Lei Liu

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Joint analysis of multi-level repeated measures data and survival: an application to the end stage renal disease (ESRD) data
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, U S A
    Stat Med 27:5679-91. 2008
  2. doi request reprint A multi-level two-part random effects model, with application to an alcohol-dependence study
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
    Stat Med 27:3528-39. 2008
  3. ncbi request reprint Analysis of longitudinal data in the presence of informative observational times and a dependent terminal event, with application to medical cost data
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia 22908 0717, USA
    Biometrics 64:950-8. 2008
  4. pmc A flexible two-part random effects model for correlated medical costs
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
    J Health Econ 29:110-23. 2010
  5. ncbi request reprint A likelihood reformulation method in non-normal random effects models
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, The University of Virginia, Charlottesville, VA 22908 0717, USA
    Stat Med 27:3105-24. 2008
  6. ncbi request reprint A shared random effects model for censored medical costs and mortality
    Lei Liu
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Stat Med 26:139-55. 2007
  7. ncbi request reprint The use of Gaussian quadrature for estimation in frailty proportional hazards models
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
    Stat Med 27:2665-83. 2008
  8. doi request reprint Joint modeling longitudinal semi-continuous data and survival, with application to longitudinal medical cost data
    Lei Liu
    Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
    Stat Med 28:972-86. 2009
  9. pmc Kinetic and cardiovascular effects of acute topiramate dosing among non-treatment-seeking, methamphetamine-dependent individuals
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:455-61. 2007
  10. ncbi request reprint Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study
    Rachel L Perlman
    Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Am J Kidney Dis 45:658-66. 2005

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Joint analysis of multi-level repeated measures data and survival: an application to the end stage renal disease (ESRD) data
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, U S A
    Stat Med 27:5679-91. 2008
    ..S. renal data system data set. Our model is very comprehensive yet easy to implement, making it appealing to general statistical practitioners...
  2. doi request reprint A multi-level two-part random effects model, with application to an alcohol-dependence study
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
    Stat Med 27:3528-39. 2008
    ..The model is applied to the analysis of repeated measures of the daily drinking record in a randomized controlled trial of topiramate for alcohol-dependence treatment...
  3. ncbi request reprint Analysis of longitudinal data in the presence of informative observational times and a dependent terminal event, with application to medical cost data
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia 22908 0717, USA
    Biometrics 64:950-8. 2008
    ..g., SAS Proc NLMIXED. An analysis of the cost-accrual process of chronic heart failure patients from the clinical data repository at the University of Virginia Health System is presented to illustrate the proposed method...
  4. pmc A flexible two-part random effects model for correlated medical costs
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
    J Health Econ 29:110-23. 2010
    ..The proposed model is used to analyze pharmacy cost data on 56,245 adult patients clustered within 239 physicians in a mid-western U.S. managed care organization...
  5. ncbi request reprint A likelihood reformulation method in non-normal random effects models
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, The University of Virginia, Charlottesville, VA 22908 0717, USA
    Stat Med 27:3105-24. 2008
    ..2006; 15:39-57). Furthermore, our method can be applied to more general situations, e.g. finite mixture random effects or correlated random effects from Clayton copula. Simulations and applications are presented to illustrate our method...
  6. ncbi request reprint A shared random effects model for censored medical costs and mortality
    Lei Liu
    Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Stat Med 26:139-55. 2007
    ..An analysis of monthly outpatient EPO medical cost data for dialysis patients is presented to illustrate the proposed methods...
  7. ncbi request reprint The use of Gaussian quadrature for estimation in frailty proportional hazards models
    Lei Liu
    Division of Biostatistics and Epidemiology, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
    Stat Med 27:2665-83. 2008
    ..The proposed method greatly simplifies the implementation of the (joint) frailty models and makes them much more accessible to general statistical practitioners...
