Fu Tong Liu

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Intracellular functions of galectins
    Fu Tong Liu
    Department of Dermatology, University of California, Davis, School of Medicine, 4860 Y Street, Suite 3400, Sacramento, CA 95817, USA
    Biochim Biophys Acta 1572:263-73. 2002
  2. ncbi request reprint Galectin 3 and its binding protein in rheumatoid arthritis
    Shiro Ohshima
    Center of Experimental Rheumatology, University Hospital, Zurich, Switzerland
    Arthritis Rheum 48:2788-95. 2003
  3. ncbi request reprint Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue
    Kohji Kiwaki
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Obesity (Silver Spring) 15:32-9. 2007
  4. pmc Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration
    Wei Liu
    Department of Dermatology, University of California, Davis, Davis, California 95816, USA
    J Invest Dermatol 132:2828-37. 2012
  5. doi request reprint Galectins in acute and chronic inflammation
    Fu Tong Liu
    Department of Dermatology, University of California Davis, School of Medicine, Sacramento, 95816, USA
    Ann N Y Acad Sci 1253:80-91. 2012
  6. pmc The antigen presentation function of bone marrow-derived mast cells is spatiotemporally restricted to a subset expressing high levels of cell surface FcepsilonRI and MHC II
    Jian Gong
    Department of Allergy and Immunology, IgE Therapeutics, Inc, San Diego, CA, USA
    BMC Immunol 11:34. 2010
  7. ncbi request reprint Galectins: novel anti-inflammatory drug targets
    Fu Tong Liu
    Department of Dermatology, University of California Davis, School of Medicine, Sacramento
    Expert Opin Ther Targets 6:461-8. 2002
  8. doi request reprint Galectins: regulators of acute and chronic inflammation
    Fu Tong Liu
    Department of Dermatology, University of California Davis, School of Medicine, Sacramento, California, USA
    Ann N Y Acad Sci 1183:158-82. 2010
  9. doi request reprint IgE, mast cells, and eosinophils in atopic dermatitis
    Fu Tong Liu
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95816, USA
    Clin Rev Allergy Immunol 41:298-310. 2011
  10. ncbi request reprint The role of galectin-3 in promotion of the inflammatory response
    Fu Tong Liu
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California 95816, USA
    Drug News Perspect 20:455-60. 2007

Research Grants

  1. Galectins and Innate Immunity
    Fu Tong Liu; Fiscal Year: 2007
  2. Validation of Galectin-3 as a Target in Cancer Therapy
    Fu Tong Liu; Fiscal Year: 2003
  3. Immunological Basis of Anti-IgE Therapy
    Fu Tong Liu; Fiscal Year: 2002
  4. GALECTINS IN ALLERGIC INFLAMMATION
    Fu Tong Liu; Fiscal Year: 2001
  5. GALECTIN 3 IN REGULATION OF CELL GROWTH AND APOPTOSIS
    Fu Tong Liu; Fiscal Year: 2000
  6. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2010
  7. GALECTINS IN ALLERGIC INFLAMMATION
    Fu Tong Liu; Fiscal Year: 2003
  8. GALECTINS IN ALLERGIC INFLAMMATION
    Fu Tong Liu; Fiscal Year: 2004
  9. Galectins and Innate Immunity
    Fu Tong Liu; Fiscal Year: 2004
  10. Galectins and Innate Immunity
    Fu Tong Liu; Fiscal Year: 2005

Detail Information

Publications81

  1. ncbi request reprint Intracellular functions of galectins
    Fu Tong Liu
    Department of Dermatology, University of California, Davis, School of Medicine, 4860 Y Street, Suite 3400, Sacramento, CA 95817, USA
    Biochim Biophys Acta 1572:263-73. 2002
    ..This review summarizes the intracellular activities displayed by several galectins and discusses the possible underlying mechanisms...
  2. ncbi request reprint Galectin 3 and its binding protein in rheumatoid arthritis
    Shiro Ohshima
    Center of Experimental Rheumatology, University Hospital, Zurich, Switzerland
    Arthritis Rheum 48:2788-95. 2003
    ....
  3. ncbi request reprint Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue
    Kohji Kiwaki
    Endocrine Research Unit, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    Obesity (Silver Spring) 15:32-9. 2007
    ..To probe the molecular basis of obesity, this study determined whether galectin-3 was present in adipose tissue and investigated its effects on fat cell number...
  4. pmc Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration
    Wei Liu
    Department of Dermatology, University of California, Davis, Davis, California 95816, USA
    J Invest Dermatol 132:2828-37. 2012
    ..Our results suggest that galectin-3 is potentially a critical regulator of a number of important cellular responses through its intracellular control of trafficking of cell surface receptors...
