Kathleen D Liu

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Clinical trials for acute kidney injury: design challenges and possible solutions
    Kathleen D Liu
    Department of Medicine, University of California, San Francisco, 94143 0532, USA
    Curr Drug Targets 10:1190-5. 2009
  2. pmc FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study
    Maryann Zhang
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA, USA
    Ann Intensive Care 1:21. 2011
  3. pmc Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study
    Magda Cepkova
    Cardiovascular Research Institute, University of California, San Francisco, CA, 94143, USA
    Ann Intensive Care 1:18. 2011
  4. pmc Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study
    Kathleen D Liu
    Divisions of Nephrology and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, CA, USA
    Crit Care 13:R104. 2009
  5. pmc Inhaled activated protein C: a novel therapy for acute lung injury?
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0624, USA
    Crit Care 13:150. 2009
  6. pmc Randomized clinical trial of activated protein C for the treatment of acute lung injury
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Department of Medicine, Box 0532, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Am J Respir Crit Care Med 178:618-23. 2008
  7. doi request reprint Renal repair and recovery
    Kathleen D Liu
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Crit Care Med 36:S187-92. 2008
  8. doi request reprint Advances in critical care for the nephrologist: acute lung injury/ARDS
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Box 0532, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Clin J Am Soc Nephrol 3:578-86. 2008
  9. pmc Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury
    Kathleen D Liu
    Division of Nephrology, University of California, San Francisco, CA, USA
    Crit Care Med 35:2755-61. 2007
  10. pmc Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials
    Ashish Agrawal
    School of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Am J Physiol Lung Cell Mol Physiol 303:L634-9. 2012

Detail Information

Publications38

  1. ncbi request reprint Clinical trials for acute kidney injury: design challenges and possible solutions
    Kathleen D Liu
    Department of Medicine, University of California, San Francisco, 94143 0532, USA
    Curr Drug Targets 10:1190-5. 2009
    ..However, these challenges are not unique to AKI; some possible solutions including alternative endpoints used in other clinical trial settings are reviewed here...
  2. pmc FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study
    Maryann Zhang
    Division of Nephrology, Department of Medicine, University of California, San Francisco, CA, USA
    Ann Intensive Care 1:21. 2011
    ..abstract:..
  3. pmc Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study
    Magda Cepkova
    Cardiovascular Research Institute, University of California, San Francisco, CA, 94143, USA
    Ann Intensive Care 1:18. 2011
    ..abstract:..
  4. pmc Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study
    Kathleen D Liu
    Divisions of Nephrology and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, CA, USA
    Crit Care 13:R104. 2009
    ..The purpose of this study was to test the role of serum cytokines as biomarkers for AKI and prolonged mechanical ventilation...
  5. pmc Inhaled activated protein C: a novel therapy for acute lung injury?
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0624, USA
    Crit Care 13:150. 2009
    ..Future studies are needed to determine plasma and airspace APC levels when administered by the inhaled route, and to determine if inhaled APC has a similar effect in other models of ALI...
  6. pmc Randomized clinical trial of activated protein C for the treatment of acute lung injury
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Department of Medicine, Box 0532, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Am J Respir Crit Care Med 178:618-23. 2008
    ..Plasma protein C levels are decreased in patients with acute lung injury and are associated with higher mortality and fewer ventilator-free days...
  7. doi request reprint Renal repair and recovery
    Kathleen D Liu
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Crit Care Med 36:S187-92. 2008
    ..To review the cellular and molecular mechanisms of renal repair and recovery after acute kidney injury (AKI)...
  8. doi request reprint Advances in critical care for the nephrologist: acute lung injury/ARDS
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Box 0532, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Clin J Am Soc Nephrol 3:578-86. 2008
    ..Pharmacologic strategies and other ventilator management strategies have not been successful to date; however, several randomized, placebo controlled treatment trials are ongoing...
  9. pmc Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury
    Kathleen D Liu
    Division of Nephrology, University of California, San Francisco, CA, USA
    Crit Care Med 35:2755-61. 2007
    ..To identify biological and clinical predictors of acute kidney injury in subjects with acute lung injury...
  10. pmc Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials
    Ashish Agrawal
    School of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Am J Physiol Lung Cell Mol Physiol 303:L634-9. 2012
    ....
  11. ncbi request reprint Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury
    Magda Cepkova
    Department of Anesthesia, University of California, San Francisco, San Francisco, CA, USA
    Chest 132:836-42. 2007
    ....
