Chang Liu

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi A genome-wide synthetic dosage lethality screen reveals multiple pathways that require the functioning of ubiquitin-binding proteins Rad23 and Dsk2
    Chang Liu
    Institute of Biotechnology, Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    BMC Biol 7:75. 2009
  2. ncbi Rad4 regulates protein turnover at a postubiquitylation step
    Yue Li
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Mol Biol Cell 21:177-85. 2010
  3. ncbi Ubiquitin chain elongation enzyme Ufd2 regulates a subset of Doa10 substrates
    Chang Liu
    Institute of Biotechnology, Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 285:10265-72. 2010
  4. ncbi Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase
    Chang Liu
    Institute of Biotechnology, Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 286:43660-7. 2011
  5. ncbi The Png1-Rad23 complex regulates glycoprotein turnover
    Ikjin Kim
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    J Cell Biol 172:211-9. 2006
  6. ncbi Proteasome inhibition in wild-type yeast Saccharomyces cerevisiae cells
    Chang Liu
    The University of Texas Health Science Center, San Antonio, TX 78245, USA
    Biotechniques 42:158, 160, 162. 2007
  7. ncbi Genome-wide approaches to systematically identify substrates of the ubiquitin-proteasome pathway
    Chang Liu
    Institute of Biotechnology, Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Trends Biotechnol 28:461-7. 2010

Collaborators

Detail Information

Publications7

  1. ncbi A genome-wide synthetic dosage lethality screen reveals multiple pathways that require the functioning of ubiquitin-binding proteins Rad23 and Dsk2
    Chang Liu
    Institute of Biotechnology, Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    BMC Biol 7:75. 2009
    ..Although many strategies have been developed for substrate isolation, the identification of physiological targets of proteolytic pathways has proven to be quite challenging...
  2. ncbi Rad4 regulates protein turnover at a postubiquitylation step
    Yue Li
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    Mol Biol Cell 21:177-85. 2010
    ..Our findings will help to unravel the detailed mechanisms underlying the roles of Rad23 and Rad4 in proteolysis and also the interplay between DNA repair and proteolysis...
  3. ncbi Ubiquitin chain elongation enzyme Ufd2 regulates a subset of Doa10 substrates
    Chang Liu
    Institute of Biotechnology, Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 285:10265-72. 2010
    ..Cells lacking UFD2 elicit an unfolded protein response, expanding the physiological function of Ufd2. Our results lead to novel insights into the biological role of Ufd2 and further underscore the significance of Ufd2 in proteolysis...
  4. ncbi Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase
    Chang Liu
    Institute of Biotechnology, Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 286:43660-7. 2011
    ..We demonstrate that Ufd2-mediated Mps1 degradation is conserved in humans. Our results underscore the significance of Ufd2 in proteolysis and further suggest that Ufd2-like enzymes regulate far more substrates than previously envisioned...
  5. ncbi The Png1-Rad23 complex regulates glycoprotein turnover
    Ikjin Kim
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
    J Cell Biol 172:211-9. 2006
    ..We propose that the substrate specificity of Rad23 and other Ub binding proteins is determined by their interactions with various cofactors involved in specific degradation pathways...
  6. ncbi Proteasome inhibition in wild-type yeast Saccharomyces cerevisiae cells
    Chang Liu
    The University of Texas Health Science Center, San Antonio, TX 78245, USA
    Biotechniques 42:158, 160, 162. 2007
  7. ncbi Genome-wide approaches to systematically identify substrates of the ubiquitin-proteasome pathway
    Chang Liu
    Institute of Biotechnology, Department of Molecular Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Trends Biotechnol 28:461-7. 2010
    ..Information that has emerged from these studies could reveal novel drug targets and strategies for treating human diseases...