Research Topics
Genomes and GenesSpecies | Lei LiuSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
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Detail Information
Publications
The use of Gaussian quadrature for estimation in frailty proportional hazards modelsLei Liu
Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
Stat Med 27:2665-83. 2008..The proposed method greatly simplifies the implementation of the (joint) frailty models and makes them much more accessible to general statistical practitioners...- A shared random effects model for censored medical costs and mortalityLei Liu
Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109 2029, USA
Stat Med 26:139-55. 2007..An analysis of monthly outpatient EPO medical cost data for dialysis patients is presented to illustrate the proposed methods... - A likelihood reformulation method in non-normal random effects modelsLei Liu
Division of Biostatistics and Epidemiology, Department of Public Health Sciences, The University of Virginia, Charlottesville, VA 22908 0717, USA
Stat Med 27:3105-24. 2008..2006; 15:39-57). Furthermore, our method can be applied to more general situations, e.g. finite mixture random effects or correlated random effects from Clayton copula. Simulations and applications are presented to illustrate our method... - Analysis of longitudinal data in the presence of informative observational times and a dependent terminal event, with application to medical cost dataLei Liu
Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia 22908 0717, USA
Biometrics 64:950-8. 2008..g., SAS Proc NLMIXED. An analysis of the cost-accrual process of chronic heart failure patients from the clinical data repository at the University of Virginia Health System is presented to illustrate the proposed method... 
A multi-level two-part random effects model, with application to an alcohol-dependence studyLei Liu
Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
Stat Med 27:3528-39. 2008..The model is applied to the analysis of repeated measures of the daily drinking record in a randomized controlled trial of topiramate for alcohol-dependence treatment...
A flexible two-part random effects model for correlated medical costsLei Liu
Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
J Health Econ 29:110-23. 2010..The proposed model is used to analyze pharmacy cost data on 56,245 adult patients clustered within 239 physicians in a mid-western U.S. managed care organization...- Joint analysis of multi-level repeated measures data and survival: an application to the end stage renal disease (ESRD) dataLei Liu
Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, U S A
Stat Med 27:5679-91. 2008..S. renal data system data set. Our model is very comprehensive yet easy to implement, making it appealing to general statistical practitioners... - Joint modeling longitudinal semi-continuous data and survival, with application to longitudinal medical cost dataLei Liu
Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
Stat Med 28:972-86. 2009..Our model is applied to longitudinal (monthly) medical costs of 1455 chronic heart-failure patients from the clinical data repository at the University of Virginia... - Kinetic and cardiovascular effects of acute topiramate dosing among non-treatment-seeking, methamphetamine-dependent individualsBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:455-61. 2007..Larger laboratory studies with chronic dosing regimens are needed to establish whether or not there is a kinetic interaction between topiramate and methamphetamine... - Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD studyRachel L Perlman
Internal Medicine, University of Michigan, Ann Arbor, MI, USA
Am J Kidney Dis 45:658-66. 2005..GFR was not significantly associated with QOL. Hemoglobin level predicted both physical and mental domains of the SF-36. Longitudinal studies are needed to define at-risk periods for decreases in QOL during progression of CKD... - Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individualsBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:123-30. 2007..Topiramate's complicated cognitive effects among methamphetamine addicts need more comprehensive examination... - Shared frailty models for recurrent events and a terminal eventLei Liu
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
