Suling Liu

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Mammary stem cells, self-renewal pathways, and carcinogenesis
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Breast Cancer Res 7:86-95. 2005
  2. ncbi request reprint Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells
    Hsiang Lin Chang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:1773-84. 2006
  3. pmc BRCA1 regulates human mammary stem/progenitor cell fate
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:1680-5. 2008
  4. pmc MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Genet 8:e1002751. 2012
  5. pmc Conjugated linoleic acid induces apoptosis through estrogen receptor alpha in human breast tissue
    Li Shu Wang
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    BMC Cancer 8:208. 2008
  6. pmc Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
    Suling Liu
    Comprehensive Cancer Center and School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 71:614-24. 2011
  7. pmc ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    Christophe Ginestier
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Stem Cell 1:555-67. 2007
  8. pmc Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
    Yanyan Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2580-90. 2010
  9. ncbi request reprint Stem cells in mammary development and carcinogenesis: implications for prevention and treatment
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Stem Cell Rev 1:207-13. 2005
  10. pmc Distinct FAK activities determine progenitor and mammary stem cell characteristics
    Ming Luo
    Divisions of Molecular Medicine and Genetics and Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, and Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 73:5591-602. 2013

Detail Information

Publications28

  1. pmc Mammary stem cells, self-renewal pathways, and carcinogenesis
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Breast Cancer Res 7:86-95. 2005
    ..If 'tumor stem cells' are inherently resistant to current therapies, targeting stem cell self-renewal pathways might provide a novel approach for breast cancer treatment...
  2. ncbi request reprint Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells
    Hsiang Lin Chang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:1773-84. 2006
    ..In the present study, ER-alpha, two estrogen-regulated genes, PR and PTPgamma, KGF and their relationship with endocrine resistance in human breast cancer cells were investigated...
  3. pmc BRCA1 regulates human mammary stem/progenitor cell fate
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 105:1680-5. 2008
    ..Because BRCA1 also plays a role in DNA repair, our work suggests that loss of BRCA1 may result in the accumulation of genetically unstable breast stem cells, providing prime targets for further carcinogenic events...
  4. pmc MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Genet 8:e1002751. 2012
    ..These studies demonstrate that miRNAs can regulate the states and fates of normal and malignant mammary stem cells, findings which have important biological and clinical implications...
  5. pmc Conjugated linoleic acid induces apoptosis through estrogen receptor alpha in human breast tissue
    Li Shu Wang
    Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    BMC Cancer 8:208. 2008
    ..Our research interest is to examine the effects of CLA on the induction of apoptosis in human breast tissues...
  6. pmc Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
    Suling Liu
    Comprehensive Cancer Center and School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 71:614-24. 2011
    ..Bone marrow-derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population...
  7. pmc ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    Christophe Ginestier
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Stem Cell 1:555-67. 2007
    ..These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts...
  8. pmc Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
    Yanyan Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2580-90. 2010
    ..In this study, we evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, for its efficacy to inhibit breast CSCs and its potential mechanism...
  9. ncbi request reprint Stem cells in mammary development and carcinogenesis: implications for prevention and treatment
    Gabriela Dontu
    Department of Internal Medicine, Hematology Oncology, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Stem Cell Rev 1:207-13. 2005
    ..Furthermore, the concept of cancer as a disease of stem and progenitor cells has profound implications for the development of new strategies for cancer prevention and therapy...
  10. pmc Distinct FAK activities determine progenitor and mammary stem cell characteristics
    Ming Luo
    Divisions of Molecular Medicine and Genetics and Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, and Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Res 73:5591-602. 2013
    ..We suggest that targeting these distinct functions may tailor therapeutic strategies to address breast cancer heterogeneity more effectively...
  11. pmc CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
    Christophe Ginestier
    University of Michigan Comprehensive Cancer Center, Department of Internal Medicine Oncology, Ann Arbor, Michigan 48109 0015, USA
    J Clin Invest 120:485-97. 2010
    ..Our data therefore suggest that CXCR1 blockade may provide a novel means of targeting and eliminating breast CSCs...
  12. pmc Targeting breast stem cells with the cancer preventive compounds curcumin and piperine
    Madhuri Kakarala
    Division of Hematology Oncology, Department of Internal Medicine and Comprehensive Cancer Center, University of Michigan, 2150 Cancer Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    Breast Cancer Res Treat 122:777-85. 2010
