Simin Liu

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Common Genetic Variants in Peroxisome Proliferator-Activated Receptor-γ (PPARG) and Type 2 Diabetes Risk Among Women's Health Initiative Postmenopausal Women
    Kei Hang K Chan
    Center for Metabolic Disease Prevention, University of California, Los Angeles, Box 951772, 650 Charles E Young Drive South, Los Angeles, California 90095
    J Clin Endocrinol Metab 98:E600-4. 2013
  2. pmc Postmenopausal estrogen and progestin effects on the serum proteome
    Sharon J Pitteri
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Genome Med 1:121. 2009
  3. pmc Prevalence and clustering of metabolic risk factors for type 2 diabetes among Chinese adults in Shanghai, China
    He Xu
    Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    BMC Public Health 10:683. 2010
  4. ncbi request reprint A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women
    Simin Liu
    Department of Epidemiology, University of California, Los Angeles, CA 90095 1772, USA
    Arch Intern Med 167:1676-85. 2007
  5. ncbi request reprint Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women
    Simin Liu
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Diabetes Care 28:2926-32. 2005
  6. ncbi request reprint A prospective study of dairy intake and the risk of type 2 diabetes in women
    Simin Liu
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 29:1579-84. 2006
  7. ncbi request reprint Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial
    Simin Liu
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Diabetes 55:2856-62. 2006
  8. pmc Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal women
    Sara A Chacko
    Department of Epidemiology and Program on Genomics and Nutrition, School of Public Health, and Center for Metabolic Diseases Prevention, UCLA, Los Angeles, California, USA
    Diabetes Care 33:304-10. 2010
  9. pmc Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts
    Brian H Chen
    Program on Genomics and Nutrition, Department of Epidemiology, UCLA School of Public Health, Los Angeles, California, USA
    Diabetes Care 32:329-34. 2009
  10. pmc FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:2472-80. 2008

Collaborators

Detail Information

Publications102 found, 100 shown here

  1. pmc Common Genetic Variants in Peroxisome Proliferator-Activated Receptor-γ (PPARG) and Type 2 Diabetes Risk Among Women's Health Initiative Postmenopausal Women
    Kei Hang K Chan
    Center for Metabolic Disease Prevention, University of California, Los Angeles, Box 951772, 650 Charles E Young Drive South, Los Angeles, California 90095
    J Clin Endocrinol Metab 98:E600-4. 2013
    ..04). Conclusions: The association between PPARG Pro12Ala SNP and increased T2D susceptibility was confirmed, with Pro12 as risk allele. Additional significant loci included 5 PPARG promoter variants...
  2. pmc Postmenopausal estrogen and progestin effects on the serum proteome
    Sharon J Pitteri
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Genome Med 1:121. 2009
    ..The biologic mechanisms underlying these effects, and these differences, have yet to be fully elucidated...
  3. pmc Prevalence and clustering of metabolic risk factors for type 2 diabetes among Chinese adults in Shanghai, China
    He Xu
    Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    BMC Public Health 10:683. 2010
    ..Type 2 diabetes is becoming an epidemic in China. To evaluate the prevalence, clustering of metabolic risk factors and their impact on type 2 diabetes, we conducted a population-based study in Shanghai, China's largest metropolitan area...
  4. ncbi request reprint A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women
    Simin Liu
    Department of Epidemiology, University of California, Los Angeles, CA 90095 1772, USA
    Arch Intern Med 167:1676-85. 2007
    ..However, prospective studies that comprehensively assess their roles in the development of type 2 diabetes are few, especially in minority populations...
  5. ncbi request reprint Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women
    Simin Liu
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Diabetes Care 28:2926-32. 2005
    ..To examine whether and to what extent intakes of calcium and vitamin D are related to the metabolic syndrome in middle-aged or older women...
  6. ncbi request reprint A prospective study of dairy intake and the risk of type 2 diabetes in women
    Simin Liu
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 29:1579-84. 2006
    ..Although studies have indicated that increased dairy intake may reduce risk of overweight and insulin resistance syndrome, data directly relating dairy intake to type 2 diabetes remain sparse...
  7. ncbi request reprint Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial
    Simin Liu
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Diabetes 55:2856-62. 2006
    ..83-1.04) (P = 0.21) compared with those randomized to placebo. In this large trial with 10-year follow-up, alternate-day doses of 600 IU vitamin E provided no significant benefit for type 2 diabetes in initially healthy women...