  5. doi request reprint Galectins in acute and chronic inflammation
    Fu Tong Liu
    Department of Dermatology, University of California Davis, School of Medicine, Sacramento, 95816, USA
    Ann N Y Acad Sci 1253:80-91. 2012
    ..Current evidence also suggests that galectins may be therapeutic targets or employed as therapeutic agents for these inflammatory responses...
  6. pmc The antigen presentation function of bone marrow-derived mast cells is spatiotemporally restricted to a subset expressing high levels of cell surface FcepsilonRI and MHC II
    Jian Gong
    Department of Allergy and Immunology, IgE Therapeutics, Inc, San Diego, CA, USA
    BMC Immunol 11:34. 2010
    ..Evidence is presented for a novel surface FcepsilonRIhi , MHC II +, and c-kit + pure mast cell subset, temporally restricted as antigen-presenting cells in the immune axis of T-cell activation...
  7. ncbi request reprint Galectins: novel anti-inflammatory drug targets
    Fu Tong Liu
    Department of Dermatology, University of California Davis, School of Medicine, Sacramento
    Expert Opin Ther Targets 6:461-8. 2002
    ..Therefore, the same inhibitors may be used regardless of whether intracellular or extracellular galectins are to be targeted...
  8. doi request reprint Galectins: regulators of acute and chronic inflammation
    Fu Tong Liu
    Department of Dermatology, University of California Davis, School of Medicine, Sacramento, California, USA
    Ann N Y Acad Sci 1183:158-82. 2010
    ..Thus, recombinant proteins or specific galectin inhibitors may be used as therapeutic agents for inflammatory diseases...
  9. doi request reprint IgE, mast cells, and eosinophils in atopic dermatitis
    Fu Tong Liu
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95816, USA
    Clin Rev Allergy Immunol 41:298-310. 2011
    ..It is further supported by information that links AD to cytokines and chemokines associated with production, recruitment, and activation of eosinophils...
  10. ncbi request reprint The role of galectin-3 in promotion of the inflammatory response
    Fu Tong Liu
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California 95816, USA
    Drug News Perspect 20:455-60. 2007
    ..The use of galectin-3-deficient mice has provided additional evidence for this protein's contribution to the inflammatory response. Thus, galectin-3 may be a therapeutic target for various inflammatory diseases...
  11. ncbi request reprint Regulatory roles of galectins in the immune response
    Fu Tong Liu
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, Calif, USA
    Int Arch Allergy Immunol 136:385-400. 2005
    ..Current research indicates that galectins play important roles in the immune response through regulating the homeostasis and functions of the immune cells...
  12. ncbi request reprint Galectins as modulators of tumour progression
    Fu Tong Liu
    Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, California, USA
    Nat Rev Cancer 5:29-41. 2005
    ..They can modulate the immune and inflammatory responses and might have a key role helping tumours to escape immune surveillance. How do the different members of the Galectin family contribute to these diverse aspects of tumour biology?..
  13. pmc Critical role for galectin-3 in airway inflammation and bronchial hyperresponsiveness in a murine model of asthma
    Riaz I Zuberi
    Division of Allergy, La Jolla Institute of Allergy and Immunology, San Diego, California, USA
    Am J Pathol 165:2045-53. 2004
    ..We conclude that galectin-3 may play an important role in the pathogenesis of asthma and inhibitors of this lectin may prove useful for treatment of this disease...
  14. ncbi request reprint IgE-dependent mast cell activation potentiates airway responses in murine asthma models
    Susanne I Mayr
    Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 169:2061-8. 2002
    ..The models used may be of value for testing inhibitors of IgE or mast cells for development of therapeutic agents for human asthma...
  15. pmc Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation
    Jun Saegusa
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California 95816, USA
    J Invest Dermatol 128:2403-11. 2008
    ..We conclude that endogenous galectin-3 is an anti-apoptotic molecule in keratinocytes functioning by suppressing ERK activation and enhancing AKT activation and may play a role in the development of apoptosis-related skin diseases...
  16. ncbi request reprint Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression
    Huan Yuan Chen
    Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CA 95817, USA
    J Immunol 177:4991-7. 2006
    ..All together, these results point to an important role of galectin-3 in mast cell biology...
  17. pmc Critical role of galectin-3 in phagocytosis by macrophages
    Hideki Sano
    Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    J Clin Invest 112:389-97. 2003
    ..Thus, galectin-3 may play an important role in both innate and adaptive immunity by contributing to phagocytic clearance of microorganisms and apoptotic cells...
  18. ncbi request reprint Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release
    Ichiro Kuwabara
    Divisions of Allergy and Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 277:3487-97. 2002
    ..Some of them are potentially contributory to this lectin's proapoptotic function and these include redox-related genes monoamine oxidase B, ryanodine receptor 2, and glutathione S-transferase Mu 3...
