Research Topics
Genomes and Genes
| Gang LiuSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
| Collaborators
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Detail Information
Publications
MicroRNAs in immune response and macrophage polarizationGang Liu
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Arterioscler Thromb Vasc Biol 33:170-7. 2013..We discuss the role of miRNAs in macrophage polarization, a molecular event that has clear effect on inflammation...- miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosisGang Liu
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Exp Med 207:1589-97. 2010..These experiments demonstrate an important role for miR-21 in fibrotic lung diseases and also suggest a novel approach using miRNA therapeutics in treating clinically refractory fibrotic diseases, such as IPF... - Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxideSami Banerjee
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
J Biol Chem 285:2665-75. 2010.... - Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injuryXia Zhao
Dept of Medicine, Univ of Alabama at Birmingham School of Medicine, BDB 420, 1530 3rd Ave S, Birmingham, AL 35294 0012, USA
Am J Physiol Lung Cell Mol Physiol 295:L497-504. 2008..These results suggest that AMPK activation reduces TLR4-induced neutrophil activation and diminishes the severity of neutrophil-driven proinflammatory processes, including acute lung injury... - The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosisSami Banerjee
University of Alabama at Birmingham, School of Medicine, 1808 7th Ave, S, Birmingham, AL 35294, USA
J Leukoc Biol 88:973-9. 2010..These results demonstrate that the HMGB1 C-terminal tail is responsible for the inhibitory effects of HMGB1 on phagocytosis of apoptotic neutrophils under in vitro and in vivo conditions... - High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserineGang Liu
Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
J Immunol 181:4240-6. 2008..These findings demonstrate that HMGB1 can modulate phagocytosis of apoptotic neutrophils and suggest an alternative mechanism by which HMGB1 is involved in enhancing inflammatory responses... - Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injuryEmmanuel Lorne
Department of Medicine, University of Alabama, Birmingham, AL, USA
Am J Respir Cell Mol Biol 41:237-45. 2009..These results indicate that mTORC1 activation is essential in TLR2- and TLR4-induced neutrophil activation, as well as in the development and severity of acute lung injury... - Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injuryJaroslaw W Zmijewski
Department of Medicine, University of Alabama at Birmingham School of Medicine, 1530 3rd Avenue S, Birmingham, AL 35294 0012, USA
Am J Respir Crit Care Med 179:694-704. 2009.... - miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responsesGang Liu
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 106:15819-24. 2009..These data demonstrate a negative-feedback loop in which TLR stimulation induces miR-147 to prevent excessive inflammatory responses... - Extracellular histones inhibit efferocytosisArnaud Friggeri
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
Mol Med 18:825-33. 2012..The present studies demonstrate that histones have inhibitory effects on efferocytosis, suggesting a new mechanism by which extracellular histones contribute to acute inflammatory processes and tissue injury... - Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injuryJaroslaw W Zmijewski
Department of Medicine, University of Alabama at Birmingham School of Medicine, 1530 Third Avenue S, Birmingham, AL 35294 0012, USA
Am J Respir Crit Care Med 178:168-79. 2008.... 
The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73Gang Liu
Department of Cell Biology, The University of Alabama, Birmingham, 35294, USA
J Biol Chem 280:20111-9. 2005..Finally, we showed that both inhibitory domains suppress the ability of p73 to interact with the transcriptional coactivators p300/CBP that are necessary for the initiation of transcription...- Participation of the urokinase receptor in neutrophil efferocytosisYoung Jun Park
Department of Medicine, University of Alabama at Birmingham, 1808 7th Avenue South, Birmingham, AL, USA
Blood 114:860-70. 2009..Expression of uPAR on the surface of apoptotic neutrophils was reduced compared with levels on viable neutrophils. These results demonstrate a novel role for uPAR in modulating recognition and clearance of neutrophils... - Intracellular HMGB1 negatively regulates efferocytosisSami Banerjee
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 187:4686-94. 2011..In particular, these experiments show that intracellular HMGB1, through associating with Src kinase and inhibiting interactions between Src and FAK, diminishes the phagocytic ability of macrophages and other cell populations... - The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophilsGang Liu
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
PLoS ONE 6:e25843. 2011.... - Participation of miR-200 in pulmonary fibrosisShanzhong Yang
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Am J Pathol 180:484-93. 2012..Thus, the miR-200 family members participate importantly in fibrotic lung diseases and suggest that restoring miR-200 expression in the lungs may represent a novel therapeutic approach in treating pulmonary fibrotic diseases... 
