Jiankang Liu

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease
    Jiankang Liu
    Nutritional Genomic Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Nutr Neurosci 8:67-89. 2005
  2. ncbi request reprint The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview
    Jiankang Liu
    Institute for Brain Aging and Dementia, University of California, 1261 Gillespie Neuroscience Research Facility, Irvine, CA 92697, USA
    Neurochem Res 33:194-203. 2008
  3. pmc A combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic Goto-Kakizaki rats
    Weili Shen
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 3:e2328. 2008
  4. pmc Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction
    Zhongbo Liu
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Neurochem 103:2690-700. 2007
  5. ncbi request reprint Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes
    Jiejie Hao
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Nutr Biochem 21:634-44. 2010
  6. doi request reprint Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model
    Haiqun Jia
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Neurobiol Aging 31:636-46. 2010
  7. doi request reprint Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats
    Jiejie Hao
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, China
    J Cell Mol Med 13:701-11. 2009
  8. doi request reprint Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease
    Hongyu Zhang
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Cell Mol Med 14:215-25. 2010
  9. doi request reprint α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells
    Zhihui Feng
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Nutr Biochem 21:1222-31. 2010
  10. doi request reprint Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease
    Xiaoqing Cai
    Laboratory of Nanobiology and Medicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    J Neurosci Res 86:3622-34. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's disease
    Jiankang Liu
    Nutritional Genomic Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Nutr Neurosci 8:67-89. 2005
    ..Thus, optimal doses of combinations of mt-nutrients to delay and repair mitochondrial decay could be a strategy for preventing and treating cognitive dysfunction, including AD and PD...
  2. ncbi request reprint The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview
    Jiankang Liu
    Institute for Brain Aging and Dementia, University of California, 1261 Gillespie Neuroscience Research Facility, Irvine, CA 92697, USA
    Neurochem Res 33:194-203. 2008
    ....
  3. pmc A combination of nutriments improves mitochondrial biogenesis and function in skeletal muscle of type 2 diabetic Goto-Kakizaki rats
    Weili Shen
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 3:e2328. 2008
    ..In the present study, we investigated the effects of a combination of nutrients on insulin resistance and mitochondrial biogenesis/function in skeletal muscle of type 2 diabetic Goto-Kakizaki rats...
  4. pmc Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction
    Zhongbo Liu
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Neurochem 103:2690-700. 2007
    ....
  5. ncbi request reprint Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes
    Jiejie Hao
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Nutr Biochem 21:634-44. 2010
    ..These data suggest that HT is able to promote mitochondrial function by stimulating mitochondrial biogenesis...
  6. doi request reprint Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model
    Haiqun Jia
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Neurobiol Aging 31:636-46. 2010
    ..These results suggest that administration of high doses of B vitamins sufficient to elevate mitochondrial enzyme cofactors may be effective in preventing PD by reducing oxidative stress and improving mitochondrial function...
  7. doi request reprint Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats
    Jiejie Hao
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, China
    J Cell Mol Med 13:701-11. 2009
    ....
  8. doi request reprint Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease
    Hongyu Zhang
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Cell Mol Med 14:215-25. 2010
    ..This study provides important evidence that combining mitochondrial antioxidant/nutrients at optimal doses might be an effective and safe prevention strategy for PD...
  9. doi request reprint α-Tocopherol is an effective Phase II enzyme inducer: protective effects on acrolein-induced oxidative stress and mitochondrial dysfunction in human retinal pigment epithelial cells
    Zhihui Feng
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Nutr Biochem 21:1222-31. 2010
    ..These results suggest that α-tocopherol protects ARPE-19 cells from acrolein-induced cellular toxicity, not only as a chain-breaking antioxidant, but also as a Phase II enzyme inducer...
  10. doi request reprint Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease
    Xiaoqing Cai
    Laboratory of Nanobiology and Medicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China
    J Neurosci Res 86:3622-34. 2008
    ..These data suggest that C(60)(OH)(24) is a mitochondrial protective antioxidant with direct radical scavenging activity and indirect antioxidant inducing activity...
  11. pmc Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine
    Jiangang Long
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Neurochem Res 34:755-63. 2009
    ....
  12. doi request reprint Hydroxytyrosol protects against oxidative damage by simultaneous activation of mitochondrial biogenesis and phase II detoxifying enzyme systems in retinal pigment epithelial cells
    Lu Zhu
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Nutr Biochem 21:1089-98. 2010
    ..Dietary supplementation of hydroxytyrosol may contribute to eye health by preventing the degeneration of retinal pigment epithelial cells induced by oxidative stress...
  13. doi request reprint Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria
    Jiangang Long
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Neurochem Res 34:786-94. 2009
    ..The results suggest that MDA-induced neuronal mitochondrial toxicity may be an important contributing factor to brain aging and neurodegenerative diseases...
  14. pmc Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway
    Weili Shen
    State Key Laboratory of Medical Genomics, and Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Br J Pharmacol 162:1213-24. 2011
    ..In a search for potent stimulators of mitochondrial biogenesis, we examined the effects and mechanisms of lipoamide and α-lipoic acid (LA) in adipocytes...
  15. doi request reprint Endurance exercise causes mitochondrial and oxidative stress in rat liver: effects of a combination of mitochondrial targeting nutrients
    Lijuan Sun
    College of Physical Education and Health, East China Normal University, Shanghai, China
    Life Sci 86:39-44. 2010
    ....
  16. ncbi request reprint D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid
    Jiangang Long
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
    Biogerontology 8:373-81. 2007
    ..These results suggest LA is effective in delaying D-gal toxicity by ameliorating mitochondrial dysfunction...