  19. pmc Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner
    Jun Saegusa
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, California 95817, USA
    J Biol Chem 283:26107-15. 2008
    ..These results suggest that integrins alphavbeta3 and alpha4beta1 may serve as receptors for sPLA2-IIA and mediate pro-inflammatory action of sPLA2-IIA, and that integrin-sPLA2-IIA interaction is a novel therapeutic target...
  20. pmc Galectin-3 modulates Th17 responses by regulating dendritic cell cytokines
    Agnes Fermin Lee
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California
    Am J Pathol 183:1209-22. 2013
    ..We conclude that galectin-3 suppresses Th17 responses by regulating DC cytokine production...
  21. pmc Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse
    Huan Yuan Chen
    Department of Dermatology, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA
    Proc Natl Acad Sci U S A 106:14496-501. 2009
    ..We conclude that galectin-3 is an inhibitory regulator of T-cell activation and functions intracellularly by promoting TCR down-regulation, possibly through modulating Alix's function at the IS...
  22. ncbi request reprint The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth
    Nobuaki Akakura
    Department of Dermatology, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Cancer Res 66:9691-7. 2006
    ..These results suggest that fibrinogen has a novel cryptic determinant, which can exert apoptosis-inducing activity on endothelial cells when exposed, and polypeptides containing this determinant have therapeutic potential...
  23. ncbi request reprint Functions of galectins in cell adhesion and chemotaxis
    Ichiro Kuwabara
    Department of Dermatology, University of California Davis, School of Medicine, 4645 Second Avenue, Sacramento, California 95817, USA
    Methods Enzymol 363:532-52. 2003
  24. ncbi request reprint Galectins-3 and -7, but not galectin-1, play a role in re-epithelialization of wounds
    Zhiyi Cao
    Department of Ophthalmology, Center for Vision Research and The New England Eye Center, Davis, California 95616, USA
    J Biol Chem 277:42299-305. 2002
    ..These findings have broad implications for developing novel therapeutic strategies for treating nonhealing wounds...
  25. ncbi request reprint The immunological potential of galectin-1 and -3
    Amy Dhirapong
    Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, School of Medicine, Davis, CA 95616, USA
    Autoimmun Rev 8:360-3. 2009
    ..Therefore, understanding the role of galectins in achieving appropriate proliferative and effector responses to antigens will yield important insights to autoimmune diseases and delineate novel strategies for disease intervention...
  26. ncbi request reprint Galectin-12 is required for adipogenic signaling and adipocyte differentiation
    Ri Yao Yang
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, California 95817, USA
    J Biol Chem 279:29761-6. 2004
    ..The findings suggest that galectin-12 is a major regulator of adipose tissue development...
  27. ncbi request reprint Galectins: structure, function and therapeutic potential
    Ri Yao Yang
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, CA 95816, USA
    Expert Rev Mol Med 10:e17. 2008
    ..Thus, galectins may be a therapeutic target or employed as therapeutic agents for inflammatory diseases, cancers and several other diseases...
  28. pmc Galectin-3 regulates the innate immune response of human monocytes
    Andrew W Chung
    Dirks Dougherty Laboratory for Cancer Research, Department of Translational Immunology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California, USA
    J Infect Dis 207:947-56. 2013
    ..These data demonstrate an association of galectin-3 with unfavorable host response in leprosy and a potential mechanism for impaired host defense in humans...
  29. pmc Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice
    Ri Yao Yang
    Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Proc Natl Acad Sci U S A 108:18696-701. 2011
    ..These findings add to the significant functions exhibited by intracellular galectins, and have important therapeutic implications for human metabolic disorders...
  30. pmc Endogenous galectin-3 is localized in membrane lipid rafts and regulates migration of dendritic cells
    Daniel K Hsu
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, California 95817, USA
    J Invest Dermatol 129:573-83. 2009
    ..In view of the participation of membrane ruffles in signal transduction and cell motility, we conclude that galectin-3 regulates cell migration by functioning at these structures...
  31. ncbi request reprint Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity
    Anthony A Horner
    Department of Medicine, and The Sam and Rose Stein Institute for Aging, University of California, San Diego, La Jolla 92093, USA
    J Allergy Clin Immunol 110:413-20. 2002
    ..However, investigations suggest that allergen/immunostimulatory sequence oligodeoxynucleotide (ISS-ODN) conjugates (AICs) might have improved safety and efficacy compared with allergen extracts...
  32. ncbi request reprint Cell mechanics using atomic force microscopy-based single-cell compression
    Valentin Lulevich
    Chemistry Department, University of California, Davis, California 95616, USA
    Langmuir 22:8151-5. 2006
    ....
