Gang Liu

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc MicroRNAs in immune response and macrophage polarization
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Arterioscler Thromb Vasc Biol 33:170-7. 2013
  2. pmc miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:1589-97. 2010
  3. pmc Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide
    Sami Banerjee
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    J Biol Chem 285:2665-75. 2010
  4. pmc Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
    Xia Zhao
    Dept of Medicine, Univ of Alabama at Birmingham School of Medicine, BDB 420, 1530 3rd Ave S, Birmingham, AL 35294 0012, USA
    Am J Physiol Lung Cell Mol Physiol 295:L497-504. 2008
  5. pmc miR-125a-5p regulates differential activation of macrophages and inflammation
    Sami Banerjee
    From the Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 and
    J Biol Chem 288:35428-36. 2013
  6. pmc MicroRNA let-7c regulates macrophage polarization
    Sami Banerjee
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 190:6542-9. 2013
  7. pmc The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis
    Sami Banerjee
    University of Alabama at Birmingham, School of Medicine, 1808 7th Ave, S, Birmingham, AL 35294, USA
    J Leukoc Biol 88:973-9. 2010
  8. pmc Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury
    Emmanuel Lorne
    Department of Medicine, University of Alabama, Birmingham, AL, USA
    Am J Respir Cell Mol Biol 41:237-45. 2009
  9. pmc miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 106:15819-24. 2009
  10. pmc Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury
    Jaroslaw W Zmijewski
    Department of Medicine, University of Alabama at Birmingham School of Medicine, 1530 3rd Avenue S, Birmingham, AL 35294 0012, USA
    Am J Respir Crit Care Med 179:694-704. 2009

Collaborators

Detail Information

Publications51

  1. pmc MicroRNAs in immune response and macrophage polarization
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Arterioscler Thromb Vasc Biol 33:170-7. 2013
    ..We discuss the role of miRNAs in macrophage polarization, a molecular event that has clear effect on inflammation...
  2. pmc miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:1589-97. 2010
    ..These experiments demonstrate an important role for miR-21 in fibrotic lung diseases and also suggest a novel approach using miRNA therapeutics in treating clinically refractory fibrotic diseases, such as IPF...
  3. pmc Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide
    Sami Banerjee
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 0012, USA
    J Biol Chem 285:2665-75. 2010
    ....
  4. pmc Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
    Xia Zhao
    Dept of Medicine, Univ of Alabama at Birmingham School of Medicine, BDB 420, 1530 3rd Ave S, Birmingham, AL 35294 0012, USA
    Am J Physiol Lung Cell Mol Physiol 295:L497-504. 2008
    ..These results suggest that AMPK activation reduces TLR4-induced neutrophil activation and diminishes the severity of neutrophil-driven proinflammatory processes, including acute lung injury...
  5. pmc miR-125a-5p regulates differential activation of macrophages and inflammation
    Sami Banerjee
    From the Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 and
    J Biol Chem 288:35428-36. 2013
    ..In addition, miR-125a-5p regulates phagocytic and bactericidal activities of macrophages. Our data suggest that miR-125a-5p has an important role in suppressing classical activation of macrophages while promoting alternative activation. ..
  6. pmc MicroRNA let-7c regulates macrophage polarization
    Sami Banerjee
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 190:6542-9. 2013
    ..Our data suggest that the miRNA let-7c plays an important role in regulating macrophage polarization...
  7. pmc The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis
    Sami Banerjee
    University of Alabama at Birmingham, School of Medicine, 1808 7th Ave, S, Birmingham, AL 35294, USA
    J Leukoc Biol 88:973-9. 2010
    ..These results demonstrate that the HMGB1 C-terminal tail is responsible for the inhibitory effects of HMGB1 on phagocytosis of apoptotic neutrophils under in vitro and in vivo conditions...
  8. pmc Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury
    Emmanuel Lorne
    Department of Medicine, University of Alabama, Birmingham, AL, USA
    Am J Respir Cell Mol Biol 41:237-45. 2009
    ..These results indicate that mTORC1 activation is essential in TLR2- and TLR4-induced neutrophil activation, as well as in the development and severity of acute lung injury...
