Edwin Liu

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout
    Jean M Jasinski
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, MS B140, Aurora, CO 80045 6511, USA
    Diabetes 55:1978-84. 2006
  2. pmc Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, Colorado, USA
    Clin Immunol 125:120-6. 2007
  3. pmc Conserved T cell receptor alpha-chain induces insulin autoantibodies
    Masakazu Kobayashi
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 105:10090-4. 2008
  4. pmc Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nature 435:220-3. 2005
  5. pmc Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center UCHSC, Aurora, CO 80045 6511, USA
    J Clin Invest 117:1835-43. 2007
  6. pmc Murine high specificity/sensitivity competitive europium insulin autoantibody assay
    Naru Babaya
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado 80045 6511, USA
    Diabetes Technol Ther 11:227-33. 2009
  7. ncbi request reprint Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetes
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann N Y Acad Sci 1029:331-3. 2004
  8. ncbi request reprint Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouse
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B140, Denver, CO 80262, USA
    J Autoimmun 21:213-9. 2003
  9. ncbi request reprint Genetic differentiation of poly I:C from B:9-23 peptide induced experimental autoimmune diabetes
    Johanna Paronen
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
    J Autoimmun 22:307-13. 2004
  10. ncbi request reprint Deleting islet autoimmunity
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO, USA
    Cell Biochem Biophys 48:177-82. 2007

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout
    Jean M Jasinski
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, P O Box 6511, MS B140, Aurora, CO 80045 6511, USA
    Diabetes 55:1978-84. 2006
    ..scid mouse. The current study demonstrates that the BDC12-4.1 TCR is sufficient to cause diabetes at NOD backcross 1, bypassing polygenic inhibition of insulitis and diabetogenesis...
  2. pmc Accepting clocks that tell time poorly: fluid-phase versus standard ELISA autoantibody assays
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, Colorado, USA
    Clin Immunol 125:120-6. 2007
    ..g. studies of type 1A diabetes) is fostered by Societies sponsoring workshops where blinded samples are evaluated with "competing" assay formats for sensitivity, specificity, and reproducibility...
  3. pmc Conserved T cell receptor alpha-chain induces insulin autoantibodies
    Masakazu Kobayashi
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 105:10090-4. 2008
    ..We suggest that a major part of the mystery as to why islet autoimmunity develops relates to recognition of a primary insulin peptide by a conserved alpha chain T cell receptor...
  4. pmc Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Nature 435:220-3. 2005
    ....
  5. pmc Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity
    Maki Nakayama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center UCHSC, Aurora, CO 80045 6511, USA
    J Clin Invest 117:1835-43. 2007
    ..Our findings demonstrate dependence on B16 alanine versus tyrosine of insulin B:9-23 for both the initial priming and the effector phase of NOD anti-islet autoimmunity...
  6. pmc Murine high specificity/sensitivity competitive europium insulin autoantibody assay
    Naru Babaya
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Aurora, Colorado 80045 6511, USA
    Diabetes Technol Ther 11:227-33. 2009
    ..There is thus a need for simpler assay formats that do not utilize radioactivity, yet retain the high specificity and sensitivity of radioassays...
  7. ncbi request reprint Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for autoimmune diabetes
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann N Y Acad Sci 1029:331-3. 2004
    ..The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin...
  8. ncbi request reprint Nondepleting anti-CD4 monoclonal antibody prevents diabetes and blocks induction of insulin autoantibodies following insulin peptide B:9-23 immunization in the NOD mouse
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B140, Denver, CO 80262, USA
    J Autoimmun 21:213-9. 2003
    ..Furthermore, recent experience has demonstrated the potential dangers of disease exacerbation or anaphylaxis with peptide immunotherapy...
  9. ncbi request reprint Genetic differentiation of poly I:C from B:9-23 peptide induced experimental autoimmune diabetes
    Johanna Paronen
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box B140, Denver, CO 80262, USA
    J Autoimmun 22:307-13. 2004
    ..Interaction of genes and environment (antigenic epitope and viral mimic) can be important in the pathogenesis of immune mediated diabetes and activation of the innate immune system (e.g. Poly I:C) may be one key determinant...
