Research Topics
Genomes and Genes | Kathleen D LiuSummaryAffiliation: University of California Country: USA Publications
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Publications
Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control studyKathleen D Liu
Divisions of Nephrology and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, CA, USA
Crit Care 13:R104. 2009..The purpose of this study was to test the role of serum cytokines as biomarkers for AKI and prolonged mechanical ventilation...- Randomized clinical trial of activated protein C for the treatment of acute lung injuryKathleen D Liu
Division of Nephrology and Critical Care Medicine, Department of Medicine, Box 0532, University of California, San Francisco, San Francisco, CA 94143 0532, USA
Am J Respir Crit Care Med 178:618-23. 2008..Plasma protein C levels are decreased in patients with acute lung injury and are associated with higher mortality and fewer ventilator-free days... - Inhaled activated protein C: a novel therapy for acute lung injury?Kathleen D Liu
Division of Nephrology and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0624, USA
Crit Care 13:150. 2009..Future studies are needed to determine plasma and airspace APC levels when administered by the inhaled route, and to determine if inhaled APC has a similar effect in other models of ALI... 
Renal repair and recoveryKathleen D Liu
Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
Crit Care Med 36:S187-92. 2008..To review the cellular and molecular mechanisms of renal repair and recovery after acute kidney injury (AKI)...- Advances in critical care for the nephrologist: acute lung injury/ARDSKathleen D Liu
Division of Nephrology and Critical Care Medicine, Box 0532, University of California, San Francisco, San Francisco, CA 94143 0532, USA
Clin J Am Soc Nephrol 3:578-86. 2008..Pharmacologic strategies and other ventilator management strategies have not been successful to date; however, several randomized, placebo controlled treatment trials are ongoing... - Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injuryKathleen D Liu
Division of Nephrology, University of California, San Francisco, CA, USA
Crit Care Med 35:2755-61. 2007..To identify biological and clinical predictors of acute kidney injury in subjects with acute lung injury... 
Clinical trials for acute kidney injury: design challenges and possible solutionsKathleen D Liu
Department of Medicine, University of California, San Francisco, 94143 0532, USA
Curr Drug Targets 10:1190-5. 2009..However, these challenges are not unique to AKI; some possible solutions including alternative endpoints used in other clinical trial settings are reviewed here...- Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort studyMagda Cepkova
Cardiovascular Research Institute, University of California, San Francisco, CA, 94143, USA
Ann Intensive Care 1:18. 2011..abstract:.. - FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series studyMaryann Zhang
Division of Nephrology, Department of Medicine, University of California, San Francisco, CA, USA
Ann Intensive Care 1:21. 2011..abstract:.. - Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trialsAshish Agrawal
School of Medicine, University of California, San Francisco, San Francisco, CA, USA
Am J Physiol Lung Cell Mol Physiol 303:L634-9. 2012.... - Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injuryMagda Cepkova
Department of Anesthesia, University of California, San Francisco, San Francisco, CA, USA
Chest 132:836-42. 2007.... - Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trialsMark D Okusa
Division of Nephrology, University of Virginia Health System, Charlottesville, VA 22908 0133, USA
Clin J Am Soc Nephrol 7:851-5. 2012..The workgroups detailed primary and secondary endpoints for studies in these groups, and explored the use of adaptive clinical trial designs for trials of novel preventive strategies to improve outcomes of patients with AKI... - The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injuryKirsten Neudoerffer Kangelaris
Department of Medicine, Division of General Internal Medicine, University of California, San Francisco, San Francisco, CA 94143 0131, USA
Chest 141:1160-9. 2012..We sought to determine the effect of the functional rs2814778 polymorphism, C/C genotype (Duffy null state), on clinical outcomes in African Americans with acute lung injury... - Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgeryThida Ong
Division of Pediatric Pulmonary Medicine, University of California, San Francisco Children s Hospital, San Francisco, California 94143 0632, USA
Pediatr Pulmonol 44:457-63. 2009..Pulmonary dead space may be a useful prognostic tool for clinicians in patients who undergo congenital heart surgery... - Diagnosis, epidemiology and outcomes of acute kidney injurySushrut S Waikar
Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Clin J Am Soc Nephrol 3:844-61. 2008..This review summarizes the major epidemiologic studies of acute kidney injury and efforts to modernize the approach to its diagnosis... - The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methodsAlan S Go
Kaiser Permanente Northern California, Oakland, CA, USA
BMC Nephrol 11:22. 2010..Previous studies on hospital-acquired AKI have important methodological limitations, especially their retrospective study designs and limited ability to control for potential confounding factors... - Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patientsThida Ong
Division of Pulmonary Medicine, Department of Pediatrics, University of California, San Francisco, California, USA
Crit Care Med 38:1845-51. 2010..We also tested the association of concentration of angiopoietin-2 relative to angiopoietin-1 with physiologic and biological markers of activated endothelium... - Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesisPAUL R BRAKEMAN
Division of Pediatric Nephrology, Department of Pediatrics, University of California, Box 0748, San Francisco, California 94143 0748, USA
Am J Physiol Renal Physiol 296:F564-74. 2009.... - Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomesKathleen D Liu
Division of Nephrology, University of California San Francisco, San Francisco, CA, USA