  33. pmc Galectin-3 modulates phagocytosis-induced stellate cell activation and liver fibrosis in vivo
    Joy X Jiang
    UC Davis Medical Center, PSSB, Sacramento, CA 95817, USA
    Am J Physiol Gastrointest Liver Physiol 302:G439-46. 2012
    ..In summary, extracellular galectin-3 plays a key role in liver fibrosis by mediating HSC phagocytosis, activation, and subsequent autocrine and paracrine signaling by a feedforward mechanism...
  34. pmc Engineered nanostructures of antigen provide an effective means for regulating mast cell activation
    Zhao Deng
    Department of Chemistry, University of California, Davis, California 95616, USA
    ACS Nano 5:8672-83. 2011
    ..This work demonstrates an important concept: that nanostructures of ligands provide new and effective cues for directing cellular signaling processes...
  35. pmc Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis
    Jun Saegusa
    Department of Dermatology, University of California, Davis, School of Medicine, 3301 C Street, Suite 1400, Sacramento, CA 95816, USA
    Am J Pathol 174:922-31. 2009
    ..This regulatory effect of galectin-3 on Th development is exerted at both the dendritic cell and T cell levels. Our studies suggest that galectin-3 may play an important role in the acute phase of human atopic dermatitis...
  36. ncbi request reprint Mast cells and immunological skin diseases
    Daniel Navi
    Department of Dermatology, School of Medicine, University of California Davis, Sacramento, CA 95816, USA
    Clin Rev Allergy Immunol 33:144-55. 2007
    ..Therapies targeting mast cells may prove beneficial for treatment of these inflammatory and autoimmune diseases...
  37. ncbi request reprint Roles of galectin-3 in immune responses
    Huan Yuan Chen
    School of Medicine, University of California Davis, 4645 Second Avenue, Sacramento, CA 95817, USA
    Arch Immunol Ther Exp (Warsz) 53:497-504. 2005
    ..This review summarizes the roles of galectin-3 in the immune system and discusses the possible underlying mechanisms...
  38. ncbi request reprint Regulation of cellular homeostasis by galectins
    Daniel K Hsu
    Department of Dermatology, University of California Davis, School of Medicine, Sacramento, CA 95817, USA
    Glycoconj J 19:507-15. 2004
    ..Nevertheless, as demonstrated for many members, it appears that a major feature of the galectin family is the homeostatic regulation of cells...
  39. pmc Therapeutic effect of cytotoxic T lymphocyte antigen 4/immunoglobulin on a murine model of primary biliary cirrhosis
    Amy Dhirapong
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 57:708-15. 2013
    ....
  40. pmc Galectin-3 and the skin
    Larissa Larsen
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, CA 95816, United States
    J Dermatol Sci 64:85-91. 2011
    ..Galectin-3 may play an important role in tumor cell growth, apoptosis, cell motility, invasion, and metastasis. Galectin-3 may be a novel therapeutic target for a variety of skin diseases...
  41. ncbi request reprint Galectin-3 functions as an adhesion molecule to support eosinophil rolling and adhesion under conditions of flow
    Savita P Rao
    Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    J Immunol 179:7800-7. 2007
    ..These findings suggest that Gal-3 functions as a cell surface adhesion molecule to support eosinophil rolling and adhesion under conditions of flow...
  42. doi request reprint Galectin-3 regulates T-cell functions
    Daniel K Hsu
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, CA 95816, USA
    Immunol Rev 230:114-27. 2009
    ..The rapid expansion of the field of galectin research has positioned galectin-3 as a key regulator in T-cell functions...
  43. pmc Applications of atomic force microscopy in biophysical chemistry of cells
    Zhao Deng
    Department of Chemistry, University of California, Davis, Davis, California 95616, USA
    J Phys Chem B 114:5971-82. 2010
    ..A future prospective of AFM is also presented...
  44. pmc Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging
    Min Ho Kim
    Department of Biomedical Engineering, University of California at Davis, Davis, California 95616, USA
    J Invest Dermatol 128:1812-20. 2008
    ....
  45. ncbi request reprint Polyphenolic antioxidants enhance IgE production
    Jian Gong
    Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, California, USA
    Immunol Invest 33:295-307. 2004
    ..Enhanced Th2 development and IgE production henceforth may counteract more severe Th1-mediated tissue damage triggered by environmental oxidative stress...
  46. ncbi request reprint Galectin-3 induces death of Candida species expressing specific beta-1,2-linked mannans
    Luciana Kohatsu
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 177:4718-26. 2006
    ....
  47. ncbi request reprint Galectins in apoptosis
    Daniel K Hsu
    Department of Dermatology, University of California, Davis School of Medicine, Sacramento, California, USA
    Methods Enzymol 417:256-73. 2006
    ..This review describes involvement of galectin-1, -2, -3, -7, -8, -9, and -12 in apoptosis...
