Xue Z Liu

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. doi request reprint Cochlear implantation in individuals with Usher type 1 syndrome
    Xue Z Liu
    Department of Otolaryngology, University of Miami, Miami, FL 33101, USA
    Int J Pediatr Otorhinolaryngol 72:841-7. 2008
  2. ncbi request reprint In vitro interaction of Pseudomonas aeruginosa with human middle ear epithelial cells
    Rahul Mittal
    Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 9:e91885. 2014
  3. pmc Modifiers of hearing impairment in humans and mice
    Denise Yan
    Department of Otolaryngology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Curr Genomics 11:269-78. 2010
  4. doi request reprint Hearing loss and PRPS1 mutations: Wide spectrum of phenotypes and potential therapy
    Xue Zhong Liu
    Department of Otolaryngology, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Int J Audiol 52:23-8. 2013
  5. pmc GJB2 mutation spectrum in 2,063 Chinese patients with nonsyndromic hearing impairment
    Pu Dai
    Department of Otolaryngology and Genetic Testing Center for Deafness, Chinese PLA General Hospital, Beijing, PR China
    J Transl Med 7:26. 2009
  6. pmc Digenic inheritance of non-syndromic deafness caused by mutations at the gap junction proteins Cx26 and Cx31
    Xue Zhong Liu
    Department of Otolaryngology D 48, University of Miami, 1666 NW 12th Avenue, Miami, FL 33136, USA
    Hum Genet 125:53-62. 2009
  7. ncbi request reprint Audiological and genetic features of the mtDNA mutations
    X Z Liu
    Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Acta Otolaryngol 128:732-8. 2008
  8. ncbi request reprint Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness
    X Z Liu
    Department of Human Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0033, USA
    Hum Mol Genet 10:2945-51. 2001
  9. ncbi request reprint Ageing and hearing loss
    X Z Liu
    Department of Otolaryngology, University of Miami, Miami, FL 33101, USA
    J Pathol 211:188-97. 2007
  10. ncbi request reprint Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss
    Xue Zhong Liu
    Department of Otolaryngology, University of Miami, Miami, FL 33101, USA
    Hum Mol Genet 12:1155-62. 2003

