Danxia Liu

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. doi request reprint The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery
    Xiang Ling
    Department of Neurology, University of Texas Medical Branch, 301 University Blvd, RT, 0881, Galveston, TX 77555 0881, USA
    BMC Neurosci 14:146. 2013
  2. pmc Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone
    Danxia Liu
    Department of Neurology, University of Texas Medical Branch, 301 University Blvd, Rt 0881, Galveston, TX 77555 0881, USA
    BMC Neurosci 14:23. 2013
  3. ncbi request reprint Mutation of superoxide dismutase elevates reactive species: comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis
    D Liu
    Department of Neurology, University of Texas Medical Branch, 301 University Boulevard, Route 0881, Galveston, TX 77555 0881, USA
    Neuroscience 146:255-64. 2007
  4. ncbi request reprint Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin
    Danxia Liu
    Departments of Neurology, Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0881, USA
    J Neurotrauma 22:1123-33. 2005
  5. ncbi request reprint The time course of hydroxyl radical formation following spinal cord injury: the possible role of the iron-catalyzed Haber-Weiss reaction
    Danxia Liu
    Department of Neurology, University of Texas Medical Branch, Galveston, 77555 0653, USA
    J Neurotrauma 21:805-16. 2004
  6. ncbi request reprint Spinal cord injury increases iron levels: catalytic production of hydroxyl radicals
    Danxia Liu
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555 0653, USA
    Free Radic Biol Med 34:64-71. 2003
  7. ncbi request reprint Superoxide production after spinal injury detected by microperfusion of cytochrome c
    D Liu
    Department of Neurology, University of Texas Medical Branch, Galveston 77555 0653, USA
    Free Radic Biol Med 25:298-304. 1998
  8. ncbi request reprint Prostaglandin release by spinal cord injury mediates production of hydroxyl radical, malondialdehyde and cell death: a site of the neuroprotective action of methylprednisolone
    D Liu
    Departments of Neurology and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas, USA
    J Neurochem 77:1036-47. 2001
  9. ncbi request reprint The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein
    D Liu
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 0653, USA
    J Neurochem 75:2144-54. 2000
  10. ncbi request reprint Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction
    D Liu
    Department of Neurology, University of Texas Medical Branch, Galveston 77555 0653, USA
    Free Radic Biol Med 27:478-82. 1999