  48. pmc Impact of actin rearrangement and degranulation on the membrane structure of primary mast cells: a combined atomic force and laser scanning confocal microscopy investigation
    Zhao Deng
    Department of Chemistry, University of California, Davis, California, USA
    Biophys J 96:1629-39. 2009
    ..This work provides what we believe is important new insight into the local membrane structures in correlation with the cytoskeleton arrangement and detailed degranulation processes...
  49. pmc B cell depletion therapy exacerbates murine primary biliary cirrhosis
    Amy Dhirapong
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA
    Hepatology 53:527-35. 2011
    ..Anti-CD20/CD79-treated mice had increased liver T cell infiltrates and higher levels of proinflammatory cytokines...
  50. ncbi request reprint Suppression of tumor growth by galectin-7 gene transfer
    Shugo Ueda
    Department of Dermatology, University of California, Davis, School of Medicine, Sacramento, California 95817, USA
    Cancer Res 64:5672-6. 2004
    ..Our results show that galectin-7 has a suppressive effect on tumor growth, suggesting that galectin-7 gene transfer or other means of specifically inducing galectin-7 expression may be a new approach for management of cancers...
  51. doi request reprint IgE peptide-specific CTL inhibit IgE production: a transient IgE suppression model in wild-type and HLA-A2.1 transgenic mice
    Swey Shen Chen
    Department of Immunology and Vaccinology, The Institute of Genetics, San Diego, CA 92121, USA
    Cell Immunol 254:28-38. 2008
    ..Taken together, these observations indicate that a CTL-based IgE peptide vaccine targeting IgE-secreting B/plasma cells may be safely employed as a therapeutic approach for suppressing IgE production...
  52. pmc The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling
    Jun Saegusa
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    J Biol Chem 284:24106-14. 2009
    ....
  53. ncbi request reprint Evaluation and comparison of store-and-forward teledermatology applications
    April W Armstrong
    Department of Dermatology, University of California, Davis, Sacramento, California 95816, USA
    Telemed J E Health 16:424-38. 2010
    ..The objectives of this study were to identify, evaluate, and compare the major S&F teledermatology applications in the United States to help referral and consultant sites select applications responsive to their needs...
  54. ncbi request reprint Homodimeric galectin-7 (p53-induced gene 1) is a negative growth regulator for human neuroblastoma cells
    Jurgen Kopitz
    Institut für Molekulare Pathologie, Klinikum der Ruprecht Karls Universtiät, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
    Oncogene 22:6277-88. 2003
    ..In addition to p53-linked proapoptotic activity intracellularly, galectin-7, acting as a lectin on the cell surface, appears to be capable of reducing cancer cell proliferation in susceptible systems...
  55. ncbi request reprint Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection
    Eva V Acosta-Rodriguez
    Immunology, Department of Clinical Biochemistry, Faculty of Chemical Sciences, National University of Cordoba, Cordoba 5000, Argentina
    J Immunol 172:493-502. 2004
    ..cruzi infection. Thus, the present study provides evidence of a novel role for Gal-3 as an intracellular mediator of B cell survival and a checkpoint in IL-4-induced B cell commitment toward a memory phenotype...
  56. ncbi request reprint Nuclear localization of Galectin-3 in transformed thyroid cells: a role in transcriptional regulation
    Igor Paron
    Dipartimento di Scienze e Tecnologie Biomediche, P le Kolbe 1, Universita Degli Studi di Udine, 33100 Udine, Italy
    Biochem Biophys Res Commun 302:545-53. 2003
    ....
  57. ncbi request reprint Craniopharyngioma: a case report and comparative galectin histochemical analysis
    Jan Plzak
    1st Faculty of Medicine, Institute of Anatomy, Charles University, Prague, Czech Republic
    Histochem J 34:117-22. 2002
    ....
  58. ncbi request reprint Galectin-3 is strongly up-regulated in nonapoptosing mammary epithelial cells during rat mammary gland involution
    Jörg Mengwasser
    Forschungszentrum Karlsruhe, Institute for Toxicology and Genetics, PO Box 3640, D 76021 Karlsruhe, Germany
    Glycobiology 12:129-34. 2002
    ....
  59. ncbi request reprint IL-1 receptor-associated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcription
    Ling Yu Chen
    Department of Molecular and Experimental Medicine and Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 169:3934-9. 2002
    ..These results indicate that RhoA and IL-1R-associated kinase are novel signal transducers for LPS-induced Toll-like receptor 4-mediated proinflammatory cytokine synthesis in human monocytes...
  60. ncbi request reprint Analysis of selected blood and immune cell responses to carbohydrate-dependent surface binding of proto- and chimera-type galectins
    Alexander V Timoshenko
    Institute of Photobiology, National Academy of Sciences of Belarus, Minsk
    Mol Cell Biochem 250:139-49. 2003
    ..Within the family of galectins, the activity profiles depend on the target cell type and the individual galectin. Notably, proto-type galectins do not necessarily share a uniform capacity as elicitor...