Crit Care Med 39:2665-71. 2011..We sought to determine the impact of fluid balance on the incidence of nondialysis requiring acute kidney injury in patients with acute lung injury and to describe associated outcomes, including mortality... - Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settingsBruce A Molitoris
Department of Medicine, Indiana University, Indianapolis, IN, USA
Clin J Am Soc Nephrol 7:856-60. 2012..The groups considered trial design issues and discussed advantages and disadvantages of several short- and long-term primary endpoints in these patients... - Protective mechanisms of activated protein C in severe inflammatory disordersArne P Neyrinck
University of California San Francisco, Cardiovascular Research Institute, San Francisco, CA, USA
Br J Pharmacol 158:1034-47. 2009..On the whole, these studies have not supported the use of APC in these populations and challenge the field of APC research to search for additional answers... - Timing of initiation of dialysis in critically ill patients with acute kidney injuryKathleen D Liu
Division of Nephrology, Department of Medicine, University of California San Francisco, USA
Clin J Am Soc Nephrol 1:915-9. 2006..Although the results could reflect residual confounding by severity of illness, they provide a rationale for prospective testing of alternative dialysis initiation strategies in critically ill patients with severe AKI... - Evolving practices in critical care and potential implications for management of acute kidney injuryKathleen D Liu
Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California, USA
Clin J Am Soc Nephrol 1:869-73. 2006 - Protein C as a surrogate end-point for clinical trials of sepsisKathleen D Liu
Divisions of Nephrology and Critical Care Medicine, Department of Medicine, University of California, 521 Parnassus Ave, C443, San Francisco, CA 94143, USA
Crit Care 12:139. 2008..Only protein C had acceptable performance characteristics as a type 2 biomarker, or surrogate end-point. The utility of protein C as a surrogate end-point for studies of severe sepsis must be validated in future prospective studies... - Fluid overload in AKI: epiphenomenon or putative effect on mortality?Brad W Butcher
Divisions of Nephrology and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, California, USA
Curr Opin Crit Care 18:593-8. 2012..Recently, several articles have suggested that fluid overload in patients with AKI is associated with an increased risk of death... - Ongoing clinical trials in AKISarah Faubel
Division of Nephrology, University of Colorado and Denver Veterans Administration Medical Center, Denver, Colorado, USA
Clin J Am Soc Nephrol 7:861-73. 2012..Finally, this review discusses research needs that are not addressed by the current clinical trials portfolio and suggests key areas for future research in AKI... - Therapeutic potential of mesenchymal stem cells for severe acute lung injuryMichael A Matthay
Department of Medicine, University of California, San Francisco, CA 94143 0624, USA
Chest 138:965-72. 2010..There is a dual focus on how to design trials for testing both safety and efficacy... - Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathwayKathleen D Liu
Division of Nephrology, University of California, San Francisco, Box 2140, San Francisco, CA 94143 2140, USA
Am J Physiol Renal Physiol 293:F1633-40. 2007..This effect cannot be overcome by constitutively active Rac1, demonstrating that both Rac1 and atypical PKC are required for reorientation of cellular polarity... - Some methodological issues in studying the long-term renal sequelae of acute kidney injuryKathleen D Liu
Division of Nephrology, University of California, San Francisco, San Francisco, California 94143 0532, USA
Curr Opin Nephrol Hypertens 18:241-5. 2009..In this study, we discuss several potential solutions to these problems. Concerted efforts to address these methodological issues will propel research in this field to a higher level... - Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) Have Different Patterns in Heart Failure ExacerbationMeyeon Park
University of California, San Francisco
Biomark Insights 8:15-8. 2013..We measured serial biomarker levels and evaluated the associations of these biomarkers with renal recovery in a cohort of hospitalized patients with acute heart failure exacerbation... - Fluid balance, diuretic use, and mortality in acute kidney injuryMorgan E Grams
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Clin J Am Soc Nephrol 6:966-73. 2011..The primary objective was to elucidate the association between fluid balance, diuretic use, and short-term mortality after AKI in critically ill patients... - Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical valueLisa M Brown
Department of Surgery, Univ of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, USA
Am J Physiol Lung Cell Mol Physiol 297:L547-58. 2009..This review critically evaluates the experimental and clinical evidence supporting the potential value of measuring extravascular lung water in patients using the single indicator method... - The incidence and prognostic significance of acute kidney injurySushrut S Waikar
Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Opin Nephrol Hypertens 16:227-36. 2007..This review summarizes the major epidemiologic studies that have informed our understanding of the incidence and prognostic significance of acute kidney injury... - Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilizationAnil Sapru
Department of Pediatrics, Cardiovascular Research Institute, University of California San Francisco, San Franscisco, California 94143, USA
J Heart Lung Transplant 30:211-7. 2011..We hypothesized that SNPs in βAR genes would be associated with rates of utilization of donor lung allografts offered for transplantation... - Molecular mechanisms of recovery from acute renal failureKathleen D Liu
Department of Medicine, Unicversity of California, San Francisco, USA
Crit Care Med 31:S572-81. 2003..Finally, several recent studies have focused on the effects of renal replacement therapy on renal recovery, but additional studies are needed to confirm and extend these results...