  10. ncbi request reprint Deleting islet autoimmunity
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO, USA
    Cell Biochem Biophys 48:177-82. 2007
    ..In this article, we review current literature regarding insulin as an autoantigen and potential approaches to deleting insulin-reactive T cells through the use of peptide vaccines and targeted T cell receptor immunizations...
  11. ncbi request reprint Type 1 diabetes: chronic progressive autoimmune disease
    Li Zhang
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver Health Sciences Center, Aurora, CO 80010, USA
    Novartis Found Symp 292:85-94; discussion 94-8, 122-9, 202-3. 2008
    ..Given the ability to predict type 1A diabetes trials at all stages of the disorder to prevent beta cell destruction are now possible...
  12. ncbi request reprint Differential immune induction with subcutaneous versus oral administration of a diabetogenic insulin peptide in the NOD mouse
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Ann N Y Acad Sci 1029:328-30. 2004
    ..Given in oral form with multiple different vehicles, it did not alter expression of insulin autoantibodies in contrast to subcutaneous administration...
  13. ncbi request reprint Interferon-alpha as a mediator of polyinosinic:polycytidylic acid-induced type 1 diabetes
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, 4200 East 9th Ave, Box B140, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Diabetes 54:2549-56. 2005
    ....
  14. ncbi request reprint Pancreatic autoimmunity induction with insulin B:9-23 peptide and viral mimics in the NZB mouse
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, P O Box 6511, Aurora, CO 80010, USA
    Ann N Y Acad Sci 1079:135-7. 2006
    ..We demonstrate insulin autoimmunity in the NZB mouse using the insulin peptide B:9-23 and viral mimics. The reason for the protection from diabetes despite the presence of autoimmunity is currently not established...
  15. ncbi request reprint Animal models of insulin-dependent diabetes
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO, USA
    Methods Mol Med 102:195-212. 2004
    ..In summary, animal models have become necessary in the study of type 1 diabetes and provide researchers important tools to conduct studies that could not otherwise be performed in humans...
  16. ncbi request reprint Natural history of antibodies to deamidated gliadin peptides and transglutaminase in early childhood celiac disease
    Edwin Liu
    Section of Gastroenterology, Hepatology and Nutrition, The Children s Hospital, and Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, Denver, CO, USA
    J Pediatr Gastroenterol Nutr 45:293-300. 2007
    ..A new generation of anti-gliadin antibody assays has been developed to detect synthetic, deamidated homologous gliadin peptides (DGP) with high sensitivity and specificity...
  17. ncbi request reprint Preventing peptide-induced anaphylaxis: addition of C-terminal amino acids to produce a neutral isoelectric point
    Edwin Liu
    Section of Gastroenterology, Hepatology and Nutrition, The Children s Hospital, Denver, Colorado, USA
    J Allergy Clin Immunol 114:607-13. 2004
    ....
  18. pmc A report on the International Transglutaminase Autoantibody Workshop for Celiac Disease
    Marcella Li
    University of Colorado Denver, Anshultz Medical Campus, Aurora, CO 80010, USA
    Am J Gastroenterol 104:154-63. 2009
    ..The primary aim of this workshop is to compare TGAA assays among various research and clinical laboratories to examine assay concordance and improve (and eventually standardize) the TGAA assay...
  19. doi request reprint Comparison of insulin autoantibody: polyethylene glycol and micro-IAA 1-day and 7-day assays
    Naru Babaya
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
    Diabetes Metab Res Rev 25:665-70. 2009
    ..Our standard micro-IAA assay (mIAA) utilizes precipitation with proteins A/G and 1-day incubation (1-day mIAA), but is less sensitive compared to the CIAA assay...
  20. ncbi request reprint Establishing insulin 1 and insulin 2 knockout congenic strains on NOD genetic background
    Johanna Paronen
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Ann N Y Acad Sci 1005:205-10. 2003
    ..Here, we present the initial establishment of congenic knockouts and characterization of the congenic intervals corresponding to insulin 1 and insulin 2 knockout genes on mouse chromosome 19 and 7, respectively...
