Bin Liu

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. doi request reprint Complex II of the mitochondrial respiratory chain is the key mediator of divalent manganese-induced hydrogen peroxide production in microglia
    Yue Liu
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA
    Toxicol Sci 132:298-306. 2013
  2. pmc Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson's disease
    Bin Liu
    Department of Pharmacodynamics, College of Pharmacy, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    AAPS J 8:E606-21. 2006
  3. pmc Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: differential involvement of microglia and astroglia
    Ping Zhang
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA
    J Neurochem 112:434-43. 2010
  4. doi request reprint Organochlorine pesticides dieldrin and lindane induce cooperative toxicity in dopaminergic neurons: role of oxidative stress
    Heera Sharma
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA
    Neurotoxicology 31:215-22. 2010
  5. doi request reprint Involvement of dopaminergic neuronal cystatin C in neuronal injury-induced microglial activation and neurotoxicity
    Garima Dutta
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    J Neurochem 122:752-63. 2012
  6. pmc Microglia enhance manganese chloride-induced dopaminergic neurodegeneration: role of free radical generation
    Ping Zhang
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Exp Neurol 217:219-30. 2009
  7. ncbi request reprint Induction of microglial reactive oxygen species production by the organochlorinated pesticide dieldrin
    Haoyu Mao
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Brain Res 1186:267-74. 2007
  8. doi request reprint Synergistic microglial reactive oxygen species generation induced by pesticides lindane and dieldrin
    Haoyu Mao
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida, USA
    Neuroreport 19:1317-20. 2008
  9. pmc PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice
    Jennifer E Embury
    Department of Biochemistry and Molecular Biology, PO Box 100245, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Brain Res 1127:136-50. 2007
  10. pmc Development and evaluation of a high-throughput, low-cost genotyping platform based on oligonucleotide microarrays in rice
    Jeremy D Edwards
    University of Florida, Gulf Coast Research and Education Center, Wimauma FL, 33598, USA
    Plant Methods 4:13. 2008

Research Grants

Collaborators

Detail Information

Publications70

  1. doi request reprint Complex II of the mitochondrial respiratory chain is the key mediator of divalent manganese-induced hydrogen peroxide production in microglia
    Yue Liu
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA
    Toxicol Sci 132:298-306. 2013
    ..These findings advance our knowledge on the mechanisms by which Mn induces oxidative stress and the potential contribution to Mn neurotoxicity...
  2. pmc Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson's disease
    Bin Liu
    Department of Pharmacodynamics, College of Pharmacy, The McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    AAPS J 8:E606-21. 2006
    ..This review discusses literature supporting the possibility of modulating the activity of microglia as a neuroprotective strategy for the treatment of PD...
  3. pmc Synergistic dopaminergic neurotoxicity of manganese and lipopolysaccharide: differential involvement of microglia and astroglia
    Ping Zhang
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA
    J Neurochem 112:434-43. 2010
    ..Moreover, these findings not only shed light on the understanding of manganese neurotoxicity but may also bear relevance to the potentially multifactorial etiology of Parkinson's disease...
  4. doi request reprint Organochlorine pesticides dieldrin and lindane induce cooperative toxicity in dopaminergic neurons: role of oxidative stress
    Heera Sharma
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA
    Neurotoxicology 31:215-22. 2010
    ..These findings may advance understanding of the role of pesticides in the multi-factorial etiology of PD...
  5. doi request reprint Involvement of dopaminergic neuronal cystatin C in neuronal injury-induced microglial activation and neurotoxicity
    Garima Dutta
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    J Neurochem 122:752-63. 2012
    ..These findings from the rat DA neuron-microglia in vitro model may help guide continued investigation to define the precise role of cystatin C in the complex interplay among neurons and glia in the pathogenesis of Parkinson's disease...
  6. pmc Microglia enhance manganese chloride-induced dopaminergic neurodegeneration: role of free radical generation
    Ping Zhang
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Exp Neurol 217:219-30. 2009
    ..These results demonstrate that microglial activation and the production of reactive nitrogen and oxygen free radicals promote the MnCl(2)-induced DA neurodegeneration...