  8. pmc Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal women
    Sara A Chacko
    Department of Epidemiology and Program on Genomics and Nutrition, School of Public Health, and Center for Metabolic Diseases Prevention, UCLA, Los Angeles, California, USA
    Diabetes Care 33:304-10. 2010
    ..Although magnesium may favorably affect metabolic outcomes, few studies have investigated the role of magnesium intake in systemic inflammation and endothelial dysfunction in humans...
  9. pmc Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts
    Brian H Chen
    Program on Genomics and Nutrition, Department of Epidemiology, UCLA School of Public Health, Los Angeles, California, USA
    Diabetes Care 32:329-34. 2009
    ..The purpose of this study was to investigate the role of circulating resistin levels in the development of type 2 diabetes using two prospective cohorts of well-characterized men and women...
  10. pmc FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:2472-80. 2008
    ..In conclusion, common genetic variants in the intron 1 of FTO gene may confer a modest susceptibility to obesity in an ethnicity-specific manner, but may be unlikely to contribute to a clinically significant diabetes risk...
  11. pmc Sex hormone-binding globulin and risk of type 2 diabetes in women and men
    Eric L Ding
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 361:1152-63. 2009
    ..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain...
  12. ncbi request reprint Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older U.S. women
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Diabetes Care 28:1438-44. 2005
    ..The aim of this study was to examine whether and to what extent magnesium intake is related to systemic inflammation and the metabolic syndrome...
  13. pmc Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive protein
    Emily B Levitan
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Metabolism 57:437-43. 2008
    ..24, and TG = 13 mg/dL). Differences in blood lipids and CRP between extreme quintiles of dietary GI and GL were small, but may translate into a clinically meaningful difference in cardiovascular risk...
  14. pmc Dietary glycemic load, glycemic index, and carbohydrate and risk of breast cancer in the Women's Health Initiative
    James M Shikany
    Division of Preventive Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham Alabama 35294, USA
    Nutr Cancer 63:899-907. 2011
    ..07). Although there was no evidence of associations between GL, GI, or carbohydrate and total breast cancer risk in WHI participants, the suggestion of an association between GL and risk of in situ cancers requires further investigation...
  15. ncbi request reprint Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort
    Nicola M McKeown
    Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Diabetes Care 27:538-46. 2004
    ..The aim of this study was to examine the relation between carbohydrate-related dietary factors, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring Cohort...
  16. ncbi request reprint The association between magnesium intake and fasting insulin concentration in healthy middle-aged women
    Teresa T Fung
    Department of Nutrition, Simmons College, 300 The Fenway, Boston, MA 02215, USA
    J Am Coll Nutr 22:533-8. 2003
    ..We assessed the association between magnesium intake and fasting insulin levels in a large cohort of women...
  17. pmc Intake of small-to-medium-chain saturated fatty acids is associated with peripheral leukocyte telomere length in postmenopausal women
    Yan Song
    Department of Epidemiology and Program on Genomics and Nutrition, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA
    J Nutr 143:907-14. 2013
    ..These findings suggest the potential roles of SMSFAs in the rate of biological aging...
  18. pmc Plasma adiponectin and the risk of hypertension in white and black postmenopausal women
    Lu Wang
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Clin Chem 58:1438-45. 2012
    ..We conducted a prospective, nested case control study to investigate the relation between baseline plasma adiponectin, measures of adiposity, and subsequent risk of hypertension...
  19. pmc Circulating inflammatory and endothelial markers and risk of hypertension in white and black postmenopausal women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Chem 57:729-36. 2011
    ..However, epidemiologic studies have yet to compare multiple corresponding biomarkers in relation to risk of hypertension, particularly in multiethnic populations...
  20. pmc Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in women
    Yiqing Song
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Med Genet 10:4. 2009
    ..However, it is unclear whether common genetic variation in TRPM6 and TRPM7 contributes to risk of type 2 diabetes...
  21. ncbi request reprint Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    J Am Coll Nutr 24:376-84. 2005
    ..The aim of the present study was to examine the association of dietary flavonol and flavone intake with type 2 diabetes, and biomarkers of insulin resistance and systemic inflammation...