  12. doi request reprint Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials
    Mark D Okusa
    Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22908 0133, USA
    Clin J Am Soc Nephrol 7:851-5. 2012
    ..The workgroups detailed primary and secondary endpoints for studies in these groups, and explored the use of adaptive clinical trial designs for trials of novel preventive strategies to improve outcomes of patients with AKI...
  13. pmc The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury
    Kirsten Neudoerffer Kangelaris
    Department of Medicine, Division of General Internal Medicine, University of California, San Francisco, San Francisco, CA 94143 0131, USA
    Chest 141:1160-9. 2012
    ..We sought to determine the effect of the functional rs2814778 polymorphism, C/C genotype (Duffy null state), on clinical outcomes in African Americans with acute lung injury...
  14. doi request reprint Diagnosis, epidemiology and outcomes of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 3:844-61. 2008
    ..This review summarizes the major epidemiologic studies of acute kidney injury and efforts to modernize the approach to its diagnosis...
  15. pmc Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery
    Thida Ong
    Division of Pediatric Pulmonary Medicine, University of California, San Francisco Children s Hospital, San Francisco, California 94143 0632, USA
    Pediatr Pulmonol 44:457-63. 2009
    ..Pulmonary dead space may be a useful prognostic tool for clinicians in patients who undergo congenital heart surgery...
  16. pmc The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods
    Alan S Go
    Kaiser Permanente Northern California, Oakland, CA, USA
    BMC Nephrol 11:22. 2010
    ..Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors...
  17. pmc Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis
    PAUL R BRAKEMAN
    Division of Pediatric Nephrology, Department of Pediatrics, University of California, Box 0748, San Francisco, California 94143 0748, USA
    Am J Physiol Renal Physiol 296:F564-74. 2009
    ....
  18. ncbi request reprint Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients
    Thida Ong
    Division of Pulmonary Medicine, Department of Pediatrics, University of California, San Francisco, California, USA
    Crit Care Med 38:1845-51. 2010
    ..We also tested the association of concentration of angiopoietin-2 relative to angiopoietin-1 with physiologic and biological markers of activated endothelium...
  19. pmc Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease
    Kathleen D Liu
    Division of Nephrology, University of California, San Francisco, San Francisco, California, USA
    Kidney Int 83:909-14. 2013
    ..Thus, while urine NGAL was an independent risk factor of progression among patients with established CKD of diverse etiology, it did not substantially improve prediction of outcome events...
  20. pmc Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes
    Kathleen D Liu
    Division of Nephrology, University of California San Francisco, San Francisco, CA, USA
    Crit Care Med 39:2665-71. 2011
    ..We sought to determine the impact of fluid balance on the incidence of nondialysis requiring acute kidney injury in patients with acute lung injury and to describe associated outcomes, including mortality...
  21. doi request reprint Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings
    Bruce A Molitoris
    Department of Medicine, Indiana University, Indianapolis, IN, USA
    Clin J Am Soc Nephrol 7:856-60. 2012
    ..The groups considered trial design issues and discussed advantages and disadvantages of several short- and long-term primary endpoints in these patients...
  22. pmc Protective mechanisms of activated protein C in severe inflammatory disorders
    Arne P Neyrinck
    University of California San Francisco, Cardiovascular Research Institute, San Francisco, CA, USA
    Br J Pharmacol 158:1034-47. 2009
    ..On the whole, these studies have not supported the use of APC in these populations and challenge the field of APC research to search for additional answers...
  23. ncbi request reprint Timing of initiation of dialysis in critically ill patients with acute kidney injury
    Kathleen D Liu
    Division of Nephrology, Department of Medicine, University of California San Francisco, USA
    Clin J Am Soc Nephrol 1:915-9. 2006
    ..Although the results could reflect residual confounding by severity of illness, they provide a rationale for prospective testing of alternative dialysis initiation strategies in critically ill patients with severe AKI...
  24. pmc Protein C as a surrogate end-point for clinical trials of sepsis
    Kathleen D Liu
    Divisions of Nephrology and Critical Care Medicine, Department of Medicine, University of California, 521 Parnassus Ave, C443, San Francisco, CA 94143, USA
    Crit Care 12:139. 2008
    ..Only protein C had acceptable performance characteristics as a type 2 biomarker, or surrogate end-point. The utility of protein C as a surrogate end-point for studies of severe sepsis must be validated in future prospective studies...