  7. ncbi request reprint Induction of microglial reactive oxygen species production by the organochlorinated pesticide dieldrin
    Haoyu Mao
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Brain Res 1186:267-74. 2007
    ..These findings provide important information on the potential role of microglia in dieldrin-induced neurodegeneration in relevance to the development of idiopathic PD...
  8. doi request reprint Synergistic microglial reactive oxygen species generation induced by pesticides lindane and dieldrin
    Haoyu Mao
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida, USA
    Neuroreport 19:1317-20. 2008
    ..As microglial ROS is a key contributor to the degeneration of the oxidative damage-vulnerable dopamine neurons, our findings shed significant light on the role of OCPs in the development of Parkinson's disease...
  9. pmc PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice
    Jennifer E Embury
    Department of Biochemistry and Molecular Biology, PO Box 100245, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Brain Res 1127:136-50. 2007
    ....
  10. pmc Development and evaluation of a high-throughput, low-cost genotyping platform based on oligonucleotide microarrays in rice
    Jeremy D Edwards
    University of Florida, Gulf Coast Research and Education Center, Wimauma FL, 33598, USA
    Plant Methods 4:13. 2008
    ..In contrast to methods employing whole-genome tiling microarrays for genotyping, our method is based on low-cost spotted microarray production, focusing only on known polymorphic features...
  11. pmc Manganese chloride stimulates rat microglia to release hydrogen peroxide
    Ping Zhang
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Toxicol Lett 173:88-100. 2007
    ..These findings may shed significant light on the potential role of microglia in the manganese-induced neurotoxicity...
  12. doi request reprint Stable isotope labeling with amino acids in cell culture-based proteomic analysis of ethanol-induced protein expression profiles in microglia
    Bin Liu
    Department of Pharmacodynamics, University of Florida, Gainesville, FL, USA
    Methods Mol Biol 829:551-65. 2012
    ....
  13. pmc The lipopolysaccharide Parkinson's disease animal model: mechanistic studies and drug discovery
    Garima Dutta
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
    Fundam Clin Pharmacol 22:453-64. 2008
    ..Furthermore, we will highlight the contribution of the LPS PD models to the mechanistic studies of PD pathogenesis and the search for neuroprotective agents for the treatment of PD...
  14. ncbi request reprint Effects of estrogen and related agents upon methamphetamine-induced neurotoxicity within an impaired nigrostriatal dopaminergic system of ovariectomized mice
    Bin Liu
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Neuroendocrinology 83:295-302. 2006
    ..This study may provide an understanding of the variations in results on the effects of estrogen upon the NSDA neurodegenerative disorder, Parkinson's disease...
  15. ncbi request reprint Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Glia 52:78-84. 2005
    ....
  16. ncbi request reprint Protective effect of the SOD/catalase mimetic MnTMPyP on inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuronal-glial cultures
    Tongguang Wang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Neuroimmunol 147:68-72. 2004
    ..These results indicate that MnTMPyP may potentially be used for the treatment of inflammation-related degenerative neurological disorders...
  17. ncbi request reprint Testosterone modulation of striatal dopamine output in orchidectomized mice
    Kamal Shemisa
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, Ohio 44272 0095, USA
    Synapse 60:347-53. 2006
    ..Such results have important implications with regard to understanding the sex differences that are present in nigrostriatal dopaminergic function within health and diseased states...
  18. ncbi request reprint 3-hydroxymorphinan is neurotrophic to dopaminergic neurons and is also neuroprotective against LPS-induced neurotoxicity
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, P O Box 12233, NC, USA
    FASEB J 19:395-7. 2005
    ..In view of the well-documented very low toxicity of DM and its analogs, this report may provide an important new direction for the development of therapeutic interventions for inflammation-related diseases such as PD...
  19. ncbi request reprint Effect of estrogen upon methamphetamine-induced neurotoxicity within the impaired nigrostriatal dopaminergic system
    Bin Liu
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Synapse 60:354-61. 2006
    ..These results demonstrate that the capacity for estrogen to protect or worsen MA-induced neurotoxicity of dopaminergic neurons is limited to female mice and depends on the condition of the NSDA system...
