Affiliation: University of Washington
Li L, Chen Y, Doan J, Murray J, Molkentin J, Liu Q. Transforming growth factor Î²-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling. Circulation. 2014;130:2162-72 pubmed publisher
..These results indicate that TAK1 functions as a key survival factor in the heart by directly antagonizing necroptosis, which is critical for the maintenance of myocardial homeostasis and the prevention of adverse myocardial remodeling. ..
Li L, Li J, Drum B, Chen Y, Yin H, Guo X, et al
. Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve. Cardiovasc Res. 2017;113:147-159 pubmed publisher
Guo X, Yin H, Li L, Chen Y, Li J, Doan J, et al
. Cardioprotective Role of Tumor Necrosis Factor Receptor-Associated Factor 2 by Suppressing Apoptosis and Necroptosis. Circulation. 2017;136:729-742 pubmed publisher
..These results identify an important Traf2-mediated, NF?B-independent, prosurvival pathway in the heart by suppressing necroptotic signaling, which may serve as a new therapeutic target for pathological remodeling and heart failure. ..