  21. ncbi request reprint Early and quantal (by litter) expression of insulin autoantibodies in the nonobese diabetic mice predict early diabetes onset
    Evie Melanitou
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 173:6603-10. 2004
    ..Pathological progression to autoimmunity is marked by the presence of immunological windows relating early steps with final disease onset...
  22. ncbi request reprint Celiac disease for the allergist: who and how to screen
    Edward J Hoffenberg
    Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Colorado Denver Health Sciences Center, USA
    Allergy Asthma Proc 28:20-4. 2007
    ..Current understanding of the pathogenesis and epidemiology of celiac disease is reviewed. Issues of screening and genetic testing are discussed and current controversies and additional resources are highlighted...
  23. pmc Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 110:1021-7. 2002
    ..Thus, the insulin peptides B:9-23 and B:13-23, even when administered subcutaneously in the absence of adjuvant, can induce a dramatic humoral response leading to fatal anaphylaxis in NOD mice...
  24. pmc Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse
    Hiroaki Moriyama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 100:10376-81. 2003
    ..These observations indicate that loss of either insulin gene can influence progression to diabetes of NOD mice and suggest that the preproinsulin 1 gene is crucial for the spontaneous development of NOD insulitis and diabetes...
  25. ncbi request reprint Insulin autoimmunity: prediction/precipitation/prevention type 1A diabetes
    George S Eisenbarth
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, B 140, Denver, CO 80262, USA
    Autoimmun Rev 1:139-45. 2002
    ..An expanding set of resources are now available for the development and testing in man of therapies to prevent type 1 diabetes, and a number of trials utilizing insulin peptides are now underway...
  26. ncbi request reprint Impact of celiac autoimmunity on children with type 1 diabetes
    Jill H Simmons
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado, USA
    J Pediatr 150:461-6. 2007
    ..Children with type 1 diabetes (T1DM) are at increased risk for celiac disease (CD); however, the benefits of screening for IgA tissue transglutaminase autoantibodies (TG), a marker for CD, are unclear...
  27. pmc Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 61:753-8. 2012
    ..Non-HLA susceptibility alleles may help estimate risk for development of type 1 diabetes in the general population. These findings require replication in different populations...
  28. pmc Antibodies to the wheat storage globulin Glo-3A in children before and at diagnosis of celiac disease
    Craig E Taplin
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, USA
    J Pediatr Gastroenterol Nutr 52:21-5. 2011
    ..Antibodies to wheat storage globulin Glo-3A have been studied in type 1 diabetes, and may be a marker of altered mucosal barrier and/or immune function. In the present study, we investigated antibody responses to Glo-3A in CD...
  29. pmc Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide
    Hiroaki Moriyama
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 99:5539-44. 2002
    ..These first PolyIC/insulin-induced murine models should provide an important tool to study the pathogenesis of type 1 diabetes with experimental autoimmune diabetes...
  30. ncbi request reprint Celiac disease associated with type 1 diabetes mellitus
    Marian Rewers
    Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, 4200 East 9th Avenue, B 140, Denver, CO 80262, USA
    Endocrinol Metab Clin North Am 33:197-214, xi. 2004
  31. ncbi request reprint Heterophile antibodies masquerade as interferon-alpha in subjects with new-onset type 1 diabetes
    Theresa Aly
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Diabetes Care 27:1205-6. 2004
  32. ncbi request reprint Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice
    Evie Melanitou
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    Ann N Y Acad Sci 1005:187-91. 2003
    ..We have therefore investigated whether absence of the T-bet gene influences diabetes-related phenotypes in Balb/c T-bet KO mice...
  33. pmc Celiac disease: pathophysiology, clinical manifestations, and associated autoimmune conditions
    Jennifer M Barker
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 N Ursula Street, PO Box 6511 A140, Aurora, CO 80045 6511, USA
    Adv Pediatr 55:349-65. 2008
    ..Practitioners can identify groups of subjects at high risk for celiac disease and perform screening with celiac disease-related antibodies...