Biometrics 60:747-56. 2004..This model avoids the difficulties encountered in alternative approaches which attempt to specify a dependent joint distribution with marginal proportional hazards and yields an estimate of the degree of dependence... - Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinkingBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
Am J Psychiatry 168:265-75. 2011.... - A joint frailty model for survival and gap times between recurrent eventsXuelin Huang
Anderson Cancer Center, Department of Biostatistics, The University of Texas, M D 1515 Holcombe Boulevard, Unit 447, Houston, Texas 77030, USA
Biometrics 63:389-97. 2007..The method is evaluated by simulation studies and illustrated through a study of patients with heart failure. Sensitivity analysis for the parametric assumption of the frailty distribution is assessed by simulations... - Can serotonin transporter genotype predict craving in alcoholism?Nassima Ait-Daoud
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22908 0623, USA
Alcohol Clin Exp Res 33:1329-35. 2009.... - Topiramate's effects on cocaine-induced subjective mood, craving and preference for money over drug takingBankole A Johnson
Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA
Addict Biol 18:405-16. 2013..Low-dose cocaine might appear to have some enhancement of its stimulant properties in the presence of topiramate's prominent sedative effects... - Buffering airway acid decreases exhaled nitric oxide in asthmaBenjamin Gaston
Department of Pediatric Respiratory Medicine, The University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Allergy Clin Immunol 118:817-22. 2006..The human airway is believed to be acidified in asthma. In an acidic environment nitrite is converted to nitric oxide (NO)... - Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cellsM Kathleen Borland
Center for the Study of Neurodegenerative Diseases and Morris K, Udall Parkinson s Disease Research Center of Excellence, University of Virginia, Charlottesville, Virginia, USA
Mol Neurodegener 3:21. 2008..The vast majority of Parkinson's disease occurs sporadically, and current models of sporadic Parkinson's disease (sPD) can utilize directly infused or systemic neurotoxins... - Obtaining the optimal dose in alcohol dependence studiesNolan A Wages
Division of Translational Research and Applied Statistics, Department of Public Health Sciences, University of Virginia Charlottesville, VA, USA
Front Psychiatry 3:100. 2012..It is believed that the introduction of adaptive design methods will enable the development of medications for the treatment of alcohol dependence to be accelerated... - The longitudinal chronic kidney disease study: a prospective cohort study of predialysis renal failureRachel L Perlman
Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Semin Dial 16:418-23. 2003..This article describes the LCKD Study in the context of current knowledge of CKD... - Effects of acute topiramate dosing on methamphetamine-induced subjective moodBankole A Johnson
Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908 0623, USA
Int J Neuropsychopharmacol 10:85-98. 2007..Thus, testing chronically administered or higher doses, or both, of topiramate would be necessary to determine conclusively whether or not it can attenuate the positive subjective and reinforcing effects of methamphetamine... - Changes in exhaled nitric oxide and breath pH during fluticasone wean in asthmaLei Liu
Departments of Pediatric Respiratory Medicine and Public Health Sciences, The University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Respiration 79:193-9. 2010..Inhaled corticosteroid (ICS) therapy improves asthma outcome. Both the anti-inflammatory efficacy and toxicities of ICS therapy are dose dependent. Therefore, there is interest in monitoring airway inflammation during ICS dose adjustments... - A semiparametric recurrent events model with time-varying coefficientsZhangsheng Yu
Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA
Stat Med 32:1016-26. 2013..We conduct simulations to evaluate the performance of the estimates for both time-varying and time-independent coefficients. We apply this method to analyze two data sets: a stroke study and a child wheeze study... - Increased systemic inflammation overnight correlates with insulin resistance among children evaluated for obstructive sleep apneaMark D DeBoer
Division of Pediatric Endocrinology, P O Box 800386, Charlottesville, VA 22908, USA
