Shiguang Liu

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc FGFR3 and FGFR4 do not mediate renal effects of FGF23
    Shiguang Liu
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Am Soc Nephrol 19:2342-50. 2008
  2. pmc Pathogenic role of Fgf23 in Dmp1-null mice
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Am J Physiol Endocrinol Metab 295:E254-61. 2008
  3. ncbi request reprint Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
    Am J Physiol Endocrinol Metab 293:E1636-44. 2007
  4. pmc Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, MS 3018, Kansas City, KS 66160, USA
    J Endocrinol 192:261-7. 2007
  5. ncbi request reprint Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
    Shiguang Liu
    Department of Internal Medicine and the Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Room 6020 WHE, MS 3018, Kansas City, KS 66160, USA
    J Am Soc Nephrol 17:1305-15. 2006
  6. ncbi request reprint Pathogenic role of Fgf23 in Hyp mice
    Shiguang Liu
    The Kidney Institute, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Am J Physiol Endocrinol Metab 291:E38-49. 2006
  7. ncbi request reprint Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization
    Shiguang Liu
    Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas 66160, USA
    Curr Opin Nephrol Hypertens 16:329-35. 2007
  8. pmc Dietary phosphate restriction suppresses phosphaturia but does not prevent FGF23 elevation in a mouse model of chronic kidney disease
    Shiqin Zhang
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
    Kidney Int 84:713-21. 2013
  9. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
  10. ncbi request reprint Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease
    Jason Stubbs
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Semin Dial 20:302-8. 2007

