Research Topics
Genomes and Genes
| Simin LiuSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Common genetic variants in peroxisome proliferator-activated receptor-γ (PPARG) and type 2 diabetes risk among Women's Health Initiative postmenopausal womenKei Hang K Chan
Department of Epidemiology, Center for Metabolic Disease Prevention, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Clin Endocrinol Metab 98:E600-4. 2013..Peroxisome proliferator-activated receptor-γ (PPARG) plays a pivotal role in adipogenesis and glucose homeostasis...- Postmenopausal estrogen and progestin effects on the serum proteomeSharon J Pitteri
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Genome Med 1:121. 2009..The biologic mechanisms underlying these effects, and these differences, have yet to be fully elucidated... - Prevalence and clustering of metabolic risk factors for type 2 diabetes among Chinese adults in Shanghai, ChinaHe Xu
Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
BMC Public Health 10:683. 2010..Type 2 diabetes is becoming an epidemic in China. To evaluate the prevalence, clustering of metabolic risk factors and their impact on type 2 diabetes, we conducted a population-based study in Shanghai, China's largest metropolitan area... 
A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal womenSimin Liu
Department of Epidemiology, University of California, Los Angeles, CA 90095 1772, USA
Arch Intern Med 167:1676-85. 2007..However, prospective studies that comprehensively assess their roles in the development of type 2 diabetes are few, especially in minority populations...- Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. womenSimin Liu
Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Diabetes Care 28:2926-32. 2005..To examine whether and to what extent intakes of calcium and vitamin D are related to the metabolic syndrome in middle-aged or older women... - Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trialSimin Liu
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Diabetes 55:2856-62. 2006..83-1.04) (P = 0.21) compared with those randomized to placebo. In this large trial with 10-year follow-up, alternate-day doses of 600 IU vitamin E provided no significant benefit for type 2 diabetes in initially healthy women... - A prospective study of dairy intake and the risk of type 2 diabetes in womenSimin Liu
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Diabetes Care 29:1579-84. 2006..Although studies have indicated that increased dairy intake may reduce risk of overweight and insulin resistance syndrome, data directly relating dairy intake to type 2 diabetes remain sparse... - Relations of dietary magnesium intake to biomarkers of inflammation and endothelial dysfunction in an ethnically diverse cohort of postmenopausal womenSara A Chacko
Department of Epidemiology and Program on Genomics and Nutrition, School of Public Health, and Center for Metabolic Diseases Prevention, UCLA, Los Angeles, California, USA
Diabetes Care 33:304-10. 2010..Although magnesium may favorably affect metabolic outcomes, few studies have investigated the role of magnesium intake in systemic inflammation and endothelial dysfunction in humans... - Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohortsBrian H Chen
Program on Genomics and Nutrition, Department of Epidemiology, UCLA School of Public Health, Los Angeles, California, USA
Diabetes Care 32:329-34. 2009..The purpose of this study was to investigate the role of circulating resistin levels in the development of type 2 diabetes using two prospective cohorts of well-characterized men and women... - Sex hormone-binding globulin and risk of type 2 diabetes in women and menEric L Ding
Department of Nutrition, Harvard School of Public Health, Boston, USA
N Engl J Med 361:1152-63. 2009..Circulating sex hormone-binding globulin levels are inversely associated with insulin resistance, but whether these levels can predict the risk of developing type 2 diabetes is uncertain... - Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive proteinEmily B Levitan
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Metabolism 57:437-43. 2008..24, and TG = 13 mg/dL). Differences in blood lipids and CRP between extreme quintiles of dietary GI and GL were small, but may translate into a clinically meaningful difference in cardiovascular risk... - Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older U.S. womenYiqing Song
Division of Preventive Medicine, Brigham and Women s Hospital, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Diabetes Care 28:1438-44. 2005..The aim of this study was to examine whether and to what extent magnesium intake is related to systemic inflammation and the metabolic syndrome... 