  22. pmc Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective study
    William G Christen
    Divisions of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
    Arch Ophthalmol 126:102-9. 2008
    ..To examine in prospective data the relation between dietary intake of carotenoids and vitamins C and E and the risk of cataract in women...
  23. ncbi request reprint Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women
    Simin Liu
    Division of Preventive Medicine and the Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 78:920-7. 2003
    ..Although increased consumption of dietary fiber and grain products is widely recommended to maintain healthy body weight, little is known about the relation of whole grains to body weight and long-term weight changes...
  24. pmc Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort
    Cathy C Lee
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Clin Chem 55:351-60. 2009
    ....
  25. ncbi request reprint Low-carbohydrate-diet score and the risk of coronary heart disease in women
    Thomas L Halton
    Departments of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 355:1991-2002. 2006
    ..Low-carbohydrate diets have been advocated for weight loss and to prevent obesity, but the long-term safety of these diets has not been determined...
  26. ncbi request reprint Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women
    Yiqing Song
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes Care 27:59-65. 2004
    ..Higher intake of magnesium appears to improve glucose and insulin homeostasis; however, there are sparse prospective data on the association between magnesium intake and incidence of type 2 diabetes...
  27. pmc Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 56:1898-904. 2007
    ..S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes...
  28. ncbi request reprint Dietary intake of whole and refined grain breakfast cereals and weight gain in men
    Lydia A Bazzano
    Department of Medicine, Beth Israel Deaconess Hospital, Boston, Massachusetts, USA
    Obes Res 13:1952-60. 2005
    ..The aim of this study was to prospectively assess the association between whole and refined grain breakfast cereal intakes and risk of overweight (BMI >or= 25 kg/m(2)) and weight gain...
  29. ncbi request reprint Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Epidemiol 164:576-85. 2006
    ..91 (95% CI: 0.46, 1.81) for beta-cryptoxanthin, and 1.35 (95% CI: 0.68, 2.69) for lutein/zeaxanthin. There was no prospective association between baseline plasma carotenoids and the risk of type 2 diabetes in middle-aged and older women...
  30. ncbi request reprint Common genetic variation in calpain-10 gene (CAPN10) and diabetes risk in a multi-ethnic cohort of American postmenopausal women
    Yiqing Song
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Hum Mol Genet 16:2960-71. 2007
    ..37 for haplotypes in block 2). In conclusion, we did not observe any significant associations of the common SNPs or haplotypes across the CAPN10 gene with diabetes risk in our large and ethnically diverse cohort of postmenopausal women...
  31. doi request reprint Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain
    Eva Qing Ye
    Program on Genomics and Nutrition, School of Public Health, University of California, Los Angeles, CA, USA
    J Nutr 142:1304-13. 2012
    ..Potential mechanisms responsible for whole grains' effects on metabolic intermediates require further investigation in large intervention trials...
  32. pmc Low-carbohydrate-diet score and risk of type 2 diabetes in women
    Thomas L Halton
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Clin Nutr 87:339-46. 2008
    ..Low-carbohydrate weight-loss diets remain popular; however, the long-term effects of these diets are not known...
  33. ncbi request reprint Whole- and refined-grain intakes and the risk of hypertension in women
    Lu Wang
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
    Am J Clin Nutr 86:472-9. 2007
    ..Prospective studies linking whole- and refined-grain intakes with the risk of hypertension, a major cardiovascular disease risk factor, remain limited...
  34. ncbi request reprint Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes Care 29:1501-5. 2006
    ..The purpose of this study was to examine the associations of dietary fibers and glycemic load with plasma adiponectin in diabetic women and investigate the modification effect of obesity...
  35. ncbi request reprint Genetic variation at the adiponectin locus and risk of type 2 diabetes in women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Diabetes 53:209-13. 2004
    ..03-2.08, P = 0.03). These data suggest a potential interaction between the adiponectin genotype and PPAR gamma genotype or obesity, but these analyses should be considered exploratory and require further investigation in larger studies...
  36. ncbi request reprint Dietary glycemic index, glycemic load, cereal fiber, and plasma adiponectin concentration in diabetic men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes Care 28:1022-8. 2005
    ..Adiponectin may improve insulin sensitivity, reduce inflammation, and ameliorate glycemic control. However, few studies have evaluated dietary predictors of plasma adiponectin levels, especially among subjects with type 2 diabetes...