Collaborators

Detail Information

Publications35

  1. doi request reprint Cochlear implantation in individuals with Usher type 1 syndrome
    Xue Z Liu
    Department of Otolaryngology, University of Miami, Miami, FL 33101, USA
    Int J Pediatr Otorhinolaryngol 72:841-7. 2008
    ..To analyze the occurrence of the Usher type 1 (USH1) gene mutations in cochlear implant recipients with deaf-blind Usher syndrome, and to assess the potential effect of these genes and other factors on the therapeutic outcome...
  2. ncbi request reprint In vitro interaction of Pseudomonas aeruginosa with human middle ear epithelial cells
    Rahul Mittal
    Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 9:e91885. 2014
    ..The survivors often suffer from hearing loss and neurological sequelae. However, no information is available regarding the interaction of P. aeruginosa with human middle ear epithelial cells (HMEECs)...
  3. pmc Modifiers of hearing impairment in humans and mice
    Denise Yan
    Department of Otolaryngology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Curr Genomics 11:269-78. 2010
    ..We also include examples of digenic inheritance of deafness, because additive or interactive effects can also result from interaction between two mutant genes...
  4. doi request reprint Hearing loss and PRPS1 mutations: Wide spectrum of phenotypes and potential therapy
    Xue Zhong Liu
    Department of Otolaryngology, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Int J Audiol 52:23-8. 2013
    ..The purpose of this review was to evaluate the current literature on phosphoribosylpyrophosphate synthetase 1 (PRPS1)-related diseases and their consequences on hearing function...
  5. pmc GJB2 mutation spectrum in 2,063 Chinese patients with nonsyndromic hearing impairment
    Pu Dai
    Department of Otolaryngology and Genetic Testing Center for Deafness, Chinese PLA General Hospital, Beijing, PR China
    J Transl Med 7:26. 2009
    ..Mutations in GJB2 are the most common molecular defects responsible for autosomal recessive nonsyndromic hearing impairment (NSHI). The mutation spectra of this gene vary among different ethnic groups...
  6. pmc Digenic inheritance of non-syndromic deafness caused by mutations at the gap junction proteins Cx26 and Cx31
    Xue Zhong Liu
    Department of Otolaryngology D 48, University of Miami, 1666 NW 12th Avenue, Miami, FL 33136, USA
    Hum Genet 125:53-62. 2009
    ..Together, our data indicate that a genetic interaction between these two connexin genes can lead to hearing loss...
  7. ncbi request reprint Audiological and genetic features of the mtDNA mutations
    X Z Liu
    Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Acta Otolaryngol 128:732-8. 2008
    ....
  8. ncbi request reprint Mutations in GJA1 (connexin 43) are associated with non-syndromic autosomal recessive deafness
    X Z Liu
    Department of Human Genetics, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA 23298 0033, USA
    Hum Mol Genet 10:2945-51. 2001
    ..Cx43 must also play a critical role in the physiology of hearing, presumably by participating in the recycling of potassium to the cochlear endolymph...
  9. ncbi request reprint Ageing and hearing loss
    X Z Liu
    Department of Otolaryngology, University of Miami, Miami, FL 33101, USA
    J Pathol 211:188-97. 2007
    ....
  10. ncbi request reprint Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss
    Xue Zhong Liu
    Department of Otolaryngology, University of Miami, Miami, FL 33101, USA
    Hum Mol Genet 12:1155-62. 2003
    ..Finally, the observation of this mutation only in the Caucasian probands indicated an association with a specific ethnic background. This study thereby reveals an essential function of prestin in human auditory processing...
  11. ncbi request reprint The clinical presentation of DFNB2
    Xue Zhong Liu
    Department of Otolaryngology, University of Miami, Fla, USA
    Adv Otorhinolaryngol 61:120-3. 2002
  12. ncbi request reprint The prevalence of connexin 26 ( GJB2) mutations in the Chinese population
    Xue Zhong Liu
    Department of Otolaryngology D 48, University of Miami, 1666 NW 12th Avenue, Miami, Florida 33136, USA
    Hum Genet 111:394-7. 2002
    ..The 235delC mutation, rather than 35delG, is the most common mutation found in the Chinese deaf population. Our data support the view that specific combinations of GJB2 mutation exist in different populations...
  13. ncbi request reprint Performance after cochlear implantation in DFNB1 patients
    Sarah S Connell
    University of Miami Ear Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Otolaryngol Head Neck Surg 137:596-602. 2007
    ..To evaluate the speech perception and language development with cochlear implants (CI) of DFNB1 children in comparison with non-DFNB1 deaf children...
  14. pmc Influence of DFNB1 status on expressive language in deaf children with cochlear implants
    Simon I Angeli
    Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Otol Neurotol 32:1437-43. 2011
    ..The objective of this study was to compare the language growth of children with connexin-related deafness (DFNB1) who received cochlear implants versus the language growth of implanted children with non-DFNB1 deafness...
  15. ncbi request reprint Coenzyme Q-10 treatment of patients with a 7445A--->G mitochondrial DNA mutation stops the progression of hearing loss
    Simon I Angeli
    Department of Otolaryngology, University of Miami School of Medicine, Miami, FL 33101, USA
    Acta Otolaryngol 125:510-2. 2005
    ..One year after being diagnosed with mitochondrial hearing loss, the patient who refused CoQ10 treatment exhibited an 11-dB deterioration of his hearing thresholds. There were no side-effects related to treatment with CoQ10...
  16. pmc Cochlear implantation in common forms of genetic deafness
    Richard J Vivero
    Department of Otolaryngology, University of Miami Ear Institute, Miami, FL 33136, United States
    Int J Pediatr Otorhinolaryngol 74:1107-12. 2010
    ..In this review article, current knowledge of cochlear implants for hereditary hearing loss will be discussed with an emphasis on relevant clinical genotype-phenotype correlations...
  17. pmc Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise
    Denise Yan
    Department of Otolaryngology, University of Miami School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 110:2228-33. 2013
    ..V60L, noise exposure exacerbated high-frequency hearing loss in young adulthood. Our results suggest that P2X(2) function is required for life-long normal hearing and for protection from exposure to noise...
  18. ncbi request reprint Etiologic diagnosis of sensorineural hearing loss in adults
    Simon I Angeli
    Department of Otolaryngology, University of Miami School of Medicine, Florida 33101, USA
    Otolaryngol Head Neck Surg 132:890-5. 2005
    ..To determine the etiology of adult-onset sensorineural hearing loss...
  19. pmc Ush1c gene expression levels in the ear and eye suggest different roles for Ush1c in neurosensory organs in a new Ush1c knockout mouse