Dietary glycemic load, glycemic index, and carbohydrate and risk of breast cancer in the Women's Health InitiativeJames M Shikany
Division of Preventive Medicine, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham Alabama 35294, USA
Nutr Cancer 63:899-907. 2011..07). Although there was no evidence of associations between GL, GI, or carbohydrate and total breast cancer risk in WHI participants, the suggestion of an association between GL and risk of in situ cancers requires further investigation...- FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal womenYiqing Song
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Obesity (Silver Spring) 16:2472-80. 2008..In conclusion, common genetic variants in the intron 1 of FTO gene may confer a modest susceptibility to obesity in an ethnicity-specific manner, but may be unlikely to contribute to a clinically significant diabetes risk... - The association between magnesium intake and fasting insulin concentration in healthy middle-aged womenTeresa T Fung
Department of Nutrition, Simmons College, 300 The Fenway, Boston, MA 02215, USA
J Am Coll Nutr 22:533-8. 2003..We assessed the association between magnesium intake and fasting insulin levels in a large cohort of women... - Carbohydrate nutrition, insulin resistance, and the prevalence of the metabolic syndrome in the Framingham Offspring CohortNicola M McKeown
Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
Diabetes Care 27:538-46. 2004..Given that both a high cereal fiber content and lower glycemic index are attributes of whole-grain foods, recommendation to increase whole-grain intake may reduce the risk of developing the metabolic syndrome... - Plasma adiponectin and the risk of hypertension in white and black postmenopausal womenLu Wang
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Clin Chem 58:1438-45. 2012..We conducted a prospective, nested case control study to investigate the relation between baseline plasma adiponectin, measures of adiposity, and subsequent risk of hypertension... - Circulating inflammatory and endothelial markers and risk of hypertension in white and black postmenopausal womenLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Clin Chem 57:729-36. 2011..However, epidemiologic studies have yet to compare multiple corresponding biomarkers in relation to risk of hypertension, particularly in multiethnic populations... - Common genetic variants of the ion channel transient receptor potential membrane melastatin 6 and 7 (TRPM6 and TRPM7), magnesium intake, and risk of type 2 diabetes in womenYiqing Song
Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
BMC Med Genet 10:4. 2009..However, it is unclear whether common genetic variation in TRPM6 and TRPM7 contributes to risk of type 2 diabetes... - Dietary carotenoids, vitamins C and E, and risk of cataract in women: a prospective studyWilliam G Christen
Divisions of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
Arch Ophthalmol 126:102-9. 2008..To examine in prospective data the relation between dietary intake of carotenoids and vitamins C and E and the risk of cataract in women... - Low-carbohydrate-diet score and the risk of coronary heart disease in womenThomas L Halton
Departments of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 355:1991-2002. 2006..When vegetable sources of fat and protein are chosen, these diets may moderately reduce the risk of coronary heart disease... - Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational CohortCathy C Lee
Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
Clin Chem 55:351-60. 2009.... - Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged womenSimin Liu
Division of Preventive Medicine and the Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Am J Clin Nutr 78:920-7. 2003..Although increased consumption of dietary fiber and grain products is widely recommended to maintain healthy body weight, little is known about the relation of whole grains to body weight and long-term weight changes... - Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysisYiqing Song
Division of Preventive Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
J Am Coll Nutr 24:376-84. 2005..The aim of the present study was to examine the association of dietary flavonol and flavone intake with type 2 diabetes, and biomarkers of insulin resistance and systemic inflammation... - Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of womenYiqing Song
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Diabetes 56:1898-904. 2007..S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes... - Dietary intake of whole and refined grain breakfast cereals and weight gain in menLydia A Bazzano