  9. pmc miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 106:15819-24. 2009
    ..These data demonstrate a negative-feedback loop in which TLR stimulation induces miR-147 to prevent excessive inflammatory responses...
  10. pmc Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury
    Jaroslaw W Zmijewski
    Department of Medicine, University of Alabama at Birmingham School of Medicine, 1530 3rd Avenue S, Birmingham, AL 35294 0012, USA
    Am J Respir Crit Care Med 179:694-704. 2009
    ....
  11. pmc miR-27a regulates inflammatory response of macrophages by targeting IL-10
    Na Xie
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294
    J Immunol 193:327-34. 2014
    ..In conclusion, our study identified miR-27a downregulation as a negative-regulatory mechanism that prevents overly exuberant TLR2- and TLR4-driven inflammatory responses. ..
  12. pmc High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine
    Gang Liu
    Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 181:4240-6. 2008
    ..These findings demonstrate that HMGB1 can modulate phagocytosis of apoptotic neutrophils and suggest an alternative mechanism by which HMGB1 is involved in enhancing inflammatory responses...
  13. pmc Extracellular histones inhibit efferocytosis
    Arnaud Friggeri
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    Mol Med 18:825-33. 2012
    ..The present studies demonstrate that histones have inhibitory effects on efferocytosis, suggesting a new mechanism by which extracellular histones contribute to acute inflammatory processes and tissue injury...
  14. pmc Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury
    Jaroslaw W Zmijewski
    Department of Medicine, University of Alabama at Birmingham School of Medicine, 1530 Third Avenue S, Birmingham, AL 35294 0012, USA
    Am J Respir Crit Care Med 178:168-79. 2008
    ....
  15. ncbi request reprint The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73
    Gang Liu
    Department of Cell Biology, The University of Alabama, Birmingham, 35294, USA
    J Biol Chem 280:20111-9. 2005
    ..Finally, we showed that both inhibitory domains suppress the ability of p73 to interact with the transcriptional coactivators p300/CBP that are necessary for the initiation of transcription...
  16. pmc Participation of the urokinase receptor in neutrophil efferocytosis
    Young Jun Park
    Department of Medicine, University of Alabama at Birmingham, 1808 7th Avenue South, Birmingham, AL, USA
    Blood 114:860-70. 2009
    ..Expression of uPAR on the surface of apoptotic neutrophils was reduced compared with levels on viable neutrophils. These results demonstrate a novel role for uPAR in modulating recognition and clearance of neutrophils...
  17. pmc The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophils
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e25843. 2011
    ....
  18. pmc Intracellular HMGB1 negatively regulates efferocytosis
    Sami Banerjee
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 187:4686-94. 2011
    ..In particular, these experiments show that intracellular HMGB1, through associating with Src kinase and inhibiting interactions between Src and FAK, diminishes the phagocytic ability of macrophages and other cell populations...
  19. pmc Participation of miR-200 in pulmonary fibrosis
    Shanzhong Yang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Pathol 180:484-93. 2012
    ..Thus, the miR-200 family members participate importantly in fibrotic lung diseases and suggest that restoring miR-200 expression in the lungs may represent a novel therapeutic approach in treating pulmonary fibrotic diseases...
  20. doi request reprint p53 Attenuates lipopolysaccharide-induced NF-kappaB activation and acute lung injury
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
    J Immunol 182:5063-71. 2009
    ..These data demonstrate that p53 regulates NF-kappaB activity in inflammatory cells and suggest that modulation of p53 may have potential therapeutic benefits in acute inflammatory conditions, such as ALI...
  21. pmc miR-145 regulates myofibroblast differentiation and lung fibrosis
    Shanzhong Yang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    FASEB J 27:2382-91. 2013
    ..miR-145 deficiency is protective against bleomycin-induced lung fibrosis, suggesting that miR-145 may be a potential target in the development of novel therapies to treat pathological fibrotic disorders...
  22. pmc miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis
    Shanzhong Yang
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    FASEB J 26:3790-9. 2012
    ....
  23. pmc HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin
    Arnaud Friggeri
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Physiol Cell Physiol 299:C1267-76. 2010
    ..These results demonstrate that HMGB1 blocks α(v)β(3)-dependent recognition and uptake of apoptotic cells...