  61. ncbi request reprint New alternatively spliced form of galectin-3, a member of the beta-galactoside-binding animal lectin family, contains a predicted transmembrane-spanning domain and a leucine zipper motif
    Jeff P Gorski
    Division of Molecular Biology and Biochemistry, School of Biological Sciences, and Department of Oral Biology, Dental School, University of Missouri Kansas City, Kansas City, Missouri 64110, USA
    J Biol Chem 277:18840-8. 2002
    ..Gal-3TM1 is the first example of a galectin superfamily member capable of being expressed as a soluble protein and as a transmembrane protein...
  62. ncbi request reprint The constitutive expression of galectin-3 is downregulated in the intestinal epithelia of Crohn's disease patients, and tumour necrosis factor alpha decreases the level of galectin-3-specific mRNA in HCT-8 cells
    Erika Jensen-Jarolim
    Department of Pathophysiology, University of Vienna, Vienna, Austria
    Eur J Gastroenterol Hepatol 14:145-52. 2002
    ..The role of cytokines on galectin-3 expression was a further aim of our study...
  63. ncbi request reprint Association of a macrophage galactoside-binding protein with Mycobacterium-containing phagosomes
    Wandy L Beatty
    Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Microbiol 4:167-76. 2002
    ..Infection of macrophages from gal-3-deficient mice indicated that the protein did not play a role in infection in vitro. In contrast, infection of gal-3-deficient mice revealed a reduced capacity to clear late but not early infection...
  64. ncbi request reprint Changes in galectin-7 and cytokeratin-19 expression during the progression of malignancy in thyroid tumors: diagnostic and biological implications
    Sandrine Rorive
    Laboratory of Pathology, Cliniques Universitaires de Bruxelles, Hopital Erasme, Belgium
    Mod Pathol 15:1294-301. 2002
    ....
  65. ncbi request reprint Galectin-7 as a potential mediator of corneal epithelial cell migration
    Zhiyi Cao
    New England Eye Center, Center for Vision Research and Department of Ophthalmology, Tufts University School of Medicine, Boston, MA 02111, USA
    Arch Ophthalmol 121:82-6. 2003
    ..To assess the role of a carbohydrate-binding protein, galectin-7, in reepithelialization of corneal wounds...
  66. doi request reprint Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study
    Hekmat Osman Abdel-Aziz
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan
    J Cancer Res Clin Oncol 134:777-88. 2008
    ..The aim of this study was to clarify the role or related mechanisms of galectin-3 in lung carcinogenesis...
  67. ncbi request reprint Impaired retinal angiogenesis in diabetes: role of advanced glycation end products and galectin-3
    Alan W Stitt
    Ophthalmic and Vision Science Research Centre, Queens University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast, BT12 6BA, Northern Ireland
    Diabetes 54:785-94. 2005
    ..The data suggest a significant suppression of angiogenesis by the retinal microvasculature during diabetes and implicate AGEs and AGE-receptor interactions in its causation...
  68. ncbi request reprint Galectin-3 and galectin-1 bind distinct cell surface glycoprotein receptors to induce T cell death
    Brianna N Stillman
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, University of California Los Angeles UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 176:778-89. 2006
    ..However, as galectin-3 and galectin-1 cell death are neither additive nor synergistic, the two death pathways may converge inside the cell...
  69. pmc Altered expression of galectin-3 induces cortical thymocyte depletion and premature exit of immature thymocytes during Trypanosoma cruzi infection
    Elizangela Silva-Monteiro
    Department of Pathology, Laboratory of Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
    Am J Pathol 170:546-56. 2007
    ..Our findings provide evidence of a novel role for galectin-3 in the regulation of thymus physiology and identify a potential mechanism based on protein-glycan interactions in thymic atrophy associated with acute T. cruzi infection...
  70. ncbi request reprint Role of galectin-3 in human pulmonary fibrosis
    Yumiko Nishi
    Department of Internal Medicine, Toho University Sakura Medical Center, and Department of Allergy and Rheumatology, Chiba East Hospital, National Hospital Organization, Japan
    Allergol Int 56:57-65. 2007
    ..The aim of this study is to determine whether galectin-3 is involved in human lung fibrosis...
  71. ncbi request reprint Role of galectin-3 in prion infections of the CNS
    Simon W F Mok
    Project Neurodegenerative Diseases, Robert Koch Institut, Nordufer 20, 13353 Berlin, Germany
    Biochem Biophys Res Commun 359:672-8. 2007
    ..The results point towards a detrimental role of galectin-3 in prion infections of the CNS and suggest that endo-/lysosomal dysfunction in combination with reduced autophagy may contribute to disease development...