p53 Attenuates lipopolysaccharide-induced NF-kappaB activation and acute lung injuryGang Liu
Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
J Immunol 182:5063-71. 2009..These data demonstrate that p53 regulates NF-kappaB activity in inflammatory cells and suggest that modulation of p53 may have potential therapeutic benefits in acute inflammatory conditions, such as ALI...- miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosisShanzhong Yang
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
FASEB J 26:3790-9. 2012.... - HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrinArnaud Friggeri
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Am J Physiol Cell Physiol 299:C1267-76. 2010..These results demonstrate that HMGB1 blocks α(v)β(3)-dependent recognition and uptake of apoptotic cells... - Identification of TLT2 as an engulfment receptor for apoptotic cellsAndressa de Freitas
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 188:6381-8. 2012..Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells. Our data also suggest a novel mechanism by which TREM receptors regulate inflammation and autoimmune response... - PAI-1 inhibits neutrophil efferocytosisYoung Jun Park
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 105:11784-9. 2008..Our data therefore indicate that PAI-1 serves as a novel "don't eat me" signal for viable and apoptotic neutrophils... - Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-kappaB activation requires cytosolic and nuclear activityGang Liu
Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
FASEB J 22:2285-96. 2008..These data indicate that both cytosolic and nuclear actions of IRAK-1 participate in the activation of NF-kappaB-dependent transcriptional events... - Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine productionEmmanuel Lorne
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
Am J Physiol Cell Physiol 294:C985-93. 2008.... - ZHX proteins regulate podocyte gene expression during the development of nephrotic syndromeGang Liu
Division of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Biol Chem 281:39681-92. 2006..In summary, ZHX proteins are major transcriptional mediators of podocyte disease... - Regulation of alveolar epithelial Na+ channels by ERK1/2 in chlorine-breathing miceAhmed Lazrak
Department of Anesthesiology, School of Medicine, University of Alabama at Birmingham, BMR II 224, 901 19th St South, Birmingham, AL 35205 3703, USA
Am J Respir Cell Mol Biol 46:342-54. 2012..The reactive intermediates formed during and after exposure to Cl(2) activated ERK1/2 in ATII cells in vitro and in vivo, leading to decreased ENaC concentrations and activity... - SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissueJennifer Beane
Section of Computational Biomedicine, Department of Medicine, Boston University Medical Center Bioinformatics Program, Boston University, Boston, Massachusetts, USA
Cancer Res 72:5702-11. 2012.... - miR-21 regulates chronic hypoxia-induced pulmonary vascular remodelingShanzhong Yang
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, USA
Am J Physiol Lung Cell Mol Physiol 302:L521-9. 2012.... - Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloraminesWeifeng Song
Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35205, USA
J Biol Chem 285:9716-28. 2010..We concluded that HOCl and its reactive intermediates (such as organic chloramines) inhibit ENaC by affecting channel gating, which could be relieved by proteases cleavage... - Urokinase-type plasminogen activator inhibits efferocytosis of neutrophilsYanping Yang
Department of Medicine, University of Alabama at Birmingham, 35294, USA
Am J Respir Crit Care Med 182:1516-23. 2010..However, the role of uPA in modulating efferocytosis of apoptotic neutrophils has not been defined... - Regulation of the p53 transcriptional activityGang Liu
Department of Cell Biology, The University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA
J Cell Biochem 97:448-58. 2006..We also discussed some potentially interesting questions and future directions in the field... - Involvement of vitronectin in lipopolysaccaride-induced acute lung injuryYuko Tsuruta
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 179:7079-86. 2007..These findings provide a novel vitronectin-dependent mechanism contributing to the development of acute lung injury... - Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in miceWeifeng Song
901 19th Street South, 224 BMR2, Birmingham, AL 35294, USA