  8. doi request reprint Joint modeling longitudinal semi-continuous data and survival, with application to longitudinal medical cost data
    Lei Liu
    Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22908 0717, USA
    Stat Med 28:972-86. 2009
    ..Our model is applied to longitudinal (monthly) medical costs of 1455 chronic heart-failure patients from the clinical data repository at the University of Virginia...
  9. pmc Kinetic and cardiovascular effects of acute topiramate dosing among non-treatment-seeking, methamphetamine-dependent individuals
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:455-61. 2007
    ..Larger laboratory studies with chronic dosing regimens are needed to establish whether or not there is a kinetic interaction between topiramate and methamphetamine...
  10. ncbi request reprint Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study
    Rachel L Perlman
    Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Am J Kidney Dis 45:658-66. 2005
    ..Dialysis patients have decreased QOL relative to healthy controls. Little is known about QOL in patients with chronic kidney disease (CKD) before renal replacement therapy...
  11. pmc Effects of topiramate on methamphetamine-induced changes in attentional and perceptual-motor skills of cognition in recently abstinent methamphetamine-dependent individuals
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, P O Box 800623, Charlottesville, VA 22908 0623, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:123-30. 2007
    ..Topiramate's complicated cognitive effects among methamphetamine addicts need more comprehensive examination...
  12. ncbi request reprint Shared frailty models for recurrent events and a terminal event
    Lei Liu
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Biometrics 60:747-56. 2004
    ..This model avoids the difficulties encountered in alternative approaches which attempt to specify a dependent joint distribution with marginal proportional hazards and yields an estimate of the degree of dependence...
  13. pmc Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908 0623, USA
    Am J Psychiatry 168:265-75. 2011
    ....
  14. ncbi request reprint A joint frailty model for survival and gap times between recurrent events
    Xuelin Huang
    Anderson Cancer Center, Department of Biostatistics, The University of Texas, M D 1515 Holcombe Boulevard, Unit 447, Houston, Texas 77030, USA
    Biometrics 63:389-97. 2007
    ..The method is evaluated by simulation studies and illustrated through a study of patients with heart failure. Sensitivity analysis for the parametric assumption of the frailty distribution is assessed by simulations...
  15. pmc Topiramate's effects on cocaine-induced subjective mood, craving and preference for money over drug taking
    Bankole A Johnson
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA
    Addict Biol 18:405-16. 2013
    ..Low-dose cocaine might appear to have some enhancement of its stimulant properties in the presence of topiramate's prominent sedative effects...
  16. pmc Can serotonin transporter genotype predict craving in alcoholism?
    Nassima Ait-Daoud
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia 22908 0623, USA
    Alcohol Clin Exp Res 33:1329-35. 2009
    ....
  17. ncbi request reprint A semiparametric recurrent events model with time-varying coefficients
    Zhangsheng Yu
    Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA
    Stat Med 32:1016-26. 2013
    ..We conduct simulations to evaluate the performance of the estimates for both time-varying and time-independent coefficients. We apply this method to analyze two data sets: a stroke study and a child wheeze study...
  18. pmc Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells
    M Kathleen Borland
    Center for the Study of Neurodegenerative Diseases and Morris K, Udall Parkinson s Disease Research Center of Excellence, University of Virginia, Charlottesville, Virginia, USA
    Mol Neurodegener 3:21. 2008
    ..The vast majority of Parkinson's disease occurs sporadically, and current models of sporadic Parkinson's disease (sPD) can utilize directly infused or systemic neurotoxins...
  19. ncbi request reprint Buffering airway acid decreases exhaled nitric oxide in asthma
    Benjamin Gaston
    Department of Pediatric Respiratory Medicine, The University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Allergy Clin Immunol 118:817-22. 2006
    ..The human airway is believed to be acidified in asthma. In an acidic environment nitrite is converted to nitric oxide (NO)...
  20. doi request reprint Joint model of recurrent events and a terminal event with time-varying coefficients
    Zhangsheng Yu
    Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biom J 56:183-97. 2014
    ..A simulation study shows that the proposed estimators perform well. The model is used to analyze the readmission rate and mortality jointly for stroke patients admitted to Veterans Administration (VA) Hospitals. ..