Department of Medicine, Beth Israel Deaconess Hospital, Boston, Massachusetts, USA
Obes Res 13:1952-60. 2005..78 and 0.88; 95% confidence interval, 0.67 to 0.91 and 0.76 to 1.00, respectively). DISCUSSION: BMI and weight gain were inversely associated with intake of breakfast cereals, independently of other risk factors... - Plasma lycopene, other carotenoids, and the risk of type 2 diabetes in womenLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Am J Epidemiol 164:576-85. 2006..91 (95% CI: 0.46, 1.81) for beta-cryptoxanthin, and 1.35 (95% CI: 0.68, 2.69) for lutein/zeaxanthin. There was no prospective association between baseline plasma carotenoids and the risk of type 2 diabetes in middle-aged and older women... - Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gainEva Qing Ye
Program on Genomics and Nutrition, School of Public Health, University of California, Los Angeles, CA, USA
J Nutr 142:1304-13. 2012..Potential mechanisms responsible for whole grains' effects on metabolic intermediates require further investigation in large intervention trials... - Low-carbohydrate-diet score and risk of type 2 diabetes in womenThomas L Halton
Department of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
Am J Clin Nutr 87:339-46. 2008..Low-carbohydrate weight-loss diets remain popular; however, the long-term effects of these diets are not known... - Whole- and refined-grain intakes and the risk of hypertension in womenLu Wang
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215, USA
Am J Clin Nutr 86:472-9. 2007..Prospective studies linking whole- and refined-grain intakes with the risk of hypertension, a major cardiovascular disease risk factor, remain limited... - Dietary glycemic index, glycemic load, cereal fiber, and plasma adiponectin concentration in diabetic menLu Qi
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Diabetes Care 28:1022-8. 2005..Adiponectin may improve insulin sensitivity, reduce inflammation, and ameliorate glycemic control. However, few studies have evaluated dietary predictors of plasma adiponectin levels, especially among subjects with type 2 diabetes... - Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetesLu Qi
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Diabetes Care 29:1501-5. 2006..The purpose of this study was to examine the associations of dietary fibers and glycemic load with plasma adiponectin in diabetic women and investigate the modification effect of obesity... - Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in womenYiqing Song
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes Care 27:59-65. 2004..5 pmol/l among those at the highest quartile (P = 0.03 for trend). CONCLUSIONS: These findings support a protective role of higher intake of magnesium in reducing the risk of developing type 2 diabetes, especially in overweight women... - Genetic variation at the adiponectin locus and risk of type 2 diabetes in womenFrank B Hu
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Diabetes 53:209-13. 2004..03-2.08, P = 0.03). These data suggest a potential interaction between the adiponectin genotype and PPAR gamma genotype or obesity, but these analyses should be considered exploratory and require further investigation in larger studies... - Common genetic variation in calpain-10 gene (CAPN10) and diabetes risk in a multi-ethnic cohort of American postmenopausal womenYiqing Song
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Hum Mol Genet 16:2960-71. 2007..37 for haplotypes in block 2). In conclusion, we did not observe any significant associations of the common SNPs or haplotypes across the CAPN10 gene with diabetes risk in our large and ethnically diverse cohort of postmenopausal women... - Insulin sensitivity and insulin secretion determined by homeostasis model assessment and risk of diabetes in a multiethnic cohort of women: the Women's Health Initiative Observational StudyYiqing Song
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Diabetes Care 30:1747-52. 2007..However, prospective data regarding its relation to diabetes risk in ethnically diverse populations are limited... - Potato and french fry consumption and risk of type 2 diabetes in womenThomas L Halton
Department of Nutrition and Epidemiology, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02215, USA