  72. pmc Inhibition of advanced glycation and absence of galectin-3 prevent blood-retinal barrier dysfunction during short-term diabetes
    Paul Canning
    Centre for Vision Science, Queen s University Belfast, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, Northern Ireland, UK
    Exp Diabetes Res 2007:51837. 2007
    ..Prevention of AGE formation or genetic deletion of Gal-3 can effectively prevent these acute diabetic retinopathy changes...
  73. ncbi request reprint LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognition
    Timo K van den Berg
    Department of Molecular Cell Biology and Immunology, Vrige University University Medical Center, Amsterdam, The Netherlands
    J Immunol 173:1902-7. 2004
    ..These findings provide evidence that LDN-glycans constitute a parasite pattern for galectin-3-mediated immune recognition...
  74. ncbi request reprint Dermal immunopathology: from genetics to effector mechanisms
    Akira Takashima
    Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, OH, USA
    Clin Rev Allergy Immunol 33:1-3. 2007
  75. ncbi request reprint Comparative phenotypic characterization of keratinocytes originating from hair follicles
    Jiri Klima
    Institute of Animal Physiology and Genetics, Academy of Sciences, Libechov, Czech Republic
    J Mol Histol 36:89-96. 2005
    ..It can be considered a potential marker of a distinct cell population, probably at the beginning of a differentiation cascade of keratinocytes...
  76. pmc Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis
    Neil C Henderson
    The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Am J Pathol 172:288-98. 2008
    ..Therefore, we demonstrate for the first time that galectin-3 expression and secretion by macrophages is a major mechanism linking macrophages to the promotion of renal fibrosis...
  77. pmc An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomas
    Katrina K Hoyer
    Department of Pathology and Laboratory Medicine, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 1732, USA
    Am J Pathol 164:893-902. 2004
    ..This pattern of expression suggests that aberrantly increased galectin-3 levels in specific B-cell populations may yield a protective advantage during transformation and/or progression of certain B-cell neoplasms...
  78. ncbi request reprint Galectin-3 is a negative regulator of lipopolysaccharide-mediated inflammation
    Yubin Li
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    J Immunol 181:2781-9. 2008
    ..Thus, galectin-3 is a previously unrecognized, naturally occurring, negative regulator of LPS function, which protects the host from endotoxin shock but, conversely, favors Salmonella survival...
  79. ncbi request reprint New aspects of galectin functionality in nuclei of cultured bone marrow stromal and epidermal cells: biotinylated galectins as tool to detect specific binding sites
    Tereza Purkrábková
    Charles University, 1st Faculty of Medicine, Clinical Department of Hematology and Nephrology, 128 08 Prague 2, Czech Republic
    Biol Cell 95:535-45. 2003
    ..In conclusion, the application of labeled galectins to localize accessible binding sites adds a new aspect to the functional analysis of these lectins in the nucleus...
  80. pmc Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:12911-6. 2003
    ..In hybridoma-transplanted mice, mucosal mast cell numbers correlate with serum IgE levels. Therefore, survival effects of IgE could contribute to the pathogenesis of allergic disease...
  81. pmc Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity
    Emerson Soares Bernardes
    Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto USP, Av dos Bandeirantes, 3900, Ribeirao Preto SP, Brazil CEP 14049 900
    Am J Pathol 168:1910-20. 2006
    ..We conclude that galectin-3 exerts an important role in innate immunity, including not only a pro-inflammatory effect but also a regulatory role on dendritic cells, capable of interfering in the adaptive immune response...

Research Grants28

  1. Galectins and Innate Immunity
    Fu Tong Liu; Fiscal Year: 2007
    ..cell lines in vitro 2) investigate whether galectin-12 expression affects the determination of cell fate in hematopoitic cells in vivo 3) elucidate the interplay between galectin-12 and major myeloid transcription factors ..
  2. Validation of Galectin-3 as a Target in Cancer Therapy
    Fu Tong Liu; Fiscal Year: 2003
    ..The effect of these inhibitors on adhesion of cancer cells to extracellular matrix proteins and invasive properties of cancer cells will be evaluated. ..
  3. Immunological Basis of Anti-IgE Therapy
    Fu Tong Liu; Fiscal Year: 2002
    ..We also hope that the studies will lead to a better understanding of the mechanisms of allergic diseases. ..
  4. GALECTINS IN ALLERGIC INFLAMMATION
    Fu Tong Liu; Fiscal Year: 2001
    ..The long-term goals are to understand the molecular and cellular mechanisms of allergic inflammation and to develop new strategies for treating allergic diseases by using inhibitors of galectin-3 and galectin-9. ..
  5. GALECTIN 3 IN REGULATION OF CELL GROWTH AND APOPTOSIS
    Fu Tong Liu; Fiscal Year: 2000
    ..The relevance of galectin-3/Bcl-2 interaction to galectin-3's anti-apoptotic activity will be investigated. Other partners of galectin-3 that may be responsible for this lectin's intracellular functions will be identified. ..