  21. pmc Obtaining the optimal dose in alcohol dependence studies
    Nolan A Wages
    Division of Translational Research and Applied Statistics, Department of Public Health Sciences, University of Virginia Charlottesville, VA, USA
    Front Psychiatry 3:100. 2012
    ..It is believed that the introduction of adaptive design methods will enable the development of medications for the treatment of alcohol dependence to be accelerated...
  22. ncbi request reprint Effects of acute topiramate dosing on methamphetamine-induced subjective mood
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, VA 22908 0623, USA
    Int J Neuropsychopharmacol 10:85-98. 2007
    ..Thus, testing chronically administered or higher doses, or both, of topiramate would be necessary to determine conclusively whether or not it can attenuate the positive subjective and reinforcing effects of methamphetamine...
  23. ncbi request reprint The longitudinal chronic kidney disease study: a prospective cohort study of predialysis renal failure
    Rachel L Perlman
    Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Semin Dial 16:418-23. 2003
    ..This article describes the LCKD Study in the context of current knowledge of CKD...
  24. ncbi request reprint Changes in exhaled nitric oxide and breath pH during fluticasone wean in asthma
    Lei Liu
    Departments of Pediatric Respiratory Medicine and Public Health Sciences, The University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Respiration 79:193-9. 2010
    ..Inhaled corticosteroid (ICS) therapy improves asthma outcome. Both the anti-inflammatory efficacy and toxicities of ICS therapy are dose dependent. Therefore, there is interest in monitoring airway inflammation during ICS dose adjustments...
  25. pmc Increased systemic inflammation overnight correlates with insulin resistance among children evaluated for obstructive sleep apnea
    Mark D DeBoer
    Division of Pediatric Endocrinology, P O Box 800386, Charlottesville, VA 22908, USA
    Sleep Breath 16:349-54. 2012
    ..Our goal was to evaluate whether inflammation increases overnight among children suspected of having OSA and to determine whether worsened inflammation is associated with the degree of OSA severity, obesity, and/or insulin resistance...
  26. pmc Determinants of exhaled breath condensate pH in a large population with asthma
    Lei Liu
    Department of Public Health Sciences at University of Virginia, Charlottesville, VA, USA
    Chest 139:328-36. 2011
    ..We hypothesized that patients with severe asthma would have low EBC pH and that there would be an asthma subpopulation of patients with characteristically low values...
  27. ncbi request reprint [Effect of basic fibroblast growth factor on change of caspase 3 gene expression after distractive spinal cord injury in rats]
    Lei Liu
    Department of Orthopaedics, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China
    Zhonghua Yi Xue Za Zhi 85:1424-7. 2005
    ..To observe the effects of basic fibroblast growth factor (bFGF) on neuronal apoptosis and caspase 3 gene expression after spinal cord injury...
  28. pmc A study of inter-lab and inter-platform agreement of DNA microarray data
    Huixia Wang
    Department of Statistics, University of Illinois at Urbana Champaign, 101 Illini Hall, 725 South Wright Street, Champaign, Illinois 61820, USA
    BMC Genomics 6:71. 2005
    ..On the other hand, the lab effect, especially when confounded with the RNA sample effect, plays a bigger role than the platform effect on data agreement...
  29. ncbi request reprint Patterns of medication use in the RRI-CKD study: focus on medications with cardiovascular effects
    George R Bailie
    Albany Nephrology Pharmacy Group, Albany College of Pharmacy, 106 New Scotland Avenue, Albany, NY 12208, USA
    Nephrol Dial Transplant 20:1110-5. 2005
    ..We report on prescription data collected as part of a multicentre longitudinal study in patients with CKD, with a focus on medications with cardiovascular or cardioprotective effects...