  34. ncbi request reprint Genetic testing: who should do the testing and what is the role of genetic testing in the setting of celiac disease?
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Gastroenterology 128:S33-7. 2005
    ....
  35. ncbi request reprint Fluctuating transglutaminase autoantibodies are related to histologic features of celiac disease
    Edwin Liu
    Section of Pediatric Gastroenterology, Hepatology and Nutrition, Roche Molecular Systems, Alameda, CA, USA
    Clin Gastroenterol Hepatol 1:356-62. 2003
    ..We have followed a group of children with serial testing for TGAA...
  36. pmc Type 1 diabetes: recent developments
    Devasenan Devendra
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    BMJ 328:750-4. 2004
  37. ncbi request reprint Type 1A diabetes mellitus-associated autoimmunity
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Box B140, 4200 East 9th Ave, Denver, CO 80262, USA
    Endocrinol Metab Clin North Am 31:391-410, vii-viii. 2002
    ..This article reviews autoimmune disorders associated with type 1A diabetes mellitus...
  38. pmc Evaluation of a scoring system for assessing prognosis in pediatric acute liver failure
    Brandy R Lu
    Department of Pediatrics, The Children s Hospital, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Clin Gastroenterol Hepatol 6:1140-5. 2008
    ..The aims of this study were to test the predictive value of the LIU score in a subsequent validation set of patients and to derive a hospital admission LIU (aLIU) score predictive of outcome...
  39. ncbi request reprint Induction of insulin autoantibodies and protection from diabetes with subcutaneous insulin B:9-23 peptide without adjuvant
    Edwin Liu
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Ann N Y Acad Sci 958:224-7. 2002
    ..We conclude that insulin B chain peptide B:9-23 can confer protection from diabetes in NOD mice even when administered subcutaneously without adjuvant...
  40. doi request reprint Combined insulin B:9-23 self-peptide and polyinosinic-polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice
    Keiko Fukushima
    Department of Endocrinology and Metabolism, Unit of Translational Medicine, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan
    Biochem Biophys Res Commun 367:719-24. 2008
    ..These results indicate that poly I:C combined with B:9-23 peptide promotes infiltration of both pathogenic T cells and predominantly Tregs into the islets, thereby inhibiting progression from insulitis to overt diabetes in NOD mice...
  41. ncbi request reprint Need for quantitative assessment of transglutaminase autoantibodies for celiac disease in screening-identified children
    Edwin Liu
    Davis Center for Childhood Diabetes, School of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Pediatr 146:494-9. 2005
    ..To assess several transglutaminase autoantibody (TGAA) assays in their ability to distinguish celiac disease (CD) in screening-identified children with abnormal intestine biopsy specimens from those with normal biopsy specimens...
  42. ncbi request reprint In vivo expression of B:9-23 peptide/I-A(g7) complex may abrogate the inhibition of diabetes induced by RGD-fiber-mutant adenovirus in NOD mice
    Norio Abiru
    Unit of Metabolism Diabetes and Clinical Nutrition, Nagasaki University School of Medicine, Nagasaki, Japan
    Ann N Y Acad Sci 1005:218-21. 2003
    ....
  43. ncbi request reprint Altered B:9-23 insulin, when administered intranasally with cholera toxin adjuvant, suppresses the expression of insulin autoantibodies and prevents diabetes
    Masakazu Kobayashi
    First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    J Immunol 179:2082-8. 2007
    ..The A16,19 altered peptide ligand, but not other native insulin peptides, suppresses insulin autoantibodies associated with protection from and remission of diabetes...
  44. ncbi request reprint Genetic testing for celiac disease
    Edwin Liu
    Section of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital, Denver, CO, USA
    MLO Med Lab Obs 38:10-3; quiz 14-5. 2006
  45. ncbi request reprint Peptide-specific amelioration of T cell-mediated pathogenesis in murine type 1 diabetes
    Edwin Liu
    Clin Immunol 113:1-2. 2004