal inflammation: functional switch by its ligandXiaoyan Wen
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 285:29981-8. 2010.... - PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expressionDan Wang
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 6:e17048. 2011..PINCH1 is induced in the fibrotic kidney after injury, and it primarily localizes at the sites of focal adhesion. Whether it can translocate to the nucleus and directly participate in gene regulation is completely unknown... - Novel actions of tissue-type plasminogen activator in chronic kidney diseaseKebin Hu
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Front Biosci 13:5174-86. 2008..These new findings have radically changed our conception of tPA in renal fibrogenesis and represent a paradigm shift towards uncovering its cytokine function... - Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesisYingjian Li
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 81:880-91. 2012.... - Blockade of Wnt/β-catenin signaling by paricalcitol ameliorates proteinuria and kidney injuryWeichun He
Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 22:90-103. 2011..In summary, these findings suggest that paricalcitol prevents podocyte dysfunction, proteinuria, and kidney injury in adriamycin nephropathy by inhibiting Wnt/β-catenin signaling... - Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1Xianghong Zhang
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Am J Physiol Renal Physiol 284:F1216-25. 2003..Our findings reveal a novel transcriptional regulatory mechanism by which Egr-1 sequesters Sp1 as a transcriptional activator of c-met via physical interaction... - Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 actionMyrto Giannopoulou
Dept. of Pathology, Univ. of Pittsburgh, S-405 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
Am J Physiol Renal Physiol 290:F1234-40. 2006..The antifibrotic action of IFN-gamma appears to be mediated through a coordinated activation of both Erk-1/2 and Stat3 signal pathways in a mutually independent fashion... - Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in miceUdayan Apte
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15216, USA
Hepatology 44:992-1002. 2006..In conclusion, beta-catenin- and HGF-mediated signaling pathways cooperate in hepatocyte proliferation, which may be crucial in liver development, regeneration following partial hepatectomy, and pathogenesis of hepatocellular carcinoma... - Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathyJunwei Yang
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Clin Invest 110:1525-38. 2002..Our findings establish a crucial and definite importance of EMT in the pathogenesis of renal interstitial fibrosis at the whole-animal level... - Transforming growth factor-beta1 potentiates renal tubular epithelial cell death by a mechanism independent of Smad signalingChunsun Dai
Division of Cellular and Molecular Pathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 278:12537-45. 2003..These results suggest that hyperactive TGF-beta1 signaling potentiates renal tubular epithelial cell apoptosis by a Smad-independent, p38 MAP kinase-dependent mechanism... - Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosisSha Hao
Department of Pathology, University of Pittsburgh School of Medicine, S 405 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 22:1642-53. 2011..Late administration of ICG-001 also effectively attenuated fibrotic lesions in obstructive nephropathy. In conclusion, inhibiting β-catenin signaling may be an effective approach to the treatment of fibrotic kidney diseases... - The modulation of caveolin-1 expression controls satellite cell activation during muscle repairDaniela Volonte
Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
FASEB J 19:237-9. 2005.... - Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in miceChunsun Dai
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Am Soc Nephrol 13:411-22. 2002..These data suggest that HGF gene therapy may provide a new avenue for exploring a novel therapeutic strategy for clinical acute renal failure... - Inhibition of proinflammatory RANTES expression by TGF-beta1 is mediated by glycogen synthase kinase-3beta-dependent beta-catenin signalingChunsun Dai
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Biol Chem 286:7052-9. 2011..We conclude that TGF-β1 inhibition of proinflammatory RANTES expression is mediated by β-catenin-triggered blockade of NF-κB signaling... - Matrix metalloproteinases in kidney homeostasis and diseasesRoderick J Tan
Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, 200 Lothrop St, Pittsburgh, PA 15261, USA
Am J Physiol Renal Physiol 302:F1351-61. 2012..The goal of this review is to summarize current findings regarding the role of MMPs in kidney diseases as well as the mechanisms of action of this family of proteases... - Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signalingChunsun Dai
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
J Am Soc Nephrol 17:2164-75. 2006..These results also illustrate that the integrin and slit diaphragm signals in podocytes are intrinsically coupled through an ILK-dependent mechanism... - Hepatocyte growth factor and the kidneyYouhua Liu
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Curr Opin Nephrol Hypertens 11:23-30. 2002.... - Systemic administration of naked plasmid encoding hepatocyte growth factor ameliorates chronic renal fibrosis in miceJ Yang
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Gene Ther 8:1470-9. 2001.... - Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathwaysY Liu
Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, USA
Kidney Int 58:2028-43. 2000..The effects of HGF on the processes of matrix synthesis and degradation in cultured renal epithelial cells were also examined... - Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuriaDan Wang
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Kidney Int 80:1159-69. 2011..These studies suggest that Wnt/β-catenin signaling may be exploited as a therapeutic target for the treatment of proteinuric kidney diseases... - Coordinated regulation of dimethylarginine dimethylaminohydrolase-1 and cationic amino acid transporter-1 by farnesoid X receptor in mouse liver and kidney and its implication in the control of blood levels of asymmetric dimethylarginineJiang Li
Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, PA 15261, USA
J Pharmacol Exp Ther 331:234-43. 2009..These data suggest that FXR may play an important role in regulating blood levels of ADMA via coordinated regulation of DDAH-1 and CAT-1 in liver and kidney... - Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosisJ Yang