Am J Clin Nutr 83:284-90. 2006..CONCLUSIONS: Our findings suggest a modest positive association between the consumption of potatoes and the risk of type 2 diabetes in women. This association was more pronounced when potatoes were substituted for whole grains... - Magnesium intake and risk of type 2 diabetes in men and womenRuy Lopez-Ridaura
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Diabetes Care 27:134-40. 2004..To examine the association between magnesium intake and risk of type 2 diabetes... - Dietary glycemic load, carbohydrate, sugar, and colorectal cancer risk in men and womenDominique S Michaud
Harvard School of Public Health, Kresge 920, 677 Huntington Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 14:138-47. 2005..High intakes of GL, fructose, and sucrose were related to an elevated colorectal cancer risk among men. For women, however, these factors did not seem to increase the risk of colorectal cancer... - A prospective study of fruit and vegetable intake and the risk of type 2 diabetes in womenSimin Liu
Division of Preventive Medicine, Brigham Women's Hospital, 900 Commonwealth Ave. East, Boston, MA 02215, USA
Diabetes Care 27:2993-6. 2004 - Insulin, proinsulin, proinsulin:insulin ratio, and the risk of developing type 2 diabetes mellitus in womenAruna D Pradhan
Center for Cardiovascular Disease Prevention, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Med 114:438-44. 2003..To assess the associations among baseline levels of fasting insulin and proinsulin, proinsulin:insulin ratio, and the development of type 2 diabetes mellitus in apparently healthy middle-aged women... - Carbohydrate intake, glycemic index, glycemic load, and dietary fiber in relation to risk of stroke in womenKyungwon Oh
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Am J Epidemiol 161:161-9. 2005..In addition, high consumption of cereal fiber was associated with lower risk of total and hemorrhagic stroke... - Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal womenAtsushi Goto
Department of Epidemiology, Center for Metabolic Disease Prevention, University of California, Los Angeles, USA
Diabetes 60:269-75. 2011..We aimed to examine whether plasma levels of sex hormones and sex hormone-binding globulin (SHBG) may account for the inverse association between coffee consumption and type 2 diabetes risk... - Associations between NBS1 polymorphisms, haplotypes and smoking-related cancersSungshim L Park
Department of Epidemiology, School of Public Health, University of California, Los Angeles, 71 225 CHS, Box 951772, 650 Charles E Young Drive, South, Los Angeles, CA 90095 1772, USA
Carcinogenesis 31:1264-71. 2010..These hypotheses should be further examined in functional studies... - Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancersSam S Oh
Department of Epidemiology, University of California, Los Angeles UCLA School of Public Health, Los Angeles, CA, USA
Int J Cancer 127:2169-82. 2010.... - Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic womenLu Qi
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Diabetes Care 29:207-11. 2006..To evaluate the dietary predictors for the markers of systemic inflammation and endothelial dysfunction in patients with type 2 diabetes... - Glycemic index, glycemic load, and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged womenMatthias B Schulze
Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
Am J Clin Nutr 80:348-56. 2004..Increasing evidence suggests an important role of carbohydrate quality in the development of type 2 diabetes... - Dietary magnesium intake and risk of incident hypertension among middle-aged and older US women in a 10-year follow-up studyYiqing Song
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Am J Cardiol 98:1616-21. 2006..In conclusion, the results suggest that higher intake of dietary magnesium may have a modest effect on the development of hypertension in women... - Dietary magnesium intake and risk of cardiovascular disease among womenYiqing Song
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 96:1135-41. 2005..In conclusion, the results do not support the hypothesis that magnesium intake reduces the development of CHD, although a modest inverse association with stroke cannot be ruled out... - Dietary glycemic load and risk of colorectal cancer in the Women's Health StudySusan Higginbotham
Department of Epidemiology, University of California at Los Angeles, USA
J Natl Cancer Inst 96:229-33. 2004..09, 95% CI = 1.13 to 3.87; P(trend) =.08) were also statistically significantly associated with increased risk. Thus, our data indicate that a diet with a high dietary glycemic load may increase the risk of colorectal cancer in women... - Dietary carbohydrates, fiber, and breast cancer riskMichelle D Holmes
