Research Topics
Species | Edwin LiuSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
Fluctuating transglutaminase autoantibodies are related to histologic features of celiac diseaseEdwin Liu
Section of Pediatric Gastroenterology, Hepatology and Nutrition, Roche Molecular Systems, Alameda, CA, USA
Clin Gastroenterol Hepatol 1:356-62. 2003..We have followed a group of children with serial testing for TGAA...- Preventing peptide-induced anaphylaxis: addition of C-terminal amino acids to produce a neutral isoelectric pointEdwin Liu
Section of Gastroenterology, Hepatology and Nutrition, The Children s Hospital, Denver, Colorado, USA
J Allergy Clin Immunol 114:607-13. 2004.... - Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetesDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, 4200 East 9th Ave, Box B140, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Diabetes 54:2549-56. 2005.... - Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac diseaseEdwin Liu
Section of Gastroenterology, Hepatology and Nutrition, The Children s Hospital, and Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
J Pediatr Gastroenterol Nutr 45:293-300. 2007..A new generation of anti-gliadin antibody assays has been developed to detect synthetic, deamidated homologous gliadin peptides (DGP) with high sensitivity and specificity... 
Prime role for an insulin epitope in the development of type 1 diabetes in NOD miceMaki Nakayama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Nature 435:220-3. 2005....- Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunityMaki Nakayama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center UCHSC, Aurora, CO 80045 6511, USA
J Clin Invest 117:1835-43. 2007..Our findings demonstrate dependence on B16 alanine versus tyrosine of insulin B:9-23 for both the initial priming and the effector phase of NOD anti-islet autoimmunity... - Conserved T cell receptor alpha-chain induces insulin autoantibodiesMasakazu Kobayashi
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 105:10090-4. 2008..We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor... - Murine high specificity/sensitivity competitive europium insulin autoantibody assayNaru Babaya
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado 80045 6511, USA
Diabetes Technol Ther 11:227-33. 2009..There is thus a need for simpler assay formats that do not utilize radioactivity, yet retain the high specificity and sensitivity of radioassays... - Genetic differentiation of poly I:C from B:9-23 peptide induced experimental autoimmune diabetesJohanna Paronen
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
J Autoimmun 22:307-13. 2004..Interaction of genes and environment (antigenic epitope and viral mimic) can be important in the pathogenesis of immune mediated diabetes and activation of the innate immune system (e.g. Poly I:C) may be one key determinant... - Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouseEdwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B140, Denver, CO 80262, USA
J Autoimmun 21:213-9. 2003..9) in NOD mice confers long-term protection from diabetes and insulitis and profoundly blocks spontaneous and B:9-23 peptide-induced insulin autoantibodies... - Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetesDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Ann N Y Acad Sci 1029:331-3. 2004..The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin... - Type 1 diabetes: chronic progressive autoimmune diseaseLi Zhang
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible... - Differential immune induction with subcutaneous versus oral administration of a diabetogenic insulin peptide in the NOD mouseDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Ann N Y Acad Sci 1029:328-30. 2004..Given in oral form with multiple different vehicles, it did not alter expression of insulin autoantibodies in contrast to subcutaneous administration... - Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouseHiroaki Moriyama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 100:10376-81. 2003..These observations indicate that loss of either insulin gene can influence progression to diabetes of NOD mice and suggest that the preproinsulin 1 gene is crucial for the spontaneous development of NOD insulitis and diabetes... - Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23Edwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
J Clin Invest 110:1021-7. 2002..Thus, the insulin peptides B:9-23 and B:13-23, even when administered subcutaneously in the absence of adjuvant, can induce a dramatic humoral response leading to fatal anaphylaxis in NOD mice... - Deleting islet autoimmunityEdwin Liu
Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO, USA
Cell Biochem Biophys 48:177-82. 2007..In this article, we review current literature regarding insulin as an autoantigen and potential approaches to deleting insulin-reactive T cells through the use of peptide vaccines and targeted T cell receptor immunizations... - Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockoutJean M Jasinski
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, MS B140, Aurora, CO 80045 6511, USA
Diabetes 55:1978-84. 2006..scid mouse. The current study demonstrates that the BDC12-4.1 TCR is sufficient to cause diabetes at NOD backcross 1, bypassing polygenic inhibition of insulitis and diabetogenesis... - Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouseDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, P O Box 6511, Aurora, CO 80010, USA
Ann N Y Acad Sci 1079:135-7. 2006..We demonstrate insulin autoimmunity in the NZB mouse using the insulin peptide B:9-23 and viral mimics. The reason for the protection from diabetes despite the presence of autoimmunity is currently not established... - Animal models of insulin-dependent diabetesEdwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
Methods Mol Med 102:195-212. 2004..In summary, animal models have become necessary in the study of type 1 diabetes and provide researchers important tools to conduct studies that could not otherwise be performed in humans... - Establishing insulin 1 and insulin 2 knockout congenic strains on NOD genetic backgroundJohanna Paronen
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Ann N Y Acad Sci 1005:205-10. 2003..Here, we present the initial establishment of congenic knockouts and characterization of the congenic intervals corresponding to insulin 1 and insulin 2 knockout genes on mouse chromosome 19 and 7, respectively... - Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptideHiroaki Moriyama
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 99:5539-44. 2002..These first PolyIC/insulin-induced murine models should provide an important tool to study the pathogenesis of type 1 diabetes with experimental autoimmune diabetes... 
Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assaysNaru Babaya
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
Diabetes Metab Res Rev 25:665-70. 2009..Our standard micro-IAA assay (mIAA) utilizes precipitation with proteins A/G and 1-day incubation (1-day mIAA), but is less sensitive compared to the CIAA assay...- Need for quantitative assessment of transglutaminase autoantibodies for celiac disease in screening-identified childrenEdwin Liu
Davis Center for Childhood Diabetes, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
J Pediatr 146:494-9. 2005..Multicenter workshops are needed to identify critical differences and to standardize TGAA assays among laboratories... - Celiac disease for the allergist: who and how to screenEdward J Hoffenberg
Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado Denver Health Sciences Center, USA
Allergy Asthma Proc 28:20-4. 2007..Current understanding of the pathogenesis and epidemiology of celiac disease is reviewed. Issues of screening and genetic testing are discussed and current controversies and additional resources are highlighted... - Early and quantal (by litter) expression of insulin autoantibodies in the nonobese diabetic mice predict early diabetes onsetEvie Melanitou
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
J Immunol 173:6603-10. 2004..Pathological progression to autoimmunity is marked by the presence of immunological windows relating early steps with final disease onset... - Evaluation of a scoring system for assessing prognosis in pediatric acute liver failureBrandy R Lu
Department of Pediatrics, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
Clin Gastroenterol Hepatol 6:1140-5. 2008..The aims of this study were to test the predictive value of the LIU score in a subsequent validation set of patients and to derive a hospital admission LIU (aLIU) score predictive of outcome... - Induction of insulin autoantibodies and protection from diabetes with subcutaneous insulin B:9-23 peptide without adjuvantEdwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Ann N Y Acad Sci 958:224-7. 2002..We conclude that insulin B chain peptide B:9-23 can confer protection from diabetes in NOD mice even when administered subcutaneously without adjuvant... - Impact of celiac autoimmunity on children with type 1 diabetesJill H Simmons
Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado, USA
J Pediatr 150:461-6. 2007..Children with type 1 diabetes (T1DM) are at increased risk for celiac disease (CD); however, the benefits of screening for IgA tissue transglutaminase autoantibodies (TG), a marker for CD, are unclear... - Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypesAndrea K Steck
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
Diabetes 61:753-8. 2012..Non-HLA susceptibility alleles may help estimate risk for development of type 1 diabetes in the general population. These findings require replication in different populations... - Celiac disease associated with type 1 diabetes mellitusMarian Rewers
Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, 4200 East 9th Avenue, B-140, Denver, CO 80262, USA
Endocrinol Metab Clin North Am 33:197-214, xi. 2004 - Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetesGeorge S Eisenbarth
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, CO 80262, USA
Autoimmun Rev 1:139-45. 2002..An expanding set of resources are now available for the development and testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin peptides are now underway... - Antibodies to the wheat storage globulin Glo-3A in children before and at diagnosis of celiac diseaseCraig E Taplin
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, USA
J Pediatr Gastroenterol Nutr 52:21-5. 2011..Antibodies to wheat storage globulin Glo-3A have been studied in type 1 diabetes, and may be a marker of altered mucosal barrier and/or immune function. In the present study, we investigated antibody responses to Glo-3A in CD... - Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c miceEvie Melanitou
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, Colorado 80262, USA