Department of Pathology, Division of Cellular and Molecular Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
Am J Pathol 159:1465-75. 2001.... - Modulation of hepatocyte growth factor gene expression by estrogen in mouse ovaryY Liu
Department of Pathology, School of Medicine, University of Pittsburgh, PA 15261
Mol Cell Endocrinol 104:173-81. 1994.... - Identification of a cell-type-specific transcriptional repressor in the promoter region of the mouse hepatocyte growth factor geneY Liu
Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15261
Mol Cell Biol 14:7046-58. 1994.... - Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growthJ Yang
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
Hepatology 33:848-59. 2001..Our results also indicate that long-term expression of human HGF in mice markedly activates growth-related signal transduction events, promotes cell proliferation, and leads to liver and overall body growth in whole adult animals... - Expression of the neutral amino acids transporter ASCT1 in esophageal carcinomasM Younes
Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Anticancer Res 20:3775-9. 2000..Additional studies with larger number of patients are needed to determine the biological significance of ASCT1 expression in esophageal carcinomas... - The mouse hepatocyte growth factor-encoding gene: structural organization and evolutionary conservationY Liu
Department of Pathology, School of Medicine, University of Pittsburgh, PA 15261
Gene 144:179-87. 1994..Our current results on mouse HGF structure provide basic and detailed information to carry out further manipulation, such as gene targeting... - Structural and functional characterization of the mouse hepatocyte growth factor gene promoterY Liu
Department of Pathology, School of Medicine, University of Pittsburgh, Pennsylvania 15261
J Biol Chem 269:4152-60. 1994..Our findings revealed a complex pattern of transcriptional regulation of the mouse HGF gene expression... - Molecular cloning and characterization of cDNA encoding mouse hepatocyte growth factorY Liu
Department of Pathology, School of Medicine, University of Pittsburgh, PA 15261
Biochim Biophys Acta 1216:299-303. 1993..Our results suggest the existence of evolutionary pressure to conserve the distinct structure, and presumably the biological functions, of HGF... - Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implicationRuoyun Tan
Department of Medicine, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China
Am J Physiol Renal Physiol 294:F1076-83. 2008..It appears that dysregulation of Smurf2 could contribute to an aberrant TGF-beta/Smad signaling in the pathogenesis of kidney fibrosis... - Cell phenotype-specific down-regulation of Smad3 involves decreased gene activation as well as protein degradationAnne Christine Poncelet
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98109, USA
J Biol Chem 282:15534-40. 2007..Smad3 down-regulation could represent a feedback loop controlling TGF-beta signaling in a cell phenotype-specific manner... - Potential role of active vitamin D in retarding the progression of chronic kidney diseaseJin Tian
Nephrol Dial Transplant 22:321-8. 2007 - Urokinase receptor deficiency accelerates renal fibrosis in obstructive nephropathyGuoqiang Zhang
Division of Nephrology, University of Washington, Children s Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, WA 98105, USA
J Am Soc Nephrol 14:1254-71. 2003..These data suggest that renal uPAR attenuates the fibrogenic response to renal injury, an outcome that is mediated in part by urokinase-dependent but plasminogen-independent functions... - Sp1 regulates expression of MET, and ribozyme-induced down-regulation of MET in fibrosarcoma-derived human cells reduces or eliminates their tumorigenicityHongyan Liang
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824-1302, USA
Int J Oncol 24:1057-67. 2004..Taken together, these results indicate that in human fibrosarcoma cells, high levels of the phosphorylated form of MET are required for tumor formation and that Sp1 can function to control the level of MET... - Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytesSvetlana Radaeva
Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA
Gastroenterology 122:1020-34. 2002..CONCLUSIONS: IFN-alpha directly targets human hepatocytes, followed by activation of multiple STATs and regulation of a wide variety of genes, which may contribute to the antiviral and antitumor activities of IFN-alpha in human liver...
Research Grants
- Renal Myofibroblast: Origins, Activation and FateYouhua Liu; Fiscal Year: 2006..abstract_text> ..
- HGF receptor and renal cell survival and differentiationYouhua Liu; Fiscal Year: 2006..Ultimately, these studies may lead to development of novel strategies to alter the course of human renal disease by manipulating the activities of HGF/c-met signaling system. ..
- HGF Gene Therapy for Chronic Renal FibrosisYouhua Liu; Fiscal Year: 2007..Ultimately, these studies may lead to development of novel strategies to alter the course of human kidney disease by manipulating the activity of HGF signaling system. ..
- Integrin-linked Kinase and Renal Interstitial FibrosisYouhua Liu; Fiscal Year: 2007..abstract_text> ..
- HGF Gene Therapy for Chronic Renal FibrosisYouhua Liu; Fiscal Year: 2009..Ultimately, these studies may lead to development of novel strategies to alter the course of human kidney disease by manipulating the activity of HGF signaling system. ..
- Renal myofibroblast: Origin, Activation and FateYouhua Liu; Fiscal Year: 2009..Resolution of these fundamental issues may offer unique opportunities for designing rational strategies for the treatment of human CKD. ..
- HGF RECEPTOR GENE REGULATION AND RENAL GROWTHYouhua Liu; Fiscal Year: 2002..Ultimately, these studies may suggest novel strategies to alter the course of human renal disease by regulating the HGF/c-met axis, and thereby, modifying cell repair and growth. ..
- HGF RECEPTOR GENE REGULATION AND RENAL GROWTHYouhua Liu; Fiscal Year: 2003..Ultimately, these studies may suggest novel strategies to alter the course of human renal disease by regulating the HGF/c-met axis. ..
- HGF Gene Therapy for Chronic Renal FibrosisYouhua Liu; Fiscal Year: 2005....
- Renal myofibroblast: Origin, Activation and FateYouhua Liu; Fiscal Year: 2010..Resolution of these fundamental issues may offer unique opportunities for designing rational strategies for the treatment of human CKD. ..