  24. pmc Identification of TLT2 as an engulfment receptor for apoptotic cells
    Andressa de Freitas
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 188:6381-8. 2012
    ..Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells. Our data also suggest a novel mechanism by which TREM receptors regulate inflammation and autoimmune response...
  25. pmc PAI-1 inhibits neutrophil efferocytosis
    Young Jun Park
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 105:11784-9. 2008
    ..Our data therefore indicate that PAI-1 serves as a novel "don't eat me" signal for viable and apoptotic neutrophils...
  26. doi request reprint Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production
    Emmanuel Lorne
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    Am J Physiol Cell Physiol 294:C985-93. 2008
    ....
  27. doi request reprint Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-kappaB activation requires cytosolic and nuclear activity
    Gang Liu
    Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    FASEB J 22:2285-96. 2008
    ..These data indicate that both cytosolic and nuclear actions of IRAK-1 participate in the activation of NF-kappaB-dependent transcriptional events...
  28. ncbi request reprint ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome
    Gang Liu
    Division of Nephrology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 281:39681-92. 2006
    ..In summary, ZHX proteins are major transcriptional mediators of podocyte disease...
  29. pmc Regulation of alveolar epithelial Na+ channels by ERK1/2 in chlorine-breathing mice
    Ahmed Lazrak
    Department of Anesthesiology, School of Medicine, University of Alabama at Birmingham, BMR II 224, 901 19th St South, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 46:342-54. 2012
    ..The reactive intermediates formed during and after exposure to Cl(2) activated ERK1/2 in ATII cells in vitro and in vivo, leading to decreased ENaC concentrations and activity...
  30. pmc The human long noncoding RNA lnc-IL7R regulates the inflammatory response
    Huachun Cui
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    Eur J Immunol 44:2085-95. 2014
    ..Our data suggest that lnc-IL7R contributes another layer of complexity in regulation of the inflammatory response. ..
  31. pmc miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling
    Shanzhong Yang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama, Birmingham, USA
    Am J Physiol Lung Cell Mol Physiol 302:L521-9. 2012
    ....
  32. pmc SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue
    Jennifer Beane
    Section of Computational Biomedicine, Department of Medicine, Boston University Medical Center Bioinformatics Program, Boston University, Boston, Massachusetts, USA
    Cancer Res 72:5702-11. 2012
    ....
  33. pmc Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils
    Yanping Yang
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Am J Respir Crit Care Med 182:1516-23. 2010
    ..However, the role of uPA in modulating efferocytosis of apoptotic neutrophils has not been defined...
  34. pmc Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines
    Weifeng Song
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35205, USA
    J Biol Chem 285:9716-28. 2010
    ..We concluded that HOCl and its reactive intermediates (such as organic chloramines) inhibit ENaC by affecting channel gating, which could be relieved by proteases cleavage...
  35. ncbi request reprint Regulation of the p53 transcriptional activity
    Gang Liu
    Department of Cell Biology, The University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294, USA
    J Cell Biochem 97:448-58. 2006
    ..We also discussed some potentially interesting questions and future directions in the field...
  36. pmc Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice
    Weifeng Song
    901 19th Street South, 224 BMR2, Birmingham, AL 35294, USA
    Am J Respir Cell Mol Biol 45:88-94. 2011
    ..Our results provide mechanistic insight into the effectiveness of long-term β(2)-agonists in reversing Cl(2)-induced reactive airway dysfunction syndrome and injury to distal lung epithelial cells...
  37. pmc Identification of a microRNA signature in renal fibrosis: role of miR-21
    Abolfazl Zarjou
    Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Am J Physiol Renal Physiol 301:F793-801. 2011
    ..Our data suggest that targeting specific miRNAs could be a novel therapeutic approach to treat renal fibrosis...
  38. ncbi request reprint Involvement of vitronectin in lipopolysaccaride-induced acute lung injury
    Yuko Tsuruta
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 179:7079-86. 2007
    ..These findings provide a novel vitronectin-dependent mechanism contributing to the development of acute lung injury...
  39. pmc Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species
    Ahmed Lazrak
    Department of Anesthesiology, Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    FASEB J 23:3829-42. 2009
    ..These novel findings suggest a mechanism for the influenza-induced rhinorrhea and life-threatening alveolar edema in humans...