  20. ncbi request reprint Oestrogen and nigrostriatal dopaminergic neurodegeneration: animal models and clinical reports of Parkinson's disease
    Bin Liu
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Clin Exp Pharmacol Physiol 34:555-65. 2007
    ..5. Oestrogen was chosen as one of the 12 neuroprotective compounds to be attractive candidates for further clinical trials (Phase II or III) in 2003...
  21. ncbi request reprint Tamoxifen protects male mice nigrostriatal dopamine against methamphetamine-induced toxicity
    Mélanie Bourque
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, CHUL, Quebec City, Quebec G1V 4G2, Canada
    Biochem Pharmacol 74:1413-23. 2007
    ..Since this is the only known hormonal protection of male mice against methamphetamine toxicity, these findings provide important new information on specific parameters of nigrostriatal dopaminergic function preserved by tamoxifen...
  22. ncbi request reprint Bak Foong protects dopaminergic neurons against MPTP-induced neurotoxicity by its anti-apoptotic activity
    Bin Liu
    Epithelial Cell Biology Research Centre, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Cell Biol Int 32:86-92. 2008
    ..The present results suggest that BFP is able to protect dopaminergic neurons from neurotoxin-induced neuronal injury with anti-apoptotic activity being one of the possible mechanisms...
  23. ncbi request reprint Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 304:1-7. 2003
    ..In addition, we also discuss novel approaches to potential therapeutic strategies...
  24. doi request reprint Striatal 19S Rpt6 deficit is related to alpha-synuclein accumulation in MPTP-treated mice
    Bin Liu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xiannongtan Street, Xuanwu District, Beijing 100050, China
    Biochem Biophys Res Commun 376:277-82. 2008
    ..Taken together, our results imply that a deficiency in 19S Rpt6 may be partially related to the MPTP-induced increase in alpha-synuclein in the striatum...
  25. ncbi request reprint Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase
    Wei Zhang
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Science, Research Triangle Park, North Carolina, USA
    FASEB J 18:589-91. 2004
    ..More importantly, due to its proven safety record of long-term clinical use in humans, DM may be a promising agent for the treatment of degenerative neurological disorders such as PD...
  26. ncbi request reprint Andrographolide reduces inflammation-mediated dopaminergic neurodegeneration in mesencephalic neuron-glia cultures by inhibiting microglial activation
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 308:975-83. 2004
    ..In addition, these results indicate that ANDRO may have clinical utility for the treatment of inflammation-related neurodegenerative disorders such as Parkinson's disease...
  27. ncbi request reprint The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy
    Shannon D Barker
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Gene Med 5:300-10. 2003
    ..We hypothesize that selective adenovirus-mediated transgene expression could be achieved through the use of the secretory leukoprotease inhibitor (SLPI) promoter in the context of ovarian cancer...
  28. ncbi request reprint Neuroprotective effect of naloxone in inflammation-mediated dopaminergic neurodegeneration. Dissociation from the involvement of opioid receptors
    Bin Liu
    Neuropharmacology Section, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, NC, USA
    Methods Mol Med 79:43-54. 2003
  29. ncbi request reprint Novel anti-inflammatory therapy for Parkinson's disease
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, NC 27709, USA
    Trends Pharmacol Sci 24:395-401. 2003
    ....
  30. ncbi request reprint Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 17:1954-6. 2003
    ..This study also suggests that NADPH oxidase may be a promising target for therapeutic interventions in Parkinson's disease...
  31. ncbi request reprint Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 23:6181-7. 2003
    ..This study also suggested that microglial NADPH oxidase may be a promising target for PD treatment...
  32. ncbi request reprint Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    Hui Ming Gao
    Neuropharmacology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 22:782-90. 2002
    ..The results of this study should advance our understanding of the mechanism of action for pesticides in the pathogenesis of Parkinson's disease...
  33. ncbi request reprint Dextromethorphan protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation
    Yuxin Liu
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Pharmacol Exp Ther 305:212-8. 2003
    ..These results suggest that DM may be a promising therapeutic agent for the treatment of Parkinson's disease...