    ..Mammosphere formation assays may be a quantifiable biomarker to assess cancer preventive agent efficacy and Wnt signaling assessment can be a mechanistic biomarker for use in human clinical trials...
  13. ncbi request reprint Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0946, USA
    Cancer Res 66:6063-71. 2006
    ..These studies support a cancer stem cell model in which the hedgehog pathway and Bmi-1 play important roles in regulating self-renewal of normal and tumorigenic human mammary stem cells...
  14. pmc Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells
    Ming Luo
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Res 69:466-74. 2009
    ..Together, these results show a novel function of FAK in maintaining the mammary cancer stem/progenitor cell population and provide a novel mechanism by which FAK may promote breast cancer development and progression...
  15. pmc Breast cancer stem cells, cytokine networks, and the tumor microenvironment
    Hasan Korkaya
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 121:3804-9. 2011
    ..Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development...
  16. doi request reprint Role of microRNAs in the regulation of breast cancer stem cells
    Suling Liu
    Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5942, USA
    J Mammary Gland Biol Neoplasia 17:15-21. 2012
    ..In addition, since CSC states are regulated by miRNAs, these small non-coding RNAs may be useful therapeutic agents to target CSCs...
  17. pmc Regulation of cancer stem cells by cytokine networks: attacking cancer's inflammatory roots
    Hasan Korkaya
    Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Clin Cancer Res 17:6125-9. 2011
    ..By blocking signals from the tumor microenvironment, these agents have the potential to target CSCs. Future clinical trials using these compounds will be needed to determine whether targeting the CSC population has clinical benefit...
  18. doi request reprint Targeting breast cancer stem cells
    Suling Liu
    Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA
    J Clin Oncol 28:4006-12. 2010
    ..The effective targeting of breast cancer stem cells has the potential to significantly improve outcome for women with both early-stage and advanced breast cancer...
  19. pmc Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population
    Hasan Korkaya
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 5942, USA
    Mol Cell 47:570-84. 2012
    ..These studies demonstrate that trastuzumab resistance may be mediated by an IL6 inflammatory loop and suggest that blocking this loop may provide alternative strategy to overcome trastuzumab resistance...
  20. pmc Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0669, USA
    Int J Cancer 130:29-39. 2012
    ..Altogether, the data suggest that ALDH+ and CD133+ cells are enriched with ovarian cancer-initiating (stem) cells and that ALDH and CD133 may be widely used as reliable markers to investigate ovarian cancer stem cell biology...
  21. ncbi request reprint Cancer stem cells: an old idea--a paradigm shift
    Max S Wicha
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48109 0942, USA
    Cancer Res 66:1883-90; discussion 1895-6. 2006
    ..The development of more effective cancer therapies may thus require targeting this important cell population...
  22. ncbi request reprint The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer
    Suling Liu
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA
    Anticancer Res 22:33-8. 2002
    ....
  23. ncbi request reprint Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha
    Suling Liu
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, Ohio State University, 1900 Coffey Road, Columbus, OH 43210 1092, USA
    Anticancer Res 22:3917-23. 2002
    ..In conclusion, results indicate that Z induces estrogenic effects in human breast relative of PTP gamma expression and the estrogenic down-regulation of PTP gamma expression in human breast is associated with ER alpha...
  24. ncbi request reprint Function analysis of estrogenically regulated protein tyrosine phosphatase gamma (PTPgamma) in human breast cancer cell line MCF-7
    Suling Liu
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Oncogene 23:1256-62. 2004
    ..Our data suggest that PTPgamma may function as an important modulator in regulating the process of tumorigenesis in human breast...
  25. ncbi request reprint Transformation of MCF-10A human breast epithelial cells by zeranol and estradiol-17beta
    Suling Liu
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, Ohio State University, 1900 Coffey Rd, Columbus, Ohio 43210 1092, USA
    Breast J 10:514-21. 2004
    ....
  26. ncbi request reprint Effects of human breast stromal cells on conjugated linoleic acid (CLA) modulated vascular endothelial growth factor-A (VEGF-A) expression in MCF-7 cells
    Li Shu Wang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 25:4061-8. 2005
    ..Our previous results indicated that CLA induced suppression of VEGF-A in MCF-7 cells, which may be one of CLA's anticancer mechanisms...
  27. ncbi request reprint Conjugated linoleic acid (CLA) up-regulates the estrogen-regulated cancer suppressor gene, protein tyrosine phosphatase gamma (PTPgama), in human breast cells
    Li Shu Wang
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Anticancer Res 26:27-34. 2006
    ..Our previous results indicated that estradiol-17beta (E2)-induced suppression of PTPgamma may play a role in mammary tumorigenesis...
  28. ncbi request reprint Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents
    Suling Liu
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus 43210 1092, USA
    Breast Cancer Res Treat 71:21-35. 2002
    ..Zeranol (Z), a nonsteroidal growth promoter with estrogenic activity that is used by the US meat industry, induces estrogenic responses in primary cultured breast cells and breast cancer cell lines...