  40. pmc Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase
    Weifeng Song
    Department of Anesthesiology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Biol Chem 284:7294-306. 2009
    ..Thus, both UTP- and iNOS-generated reactive species contribute to ENaC down-regulation in RSV-infected airway epithelial cells...
  41. pmc Histone modifications in senescence-associated resistance to apoptosis by oxidative stress
    Yan Y Sanders
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine University of Alabama at Birmingham, Birmingham, AL, 35294, USA
    Redox Biol 1:8-16. 2013
    ..These data indicate that both global and locus-specific histone modifications of chromatin regulate altered Bcl-2:Bax gene expression in senescent fibroblasts, contributing to its apoptosis-resistant phenotype...
  42. ncbi request reprint Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity
    Gang Liu
    Department of Medicine, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 179:4125-34. 2007
    ....
  43. pmc New insights into the pathogenesis and treatment of idiopathic pulmonary fibrosis
    Qiang Ding
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, USA
    Drugs 71:981-1001. 2011
    ..Heterogeneity in biological and clinical phenotypes of IPF warrants a personalized medicine approach to diagnosis and treatment of this lung disorder...
  44. ncbi request reprint Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis
    David G Stokes
    Department of Medicine, Division of Rheumatology, Jefferson Medical College, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Arthritis Rheum 46:404-19. 2002
    ....
  45. pmc Potential role of high-mobility group box 1 in cystic fibrosis airway disease
    Steven M Rowe
    Department University of Alabama at Birmingham, Birmingham, AL 35294 0006, USA
    Am J Respir Crit Care Med 178:822-31. 2008
    ..High-mobility group box 1 (HMGB1) is a potent inflammatory mediator elevated in sepsis and rheumatoid arthritis, although its role in cystic fibrosis (CF) lung disease is unknown...
  46. pmc DeltaNp73beta is active in transactivation and growth suppression
    Gang Liu
    Department of Cell Biology, The University of Alabama at Birmingham, 1530 3rd Avenue, Birmingham, AL 35294 0005, USA
    Mol Cell Biol 24:487-501. 2004
    ..However, unlike DeltaNp73beta, DeltaNp73alpha is inactive in suppressing cell growth. Our data, together with others' previous findings, suggest that DeltaNp73beta may have distinct functions under certain cellular circumstances...
  47. pmc Myosin VI is a mediator of the p53-dependent cell survival pathway
    Eun Joo Jung
    Department of Cell Biology, MCLM 660, 1530 3rd Ave S, Birmingham, AL 35294 0005, USA
    Mol Cell Biol 26:2175-86. 2006
    ..Taken together, we found a novel function for p53 in the maintenance of Golgi complex integrity and for myosin VI in the p53-dependent prosurvival pathway...
  48. ncbi request reprint Gene expression in lung adenocarcinomas of smokers and nonsmokers
    Charles A Powell
    Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, USA
    Am J Respir Cell Mol Biol 29:157-62. 2003
    ..Our findings, although limited by small sample size, suggest that additional studies comparing noninvolved to tumor tissue may identify pathogenetic mechanisms and therapeutic targets that differ in AC of smokers and nonsmokers...
  49. doi request reprint Molecular mechanisms of asbestos-induced lung epithelial cell apoptosis
    Gang Liu
    Department of Medicine, Pulmonary and Critical Care Medicine, Jesse Brown VA Medical Center and Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Chem Biol Interact 188:309-18. 2010
    ..Importantly, the asbestos paradigm is elucidating pathophysiologic insights into other more common pulmonary diseases, such as IPF and lung cancer, for which better therapy is required...
  50. ncbi request reprint Relation of endothelial nitric oxide synthase gene to plasma nitric oxide level, endothelial function, and blood pressure in African Americans
    Rongling Li
    Department of Medicine, Clinical Research Center, Atlanta, Georgia, USA
    Am J Hypertens 17:560-7. 2004
    ..The role of eNOS gene polymorphisms on plasma nitrite or nitrate (NOx) level, endothelial function, and blood pressure (BP) remains unclear...
  51. pmc Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability
    Gang Liu
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Invest 112:209-21. 2003
    ..The interaction between nephrin and Neph1 therefore appears to be an important determinant of glomerular permeability...