Collaborators

Detail Information

Publications28

  1. pmc FGFR3 and FGFR4 do not mediate renal effects of FGF23
    Shiguang Liu
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Am Soc Nephrol 19:2342-50. 2008
    ..In summary, neither FGFR3 nor FGFR4 is the principal mediator of FGF23 effects in the proximal tubule, and co-localization of FGFR1 and Klotho suggests that the distal tubule may be an effector site of FGF23...
  2. pmc Pathogenic role of Fgf23 in Dmp1-null mice
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Am J Physiol Endocrinol Metab 295:E254-61. 2008
    ..These data suggest that the regulation of extracellular matrix mineralization by DMP1 is coupled to renal phosphate handling and vitamin D metabolism through a DMP1-dependent regulation of FGF23 production by osteocytes...
  3. ncbi request reprint Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
    Am J Physiol Endocrinol Metab 293:E1636-44. 2007
    ..In addition, systemic counterregulatory factors that attenuate the upregulation of FGF23 expression in Hyp mouse osteocytes are present in older mice...
  4. pmc Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, MS 3018, Kansas City, KS 66160, USA
    J Endocrinol 192:261-7. 2007
    ..The resulting coordination of mineralization and release of a phosphaturic factor by MEPE may serve a physiological role in regulating systemic phosphate homeostasis to meet the needs for bone mineralization...
  5. ncbi request reprint Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D
    Shiguang Liu
    Department of Internal Medicine and the Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Room 6020 WHE, MS 3018, Kansas City, KS 66160, USA
    J Am Soc Nephrol 17:1305-15. 2006
    ..The physiologic role of FGF23 may be to act as a counterregulatory phosphaturic hormone to maintain phosphate homeostasis in response to vitamin D...
  6. ncbi request reprint Pathogenic role of Fgf23 in Hyp mice
    Shiguang Liu
    The Kidney Institute, The University of Kansas Medical Center, Kansas City, KS 66160, USA
    Am J Physiol Endocrinol Metab 291:E38-49. 2006
    ..These results suggest that Fgf23 acts downstream of Phex to cause both the renal and bone phenotypes in Hyp mice...
  7. ncbi request reprint Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization
    Shiguang Liu
    Department of Internal Medicine, The Kidney Institute and Division of Nephrology, Kansas City, Kansas 66160, USA
    Curr Opin Nephrol Hypertens 16:329-35. 2007
    ....
  8. pmc Dietary phosphate restriction suppresses phosphaturia but does not prevent FGF23 elevation in a mouse model of chronic kidney disease
    Shiqin Zhang
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA
    Kidney Int 84:713-21. 2013
    ..Thus, dietary phosphate restriction reduces the fractional excretion of phosphorus independent of serum FGF23 levels in mice with CKD...
  9. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
    ..Our findings suggest a bone-renal axis that is central to guiding proper mineral metabolism...
  10. ncbi request reprint Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease
    Jason Stubbs
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Semin Dial 20:302-8. 2007
    ....
  11. pmc Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease
    Jason R Stubbs
    The Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Bone Miner Res 27:38-46. 2012
    ..Elevations in FGF23 and PTH coincide with an increase in urinary phosphate excretion that likely prevents the early onset of hyperphosphatemia in the face of increased bone turnover and a progressive decline in functional renal mass...
  12. pmc Novel regulators of Fgf23 expression and mineralization in Hyp bone
    Shiguang Liu
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Endocrinol 23:1505-18. 2009
    ....
  13. ncbi request reprint Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice
    Jason R Stubbs
    The Kidney Institute, University of Kansas Medical Center, Kansas City, KS 66160, USA
    J Am Soc Nephrol 18:2116-24. 2007
    ....
  14. pmc Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin
    Peter S N Rowe
    Department of Internal Medicine, The Kidney Institute and Division of Nephrology, MS 3018, University of Kansas Medical Center, 3901 Rainbow Boulevard, 6020B Wahl Hall East, Kansas City, KS 66160, USA
    Bone 39:773-86. 2006
    ..This may be due to a protease inhibitor mediated decrease in proteolytic degradation of the extracellular matrix and a reduced release of ASARM peptides (potent mineralization inhibitors)...
  15. pmc Effects of cinacalcet and concurrent low-dose vitamin D on FGF23 levels in ESRD
    James B Wetmore
    University of Kansas Medical Center, MS 3002, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Clin J Am Soc Nephrol 5:110-6. 2010
    ..The effects of various treatments for secondary hyperparathyroidism on FGF23 levels in ESRD have not been examined in a clinical trial...
  16. pmc Calcimimetics as an adjuvant treatment for familial hypophosphatemic rickets
    Uri S Alon
    Pediatric Nephrology, Bone and Mineral Disorders Clinic, Children s Mercy Hospital, University of Missouri, Kansas City, MO 64108, USA
    Clin J Am Soc Nephrol 3:658-64. 2008
    ....
  17. pmc Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia
    Shiguang Liu
    Department of Internal Medicine and the Kidney Institute, University of Kansas Medical Center, MS 3018, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    J Am Soc Nephrol 16:1645-53. 2005
    ..These results demonstrate that MEPE elevation in Hyp mice does not contribute to the hypophosphatemia associated with inactivating Phex mutations and is therefore not phosphatonin...
  18. pmc Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice
    Zhousheng Xiao
    Internal Medicine The Kidney Institute, University of Kansas Medical Center, 6018 Wahl Hall East, Kansas City, 66160, USA
    Dev Biol 283:345-56. 2005
    ..Thus, selective Runx2-II mutation causes diminished osteoblastic function in an adult mouse leading to low-turnover osteopenia and suggest that Runx2-I and II have distinct functions imparted by their different N-termini...
  19. ncbi request reprint How fibroblast growth factor 23 works
    Shiguang Liu
    Kidney Institute, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    J Am Soc Nephrol 18:1637-47. 2007
    ..Further understanding of this primary phosphate homeostatic pathway has the potential to have a significant impact on the diagnosis and treatment of disorders of bone and mineral metabolism...
  20. ncbi request reprint Inhibition of MEPE cleavage by Phex
    Rong Guo
    Department of Medicine, The Center for Bone and Mineral Disorders, Duke University Medical Center, Box 3036, Durham, NC 27710, USA
    Biochem Biophys Res Commun 297:38-45. 2002
    ....
  21. ncbi request reprint Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype
    Shiguang Liu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:3686-97. 2002
    ....
  22. pmc Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background
    Qisheng Tu
    Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 111:1029-37. 2003
    ..Double Gcm2- and CasR-deficient mice provide an important model for evaluating the extraparathyroid functions of CasR...
  23. ncbi request reprint Serum FGF23 levels in normal and disordered phosphorus homeostasis
    Thomas J Weber
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Bone Miner Res 18:1227-34. 2003
    ..In contrast, FGF23 levels were markedly increased in subjects with ESRD and correlated inversely with the degree of hyperphosphatemia...
  24. ncbi request reprint Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX
    Shiguang Liu
    Department of Medicine, Center for Bone and Mineral Disorders, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:37419-26. 2003
    ....
  25. ncbi request reprint Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss
    Liming Wang
    Division of Nephrology, Department of Medicine, Duke University, Durham, North Carolina, USA
    Am J Physiol Endocrinol Metab 288:E826-34. 2005
    ..Taken together, these data suggest that enhancing GRK2 activity and consequently reducing GPCR activity in osteoblasts produces a low bone-turnover state that reduces bone mass...
  26. pmc Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts
    Robert F Spurney
    Division of Nephrology, Department of Medicine, Duke University and Durham Veterans Administration Medical Centers, North Carolina 27710, USA
    J Clin Invest 109:1361-71. 2002
    ..The predominant effect of the transgene, however, was anabolic, as evidenced by an increase in bone density and trabecular bone volume in the transgenic mice compared with nontransgenic littermate controls...
  27. ncbi request reprint The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock
    Kathleen G Raman
    Univ of Pittsburgh School of Medicine, 616 Scaife Hall, 3550 Terrace St, Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 291:G556-65. 2006
    ..Circulating IL-10 levels were higher in rage(-/-) compared with rage(+/+) mice. These results suggest that activation of RAGE-dependent signaling is a key factor leading to gut mucosal barrier dysfunction after HS/R...
  28. ncbi request reprint HMGB1 is secreted by immunostimulated enterocytes and contributes to cytomix-induced hyperpermeability of Caco-2 monolayers
    Shiguang Liu
    Department of Critical Care Medicine, Univ of Pittsburgh School of Medicine, 616 Scaife Hall, 3550 Terrace St, PA 15261, USA
    Am J Physiol Cell Physiol 290:C990-9. 2006
    ..Collectively, these data support the view that HMGB1 is secreted by immunostimulated enterocytes. This process may exacerbate inflammation-induced epithelial hyperpermeability via an autocrine feedback loop...