  34. ncbi request reprint A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model
    Akseli Hemminki
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Mol Ther 7:163-73. 2003
    ..Therefore, immunomodulation for increased oncolytic potency could be studied with clinical trials in this population. This could eventually translate into human trials...
  35. ncbi request reprint Synergistic dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Neurosci 23:1228-36. 2003
    ..Findings from this study may be highly relevant to the elucidation of the multifactorial etiology of PD and the discovery of effective therapeutic agents for the treatment of the disease...
  36. ncbi request reprint Microglia enhance beta-amyloid peptide-induced toxicity in cortical and mesencephalic neurons by producing reactive oxygen species
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    J Neurochem 83:973-83. 2002
    ..This study demonstrates that one of the mechanisms by which microglia can enhance the neurotoxicity of Abeta is via the production of reactive oxygen species...
  37. ncbi request reprint Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    FASEB J 17:1957-9. 2003
    ..This study lends strong support for a multifactorial etiology of PD and provides clues for therapeutic interventions...
  38. ncbi request reprint In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus
    Akseli Hemminki
    Division of Human Gene Therapy and Gene Therapy Center, Department of Medicine, University of Alabama at Birmingham, 35294 3300, USA
    J Natl Cancer Inst 94:741-9. 2002
    ..We used noninvasive imaging to investigate the in vivo antitumor efficacy of gene therapy using this adenovirus in an animal model of ovarian cancer...
  39. ncbi request reprint Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease
    Hui Ming Gao
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, North Carolina, USA
    J Neurochem 81:1285-97. 2002
    ....
  40. ncbi request reprint Role of nitric oxide in inflammation-mediated neurodegeneration
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27710, USA
    Ann N Y Acad Sci 962:318-31. 2002
    ..Among these agents, the opioid receptor antagonist naloxone, especially its non-opioid enantiomer (+)-naloxone, promises to be of potential therapeutic value for the treatment of inflammation-related diseases...
  41. ncbi request reprint p38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures
    Gwang Ho Jeohn
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, North Carolina 27709, USA
    Ann N Y Acad Sci 962:332-46. 2002
    ..The results suggest that p38 MAPK in glia plays a significant role in the LPS-induced death of mesencephalic neurons through induction of nitric oxide synthase and resulting NO production...
  42. ncbi request reprint NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 279:1415-21. 2004
    ....
  43. ncbi request reprint Inhibition by naloxone stereoisomers of beta-amyloid peptide (1-42)-induced superoxide production in microglia and degeneration of cortical and mesencephalic neurons
    Yuxin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    J Pharmacol Exp Ther 302:1212-9. 2002
    ..Combined with our previous observations with inflammagen-induced neurodegeneration, naloxone analogs, especially (+)-naloxone, may have potential therapeutic efficacy for the treatment of Alzheimer's and Parkinson's disease...
  44. ncbi request reprint In vitro neuronal differentiation of cultured human embryonic germ cells
    YuQiong Pan
    Department of Anatomy, Histology and Embryology, Peking University Health Science Center, 38 Xue Yuan Road, Beijing 100083, China
    Biochem Biophys Res Commun 327:548-56. 2005
    ..The data suggested that hEG cells may provide a potential source of cells for use in transplantation therapy for neurological degenerative diseases...
  45. ncbi request reprint Exploring cell type-specific internalizing antibodies for targeted delivery of siRNA
    Bin Liu
    Department of Anesthesia, University of California at San Francisco, CA 94110, USA
    Brief Funct Genomic Proteomic 6:112-9. 2007
    ..The demonstrated specificity of in vivo gene silencing and the lack of nonspecific immune activation and systemic toxicity encourage further development of therapies based on cell type-specific delivery of siRNA...
  46. ncbi request reprint [Differential role of estrogen in dopamine metabolism in the amygdala and striatum of female rats]
    Bin Liu
    Department of Physiology, Medical College of Qingdao University, Qingdao 266021
    Sheng Li Xue Bao 54:121-4. 2002
    ..The results obtained imply that serum concentration of estrogen is one of the important factors which affect the DA metabolism and content in the Amy of female rats, while the Str is not influenced by estrogen...