  37. ncbi request reprint Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Diabetes Care 29:207-11. 2006
    ..To evaluate the dietary predictors for the markers of systemic inflammation and endothelial dysfunction in patients with type 2 diabetes...
  38. ncbi request reprint Insulin, proinsulin, proinsulin:insulin ratio, and the risk of developing type 2 diabetes mellitus in women
    Aruna D Pradhan
    Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Med 114:438-44. 2003
    ..To assess the associations among baseline levels of fasting insulin and proinsulin, proinsulin:insulin ratio, and the development of type 2 diabetes mellitus in apparently healthy middle-aged women...
  39. pmc Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women's Health Initiative Observational Study
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Diabetes Care 30:1747-52. 2007
    ..However, prospective data regarding its relation to diabetes risk in ethnically diverse populations are limited...
  40. ncbi request reprint Potato and french fry consumption and risk of type 2 diabetes in women
    Thomas L Halton
    Department of Nutrition and Epidemiology, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02215, USA
    Am J Clin Nutr 83:284-90. 2006
    ..Potatoes, a high glycemic form of carbohydrate, are hypothesized to increase insulin resistance and risk of type 2 diabetes...
  41. ncbi request reprint Magnesium intake and risk of type 2 diabetes in men and women
    Ruy Lopez-Ridaura
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Diabetes Care 27:134-40. 2004
    ..To examine the association between magnesium intake and risk of type 2 diabetes...
  42. ncbi request reprint Dietary glycemic load, carbohydrate, sugar, and colorectal cancer risk in men and women
    Dominique S Michaud
    Harvard School of Public Health, Kresge 920, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:138-47. 2005
    ..High intakes of GL, fructose, and sucrose were related to an elevated colorectal cancer risk among men. For women, however, these factors did not seem to increase the risk of colorectal cancer...
  43. ncbi request reprint Carbohydrate intake, glycemic index, glycemic load, and dietary fiber in relation to risk of stroke in women
    Kyungwon Oh
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Am J Epidemiol 161:161-9. 2005
    ..In addition, high consumption of cereal fiber was associated with lower risk of total and hemorrhagic stroke...
  44. ncbi request reprint A prospective study of fruit and vegetable intake and the risk of type 2 diabetes in women
    Simin Liu
    Division of Preventive Medicine, Brigham Women s Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Diabetes Care 27:2993-6. 2004
  45. doi request reprint Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the Women's Health Initiative Observational Study
    Yi Hsiang Hsu
    Institute for Aging Research, Hebrew Senior Life and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:1101-7. 2008
    ..Genetic variants in the UCP2-UCP3 gene cluster, located on chromosome 11q13, may play a significant role in the development of type 2 diabetes...
  46. pmc Elevated depressive symptoms, antidepressant use, and diabetes in a large multiethnic national sample of postmenopausal women
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Diabetes Care 34:2390-2. 2011
    ..To examine elevated depressive symptoms and antidepressant use in relation to diabetes incidence in the Women's Health Initiative...
  47. pmc Common genetic variants in fatty acid-binding protein-4 (FABP4) and clinical diabetes risk in the Women's Health Initiative Observational Study
    Kei Hang K Chan
    Program on Genomics and Nutrition, Department of Epidemiology, University of California, Los Angeles, California, USA
    Obesity (Silver Spring) 18:1812-20. 2010
    ..The observed significant association between reduced VCAM-1 levels and FABP4 genotypes in African-American women warrant further confirmation...
  48. ncbi request reprint Dietary magnesium intake and risk of cardiovascular disease among women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:1135-41. 2005
    ..In conclusion, the results do not support the hypothesis that magnesium intake reduces the development of CHD, although a modest inverse association with stroke cannot be ruled out...
  49. ncbi request reprint Dietary glycemic load and risk of colorectal cancer in the Women's Health Study
    Susan Higginbotham
    Department of Epidemiology, University of California at Los Angeles, USA
    J Natl Cancer Inst 96:229-33. 2004
    ..09, 95% CI = 1.13 to 3.87; P(trend) =.08) were also statistically significantly associated with increased risk. Thus, our data indicate that a diet with a high dietary glycemic load may increase the risk of colorectal cancer in women...
  50. ncbi request reprint Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up study
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Cardiol 98:1616-21. 2006
    ..In conclusion, the results suggest that higher intake of dietary magnesium may have a modest effect on the development of hypertension in women...