Ann N Y Acad Sci 1005:187-91. 2003..We have therefore investigated whether absence of the T-bet gene influences diabetes-related phenotypes in Balb/c T-bet KO mice... - Heterophile antibodies masquerade as interferon-alpha in subjects with new-onset type 1 diabetesTheresa Aly
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Diabetes Care 27:1205-6. 2004 - Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assaysEdwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, Colorado, USA
Clin Immunol 125:120-6. 2007..g. studies of type 1A diabetes) is fostered by Societies sponsoring workshops where blinded samples are evaluated with "competing" assay formats for sensitivity, specificity, and reproducibility... - Genetic testing: who should do the testing and what is the role of genetic testing in the setting of celiac disease?Edwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Gastroenterology 128:S33-7. 2005.... - Type 1A diabetes mellitus-associated autoimmunityEdwin Liu
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, 4200 East 9th Ave, Denver, CO 80262, USA
Endocrinol Metab Clin North Am 31:391-410, vii-viii. 2002..This article reviews autoimmune disorders associated with type 1A diabetes mellitus... - Celiac disease: pathophysiology, clinical manifestations, and associated autoimmune conditionsJennifer M Barker
Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 N Ursula Street, PO Box 6511 A140, Aurora, CO 80045 6511, USA
Adv Pediatr 55:349-65. 2008..Practitioners can identify groups of subjects at high risk for celiac disease and perform screening with celiac disease-related antibodies... - Change you can B(cell)eive in: recent progress confirms a critical role for B cells in type 1 diabetesShannon K O'Neill
University of Colorado Denver and National Jewish Health, 1400 Jackson Street, Denver, Colorado 80206, USA
Curr Opin Endocrinol Diabetes Obes 16:293-8. 2009..Finally, we discuss the use of B cell-targeted therapies for treatment of autoimmunity... - Type 1 diabetes: recent developmentsDevasenan Devendra
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
BMJ 328:750-4. 2004 - Genetic testing for celiac diseaseEdwin Liu
Section of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital, Denver, CO, USA
MLO Med Lab Obs 38:10-3; quiz 14-5. 2006 - Characterization of acute liver failure and development of a continuous risk of death staging system in childrenEdwin Liu
Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Children's Hospital and University of Colorado Health Sciences Center, 1056 East 19th Avenue, Box B290, Denver, CO 80218-1088, USA
J Hepatol 44:134-41. 2006..Risk staging for ALF could potentially be used in clinical research for risk-adjusted outcomes analysis and to help stratify patients for clinical studies according to mortality risk... - Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic miceKeiko Fukushima
Department of Endocrinology and Metabolism, Unit of Translational Medicine, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan
Biochem Biophys Res Commun 367:719-24. 2008..These results indicate that poly I:C combined with B:9-23 peptide promotes infiltration of both pathogenic T cells and predominantly Tregs into the islets, thereby inhibiting progression from insulitis to overt diabetes in NOD mice... - Altered B:9-23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetesMasakazu Kobayashi
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
J Immunol 179:2082-8. 2007..The A16,19 altered peptide ligand, but not other native insulin peptides, suppresses insulin autoantibodies associated with protection from and remission of diabetes... - In vivo expression of B:9-23 peptide/I-A(g7) complex may abrogate the inhibition of diabetes induced by RGD-fiber-mutant adenovirus in NOD miceNorio Abiru
Unit of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University School of Medicine, Nagasaki, Japan
Ann N Y Acad Sci 1005:218-21. 2003.... - Peptide-specific amelioration of T cell-mediated pathogenesis in murine type 1 diabetesEdwin Liu
Clin Immunol 113:1-2. 2004
Research Grants
- Altering the pl of peptide vaccines to avoid anaphylaxisEdwin Liu; Fiscal Year: 2007..It is hypothesized that alteration of the pl of peptides may be a generalizable technique to prevent peptide-induced anaphylaxis while retaining immunomodulatory capacity. ..