  6. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2010
    ..We also plan to elucidate the cellular basis for galectin-3's regulatory role in a mouse model of atopic dermatitis. ..
  7. GALECTINS IN ALLERGIC INFLAMMATION
    Fu Tong Liu; Fiscal Year: 2003
    ..The long-term goals are to understand the molecular and cellular mechanisms of allergic inflammation and to develop new strategies for treating allergic diseases by using inhibitors of galectin-3 and galectin-9. ..
  8. GALECTINS IN ALLERGIC INFLAMMATION
    Fu Tong Liu; Fiscal Year: 2004
    ..The long-term goals are to understand the molecular and cellular mechanisms of allergic inflammation and to develop new strategies for treating allergic diseases by using inhibitors of galectin-3 and galectin-9. ..
  9. Galectins and Innate Immunity
    Fu Tong Liu; Fiscal Year: 2004
    ..cell lines in vitro 2) investigate whether galectin-12 expression affects the determination of cell fate in hematopoitic cells in vivo 3) elucidate the interplay between galectin-12 and major myeloid transcription factors ..
  10. Galectins and Innate Immunity
    Fu Tong Liu; Fiscal Year: 2005
    ..cell lines in vitro 2) investigate whether galectin-12 expression affects the determination of cell fate in hematopoitic cells in vivo 3) elucidate the interplay between galectin-12 and major myeloid transcription factors ..
  11. Galectins and Innate Immunity
    Fu Tong Liu; Fiscal Year: 2006
    ..cell lines in vitro 2) investigate whether galectin-12 expression affects the determination of cell fate in hematopoitic cells in vivo 3) elucidate the interplay between galectin-12 and major myeloid transcription factors ..
  12. GALECTIN 3 IN REGULATION OF CELL GROWTH AND APOPTOSIS
    Fu Tong Liu; Fiscal Year: 2001
    ..The relevance of galectin-3/Bcl-2 interaction to galectin-3's anti-apoptotic activity will be investigated. Other partners of galectin-3 that may be responsible for this lectin's intracellular functions will be identified. ..
  13. GALECTIN 3 IN REGULATION OF CELL GROWTH AND APOPTOSIS
    Fu Tong Liu; Fiscal Year: 1999
    ..The relevance of galectin-3/Bcl-2 interaction to galectin-3's anti-apoptotic activity will be investigated. Other partners of galectin-3 that may be responsible for this lectin's intracellular functions will be identified. ..
  14. GALECTIN-2, AN ANIMAL LECTIN, IN ALLERGIC INFLAMMATION
    Fu Tong Liu; Fiscal Year: 1999
    ..Covalent galectin-3 dimers will be generated and compared with the mononomeric protein for various activities. AMino acid sequence in the amino-terminal region that is responsible for galectin-3's self association will be identified. ..
  15. Immunological Basis of Anti-IgE Therapy
    Fu Tong Liu; Fiscal Year: 2001
    ..We also hope that the studies will lead to a better understanding of the mechanisms of allergic diseases. ..
  16. GALECTIN 3 IN REGULATION OF CELL GROWTH AND APOPTOSIS
    Fu Tong Liu; Fiscal Year: 2001
    ..The relevance of galectin-3/Bcl-2 interaction to galectin-3's anti-apoptotic activity will be investigated. Other partners of galectin-3 that may be responsible for this lectin's intracellular functions will be identified. ..
  17. GALECTINS IN ALLERGIC INFLAMMATION
    Fu Tong Liu; Fiscal Year: 2002
    ..The long-term goals are to understand the molecular and cellular mechanisms of allergic inflammation and to develop new strategies for treating allergic diseases by using inhibitors of galectin-3 and galectin-9. ..
  18. Immunological Basis of Anti-IgE Therapy
    Fu Tong Liu; Fiscal Year: 2003
    ..We also hope that the studies will lead to a better understanding of the mechanisms of allergic diseases. ..
  19. Galectin-3 in regulation of allergic skin inflammation
    Fu Tong Liu; Fiscal Year: 2011
    ..We also plan to elucidate the cellular basis for galectin-3's regulatory role in a mouse model of atopic dermatitis. ..
  20. GALECTINS IN ALLERGIC INFLAMMATION
    Fu Tong Liu; Fiscal Year: 2005
    ..The long-term goals are to understand the molecular and cellular mechanisms of allergic inflammation and to develop new strategies for treating allergic diseases by using inhibitors of galectin-3 and galectin-9. ..
  21. Regulation of Skin Wound Epithelialization by Galectin-3
    Fu Tong Liu; Fiscal Year: 2007
    ..The long-term goal is to develop improved methods for treatment of skin wounds. ..