  51. pmc Selected antioxidants and risk of hormone receptor-defined invasive breast cancers among postmenopausal women in the Women's Health Initiative Observational Study
    Yan Cui
    Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, CA 90012, USA
    Am J Clin Nutr 87:1009-18. 2008
    ..Few studies have evaluated carotenoids and vitamins C and E in association with the risk of breast cancers defined by estrogen receptor (ER) and progesterone receptor (PR) status...
  52. pmc Associations between NBS1 polymorphisms, haplotypes and smoking-related cancers
    Sungshim L Park
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, 71 225 CHS, Box 951772, 650 Charles E Young Drive, South, Los Angeles, CA 90095 1772, USA
    Carcinogenesis 31:1264-71. 2010
    ..These hypotheses should be further examined in functional studies...
  53. ncbi request reprint Dietary carbohydrates, fiber, and breast cancer risk
    Michelle D Holmes
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Epidemiol 159:732-9. 2004
    ..This study also confirmed the lack of an overall association between intake of fiber and fiber types and breast cancer risk observed in other prospective studies...
  54. ncbi request reprint Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women
    Matthias B Schulze
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Am J Clin Nutr 80:348-56. 2004
    ..Increasing evidence suggests an important role of carbohydrate quality in the development of type 2 diabetes...
  55. pmc Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women
    Atsushi Goto
    Department of Epidemiology, Center for Metabolic Disease Prevention, University of California, Los Angeles, USA
    Diabetes 60:269-75. 2011
    ..We aimed to examine whether plasma levels of sex hormones and sex hormone-binding globulin (SHBG) may account for the inverse association between coffee consumption and type 2 diabetes risk...
  56. pmc Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers
    Sam S Oh
    Department of Epidemiology, University of California, Los Angeles UCLA School of Public Health, Los Angeles, CA, USA
    Int J Cancer 127:2169-82. 2010
    ....
  57. pmc Determinants of racial/ethnic disparities in incidence of diabetes in postmenopausal women in the U.S.: The Women's Health Initiative 1993-2009
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Diabetes Care 35:2226-34. 2012
    ..To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating in the Women's Health Initiative...
  58. pmc Common variations in the genes encoding C-reactive protein, tumor necrosis factor-alpha, and interleukin-6, and the risk of clinical diabetes in the Women's Health Initiative Observational Study
    Kei Hang K Chan
    Program on Genomics and Nutrition, Department of Epidemiology, UCLA, Los Angeles, CA 90095, USA
    Clin Chem 57:317-25. 2011
    ..Circulating concentrations of high-sensitivity C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) have been associated with an increased risk of diabetes...
  59. pmc A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal women
    Nai Chieh Y You
    Program on Genomics and Nutrition, Department of Epidemiology, Fielding School of Public Health, and Departments of Medicine and Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles UCLA, Los Angeles, CA, USA
    Diabetes 61:2998-3004. 2012
    ..These prospective findings indicate limited clinical utility of TL in diabetes risk stratification among postmenopausal women...
  60. ncbi request reprint Sex hormone-binding globulin and risk of clinical diabetes in American black, Hispanic, and Asian/Pacific Islander postmenopausal women
    Brian H Chen
    Program on Genomics and Nutrition, Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA
    Clin Chem 58:1457-66. 2012
    ..However, it remains unclear whether this relationship extends to other racial/ethnic populations...
  61. ncbi request reprint Is intake of breakfast cereals related to total and cause-specific mortality in men?
    Simin Liu
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 77:594-9. 2003
    ..Although breakfast cereals are a major source of whole and refined grains, little is known about their direct association with the risk of premature mortality...
  62. ncbi request reprint Dietary fiber intake, dietary glycemic load, and the risk for gestational diabetes mellitus
    Cuilin Zhang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes Care 29:2223-30. 2006
    ..We aimed to examine whether pregravid dietary fiber consumptions from cereal, fruit, and vegetable sources and dietary glycemic load were related to gestational diabetes mellitus (GDM) risk...
  63. ncbi request reprint The consumption of lycopene and tomato-based food products is not associated with the risk of type 2 diabetes in women
    Lu Wang
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Nutr 136:620-5. 2006
    ..Our study found little evidence for an association between dietary intake of lycopene or lycopene-containing foods and the risk of type 2 DM...