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Epidemiol 159:732-9. 2004..This study also confirmed the lack of an overall association between intake of fiber and fiber types and breast cancer risk observed in other prospective studies... - Genetic variants in the UCP2-UCP3 gene cluster and risk of diabetes in the Women's Health Initiative Observational StudyYi Hsiang Hsu
Institute for Aging Research, Hebrew Senior Life and Harvard Medical School, Boston, Massachusetts, USA
Diabetes 57:1101-7. 2008..Genetic variants in the UCP2-UCP3 gene cluster, located on chromosome 11q13, may play a significant role in the development of type 2 diabetes... - Selected antioxidants and risk of hormone receptor-defined invasive breast cancers among postmenopausal women in the Women's Health Initiative Observational StudyYan Cui
Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, CA 90012, USA
Am J Clin Nutr 87:1009-18. 2008..Few studies have evaluated carotenoids and vitamins C and E in association with the risk of breast cancers defined by estrogen receptor (ER) and progesterone receptor (PR) status... - Elevated depressive symptoms, antidepressant use, and diabetes in a large multiethnic national sample of postmenopausal womenYunsheng Ma
Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Diabetes Care 34:2390-2. 2011..To examine elevated depressive symptoms and antidepressant use in relation to diabetes incidence in the Women's Health Initiative... - A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal womenNai Chieh Y You
Program on Genomics and Nutrition, Department of Epidemiology, Fielding School of Public Health, and Departments of Medicine and Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles UCLA, Los Angeles, CA, USA
Diabetes 61:2998-3004. 2012..These prospective findings indicate limited clinical utility of TL in diabetes risk stratification among postmenopausal women... - Common variations in the genes encoding C-reactive protein, tumor necrosis factor-alpha, and interleukin-6, and the risk of clinical diabetes in the Women's Health Initiative Observational StudyKei Hang K Chan
Program on Genomics and Nutrition, Department of Epidemiology, UCLA, Los Angeles, CA 90095, USA
Clin Chem 57:317-25. 2011..Circulating concentrations of high-sensitivity C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) have been associated with an increased risk of diabetes... - Common genetic variants in fatty acid-binding protein-4 (FABP4) and clinical diabetes risk in the Women's Health Initiative Observational StudyKei Hang K Chan
Program on Genomics and Nutrition, Department of Epidemiology, University of California, Los Angeles, California, USA
Obesity (Silver Spring) 18:1812-20. 2010..The observed significant association between reduced VCAM-1 levels and FABP4 genotypes in African-American women warrant further confirmation... - Sex hormone-binding globulin and risk of clinical diabetes in American black, Hispanic, and Asian/Pacific Islander postmenopausal womenBrian H Chen
Program on Genomics and Nutrition, Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA, USA
Clin Chem 58:1457-66. 2012..However, it remains unclear whether this relationship extends to other racial/ethnic populations... - Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal womenSara A Chacko
Department of Epidemiology and the Program on Genomics and Nutrition, University of California, Los Angeles, Los Angeles, CA
Am J Clin Nutr 94:209-17. 2011..Low concentrations of serum 25-hydroxyvitamin D [25(OH)D] may be associated with cardiometabolic disorders; however, little is known about their relation to intermediate metabolic and lipid markers... - Dietary fiber intake, dietary glycemic load, and the risk for gestational diabetes mellitusCuilin Zhang
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
Diabetes Care 29:2223-30. 2006..We aimed to examine whether pregravid dietary fiber consumptions from cereal, fruit, and vegetable sources and dietary glycemic load were related to gestational diabetes mellitus (GDM) risk... - A prospective study of red meat consumption and type 2 diabetes in middle-aged and elderly women: the women's health studyYiqing Song
Division of Preventive Medicine, Department of Medicine, BrighamWomen's Hospital, Harvard Medical School, 900 Commonwealth Ave. East, Boston, MA 02215, USA
Diabetes Care 27:2108-15. 2004..CONCLUSIONS: Our data indicate that higher consumption of total red meat, especially various processed meats, may increase risk of developing type 2 diabetes in women... - Dietary intakes of fruit, vegetables, and fiber, and risk of colorectal cancer in a prospective cohort of women (United States)Jennifer Lin