  47. ncbi request reprint Increased dopamine release in vivo by estradiol benzoate from the central amygdaloid nucleus of Parkinson's disease model rats
    Bin Liu
    Department of Physiology, Medical College of Qingdao University, Qingdao, China
    J Neurochem 90:654-8. 2004
    ..The well established neuroprotective effects of estrogen may be beneficial for reducing the dysfunction of dopaminergic neurons in mesolimbic structures of rat PD models and PD patients...
  48. ncbi request reprint Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression
    Akseli Hemminki
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Res 63:847-53. 2003
    ..Possible clinical application was tested using i.p. administration in an orthotopic ovarian cancer animal model. This approach could be useful for increasing adenoviral transgene expression in the context of clinical trials...
  49. pmc Phosphorylation state of tyrosine hydroxylase in the stalk-median eminence is decreased by progesterone in cycling female rats
    Bin Liu
    Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901 6523, USA
    Endocrinology 149:1462-9. 2008
    ....
  50. ncbi request reprint Primary rat mesencephalic neuron-glia, neuron-enriched, microglia-enriched, and astroglia-enriched cultures
    Bin Liu
    Neuropharmacology Section, National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, NC, USA
    Methods Mol Med 79:387-95. 2003
  51. doi request reprint Overexpression of ACE2 enhances plaque stability in a rabbit model of atherosclerosis
    Bo Dong
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, P R China
    Arterioscler Thromb Vasc Biol 28:1270-6. 2008
    ..The purpose of this study was to test the hypothesis that ACE2 overexpression may enhance atherosclerotic plaque stability by antagonizing ACE activity and converting angiotensin II to angiotensin 1-7...
  52. ncbi request reprint Activation of epidermal growth factor receptors in astrocytes: from development to neural injury
    Bin Liu
    Department of Ophthalmology, Northwestern University School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Neurosci Res 85:3523-9. 2007
    ..Regulation of EGFR function in astrocytes may be a new therapeutic strategy for the treatment of neural disorders...
  53. ncbi request reprint Ischemic preconditioning prevents in vivo hyperoxygenation in postischemic myocardium with preservation of mitochondrial oxygen consumption
    Xuehai Zhu
    Center for Biomedical Electron Paramagnetic Resonance Spectroscopy and Imaging, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, Ohio, USA
    Am J Physiol Heart Circ Physiol 293:H1442-50. 2007
    ..Thus IPC markedly attenuates postischemic myocardial hyperoxygenation with less ROS/RNS generation and preservation of mitochondrial O(2) metabolism because of conserved NADH-DH and CcO activities...
  54. ncbi request reprint Glaucomatous optic neuropathy: when glia misbehave
    Arthur H Neufeld
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuroscientist 9:485-95. 2003
    ..Pharmacological inhibition of the activity or the induction of inducible nitric oxide synthase may provide neuroprotection for the treatment of glaucoma...
  55. ncbi request reprint Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina 27709, USA
    J Neurochem 88:939-47. 2004
    ..These findings suggest a potential therapeutic intervention strategy for the treatment of inflammation-mediated neurodegenerative diseases...
  56. ncbi request reprint Transcriptional targeting of tumors with a novel tumor-specific survivin promoter
    Zeng B Zhu
    Division of Human Gene Therapy, Department of Medicine, Pathology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham AL 35291, USA
    Cancer Gene Ther 11:256-62. 2004
    ....
  57. pmc A novel replicating circular DNAzyme
    Fei Chen
    Key Lab for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun, 130023, P R China
    Nucleic Acids Res 32:2336-41. 2004
    ..This study thus provides a novel strategy to produce replicating DNAzymes which may find widespread applications...
  58. ncbi request reprint Neuroprotective effects of Bak Foong Pill in 1-methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)-induced Parkinson's disease model mice
    Bin Liu
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, P R China
    Biol Pharm Bull 27:1245-50. 2004
    ..These results suggest that BFP is able to protect dopaminergic neurons against MPTP-induced neuronal damage in a mechanism that is different from the protective effect of estrogen...