  64. ncbi request reprint A prospective study of red meat consumption and type 2 diabetes in middle-aged and elderly women: the women's health study
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, BrighamWomen s Hospital, Harvard Medical School, 900 Commonwealth Ave East, Boston, MA 02215, USA
    Diabetes Care 27:2108-15. 2004
    ..The aim of this study was to prospectively assess the relation between red meat intake and incidence of type 2 diabetes...
  65. ncbi request reprint Dietary intakes of fruit, vegetables, and fiber, and risk of colorectal cancer in a prospective cohort of women (United States)
    Jennifer Lin
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Cancer Causes Control 16:225-33. 2005
    ..We prospectively examined the association between dietary intakes of fruit, vegetables, and fiber and colorectal cancer risk in a large female cohort from the Women's Health Study...
  66. ncbi request reprint Whole-grain intake and the risk of type 2 diabetes: a prospective study in men
    Teresa T Fung
    Programs in Nutrition, Simmons College, Boston, MA 02115, USA
    Am J Clin Nutr 76:535-40. 2002
    ..Certain dietary components may play a role in the prevention of type 2 diabetes...
  67. pmc Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women
    Sara A Chacko
    Department of Epidemiology and the Program on Genomics and Nutrition, University of California, Los Angeles, Los Angeles, CA
    Am J Clin Nutr 94:209-17. 2011
    ..Low concentrations of serum 25-hydroxyvitamin D [25(OH)D] may be associated with cardiometabolic disorders; however, little is known about their relation to intermediate metabolic and lipid markers...
  68. ncbi request reprint A prospective study of the association between APOE genotype and the risk of myocardial infarction among apparently healthy men
    Simin Liu
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 166:323-9. 2003
    ..Apolipoprotein E (apoE) plays an important role in lipid metabolism. Three common alleles in the APOE gene, E2/E3/E4, have been associated with lipoprotein disorders but their effects on myocardial infarction (MI) risk remain uncertain...
  69. pmc Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals
    Sara A Chacko
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Clin Nutr 93:463-73. 2011
    ....
  70. ncbi request reprint A prospective study of sugar intake and risk of type 2 diabetes in women
    Sok Ja Janket
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 26:1008-15. 2003
    ..The contribution of sugar intake to the pathogenesis of type 2 diabetes has not been settled in the context of primary prevention because of limited prospective data...
  71. ncbi request reprint A prospective study of the APOA1 XmnI and APOC3 SstI polymorphisms in the APOA1/C3/A4 gene cluster and risk of incident myocardial infarction in men
    Simin Liu
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
    Atherosclerosis 177:119-26. 2004
    ..However, whether genetic variations in the APOA1/C3/A4 gene cluster are associated with the risk of myocardial infarction (MI) remains uncertain and prospective data are sparse...
  72. ncbi request reprint Dietary glycemic load and breast cancer risk in the Women's Health Study
    Susan Higginbotham
    Department of Epidemiology, UCLA School of Public Health, University of California at Los Angeles UCLA, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 13:65-70. 2004
    ..Prospective studies of a larger sample size and longer duration are warranted to confirm our findings...
  73. pmc Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial
    James M Shikany
    Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Clin Nutr 94:75-85. 2011
    ..Glycemic effects of the Women's Health Initiative (WHI) low-fat dietary intervention are unknown...
  74. ncbi request reprint Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese women
    Raquel Villegas
    Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, 2525 West End Ave, Ste 600, Nashville, TN 37203 1738, USA
    Arch Intern Med 167:2310-6. 2007
    ..Much uncertainty exists about the role of dietary glycemic index and glycemic load in the development of type 2 diabetes mellitus, especially in populations that traditionally subsist on a diet high in carbohydrates...
  75. ncbi request reprint Prevention of type 2 diabetes by diet and lifestyle modification
    Lydia A Bazzano
    Department of Medicine, Beth Israel Deaconess Hospital, Boston, MA 02215, USA
    J Am Coll Nutr 24:310-9. 2005
    ..Prevention of this devastating disease calls for the identification of culture-sensitive measures that can be applied to the population in general and some high-risk minority groups in particular...
  76. ncbi request reprint Nut and peanut butter consumption and risk of type 2 diabetes in women
    Rui Jiang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    JAMA 288:2554-60. 2002
    ..Nuts are high in unsaturated (polyunsaturated and monounsaturated) fat and other nutrients that may improve glucose and insulin homeostasis...