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Cancer Causes Control 16:225-33. 2005..We prospectively examined the association between dietary intakes of fruit, vegetables, and fiber and colorectal cancer risk in a large female cohort from the Women's Health Study... - Is intake of breakfast cereals related to total and cause-specific mortality in men?Simin Liu
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Am J Clin Nutr 77:594-9. 2003..Although breakfast cereals are a major source of whole and refined grains, little is known about their direct association with the risk of premature mortality... - The consumption of lycopene and tomato-based food products is not associated with the risk of type 2 diabetes in womenLu Wang
Division of Aging, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
J Nutr 136:620-5. 2006..Our study found little evidence for an association between dietary intake of lycopene or lycopene-containing foods and the risk of type 2 DM... - Whole-grain intake and the risk of type 2 diabetes: a prospective study in menTeresa T Fung
Programs in Nutrition, Simmons College, Boston, MA 02115, USA
Am J Clin Nutr 76:535-40. 2002..Certain dietary components may play a role in the prevention of type 2 diabetes... - Dietary glycemic load and breast cancer risk in the Women's Health StudySusan Higginbotham
Department of Epidemiology, UCLA School of Public Health, University of California at Los Angeles (UCLA, Los Angeles, California, USA
Cancer Epidemiol Biomarkers Prev 13:65-70. 2004..Prospective studies of a larger sample size and longer duration are warranted to confirm our findings... - A prospective study of sugar intake and risk of type 2 diabetes in womenSok-Ja Janket
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Diabetes Care 26:1008-15. 2003..These prospective data support the recent American Diabetes Association's guideline that a moderate amount of sugar can be incorporated in a healthy diet... - Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individualsSara A Chacko
Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095, USA
Am J Clin Nutr 93:463-73. 2011.... - A prospective study of the association between APOE genotype and the risk of myocardial infarction among apparently healthy menSimin Liu
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Atherosclerosis 166:323-9. 2003..Apolipoprotein E (apoE) plays an important role in lipid metabolism. Three common alleles in the APOE gene, E2/E3/E4, have been associated with lipoprotein disorders but their effects on myocardial infarction (MI) risk remain uncertain... - Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese womenRaquel Villegas
Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, 2525 West End Ave, Ste 600, Nashville, TN 37203 1738, USA
Arch Intern Med 167:2310-6. 2007..Much uncertainty exists about the role of dietary glycemic index and glycemic load in the development of type 2 diabetes mellitus, especially in populations that traditionally subsist on a diet high in carbohydrates... - Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trialJames M Shikany
Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Am J Clin Nutr 94:75-85. 2011..Glycemic effects of the Women's Health Initiative (WHI) low-fat dietary intervention are unknown... - A prospective study of the APOA1 XmnI and APOC3 SstI polymorphisms in the APOA1/C3/A4 gene cluster and risk of incident myocardial infarction in menSimin Liu
Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, 900 Commonwealth Avenue East, Boston, MA 02215, USA
Atherosclerosis 177:119-26. 2004..However, whether genetic variations in the APOA1/C3/A4 gene cluster are associated with the risk of myocardial infarction (MI) remains uncertain and prospective data are sparse... - Nut and peanut butter consumption and risk of type 2 diabetes in womenRui Jiang
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
JAMA 288:2554-60. 2002..Nuts are high in unsaturated (polyunsaturated and monounsaturated) fat and other nutrients that may improve glucose and insulin homeostasis... - Effects of glycemic load on metabolic health and type 2 diabetes mellitusChristian K Roberts
Program on Genomics and Nutrition, Department of Epidemiology, University of California, Los Angeles, School of Public Health, Los Angeles, California 90095 1772, USA