Sleep Breath 16:349-54. 2012..Our goal was to evaluate whether inflammation increases overnight among children suspected of having OSA and to determine whether worsened inflammation is associated with the degree of OSA severity, obesity, and/or insulin resistance... - Determinants of exhaled breath condensate pH in a large population with asthmaLei Liu
Department of Public Health Sciences at University of Virginia, Charlottesville, VA, USA
Chest 139:328-36. 2011..We hypothesized that patients with severe asthma would have low EBC pH and that there would be an asthma subpopulation of patients with characteristically low values... - Patterns of medication use in the RRI-CKD study: focus on medications with cardiovascular effectsGeorge R Bailie
Albany Nephrology Pharmacy Group, Albany College of Pharmacy, 106 New Scotland Avenue, Albany, NY 12208, USA
Nephrol Dial Transplant 20:1110-5. 2005..We report on prescription data collected as part of a multicentre longitudinal study in patients with CKD, with a focus on medications with cardiovascular or cardioprotective effects... - Exploring photosynthesis evolution by comparative analysis of metabolic networks between chloroplasts and photosynthetic bacteriaZhuo Wang
The W M Keck Center for Comparative and Functional Genomics, University of Illinois at Urbana Champaign, 1201 W, Gregory Dr, Urbana, Illinois 61801, USA
BMC Genomics 7:100. 2006.... - A study of inter-lab and inter-platform agreement of DNA microarray dataHuixia Wang
Department of Statistics, University of Illinois at Urbana Champaign, 101 Illini Hall, 725 South Wright Street, Champaign, Illinois 61820, USA
BMC Genomics 6:71. 2005..On the other hand, the lab effect, especially when confounded with the RNA sample effect, plays a bigger role than the platform effect on data agreement... - Erianin induces a JNK/SAPK-dependent metabolic inhibition in human umbilical vein endothelial cellsYanqing Gong
Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, P.R. China
In Vivo 18:223-8. 2004..CONCLUSION: Erianin inhibited endothelial metabolism in a JNK/SAPK-dependent manner. This mechanism may be involved in the potential antitumnor and antiangiogenic actions of erianin... - Multi-species comparative mapping in silico using the COMPASS strategyLei Liu
The W M Keck Center for Comparative and Functional Genomics, University of Illinois at Urbana Champaign, 1201 W Gregory Drive, Urbana, IL 61801, USA
Bioinformatics 20:148-54. 2004..An automated multiple-species COMPASS tool can facilitate in the genome sequencing effort and comparative genomics study of other mammalian species... - The analysis of epidemiological characteristics of road traffic crashes in a mountain city in western ChinaJi Hong Zhou
The Institute for Traffic Medicine, Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China
Chin J Traumatol 6:355-8. 2003..To study the epidemiological characteristics and preventive methods of road traffic crashes in a mountain city in western China through sampling investigation of traffic crashes in different regions of Chongqing city in recent years... - [The changes of IL-1 and NO levels in the testes of rats with experimental varicocele]Li Ping Chen
Department of Obstetric and Gynecology, Jiamusi Center Hospital, Jiamusi, Heilongjiang 154002, China
Zhonghua Nan Ke Xue 8:125-6. 2002..To evaluate the effects of varicocele (VC) on IL-1 and NO levels in testes of rats with VC... - [Different levels of nitric oxide in seminal plasma of fertile and abnormospermic men]Lei Liu
Department of Microbiology and Immunology, Shanxi Medical University, Taiyuan, Shanxi 030001, China
Zhonghua Nan Ke Xue 9:254-6. 2003..CONCLUSIONS: This results confirmed that proper level of NO in seminal plasma may regulate the spermatogenesis... - [Effect of basic fibroblast growth factor on change of caspase 3 gene expression after distractive spinal cord injury in rats]Lei Liu
Department of Orthopaedics, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China
Zhonghua Yi Xue Za Zhi 85:1424-7. 2005..05 or P < 0.01). CONCLUSION: bFGF inhibits the expression of caspase 3 protein, reduces the caspase 3 activity, lessens the secondary cell apoptosis in the injured spinal cord, and promotes nerve function recovery of spinal cord... - [Intermediate-term and long-term clinical evaluation of the Ahmed glaucoma valve implantation]Hong Chen
Beijing Tongren Ophthalmic Center, Capital University of Medical Sciences Beijing 100730, China