  77. pmc Effects of glycemic load on metabolic health and type 2 diabetes mellitus
    Christian K Roberts
    Program on Genomics and Nutrition, Department of Epidemiology, University of California, Los Angeles, School of Public Health, Los Angeles, California 90095 1772, USA
    J Diabetes Sci Technol 3:697-704. 2009
    ..Overall, a low dietary GL may be protective against metabolic disease and should be considered as a healthful dietary component...
  78. ncbi request reprint Intake of refined carbohydrates and whole grain foods in relation to risk of type 2 diabetes mellitus and coronary heart disease
    Simin Liu
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard School of Medicine, Boston, Massachusetts 02115, USA
    J Am Coll Nutr 21:298-306. 2002
    ..It seems prudent, therefore, to distinguish whole-grain rather than refined-grain cereal products for the prevention of chronic diseases...
  79. pmc Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study
    Yunsheng Ma
    Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nutrition 24:941-9. 2008
    ....
  80. ncbi request reprint Types of carbohydrates and risk of cardiovascular disease
    Mark A Pereira
    Department of Pediatrics, Harvard Medical School and Children s Hospital, Boston, Massachusetts 02115, USA
    J Womens Health (Larchmt) 12:115-22. 2003
    ..More long-term controlled trials are needed to improve our understanding of efficacy and mechanisms. Women and a variety of racial/ethnic groups should be represented in these studies whenever possible...
  81. ncbi request reprint Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination Survey
    Hyon K Choi
    Rheumatology Unit, Bulfinch 165, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Arthritis Rheum 52:283-9. 2005
    ..Our objective was to evaluate the relationship between dietary factors and serum uric acid levels in a nationally representative sample of men and women in the US...
  82. ncbi request reprint Dietary intake of fruits and vegetables and risk of cardiovascular disease
    Lydia A Bazzano
    Division of Preventive Medicine, Harvard Medical School and Brigham and Women s Hospital, 900 Commonwealth Avenue, Boston, MA 02215, USA
    Curr Atheroscler Rep 5:492-9. 2003
    ....
  83. ncbi request reprint Flavonoid intake and the risk of cardiovascular disease in women
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 77:1400-8. 2003
    ..Despite emerging evidence of the role of flavonoids in cardiovascular disease (CVD) prevention, the association remains unclear...
  84. ncbi request reprint Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women
    Simin Liu
    Center of Cardiovascular Prevention, the Division of Preventive Medicine, Harvard Medical School, Boston 02215, USA
    Am J Clin Nutr 75:492-8. 2002
    ..Recent prospective data suggest that intake of rapidly digested and absorbed carbohydrates with a high dietary glycemic load is associated with an increased risk of ischemic heart disease...
  85. ncbi request reprint Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study
    Nicola M McKeown
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 76:390-8. 2002
    ..The influence of whole grains on cardiovascular disease risk may be mediated through multiple pathways, eg, a reduction in blood lipids and blood pressure, an enhancement of insulin sensitivity, and an improvement in blood glucose control...
  86. pmc Maternal dietary glycemic intake and the risk of neural tube defects
    Mahsa M Yazdy
    Slone Epidemiology Center, Boston University, Boston, MA02215, USA
    Am J Epidemiol 171:407-14. 2010
    ..0); for high DGL, it was 1.8 (95% confidence interval: 0.8, 4.0). Diets with proportionally high DGI or DGL may put the developing fetus at risk of an NTD, adding further evidence that hyperglycemia lies within the pathogenic pathway...
  87. pmc Comparison of usefulness of body mass index versus metabolic risk factors in predicting 10-year risk of cardiovascular events in women
    Yiqing Song
    Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 100:1654-8. 2007
    ..In conclusion, MS may largely account for the increased risk of CVD associated with BMI in apparently healthy women...
  88. ncbi request reprint Dietary lycopene, tomato-based food products and cardiovascular disease in women
    Howard D Sesso
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    J Nutr 133:2336-41. 2003
    ....
  89. ncbi request reprint Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetes
    Asli Memisoglu
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Diabetes Care 26:2915-7. 2003
    ..To determine whether the Pro12Ala polymorphism in the PPARgamma gene was associated with risk of type 2 diabetes in the Nurses' Health Study...