  30. ncbi request reprint Erianin induces a JNK/SAPK-dependent metabolic inhibition in human umbilical vein endothelial cells
    Yanqing Gong
    Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, P R China
    In Vivo 18:223-8. 2004
    ..Erianin is a natural product derived from Dendrobium chrysotoxum, with promising antitumor activity...
  31. ncbi request reprint Multi-species comparative mapping in silico using the COMPASS strategy
    Lei Liu
    The W M Keck Center for Comparative and Functional Genomics, University of Illinois at Urbana Champaign, 1201 W Gregory Drive, Urbana, IL 61801, USA
    Bioinformatics 20:148-54. 2004
    ..An automated multiple-species COMPASS tool can facilitate in the genome sequencing effort and comparative genomics study of other mammalian species...
  32. ncbi request reprint [The changes of IL-1 and NO levels in the testes of rats with experimental varicocele]
    Li Ping Chen
    Department of Obstetric and Gynecology, Jiamusi Center Hospital, Jiamusi, Heilongjiang 154002, China
    Zhonghua Nan Ke Xue 8:125-6. 2002
    ..To evaluate the effects of varicocele (VC) on IL-1 and NO levels in testes of rats with VC...
  33. ncbi request reprint The analysis of epidemiological characteristics of road traffic crashes in a mountain city in western China
    Ji Hong Zhou
    The Institute for Traffic Medicine, Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China
    Chin J Traumatol 6:355-8. 2003
    ..To study the epidemiological characteristics and preventive methods of road traffic crashes in a mountain city in western China through sampling investigation of traffic crashes in different regions of Chongqing city in recent years...
  34. ncbi request reprint [Different levels of nitric oxide in seminal plasma of fertile and abnormospermic men]
    Lei Liu
    Department of Microbiology and Immunology, Shanxi Medical University, Taiyuan, Shanxi 030001, China
    Zhonghua Nan Ke Xue 9:254-6. 2003
    ..To understand the relation between nitric oxide (NO) level in seminal plasma and male fertility...
  35. pmc Modeling the effects of cell cycle M-phase transcriptional inhibition on circadian oscillation
    Bin Kang
    Laboratory of Systems Biology corrected Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS Comput Biol 4:e1000019. 2008
    ....
  36. ncbi request reprint [Intermediate-term and long-term clinical evaluation of the Ahmed glaucoma valve implantation]
    Hong Chen
    Beijing Tongren Ophthalmic Center, Capital University of Medical Sciences Beijing 100730, China
    Zhonghua Yan Ke Za Zhi 41:796-802. 2005
    ..To evaluate the Intermediate-term and long-term clinical results of Ahmed glaucoma valve (AGV) implantation in refractory glaucoma...
  37. ncbi request reprint Two-stage fuzzy-stochastic robust programming: a hybrid model for regional air quality management
    Yongping Li
    Environmental Systems Engineering Program, University of Regina, Regina, Saskatchewan, Canada
    J Air Waste Manag Assoc 56:1070-82. 2006
    ..The solutions can be used for further generating pollution-mitigation alternatives with minimized system costs and for providing a more solid support for sound environmental decisions...
  38. pmc Exploring photosynthesis evolution by comparative analysis of metabolic networks between chloroplasts and photosynthetic bacteria
    Zhuo Wang
    The W M Keck Center for Comparative and Functional Genomics, University of Illinois at Urbana Champaign, 1201 W, Gregory Dr, Urbana, Illinois 61801, USA
    BMC Genomics 7:100. 2006
    ....
  39. pmc In silico discovery of human natural antisense transcripts
    Yuan Yuan Li
    Shanghai Center for Bioinformation Technology, Shanghai 200235, China
    BMC Bioinformatics 7:18. 2006
    ..A thorough in silico analysis of human transcripts will help expand our knowledge of NATs...