  17. pmc Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction
    Xuesen Li
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Free Radic Biol Med 44:1465-74. 2008
    ..These results suggest that LM is a more potent mitochondrial-protective agent and antioxidant than LA in protecting RPE from oxidative damage...
  18. doi request reprint The polyhydroxylated fullerene derivative C60(OH)24 protects mice from ionizing-radiation-induced immune and mitochondrial dysfunction
    Xiaoqing Cai
    Laboratory of Physical Biology, Shanghai Institure of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
    Toxicol Appl Pharmacol 243:27-34. 2010
    ....
  19. ncbi request reprint High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease
    Haiqun Jia
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Neurosci Res 86:2083-90. 2008
    ....
  20. pmc Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid
    Jiankang Liu
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:2356-61. 2002
    ..These results suggest that feeding ALCAR and LA to old rats improves performance on memory tasks by lowering oxidative damage and improving mitochondrial function...
  21. doi request reprint Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: regulatory effects of hydroxytyrosol
    Zhihui Feng
    Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Free Radic Biol Med 50:1437-46. 2011
    ..HT supplementation may regulate mitochondrial dynamic remodeling and enhance antioxidant defenses and thus improve exercise capacity under Exe conditions...
  22. ncbi request reprint An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates
    Cheng Luo
    Institute for Nutritional Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, PR China
    J Biochem Biophys Methods 68:101-11. 2006
    ..5 microg protein of isolated mitochondria or crude tissue homogenate. These results suggest that this assay is a simple, sensitive, stable and inexpensive method with wide application...
  23. ncbi request reprint Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites
    Jiankang Liu
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720, USA
    Ann N Y Acad Sci 959:133-66. 2002
    ..This loss of activity due to coenzyme or substrate binding appears to be true for a number of other enzymes as well, including mitochondrial complex III and IV...
  24. doi request reprint An improved spectrophotometric method for a more specific and accurate assay of mitochondrial complex III activity
    Cheng Luo
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Clin Chim Acta 395:38-41. 2008
    ..However, great variations have been seen in the literature due to the use of different assays...
  25. pmc (R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage
    Ludmila A Voloboueva
    Biophysics Graduate Group, University of California, Berkeley, USA
    Invest Ophthalmol Vis Sci 46:4302-10. 2005
    ..To determine whether (R)-alpha-lipoic acid (LA) protects cultured human fetal retinal pigment epithelial (hfRPE) cells against oxidative injury and identify the pathways that may mediate protection...
  26. ncbi request reprint Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria
    Jiangang Long
    Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P R China
    Life Sci 79:1466-72. 2006
    ....
  27. pmc Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid
    Jiankang Liu
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:1876-81. 2002
    ..Thus, feeding old rats high levels of key mitochondrial metabolites can ameliorate oxidative damage, enzyme activity, substrate-binding affinity, and mitochondrial dysfunction...
  28. ncbi request reprint Delaying the mitochondrial decay of aging with acetylcarnitine
    Bruce N Ames
    Nutritional Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Ann N Y Acad Sci 1033:108-16. 2004
    ..placebo. A meta-analysis of 4 clinical trials of LA for treatment of neuropathic deficits in diabetes showed significant efficacy vs. placebo...
  29. ncbi request reprint (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis
    Jung H Suh
    Department of Biochemistry and Biophysics, Linus Pauling Insitute, Oregon State University, USA
    Arch Biochem Biophys 423:126-35. 2004
    ..These results demonstrate that LA is an effective agent to restore both the age-associated decline in thiol redox ratio as well as increase cerebral GSH levels that otherwise decline with age...
  30. doi request reprint NF-kappaB regulates prenatal stress-induced cognitive impairment in offspring rats
    Hui Li
    Xi an Jiaotong University
    Behav Neurosci 122:331-9. 2008
    ..These results suggest that NF-kappaB complex may be acting in a positive regulatory fashion in prenatal stress-induced cognitive impairment and that oxidative DNA damage may exacerbate the activation of NF-kappaB...
  31. ncbi request reprint Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid
    Xu Cui
    Institute of Gerontology and Geriatrics, Chinese PLA General Hospital, Beijing, People s Republic of China
    J Neurosci Res 83:1584-90. 2006
    ..In addition, D-galactose-induced toxicity in mice is a useful model for studying the mechanisms of neurodegeneration and neuroprotective drugs and agents...
  32. ncbi request reprint Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid
    Xu Cui
    Institute of Gerontology and Geriatrics, Chinese PLA General Hospital, Beijing, People s Republic of China
    J Neurosci Res 84:647-54. 2006
    ..In addition, D-galactose-induced toxicity in mice is a useful model for studying the mechanisms of neurodegeneration and neuroprotective drugs and agents...
  33. pmc Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid
    Lihong Jia
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Invest Ophthalmol Vis Sci 48:339-48. 2007
    ....
  34. ncbi request reprint Mitochondrial dysfunction enhances susceptibility to oxidative stress by down-regulation of thioredoxin in human neuroblastoma cells
    Hongqun Ding
    School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China
    Neurochem Res 33:43-50. 2008
    ....
  35. ncbi request reprint Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid
    Weili Shen
    Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    J Cell Biochem 104:1232-43. 2008
    ....
  36. pmc Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress
    Tory M Hagen
    Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Proc Natl Acad Sci U S A 99:1870-5. 2002
    ..Feeding ALCAR in combination with LA increased metabolism and lowered oxidative stress more than either compound alone...