    Cong Tian
    Department of Otolaryngology, Case Western Reserve University, Cleveland, OH 44106, USA
    Brain Res 1328:57-70. 2010
    ..The fact that Ush1c expression is much higher in the ear than in the eye suggests a different role for Ush1c in ear function than in the eye and may explain why Ush1c mutant mice do not recapitulate vision defects...
  20. doi request reprint Genetics and pathological mechanisms of Usher syndrome
    Denise Yan
    Department of Otolaryngology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Hum Genet 55:327-35. 2010
    ..Understanding the molecular basis of phenotypic variation and pathogenesis of USH is important toward discovery of new molecular targets for diagnosis, prevention and treatment of this debilitating disorder...
  21. ncbi request reprint Mutations in the alternatively spliced exons of USH1C cause non-syndromic recessive deafness
    Xiao Mei Ouyang
    Department of Otolaryngology D 48, University of Miami, 1666 NW 12th Avenue, FL 33136, USA
    Hum Genet 111:26-30. 2002
    ..None carried any mutations in these exons of USH1C. Our findings show that USH1C mutations can also cause non-syndromic deafness and that some harmonin isoforms are specifically required for inner ear function...
  22. ncbi request reprint Cochlear molecules and hereditary deafness
    Denise Yan
    Department of Otolaryngology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Front Biosci 13:4972-83. 2008
    ..Here, we review some of the major advances in our knowledge of auditory function within an evolving understanding of the structure and regulation of the machinery of hearing...
  23. ncbi request reprint Audiological features of GJB2 (connexin 26) deafness
    Xue Zhong Liu
    Department of Otolaryngology, University of Miami, Miami, Florida 33136, USA
    Ear Hear 26:361-9. 2005
    ..The aim of the present study was to characterize audiological profiles in patients with GJB2 deafness..
  24. pmc A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss
    Asli Sirmaci
    Dr John T Macdonald Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Am J Hum Genet 86:797-804. 2010
    ..We propose that SERPINB6 plays an important role in the inner ear in the protection against leakage of lysosomal content during stress and that loss of this protection results in cell death and sensorineural hearing loss...
  25. pmc Analysis of miR-376 RNA cluster members in the mouse inner ear
    Denise Yan
    Department of Otolaryngology, University of Miami, Miami, FL 33136, USA
    Int J Exp Pathol 93:450-7. 2012
    ..Only unedited pri-miR-376 RNAs were detected in the cochlea suggesting that the activity of PRPS1 in the inner ear may not be regulated through the editing of miR-376 cluster...
  26. doi request reprint The genetic bases for non-syndromic hearing loss among Chinese
    Xiao Mei Ouyang
    Department of Otolaryngology, University of Miami, Miami, FL 33136, USA
    J Hum Genet 54:131-40. 2009
    ..Better understanding of the genetic causes of deafness in the Chinese population is important for accurate genetics counseling and early diagnosis for timely intervention and treatment options...
  27. ncbi request reprint Evidence of a founder effect for the 235delC mutation of GJB2 (connexin 26) in east Asians
    Denise Yan
    Department of Otolaryngology, University of Miami, 1666 NW 12th Avenue, Miami, FL 33136, USA
    Hum Genet 114:44-50. 2003
    ..Similarly, the finding that this mutation appears on a single haplotype provides no support for the possibility that recurrent mutation is the explanation for the high frequency of the allele...
  28. pmc Antioxidant enzymes, presbycusis, and ethnic variability
    Anthony Bared
    Department of Otolaryngology, University of Miami, Miami, FL 33136, USA
    Otolaryngol Head Neck Surg 143:263-8. 2010
    ..In this work, we sought to investigate the association of different polymorphisms of GSTM1, GSTT1, and NAT2 and presbycusis and analyze whether ethnicity has an effect in the genotype-phenotype associations...
  29. doi request reprint Mutation analysis in the long isoform of USH2A in American patients with Usher Syndrome type II
    Denise Yan
    Department of Otolaryngology, University of Miami, Miami, FL 33136, USA
    J Hum Genet 54:732-8. 2009
    ..2299delG/p.E767fs is indeed the most common USH2A mutation found in USH2 patients of European Caucasian background. Thus, if screening for mutations in USH2A is considered, it is reasonable to screen for the c.2299delG mutation first...
  30. pmc Mutation analysis of SLC26A4 in mainland Chinese patients with enlarged vestibular aqueduct
    Samuel Reyes
    Department of Otolaryngology, University of Miami, Miami, FL 33136, USA
    Otolaryngol Head Neck Surg 141:502-8. 2009
    ..We have characterized the spectrum of SLC26A4 mutations and clinical features in a population of mainland Chinese patients with nonsyndromic sensorineural hearing loss (SNHL) and enlarged vestibular aqueduct (EVA)...
  31. ncbi request reprint Refinement of the DFNA41 locus and candidate genes analysis
    Denise Yan
    Department of Otolaryngology D 48, University of Miami, Miami, FL 33136, USA
    J Hum Genet 50:516-22. 2005
    ..This study represents a significant refinement of the DFNA41 locus and should facilitate positional cloning of the disease gene...
  32. ncbi request reprint Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31
    Philomena Mburu
    MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, Oxon OX11 ORD, UK
    Nat Genet 34:421-8. 2003
    ..Our findings suggest that this novel PDZ domain-containing molecule acts as an organizer of submembranous molecular complexes that control the coordinated actin polymerization and membrane growth of stereocilia...
  33. pmc Digenic inheritance of deafness caused by mutations in genes encoding cadherin 23 and protocadherin 15 in mice and humans
    Qing Yin Zheng
    Jackson Laboratory, Bar Harbor, ME 04609, USA
    Hum Mol Genet 14:103-11. 2005
    ..Altogether, our data indicate that CDH23 and PCDH15 play an essential long-term role in maintaining the normal organization of the stereocilia bundle...
  34. pmc Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22
    Ingrid Zwaenepoel
    Unité de Génétique des Déficits Sensoriels, Centre National de la Recherche Scientifique, Paris Cedex 15, France
    Proc Natl Acad Sci U S A 99:6240-5. 2002
    ..We propose that otoancorin ensures the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells...
  35. ncbi request reprint Characterization of Usher syndrome type I gene mutations in an Usher syndrome patient population
    Xiao Mei Ouyang
    Department of Otolaryngology D 48, University of Miami, 1666 NW 12th Avenue, Miami, FL 33136, USA
    Hum Genet 116:292-9. 2005
    ..The present study suggests that mutations in MYO7A and CDH23 are the two major components of causes for USH1, while PCDH15, USH1C, and SANS are less frequent causes...