Collaborators

Detail Information

Publications16

  1. doi request reprint The temporal and spatial profiles of cell loss following experimental spinal cord injury: effect of antioxidant therapy on cell death and functional recovery
    Xiang Ling
    Department of Neurology, University of Texas Medical Branch, 301 University Blvd, RT, 0881, Galveston, TX 77555 0881, USA
    BMC Neurosci 14:146. 2013
    ....
  2. pmc Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: comparison with methylprednisolone
    Danxia Liu
    Department of Neurology, University of Texas Medical Branch, 301 University Blvd, Rt 0881, Galveston, TX 77555 0881, USA
    BMC Neurosci 14:23. 2013
    ..The efficiency of MnTBAP was also compared with that of methylprednisolone - the only drug used clinically in treating acute SCI...
  3. ncbi request reprint Mutation of superoxide dismutase elevates reactive species: comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis
    D Liu
    Department of Neurology, University of Texas Medical Branch, 301 University Boulevard, Route 0881, Galveston, TX 77555 0881, USA
    Neuroscience 146:255-64. 2007
    ..Our in vivo evidence correlates mutation of the SOD1 gene to increased nitric oxide, nitration and oxidation of proteins in ALS...
  4. ncbi request reprint Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: reduction by a metalloporphyrin
    Danxia Liu
    Departments of Neurology, Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0881, USA
    J Neurotrauma 22:1123-33. 2005
    ....
  5. ncbi request reprint The time course of hydroxyl radical formation following spinal cord injury: the possible role of the iron-catalyzed Haber-Weiss reaction
    Danxia Liu
    Department of Neurology, University of Texas Medical Branch, Galveston, 77555 0653, USA
    J Neurotrauma 21:805-16. 2004
    ..All together, we demonstrated that *OH is an endogenous secondary damaging agent following SCI and the metal-catalyzed Haber-Weiss reaction may contribute to early *OH formation after SCI...
  6. ncbi request reprint Spinal cord injury increases iron levels: catalytic production of hydroxyl radicals
    Danxia Liu
    Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555 0653, USA
    Free Radic Biol Med 34:64-71. 2003
    ..Our results support that iron-catalyzed (*)OH formation plays a role in the early stage of secondary SCI...
  7. ncbi request reprint Superoxide production after spinal injury detected by microperfusion of cytochrome c
    D Liu
    Department of Neurology, University of Texas Medical Branch, Galveston 77555 0653, USA
    Free Radic Biol Med 25:298-304. 1998
    ..The relatively long-lasting formation of superoxide reported herein suggests that removal of superoxide may be a realistic treatment strategy for reducing injury caused by free radicals...
  8. ncbi request reprint Prostaglandin release by spinal cord injury mediates production of hydroxyl radical, malondialdehyde and cell death: a site of the neuroprotective action of methylprednisolone
    D Liu
    Departments of Neurology and Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas, USA
    J Neurochem 77:1036-47. 2001
    ....
  9. ncbi request reprint The role of reactive nitrogen species in secondary spinal cord injury: formation of nitric oxide, peroxynitrite, and nitrated protein
    D Liu
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 0653, USA
    J Neurochem 75:2144-54. 2000
    ....
  10. ncbi request reprint Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction
    D Liu
    Department of Neurology, University of Texas Medical Branch, Galveston 77555 0653, USA
    Free Radic Biol Med 27:478-82. 1999
    ....
  11. ncbi request reprint The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids
    D Liu
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 0653, USA
    FASEB J 13:2318-28. 1999
    ..Liu, D., Wen, J., Liu, J., Li, L. The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids...
  12. ncbi request reprint Mn (III) tetrakis (4-benzoic acid) porphyrin protects against neuronal and glial oxidative stress and death after spinal cord injury
    Lokanatha Valluru
    Department of Neurology, University of Texas Medical Branch, 301 University Blvd, Rt 0881, Galveston, TX 77555 0881, USA
    CNS Neurol Disord Drug Targets 11:774-90. 2012
    ..Our results demonstrated that MnTBAP combats oxidative stress, thereby attenuating all types of cell death after SCI...
  13. ncbi request reprint Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin
    Feng Bao
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 0653, USA
    J Neurosci Res 71:220-7. 2003
    ..7 for DNP and 0.2 for Ntyr). These results further demonstrate peroxynitrite-induced protein oxidation and nitration and the efficiency of MnTBAP in scavenging peroxynitrite...
  14. ncbi request reprint Mn (III) tetrakis (4-benzoic acid) porphyrin administered into the intrathecal space reduces oxidative damage and neuron death after spinal cord injury: a comparison with methylprednisolone
    Jorge E Hachmeister
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 0881, USA
    J Neurotrauma 23:1766-78. 2006
    ....
  15. ncbi request reprint Temporal and spatial profiles of cell loss after spinal cord injury: Reduction by a metalloporphyrin
    Xiang Ling
    Department of Neurology, University of Texas Medical Branch, Galveston, Texas 77555 0881, USA
    J Neurosci Res 85:2175-85. 2007
    ..Our profiles provide a database for pharmacological intervention, and our results on MnTBAP treatment support an important role for antioxidant therapy in spinal cord injury...
  16. ncbi request reprint Stability, disposition, and penetration of catalytic antioxidants Mn-porphyrin and Mn-salen and of methylprednisolone in spinal cord injury
    Liqin Wu
    Department of Neurology, University of Texas Medical Branch, 301 University Blvd, Rt 0881, Galveston, TX 77555 0881, USA
    Cent Nerv Syst Agents Med Chem 12:122-30. 2012
    ..This finding supports further exploration of MnTBAP as a potential treatment for SCI...

Research Grants9

  1. OXIDATION OF MACROMOLECULES IN SPINAL CORD INJURY
    Danxia Liu; Fiscal Year: 2001
    ..This will directly test whether free radicals damage neurons by inducing oxidation of major cell components and will provide strategies for therapy. ..
  2. Neuroprotection by a metalloporphyrin in spinal injury
    Danxia Liu; Fiscal Year: 2007
    ..The immunohistochemical stained cells will be counted to determine the effect of MnTBAP on cell death. The therapeutic potential of MnTBAP will be assessed by behavioral tests. ..
  3. Neuroprotection by a metalloporphyrin in spinal injury
    Danxia Liu; Fiscal Year: 2009
    ..The immunohistochemical stained cells will be counted to determine the effect of MnTBAP on cell death. The therapeutic potential of MnTBAP will be assessed by behavioral tests. ..