  40. ncbi request reprint Legibility variations of Chinese characters and implications for visual acuity measurement in Chinese reading population
    Jun Yun Zhang
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
    Invest Ophthalmol Vis Sci 48:2383-90. 2007
    ..The purpose of this study was to suggest a solution to the challenge through psychophysical studies of Chinese character legibility...
  41. ncbi request reprint Relationships between feature search and mobility performance in persons with severe visual impairment
    Patti S Fuhr
    Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    Optom Vis Sci 84:393-400. 2007
    ....
  42. ncbi request reprint [In vitro and in vivo stability of 9-nitrocamptothecin lactone form in rats]
    Jun Chen
    Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
    Yao Xue Xue Bao 40:888-92. 2005
    ..To investigate the in vitro and in vivo stability of 9-nitrocamptothecin lactone form in rat plasma...
  43. ncbi request reprint Visual search training in subjects with severe to profound low vision
    Lei Liu
    School of Optometry, University of Alabama at Birmingham, 1716 University Blvd, Birmingham, AL 35294, USA
    Vision Res 47:2627-36. 2007
    ..The fact that feature search training is equally efficient in VI and NV subjects encourages development of general purpose perceptual training protocols for low vision rehabilitation...
  44. ncbi request reprint Weak polyelectrolyte control of carbon nanotube dispersion in water
    Jaime C Grunlan
    Department of Mechanical Engineering, Texas A and M University, College Station, TX, USA
    J Colloid Interface Sci 317:346-9. 2008
    ....
  45. ncbi request reprint Quantum-chemical predictions of redox potentials of organic anions in dimethyl sulfoxide and reevaluation of bond dissociation enthalpies measured by the electrochemical methods
    Yao Fu
    Department of Chemistry, University of Science and Technology of China, Hefei
    J Phys Chem A 110:5874-86. 2006
    ....
  46. ncbi request reprint First-principle calculation of equilibrium cesium ion-pair acidities in tetrahydrofuran
    Yao Fu
    Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China
    J Am Chem Soc 129:13510-9. 2007
    ..Consequently, one can easily estimate the cesium ion-pair acidities of almost all types of organic nitrogen acids in THF on the basis of Bordwell's data...
  47. ncbi request reprint Molecular and cellular characterization during chondrogenic differentiation of adipose tissue-derived stromal cells in vitro and cartilage formation in vivo
    Yunfeng Lin
    Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu
    J Cell Mol Med 9:929-39. 2005
    ..Therefore, it is suggested that human adipose tissue may represent a novel plentiful source of multipotential stem cells capable of undergoing chondrogenesis and forming engineered cartilage...
  48. ncbi request reprint Knowledge guided analysis of microarray data
    Zhuo Fang
    Hubei Bioinformatics and Molecular Imaging Key Laboratory, Huazhong University of Science and Technology, Wuhan, Hubei 430074, PR China
    J Biomed Inform 39:401-11. 2006
    ..Furthermore, the clustering results can be adjusted according to different stringency requirements. It is expected that our algorithm can be extended to other biological knowledge, for example, metabolic networks...
  49. ncbi request reprint Comparisons of graph-structure clustering methods for gene expression data
    Zhuo Fang
    Hubei Bioinformatics and Molecular Imaging Key Laboratory, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China
    Acta Biochim Biophys Sin (Shanghai) 38:379-84. 2006
    ..Moreover, knowledge-guided analysis seems much more applicable than GO-Cluster in a larger dataset...

Research Grants2

  1. Statistical Analysis of Longitudinal Medical Cost Data
    Lei Liu; Fiscal Year: 2007
    ..unreadable] [unreadable] Finally, we will develop ready-to-use software to facilitate the application of our methods in practical data analysis. [unreadable] [unreadable] [unreadable]..
  2. Statistical Analysis of Longitudinal Medical Cost Data
    Lei Liu; Fiscal Year: 2008
    ..unreadable] [unreadable] Finally, we will develop ready-to-use software to facilitate the application of our methods in practical data analysis. [unreadable] [unreadable] [unreadable]..