Research Grants14

  1. Molecular Genetics of Non-Syndromic Deafness
    Xue Z Liu; Fiscal Year: 2010
    ....
  2. Molecular Genetics of Non-Syndromic Deafness
    Xue Liu; Fiscal Year: 2009
    ....
  3. Molecular Genetics of Non-Syndromic Deafness
    Xue Liu; Fiscal Year: 2007
    ....
  4. Molecular Genetics of Non-Syndromic Deafness
    Xue Liu; Fiscal Year: 2006
    ....
  5. Molecular Genetics of Non-Syndromic Deafness
    Xue Liu; Fiscal Year: 2005
    ..This knowledge is an essential prerequisite to the development and provision of molecular diagnostic services for families with non-syndromic deafness. ..
  6. Molecular Genetics of Non-Syndromic Deafness
    Xue Liu; Fiscal Year: 2004
    ..This knowledge is an essential prerequisite to the development and provision of molecular diagnostic services for families with non-syndromic deafness. ..
  7. Molecular Genetics of Non-Syndromic Deafness
    Xue Liu; Fiscal Year: 2002
    ..This knowledge is an essential prerequisite to the development and provision of molecular diagnostic services for families with non-syndromic deafness. ..
  8. Molecular Genetics of Non-Syndromic Deafness
    Xue Liu; Fiscal Year: 2002
    ..This knowledge is an essential prerequisite to the development and provision of molecular diagnostic services for families with non-syndromic deafness. ..
  9. SEARCH FOR NEW GENES CAUSING NON-SYNDROMIC DEAFNESS
    Xue Liu; Fiscal Year: 2002
    ..This knowledge is an essential prerequisite to the development and provision of molecular diagnostic services for families with NSHL, as well as the further delineation of the functional genomics of the cochlea. ..
  10. Molecular Genetics of Non-Syndromic Deafness
    Xue Liu; Fiscal Year: 2001
    ..This knowledge is an essential prerequisite to the development and provision of molecular diagnostic services for families with non-syndromic deafness. ..
  11. Molecular Genetics of Non-Syndromic Deafness
    Xue Liu; Fiscal Year: 2003
    ..This knowledge is an essential prerequisite to the development and provision of molecular diagnostic services for families with non-syndromic deafness. ..
  12. Molecular Genetics of Non-Syndromic Deafness
    Xue Liu; Fiscal Year: 2009
    ....