J Diabetes Sci Technol 3:697-704. 2009..Overall, a low dietary GL may be protective against metabolic disease and should be considered as a healthful dietary component... - Prevention of type 2 diabetes by diet and lifestyle modificationLydia A Bazzano
Department of Medicine, Beth Israel Deaconess Hospital, Boston, MA 02215, USA
J Am Coll Nutr 24:310-9. 2005..Prevention of this devastating disease calls for the identification of culture-sensitive measures that can be applied to the population in general and some high-risk minority groups in particular... - Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational StudyYunsheng Ma
Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nutrition 24:941-9. 2008.... - Intake of refined carbohydrates and whole grain foods in relation to risk of type 2 diabetes mellitus and coronary heart diseaseSimin Liu
Division of Preventive Medicine, Brigham and Women s Hospital and Harvard School of Medicine, Boston, Massachusetts 02115, USA
J Am Coll Nutr 21:298-306. 2002..It seems prudent, therefore, to distinguish whole-grain rather than refined-grain cereal products for the prevention of chronic diseases... - Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring StudyNicola M McKeown
Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
Am J Clin Nutr 76:390-8. 2002..CONCLUSION: Increased intakes of whole grains may reduce disease risk by means of favorable effects on metabolic risk factors... - Comparison of usefulness of body mass index versus metabolic risk factors in predicting 10-year risk of cardiovascular events in womenYiqing Song
Department of Medicine, Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 100:1654-8. 2007..In conclusion, MS may largely account for the increased risk of CVD associated with BMI in apparently healthy women... - Association between consumption of beer, wine, and liquor and plasma concentration of high-sensitivity C-reactive protein in women aged 39 to 89 yearsEmily B Levitan
Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 96:83-8. 2005..09 mg/L (p = 0.43). The association between alcohol and hs-CRP concentration appears to be mediated primarily by ethanol and was independent of the type of alcoholic beverage consumed once BMI was taken into account... - Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the Third National Health and Nutrition Examination SurveyHyon K Choi
Rheumatology Unit, Bulfinch 165, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
Arthritis Rheum 52:283-9. 2005..Our objective was to evaluate the relationship between dietary factors and serum uric acid levels in a nationally representative sample of men and women in the US... - Types of carbohydrates and risk of cardiovascular diseaseMark A Pereira
Department of Pediatrics, Harvard Medical School and Children s Hospital, Boston, Massachusetts 02115, USA
J Womens Health (Larchmt) 12:115-22. 2003..More long-term controlled trials are needed to improve our understanding of efficacy and mechanisms. Women and a variety of racial/ethnic groups should be represented in these studies whenever possible... - Flavonoid intake and the risk of cardiovascular disease in womenHoward D Sesso
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
Am J Clin Nutr 77:1400-8. 2003..Despite emerging evidence of the role of flavonoids in cardiovascular disease (CVD) prevention, the association remains unclear... - Dietary lycopene, tomato-based food products and cardiovascular disease in womenHoward D Sesso
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
J Nutr 133:2336-41. 2003.... - Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARgamma gene and type 2 diabetesAsli Memisoglu
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Diabetes Care 26:2915-7. 2003..To determine whether the Pro12Ala polymorphism in the PPARgamma gene was associated with risk of type 2 diabetes in the Nurses' Health Study... - Dietary intake of fruits and vegetables and risk of cardiovascular diseaseLydia A Bazzano
Division of Preventive Medicine, Harvard Medical School and Brigham and Women's Hospital, 900 Commonwealth Avenue, Boston, MA 02215, USA
Curr Atheroscler Rep 5:492-9. 2003.... - Maternal dietary glycemic intake and the risk of neural tube defectsMahsa M Yazdy
Slone Epidemiology Center, Boston University, Boston, MA02215, USA
Am J Epidemiol 171:407-14. 2010..0); for high DGL, it was 1.8 (95% confidence interval: 0.8, 4.0). Diets with proportionally high DGI or DGL may put the developing fetus at risk of an NTD, adding further evidence that hyperglycemia lies within the pathogenic pathway... - Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged womenSimin Liu