Zhonghua Yan Ke Za Zhi 41:796-802. 2005..To evaluate the Intermediate-term and long-term clinical results of Ahmed glaucoma valve (AGV) implantation in refractory glaucoma... - Comparisons of graph-structure clustering methods for gene expression dataZhuo Fang
Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
Acta Biochim Biophys Sin (Shanghai) 38:379-84. 2006..Moreover, knowledge-guided analysis seems much more applicable than GO-Cluster in a larger dataset... - Two-stage fuzzy-stochastic robust programming: a hybrid model for regional air quality managementYongping Li
Environmental Systems Engineering Program, University of Regina, Regina, Saskatchewan, Canada
J Air Waste Manag Assoc 56:1070-82. 2006..The solutions can be used for further generating pollution-mitigation alternatives with minimized system costs and for providing a more solid support for sound environmental decisions... - In silico discovery of human natural antisense transcriptsYuan Yuan Li
Shanghai Center for Bioinformation Technology, Shanghai 200235, China
BMC Bioinformatics 7:18. 2006..A thorough in silico analysis of human transcripts will help expand our knowledge of NATs... - [In vitro and in vivo stability of 9-nitrocamptothecin lactone form in rats]Jun Chen
Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
Yao Xue Xue Bao 40:888-92. 2005..However, the process of 9-nitrocamptothecin carboxylate form in vivo was best fitted to a one-compartment model... - Legibility variations of Chinese characters and implications for visual acuity measurement in Chinese reading populationJun Yun Zhang
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
Invest Ophthalmol Vis Sci 48:2383-90. 2007..The purpose of this study was to suggest a solution to the challenge through psychophysical studies of Chinese character legibility... - Relationships between feature search and mobility performance in persons with severe visual impairmentPatti S Fuhr
Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Optom Vis Sci 84:393-400. 2007.... - Molecular and cellular characterization during chondrogenic differentiation of adipose tissue-derived stromal cells in vitro and cartilage formation in vivoYunfeng Lin
Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu
J Cell Mol Med 9:929-39. 2005..Therefore, it is suggested that human adipose tissue may represent a novel plentiful source of multipotential stem cells capable of undergoing chondrogenesis and forming engineered cartilage... - Visual search training in subjects with severe to profound low visionLei Liu
School of Optometry, University of Alabama at Birmingham, 1716 University Blvd, Birmingham, AL 35294, USA
Vision Res 47:2627-36. 2007..The fact that feature search training is equally efficient in VI and NV subjects encourages development of general purpose perceptual training protocols for low vision rehabilitation... - Weak polyelectrolyte control of carbon nanotube dispersion in waterJaime C Grunlan
Department of Mechanical Engineering, Texas A and M University, College Station, TX, USA
J Colloid Interface Sci 317:346-9. 2008.... - Quantum-chemical predictions of redox potentials of organic anions in dimethyl sulfoxide and reevaluation of bond dissociation enthalpies measured by the electrochemical methodsYao Fu
Department of Chemistry, University of Science and Technology of China, Hefei
J Phys Chem A 110:5874-86. 2006.... - First-principle calculation of equilibrium cesium ion-pair acidities in tetrahydrofuranYao Fu
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China
J Am Chem Soc 129:13510-9. 2007..Consequently, one can easily estimate the cesium ion-pair acidities of almost all types of organic nitrogen acids in THF on the basis of Bordwell's data... - Knowledge guided analysis of microarray dataZhuo Fang
Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China
J Biomed Inform 39:401-11. 2006..Furthermore, the clustering results can be adjusted according to different stringency requirements. It is expected that our algorithm can be extended to other biological knowledge, for example, metabolic networks... - Modeling the effects of cell cycle M-phase transcriptional inhibition on circadian oscillationBin Kang
Laboratory of Systems Biology corrected Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
PLoS Comput Biol 4:e1000019. 2008....
Research Grants
- Statistical Analysis of Longitudinal Medical Cost DataLei Liu; Fiscal Year: 2007..Finally, we will develop ready-to-use software to facilitate the application of our methods in practical data analysis. ..