Research Topics
| Jiankang LiuSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction, Alzheimer's disease, and Parkinson's diseaseJiankang Liu
Nutritional Genomic Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Nutr Neurosci 8:67-89. 2005..Thus, optimal doses of combinations of mt-nutrients to delay and repair mitochondrial decay could be a strategy for preventing and treating cognitive dysfunction, including AD and PD...- The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overviewJiankang Liu
Institute for Brain Aging and Dementia, University of California, 1261 Gillespie Neuroscience Research Facility, Irvine, CA 92697, USA
Neurochem Res 33:194-203. 2008.... 
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitineJiangang Long
Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
Neurochem Res 34:755-63. 2009....
Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondriaJiangang Long
Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
Neurochem Res 34:786-94. 2009..The results suggest that MDA-induced neuronal mitochondrial toxicity may be an important contributing factor to brain aging and neurodegenerative diseases...- Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acidJiankang Liu
Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 99:2356-61. 2002..These results suggest that feeding ALCAR and LA to old rats improves performance on memory tasks by lowering oxidative damage and improving mitochondrial function... - Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolitesJiankang Liu
Division of Biochemistry and Molecular Biology, University of California, Berkeley, California 94720, USA
Ann N Y Acad Sci 959:133-66. 2002..This loss of activity due to coenzyme or substrate binding appears to be true for a number of other enzymes as well, including mitochondrial complex III and IV... - (R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damageLudmila A Voloboueva
Biophysics Graduate Group, University of California, Berkeley, USA
Invest Ophthalmol Vis Sci 46:4302-10. 2005..CONCLUSIONS: The present study suggests that the protective effect of LA involves multiple pathways and that LA could be effective against age-associated increase in oxidative stress and mitochondrial dysfunction in RPE cells... - Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acidJiankang Liu
Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 99:1876-81. 2002..Thus, feeding old rats high levels of key mitochondrial metabolites can ameliorate oxidative damage, enzyme activity, substrate-binding affinity, and mitochondrial dysfunction... - D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acidJiangang Long
Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
Biogerontology 8:373-81. 2007..These results suggest LA is effective in delaying D-gal toxicity by ameliorating mitochondrial dysfunction... - An improved spectrophotometric method for a more specific and accurate assay of mitochondrial complex III activityCheng Luo
Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Clin Chim Acta 395:38-41. 2008..However, great variations have been seen in the literature due to the use of different assays... - High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's diseaseHaiqun Jia
Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China
J Neurosci Res 86:2083-90. 2008.... - Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acidWeili Shen
Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
J Cell Biochem 104:1232-43. 2008.... - Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunctionXuesen Li
Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Free Radic Biol Med 44:1465-74. 2008..These results suggest that LM is a more potent mitochondrial-protective agent and antioxidant than LA in protecting RPE from oxidative damage... - NF-kappaB regulates prenatal stress-induced cognitive impairment in offspring ratsHui Li
Xi an Jiaotong University
Behav Neurosci 122:331-9. 2008..These results suggest that NF-kappaB complex may be acting in a positive regulatory fashion in prenatal stress-induced cognitive impairment and that oxidative DNA damage may exacerbate the activation of NF-kappaB... - Mitochondrial dysfunction enhances susceptibility to oxidative stress by down-regulation of thioredoxin in human neuroblastoma cellsHongqun Ding
School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China
Neurochem Res 33:43-50. 2008.... - Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acidLihong Jia
Children s Hospital Oakland Research Institute, Oakland, California, USA
Invest Ophthalmol Vis Sci 48:339-48. 2007.... - Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondriaJiangang Long
Institute for Nutritional Science, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P R China
Life Sci 79:1466-72. 2006.... - Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acidXu Cui
Institute of Gerontology and Geriatrics, Chinese PLA General Hospital, Beijing, People's Republic of China
J Neurosci Res 84:647-54. 2006..In addition, D-galactose-induced toxicity in mice is a useful model for studying the mechanisms of neurodegeneration and neuroprotective drugs and agents... - Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acidXu Cui
Institute of Gerontology and Geriatrics, Chinese PLA General Hospital, Beijing, People's Republic of China
J Neurosci Res 83:1584-90. 2006..In addition, D-galactose-induced toxicity in mice is a useful model for studying the mechanisms of neurodegeneration and neuroprotective drugs and agents... - Delaying the mitochondrial decay of aging with acetylcarnitineBruce N Ames
Nutritional Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
Ann N Y Acad Sci 1033:108-16. 2004..placebo. A meta-analysis of 4 clinical trials of LA for treatment of neuropathic deficits in diabetes showed significant efficacy vs. placebo... - (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesisJung H Suh
Department of Biochemistry and Biophysics, Linus Pauling Insitute, Oregon State University, USA
Arch Biochem Biophys 423:126-35. 2004..These results demonstrate that LA is an effective agent to restore both the age-associated decline in thiol redox ratio as well as increase cerebral GSH levels that otherwise decline with age... - Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stressTory M Hagen
Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
Proc Natl Acad Sci U S A 99:1870-5. 2002..Feeding ALCAR in combination with LA increased metabolism and lowered oxidative stress more than either compound alone...