  25. ncbi request reprint Evolving practices in critical care and potential implications for management of acute kidney injury
    Kathleen D Liu
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Clin J Am Soc Nephrol 1:869-73. 2006
  26. pmc Fluid overload in AKI: epiphenomenon or putative effect on mortality?
    Brad W Butcher
    Divisions of Nephrology and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, California, USA
    Curr Opin Crit Care 18:593-8. 2012
    ..Recently, several articles have suggested that fluid overload in patients with AKI is associated with an increased risk of death...
  27. doi request reprint Ongoing clinical trials in AKI
    Sarah Faubel
    Division of Nephrology, University of Colorado and Denver Veterans Administration Medical Center, Denver, Colorado, USA
    Clin J Am Soc Nephrol 7:861-73. 2012
    ..Finally, this review discusses research needs that are not addressed by the current clinical trials portfolio and suggests key areas for future research in AKI...
  28. ncbi request reprint Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway
    Kathleen D Liu
    Division of Nephrology, University of California, San Francisco, Box 2140, San Francisco, CA 94143 2140, USA
    Am J Physiol Renal Physiol 293:F1633-40. 2007
    ..This effect cannot be overcome by constitutively active Rac1, demonstrating that both Rac1 and atypical PKC are required for reorientation of cellular polarity...
  29. pmc Therapeutic potential of mesenchymal stem cells for severe acute lung injury
    Michael A Matthay
    Department of Medicine, University of California, San Francisco, CA 94143 0624, USA
    Chest 138:965-72. 2010
    ..There is a dual focus on how to design trials for testing both safety and efficacy...
  30. doi request reprint Some methodological issues in studying the long-term renal sequelae of acute kidney injury
    Kathleen D Liu
    Division of Nephrology, University of California, San Francisco, San Francisco, California 94143 0532, USA
    Curr Opin Nephrol Hypertens 18:241-5. 2009
    ..In this study, we discuss several potential solutions to these problems. Concerted efforts to address these methodological issues will propel research in this field to a higher level...
  31. pmc Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) Have Different Patterns in Heart Failure Exacerbation
    Meyeon Park
    University of California, San Francisco
    Biomark Insights 8:15-8. 2013
    ..We measured serial biomarker levels and evaluated the associations of these biomarkers with renal recovery in a cohort of hospitalized patients with acute heart failure exacerbation...
  32. pmc The incidence and prognostic significance of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Nephrol Hypertens 16:227-36. 2007
    ..This review summarizes the major epidemiologic studies that have informed our understanding of the incidence and prognostic significance of acute kidney injury...
  33. pmc Fluid balance, diuretic use, and mortality in acute kidney injury
    Morgan E Grams
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Clin J Am Soc Nephrol 6:966-73. 2011
    ..The primary objective was to elucidate the association between fluid balance, diuretic use, and short-term mortality after AKI in critically ill patients...
  34. pmc Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value
    Lisa M Brown
    Department of Surgery, Univ of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 297:L547-58. 2009
    ..This review critically evaluates the experimental and clinical evidence supporting the potential value of measuring extravascular lung water in patients using the single indicator method...
  35. doi request reprint Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth
    Sang Ho Kwon
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA
    Curr Biol 24:199-204. 2014
    ....
  36. doi request reprint Evolving practices in critical care and their influence on acute kidney injury
    Jennifer G Wilson
    aDepartment of Medicine and Anesthesia, Division of Critical Care Medicine bDepartment of Medicine and Anesthesia, Divisions of Nephrology and Critical Care Medicine, University of California, San Francisco, California, USA Jennifer G Wilson and Brad W Butcher contributed equally to the writing of the article
    Curr Opin Crit Care 19:523-30. 2013
    ..This review highlights the principal advances in critical care over the past year, and discusses the impact of these advances on the diagnosis and management of acute kidney injury (AKI)...
  37. pmc Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization
    Anil Sapru
    Department of Pediatrics, Cardiovascular Research Institute, University of California San Francisco, San Franscisco, California 94143, USA
    J Heart Lung Transplant 30:211-7. 2011
    ..We hypothesized that SNPs in βAR genes would be associated with rates of utilization of donor lung allografts offered for transplantation...
  38. ncbi request reprint Molecular mechanisms of recovery from acute renal failure
    Kathleen D Liu
    Department of Medicine, Unicversity of California, San Francisco, USA
    Crit Care Med 31:S572-81. 2003
    ..In this article I review recent research aimed at elucidating mechanisms of renal recovery from acute injury...