  90. ncbi request reprint Association between consumption of beer, wine, and liquor and plasma concentration of high-sensitivity C-reactive protein in women aged 39 to 89 years
    Emily B Levitan
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:83-8. 2005
    ..09 mg/L (p = 0.43). The association between alcohol and hs-CRP concentration appears to be mediated primarily by ethanol and was independent of the type of alcoholic beverage consumed once BMI was taken into account...
  91. ncbi request reprint Glycemic index, glycemic load, and risk of type 2 diabetes
    Walter Willett
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 76:274S-80S. 2002
    ....
  92. ncbi request reprint Dietary glycemic load and atherothrombotic risk
    Simin Liu
    Division of Preventive Medicine, Harvard Medical School and Brigham and Women s Hospital, 900 Commonwealth Avenue, Boston, MA 02215, USA
    Curr Atheroscler Rep 4:454-61. 2002
    ....
  93. ncbi request reprint Fruit and vegetable intake and the risk of cataract in women
    William G Christen
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 81:1417-22. 2005
    ..Prospective data on cataract in relation to total fruit and vegetable intake are limited...
  94. pmc Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies
    Yiqing Song
    Division of Preventive Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02215, USA
    Am J Hum Genet 74:208-22. 2004
    ..Our findings also suggest that both large-scale, well-designed association studies and functional studies are warranted to either reliably confirm or conclusively refute the initial hypothesis regarding the role of CAPN10 in T2D risk...
  95. ncbi request reprint Intake of dietary magnesium and the prevalence of the metabolic syndrome among U.S. adults
    Earl S Ford
    Centers for Disease Control and Prevention, 4770 Buford Highway, MS K66, Atlanta, GA 30341, USA
    Obesity (Silver Spring) 15:1139-46. 2007
    ..The aim of this study was to examine the associations between dietary intake of magnesium and the prevalence of the metabolic syndrome in a nationally representative sample of U.S. adults...
  96. pmc Effects of estrogen with and without progestin and obesity on symptomatic gastroesophageal reflux
    Zongli Zheng
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Gastroenterology 135:72-81. 2008
    ..An association between female hormones and symptomatic gastroesophageal reflux disease (GERD) and may be modified by obesity is suggested but not proven. Factors affecting GERD progression, however, are largely unknown...
  97. ncbi request reprint Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment
    Lee S Gross
    Inter Medic Medical Group, 2630 Bobcat Village Center Road, North Port, FL 34288, USA
    Am J Clin Nutr 79:774-9. 2004
    ....
  98. ncbi request reprint Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts
    Paul Knekt
    National Public Health Institute, Helsinki, Finland
    Am J Clin Nutr 80:1508-20. 2004
    ..Epidemiologic studies have suggested a lower risk of coronary heart disease (CHD) at higher intakes of fruit, vegetables, and whole grain. Whether this association is due to antioxidant vitamins or some other factors remains unclear...
  99. ncbi request reprint Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, MS K66, Atlanta, GA 30341, USA
    Diabetes Care 28:1228-30. 2005
  100. ncbi request reprint Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies
    Mark A Pereira
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN55454, USA
    Arch Intern Med 164:370-6. 2004
    ..The purpose of this study was to conduct a pooled analysis of dietary fiber and its subtypes and risk of coronary heart disease...
  101. ncbi request reprint Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL cholesterol levels in women with type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, United States
    Atherosclerosis 192:204-10. 2007
    ..006), whereas APOA4 +347T/A showed significant associations with lower levels of HDL-C (P=0.017). Our results indicate that the variability in APOA1/C3/A4/A5 gene cluster may affect TG and HDL levels in women with type 2 diabetes...

Research Grants12

  1. HIGH GLYCEMIC DIET AND RISK OF NIDDM AND CHD
    Simin Liu; Fiscal Year: 2002
    ..Through the process, Dr. Liu will acquire ample skills and experience to become an independent clinician scientist and educator in the field of nutrition and chronic disease prevention and control. ..
  2. Steroid Hormones, Adipose-cytokines, and Diabetes Risk
    Simin Liu; Fiscal Year: 2007
    ....
  3. Genetic and Biochemical Predictors of Type 2 DM in Women
    Simin Liu; Fiscal Year: 2006
    ..Knowledge gained from this proposed study may suggest new intervention strategies to lower the incidence of type 2 DM in the general population. ..