  59. ncbi request reprint Inter-patient variation in efficacy of five oncolytic adenovirus candidates for ovarian cancer therapy
    John T Lam
    Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Gene Med 6:1333-42. 2004
    ..We evaluated five CRAds as candidate clinical agents for ovarian cancer therapy: RGDCRADcox-2R, Ad5VEGFE1, Ad5/3VEGFE1, Ad5-Delta24RGD, and Ad5/3-Delta24...
  60. ncbi request reprint Effects of L-tetrahydropalmatine on the expressions of bcl-2 and bax in rat after acute global cerebral ischemia and reperfusion
    Bin Liu
    Department of Emergency, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 24:445-8. 2004
    ..L-THP could ameliorate cerebral ischemia and reperfusion damage by reducing the apoptosis through regulating bcl-2 and bax...
  61. ncbi request reprint MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration
    Tongguang Wang
    Neuropharmacology Section, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    FASEB J 19:1134-6. 2005
    ..Thus inhibition of microgliosis and COX-2 activity may stop this vicious circle and be valuable strategies in PD therapy...
  62. ncbi request reprint Characterization and neural differentiation of fetal lung mesenchymal stem cells
    Cun Gang Fan
    National Research Center for Stem Cell Engineering and Technology, State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People s Republic of China
    Cell Transplant 14:311-21. 2005
    ..Our data suggest that the fetal lung MSC population is an alternative source of stem cells for cell-based therapy of neurological defects or mesenchymal-originating diseases...
  63. ncbi request reprint Live attenuated Salmonella carrying platelet factor 4 cDNAs as radioprotectors
    Bin Liu
    State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, PR of China
    Radiat Res 166:352-9. 2006
    ..These data demonstrate a novel biological function of PF4 as a protector against radiation injury and suggest that attenuated Salmonella could be used in vivo as a PF4 DNA delivery vector in the management of radiation injury...
  64. ncbi request reprint Sex differences in methamphetamine-evoked striatal dopamine of mice are reversed by nomifensine
    Vidhya Kunnathur
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272 0095, United States
    Neurotoxicol Teratol 28:557-62. 2006
    ..In particular, the present findings have important implications in suggesting an alternative, non-traditional, mechanism for MA effects and indicate that such a function is limited to females...
  65. pmc Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1065-73. 2003
    ....
  66. ncbi request reprint Epidermal growth factor receptor in adult retinal neurons of rat, mouse, and human
    Huiyi Chen
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 500:299-310. 2007
    ..Our work localizes EGFR and its ligands in the adult retinas of several species as a step toward investigating the nonmitogenic functions of EGFR in adult neurons...
  67. ncbi request reprint PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4
    Taruna Arora
    Division of Hematology Oncology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
    J Biol Chem 278:21327-30. 2003
    ..Finally the inhibitory activity of PIASx on Stat4-mediated gene activation is abolished by the histone deacetylase inhibitor trichostatin A. Our results suggest that PIASx may function as a co-repressor of Stat4...
  68. ncbi request reprint Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells
    Na Li
    Department of Physiology, Medical College of Qingdao University, Qingdao 266071, PR China
    J Ethnopharmacol 111:458-63. 2007
    ..In addition, the inhibitory effect of ginsenoside Rg2 against the formation of Abeta1-40 suggests that ginsenoside Rg2 may also represent a potential treatment strategy for Alzheimer's disease...
  69. ncbi request reprint [The effects of somatostatin on serum interleukin-6 and tumor necrosis factor-alpha in lipopolysaccharide-induced septic shock: experiment with rats]
    Tuan jie Zhu
    Intensive Care Unit, Hunan Wangwang Hospital, Changsha 410016, China
    Zhonghua Yi Xue Za Zhi 87:345-7. 2007
    ..To explore the effect of somatostatin on serum interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in lipopolysaccharide (LPS)-induced septic shock...
  70. ncbi request reprint Inhibition of K562 leukemia angiogenesis and growth by expression of antisense vascular endothelial growth factor (VEGF) sequence
    Rui He
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, China
    Cancer Gene Ther 10:879-86. 2003
    ..These results suggest that the efficient downregulation of the VEGF production in leukemic cells using antisense-VEGF may constitute a novel strategy of treatment in leukemia...

Research Grants3