Center of Cardiovascular Prevention, the Division of Preventive Medicine, Harvard Medical School, Boston 02215, USA
Am J Clin Nutr 75:492-8. 2002..Recent prospective data suggest that intake of rapidly digested and absorbed carbohydrates with a high dietary glycemic load is associated with an increased risk of ischemic heart disease... - Glycemic index, glycemic load, and risk of type 2 diabetesWalter Willett
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Am J Clin Nutr 76:274S-80S. 2002.... - Dietary glycemic load and atherothrombotic riskSimin Liu
Division of Preventive Medicine, Harvard Medical School and Brigham and Women s Hospital, 900 Commonwealth Avenue, Boston, MA 02215, USA
Curr Atheroscler Rep 4:454-61. 2002.... - Fruit and vegetable intake and the risk of cataract in womenWilliam G Christen
Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Clin Nutr 81:1417-22. 2005..Prospective data on cataract in relation to total fruit and vegetable intake are limited... - Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studiesYiqing Song
Division of Preventive Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02215, USA
Am J Hum Genet 74:208-22. 2004..Our findings also suggest that both large-scale, well-designed association studies and functional studies are warranted to either reliably confirm or conclusively refute the initial hypothesis regarding the role of CAPN10 in T2D risk... - Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessmentLee S Gross
Inter Medic Medical Group, 2630 Bobcat Village Center Road, North Port, FL 34288, USA
Am J Clin Nutr 79:774-9. 2004.... - Intake of dietary magnesium and the prevalence of the metabolic syndrome among U.S. adultsEarl S Ford
Centers for Disease Control and Prevention, 4770 Buford Highway, MS K66, Atlanta, GA 30341, USA
Obesity (Silver Spring) 15:1139-46. 2007..The aim of this study was to examine the associations between dietary intake of magnesium and the prevalence of the metabolic syndrome in a nationally representative sample of U.S. adults... - Concentrations of serum vitamin D and the metabolic syndrome among U.S. adultsEarl S Ford
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, MS K66, Atlanta, GA 30341, USA
Diabetes Care 28:1228-30. 2005 - Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohortsPaul Knekt
National Public Health Institute, Helsinki, Finland
Am J Clin Nutr 80:1508-20. 2004..Epidemiologic studies have suggested a lower risk of coronary heart disease (CHD) at higher intakes of fruit, vegetables, and whole grain. Whether this association is due to antioxidant vitamins or some other factors remains unclear... - Effects of estrogen with and without progestin and obesity on symptomatic gastroesophageal refluxZongli Zheng
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Gastroenterology 135:72-81. 2008..An association between female hormones and symptomatic gastroesophageal reflux disease (GERD) and may be modified by obesity is suggested but not proven. Factors affecting GERD progression, however, are largely unknown... - Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL cholesterol levels in women with type 2 diabetesLu Qi
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, United States
Atherosclerosis 192:204-10. 2007..006), whereas APOA4 +347T/A showed significant associations with lower levels of HDL-C (P=0.017). Our results indicate that the variability in APOA1/C3/A4/A5 gene cluster may affect TG and HDL levels in women with type 2 diabetes... - Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studiesMark A Pereira
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN55454, USA
Arch Intern Med 164:370-6. 2004..The purpose of this study was to conduct a pooled analysis of dietary fiber and its subtypes and risk of coronary heart disease... - Whole-grain foods, dietary fiber, and type 2 diabetes: searching for a kernel of truthSimin Liu
Am J Clin Nutr 77:527-9. 2003
Research Grants
- HIGH GLYCEMIC DIET AND RISK OF NIDDM AND CHDSimin Liu; Fiscal Year: 2002..Through the process, Dr. Liu will acquire ample skills and experience to become an independent clinician scientist and educator in the field of nutrition and chronic disease prevention and control. ..
- Steroid Hormones, Adipose-cytokines, and Diabetes RiskSimin Liu; Fiscal Year: 2007....
- Genetic and Biochemical Predictors of Type 2 DM in WomenSimin Liu; Fiscal Year: 2006..Knowledge gained from this proposed study may suggest new intervention strategies to lower the incidence of type 2 DM in the general population. ..