Am J Respir Cell Mol Biol 45:88-94. 2011..Our results provide mechanistic insight into the effectiveness of long-term β(2)-agonists in reversing Cl(2)-induced reactive airway dysfunction syndrome and injury to distal lung epithelial cells... - Identification of a microRNA signature in renal fibrosis: role of miR-21Abolfazl Zarjou
Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Am J Physiol Renal Physiol 301:F793-801. 2011..Our data suggest that targeting specific miRNAs could be a novel therapeutic approach to treat renal fibrosis... - Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthaseWeifeng Song
Department of Anesthesiology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
J Biol Chem 284:7294-306. 2009..Thus, both UTP- and iNOS-generated reactive species contribute to ENaC down-regulation in RSV-infected airway epithelial cells... - Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen speciesAhmed Lazrak
Department of Anesthesiology, Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
FASEB J 23:3829-42. 2009..These novel findings suggest a mechanism for the influenza-induced rhinorrhea and life-threatening alveolar edema in humans... - Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activityGang Liu
Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
J Immunol 179:4125-34. 2007.... - Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysisDavid G Stokes
Department of Medicine, Division of Rheumatology, Jefferson Medical College, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
Arthritis Rheum 46:404-19. 2002..At least 3 of the genes that were regulated in response to dedifferentiation were also found to be expressed in adult normal and OA articular cartilage and chondrocytes... - Potential role of high-mobility group box 1 in cystic fibrosis airway diseaseSteven M Rowe
Department University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
Am J Respir Crit Care Med 178:822-31. 2008..High-mobility group box 1 (HMGB1) is a potent inflammatory mediator elevated in sepsis and rheumatoid arthritis, although its role in cystic fibrosis (CF) lung disease is unknown... - DeltaNp73beta is active in transactivation and growth suppressionGang Liu
Department of Cell Biology, The University of Alabama at Birmingham, 1530 3rd Avenue, Birmingham, AL 35294 0005, USA
Mol Cell Biol 24:487-501. 2004..However, unlike DeltaNp73beta, DeltaNp73alpha is inactive in suppressing cell growth. Our data, together with others' previous findings, suggest that DeltaNp73beta may have distinct functions under certain cellular circumstances... - Myosin VI is a mediator of the p53-dependent cell survival pathwayEun Joo Jung
Department of Cell Biology, MCLM 660, 1530 3rd Ave S, Birmingham, AL 35294 0005, USA
Mol Cell Biol 26:2175-86. 2006..Taken together, we found a novel function for p53 in the maintenance of Golgi complex integrity and for myosin VI in the p53-dependent prosurvival pathway... - Gene expression in lung adenocarcinomas of smokers and nonsmokersCharles A Powell
Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, USA
Am J Respir Cell Mol Biol 29:157-62. 2003..Our findings, although limited by small sample size, suggest that additional studies comparing noninvolved to tumor tissue may identify pathogenetic mechanisms and therapeutic targets that differ in AC of smokers and nonsmokers... - Molecular mechanisms of asbestos-induced lung epithelial cell apoptosisGang Liu
Department of Medicine, Pulmonary and Critical Care Medicine, Jesse Brown VA Medical Center and Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Chem Biol Interact 188:309-18. 2010..Importantly, the asbestos paradigm is elucidating pathophysiologic insights into other more common pulmonary diseases, such as IPF and lung cancer, for which better therapy is required... - New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosisQiang Ding
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, USA
Drugs 71:981-1001. 2011..Heterogeneity in biological and clinical phenotypes of IPF warrants a personalized medicine approach to diagnosis and treatment of this lung disorder... - Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African AmericansRongling Li
Department of Medicine, Clinical Research Center, Atlanta, Georgia, USA
Am J Hypertens 17:560-7. 2004..The role of eNOS gene polymorphisms on plasma nitrite or nitrate (NOx) level, endothelial function, and blood pressure (BP) remains unclear... - Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeabilityGang Liu
Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Clin Invest 112:209-21. 2003..The interaction between nephrin and Neph1 therefore appears to be an important determinant of glomerular permeability...